KR20200107809A - Vitamin complex formula coated with xylitol and or Enzymatically Modified Stevia - Google Patents

Abstract

The present invention relates to a complex vitamin microgranule formulation. More specifically, the present invention relates to a complex vitamin microgranule formulation comprising a coating made of a mixture of xylitol and/or enzyme-treated stevia surrounding a complex vitamin core. Especially, the formulation of the present invention relates to the complex vitamin microgranule formulation which has a technical feature of using xylitol and/or enzyme-treated stevia as a coating material surrounding the complex vitamin core containing vitamin C, but not using animal fat or butter.

Description

Compound vitamin granules coated with xylitol and/or enzyme-treated stevia {Vitamin complex formula coated with xylitol and or Enzymatically Modified Stevia}

The present invention relates to a multi-vitamin microgranule, and more particularly, to a multi-vitamin microgranule formulation comprising a coating made of a mixture of xylitol and or enzyme-treated stevia surrounding a vitamin complex core.

In particular, the formulation of the present invention is technically characterized in that xylitol and or enzyme-treated stevia are included in the coating material surrounding the complex vitamin core containing vitamin C (C), but animal fat or butter is not used. It is about complex vitamin fine granule formulation.

In the prior art, when a coating is formed on a core containing a water-soluble substance such as vitamin C or vitamin B with a water-soluble substance, it is difficult to stabilize the coating due to moisture present in the core, so in the prior art, a substance derived from butter or animal fat It was necessary to form a coating using a material containing.

However, the fat component or butter used as a coating material of the prior art has a problem in that the amount of cholesterol in the blood increases when taken for a long time, which can cause cardiovascular disease.

In the present invention, water-soluble vitamins such as vitamin C, vitamin B2, vitamin B6, and vitamin B12, vitamin D3 and folic acid, biotin, lactic acid bacteria, zinc oxide, hyaluronic acid, dry yeast, rice bran extract or turmeric extract Is added to form a core together with an excipient, and the thus prepared core is coated with a coating material containing a sweetener such as xylitol and or enzyme-treated stevia to prepare a fine granule form.

The present invention uses water-soluble polymeric materials used in the prior art, in that it does not use animal fat or butter at all, unlike the coating of the composite vitamin fine granule formulation according to the prior art to cover the complex vitamins described above. It is a technical feature that it does not.

Since animal fat or butter is used in the prior art for the covering material of the complex vitamin preparation that is to be taken for a long period of at least 6 months to 1 year, the multivitamin users inevitably take animal fat or butter for a long time at the same time.

These long-term use of animal fats or butters increases blood cholesterol in multivitamins and increases the risk of potential side effects such as cardiovascular disease.

In recent years, health hazards due to continuous consumption of butter, that is, continuous consumption of butter are pointed out as a major cause of various lifestyle diseases such as obesity and diabetes, and the need for a clothing supplement that can replace this is emerging.

Therefore, in the complex vitamin preparation of the present invention, the use of animal fats or butter as a covering material is completely excluded, and the use of sugar harmful to human health when taken for a long time is completely excluded, and the main ingredient is xylitol sweetener or enzyme-treated stevia. Use only the covering material to properly wrap the complex vitamin core.

The coating containing xylitol or enzyme-treated stevia used in the fine granule formulation of the present invention performs a function of blocking the sour taste peculiar to vitamin C (C) in the oral cavity, so it is easy to administer to the oral cavity.

In addition, the fine granule formulation of the present invention has the advantage of overcoming the problem of applying a strong acidic stimulus to the stomach wall while it takes a considerable time for the large vitamin (C) tablet to disintegrate in the stomach.

In addition, the complex vitamin fine granule formulation of the present invention has a positive effect exerted by xylitol or enzyme-treated stevia itself used as a coating material, but can also solve the problems of the prior art caused by long-term use of animal fats such as butter. .

In addition, xylitol or enzyme-treated stevia are substances originally used as sweeteners, but the present invention shows that they can be used for a new purpose that can be a coating material for water-soluble vitamins.

In addition, another advantage that xylitol or enzyme-treated stevia used as a coating material can act as a supplementary active ingredient of vitamins by working with sugars such as oligosaccharides, that is, shows unexpected new effects in the prior art.

Therefore, the complex vitamin fine granule formulation of the present invention overcomes the problems of the coating material of the prior art, while solving the gastrointestinal disorder problem caused by the large size of the vitamin tablet through fine granulation, and overcomes the two problems of the prior art at the same time. It is an advanced complex vitamin formulation technology.

In vivo, 3 mol of ATP is produced through anoxic glycolysis of 1 mol of glycogen, and 39 mol of ATP is produced by aerobic glycolysis. In the process of producing ATP, oxygen free radicals are generated, which change the composition of cell membranes or the actions of enzymes, thereby exerting oxidative stress on human tissues.

Antioxidants that remove free radicals and prevent tissue damage can be divided into enzyme-based antioxidants and non-enzymatic antioxidants, and non-enzymatic antioxidants include vitamin E, vitamin C, glutathione, and sullenium lipoic acid. Fat-soluble vitamin E is present in cell membrane lipids and prevents damage to cell membranes.

There are many antioxidant enzymes in the mitochondria where ATP is produced, and thus it plays a role of defense against free radicals generated in the ATP production process.

Vitamin C, ascorbic acid, is a water-soluble substance that performs an antioxidant function and has a strong antioxidant activity, which prevents oxidation in the human body by returning oxidized substances in the human body to a reduced form, and lowers cholesterol levels, resulting in hardening of the arteries. It prevents and lowers blood pressure.

The electron-providing function of vitamin C performs an antioxidant action that removes free radicals such as reactive oxygen species (ROS) and reactive nitrogen species (RNS). It prevents the initiation of lipid peroxidation such as low-density lipoprotein (LDL), so it is also involved in the saving action of vitamin E.

Vitamin C radicals have a relatively long half-life compared to other antioxidants, so they are evaluated as stable antioxidants.

Mammals and plants can use glucose to synthesize vitamin C by themselves. However, although all of the enzymes related to the synthesis of vitamin C exist in the human body, the enzyme that catalyzes the last step is denatured and does not function. Therefore, vitamin C is not produced in the human body, so vitamin C is a nutrient that must be consumed through food.

Vitamin C also acts as a coenzyme for enzymatic reactions in the human body, contributing to the synthesis of collagen, which is a major protein that composes connective tissue, and hydroxyproline and hydroxylysine are hydrated by proline and lysine. When (hydroxylysine) is formed, vitamin C plays a role in maintaining the iron content of hydroxylase in a reduced form, thereby protecting the collagen tissue.

Vitamin C deficiency in the human body causes scurvy. Vitamin C is a basic substance for the formation of collagen, so it is necessary for the growth and repair of tissues, and it is also an essential component for the treatment of fractures. Vitamin C strengthens the gums and improves adrenal function, and vitamin C improves the absorption of vegetable iron that is not bound to hemoglobin by converting iron into a reduced form in the small intestine.

However, since vitamin C is an acidic substance, it has a characteristic strong acidity, and acts as an acidic substance, causing damage to the stomach wall. Therefore, conventionally, in order to ingest a large amount of vitamin C at once, it was common to manufacture or refine it in a liquid form.

However, liquids are not only bulky and likely to be spoiled, but also have disadvantages in that storage and distribution are inconvenient, and tablets have disadvantages in that they are inferior in digestion and absorption, and are difficult to take without water.

Vitamin C tablets have a detrimental effect on the stomach wall, as vitamin C tablets, usually 500 mg or more, contact the lining of the gastrointestinal tract and exert a strong acidic attack on the lining of the stomach during the disintegration period. If you take 1000 mg of vitamin C tablets, the harmful effects on the stomach wall are even greater.

In the present invention, the multivitamin refers to a preparation made by uniformly combining water-soluble or fat-soluble vitamins in an appropriate ratio as needed, rather than including one type of vitamin in a single formulation.

The vitamins used in the complex vitamin granule formulation of the present invention do not select water-soluble fat-soluble vitamins such as vitamins A, B, C, D, E, K, etc., and all vitamins known in the art can be utilized.

Vitamin A acts as an antioxidant that strengthens the body's resistance and prevents cell oxidation. As a growth factor of epithelial cells, it protects the mucous membranes of the oral cavity, airways, stomach and intestines by promoting cell regeneration. It is also necessary for the production of rhodopsin, a photosensitive pigment that detects the light of an object.

Vitamin D accumulates calcium absorbed in the body in bones and teeth, and helps the thymus to produce immune cells. It helps reabsorption of calcium and phosphate in the kidneys, which is essential for bone calcification and reduces the risk of cancer. Vitamin D enters the body and is absorbed by adipose tissue, but the fat tissue does not release vitamin D easily, so the more obese patients, the more easily vitamin D deficiency comes.

Vitamin E plays a role in maintaining cell membranes. Vitamin E is an antioxidant that neutralizes free radicals and is effective in preventing and treating cancer. In addition, in the epidemiologic investigation of cardiovascular disease prevention, those with high vitamin E intake have a lower incidence of heart disease and a lower incidence of diabetes.

In addition, vitamin E helps reduce harmful LDL cholesterol levels, reduces the risk of cardiovascular disease, prevents cataracts, promotes wound healing, and reduces symptoms such as atopic dermatitis and arthritis.

Vitamin K is abundant in animal and plant foods, so it is difficult to find a deficiency in generally healthy people. An important function of vitamin K is the blood clotting reaction, and it is necessary for the biosynthesis of certain proteins found in plasma, bones and kidneys.

Vitamin B2, also called riboflavin, is a yellowish crystal. If you eat a diet low in vitamin B2 for about two months, you will see evidence of deficiency symptoms in your mouth and tongue. Since vitamin B2 has a limited absorption capacity and is excreted through urine at a rapid rate, toxicity to humans due to excessive intake of vitamin B2 is hardly observed.

Vitamin M, an essential nutrient for the synthesis of amino acids and nucleic acids, is a vitamin that binds with vitamin B12 to help develop growth and produce red blood cells, and promotes the secretion of noradrenaline. Vitamin M plays an important role in cell division and growth as it is involved as a coenzyme for enzymes involved in DNA replication.

Most of the vitamins except vitamin B12 can be chemically synthesized and manufactured in large quantities, so most complex vitamins are manufactured in large quantities using synthetic vitamins as raw materials.

Vitamin B12 used in the present invention is derived from animal foods, and unlike other vitamins, higher plants cannot synthesize vitamin B12, so they are hardly present in plant foods.

Vitamin B12, present in plant foods, is mainly derived from microorganisms, soil, and insects. Vitamin B12 is one of group B vitamins separated by an antipernicious anemia factor contained in the liver, and is a red water-soluble vitamin containing cobalt atoms.

Vitamin B12 is essential for the normal development of animals. In particular, it is involved in the production of blood cells, maturation of intestinal epithelial cells, synthesis of nucleic acids and proteins, and metabolism of fats and carbohydrates.

Health functional foods consumed for the purpose of supplementing vitamin B12, which are insufficient in daily meals, are involved in nucleic acid synthesis and hematopoietic action, and play an auxiliary role in the formation of red blood cells.

Vitamin B12 in food is released from proteins by the action of gastric acid and pepsin in the stomach, and then moves to the small intestine by binding with R-protein secreted from the salivary glands and gastric mucosa. The vitamin B12 complex is absorbed after binding to the vitamin B12 receptor present in the mucous membrane of the ileum, the tip of the small intestine.

Vitamin B12 used in the present invention is a water-soluble vitamin that participates in metabolism, and is involved in activating folic acid coenzyme. Folic acid provides the methyl group needed to activate vitamin B12 coenzyme.

Vitamin B12 is also involved in maintaining normal myelin sheaths, which wrap and protect nerve fibers. Therefore, proper intake of vitamin B12 is essential for normal blood production and nerve function.

Enzymes that require vitamin B12 coenzyme (coenzyme 5-deoxyadenosyl cobalamin) include methylmalonyl, CoA mutase, and methionine synthase. In addition, vitamin B12 coenzyme helps regeneration of folic acid coenzyme.

Vitamin B12 is partially reused by the enterohepatic circulation. People lacking intrinsic factors cannot reabsorb vitamin B12, which is secreted by bile. Muco protein secreted from the cells of the gastrointestinal mucosa is a factor necessary for absorption of vitamin B12 into the body.

Therefore, those who have decreased intrinsic factor due to gastric resection surgery, those who are not secreted, and those with vitamin B12 malabsorption disorders easily develop vitamin B12 deficiency.

When vitamin B12 is insufficient, DNA synthesis is not performed normally, as in folic acid deficiency, resulting in disorders in the development of red blood cells and megaloblastic anemia.

In other words, abnormally large red blood cells are formed because cells cannot divide in the bone marrow, and megaloblasts are abnormally accumulated in the bone marrow. Patients with vitamin B12 deficiency have neurological disorders and are accompanied by fatigue, paleness, shortness of breath, and decreased motor skills.

Vitamin B12 used in the present invention is a safe vitamin from toxicity caused by overdose. When you take a lot of vitamin B12 products, your body excretes unnecessary amounts in your urine. The absorption rate of dietary vitamin B12 is reported to be 9-65%, and when the recommended amount is set, the absorption rate is considered as 50%. The recommended intake of vitamin B12 for adults in Korea is 2.4㎍. Vitamin B12 contained in food is not easily destroyed by heat because it has chemically stable properties.

Enzymatically Modified Stevia Glucosyl Stevia used as the coating material of the present invention is an α-glucosyl stevioside showing properties recognized by acid and heat. It is prepared by purifying α-glucosyl stevioside and α-glucosylbaudioside A prepared by reacting α-Glucosyltransferase (α-glucosyl transferase) or the like to the stevia extract.

The main ingredient that gives off the sweet taste is α-glucosyl stevioside. Because the sweetness is about 100 to 200 times that of sugar, the sweetness performance is excellent. It is used in conjunction with sugars to further improve sweetness. It is traded at room temperature as an off-white powder, sometimes as a flake or liquid. It is very soluble in water and soluble in 50% alcohol.

Xylitol, which is used as the coating material of the present invention, is a natural sweetener extracted from plants, and has a sweet taste and sugar content similar to that of enzyme-treated stevia, and is a sweetener that has recently attracted attention as a substitute for enzyme-treated stevia in the food industry.

Xylitol acts as a sweetener almost similar to enzyme-treated stevia, but has a refreshing effect to cool the mouth, promotes saliva secretion, inhibits the formation of plaque and acid in the oral cavity, and inhibits the growth of caries bacteria, leading to the risk of tooth decay. It has the function of reducing.

In addition, since xylitol promotes insulin secretion, it does not mediate insulin action and enters cells and does not affect blood sugar, so it is used for medical purposes as a substitute for glucose for diabetic patients for energy supply.

Korean Patent Application No. 10-2015-0128157 discloses that the coating layer of vitamin C granules does not contain a conventional coating hydrophilic polymer is more effective for taste masking purposes. Hydrophilic polymers included in the coating composition of this prior art, for example, hydroxypropylmethylcellulose, polyvinylpyrrolidone, polyvinyl alcohol, vinylpyrrolidone-vinyl acetate copolymer, polyethylene glycol, etc. ) Contains 4% by weight or less of the total dry weight of the vitamin C granules. However, in the disclosure of this prior art, the features or effects of the present invention that the core containing water-soluble vitamins such as vitamin C can be stably wrapped with a coating containing xylitol or enzyme-treated stevia without using butter that is harmful to the body. It is not mentioned. International patent application PCT/EP2000/13385 (Korean Patent Application Publication No. 2002-0059668) discloses a particulate vitamin composition. In this prior art, a vitamin oil or derivative is gelled using a gelling agent of vegetable origin to prepare a particulate vitamin composition. In this prior art, the gelling agent is a substance that binds the components of the composition together and forms a coating or film around the resulting particles. As suitable gelling agents agarose, carrageenan, carrageenan-carrageenan mixture, natural or modified starch, natural or modified cellulose, xanthan gum, gum arabic, gum acacia, gum gellan and guar Although rubber is disclosed, it does not mention or suggest xylitol or enzyme-treated stevia, which are characteristic coating materials of the present invention. On the other hand, International Publication No. WO 2004/069135 of International Patent Application PCT/EP2004/050035 discloses a method for preparing a fine granule formulation for blocking the unpleasant taste of the core component. This prior art demonstrates the technical feature that both the core and the coating composition contain an active ingredient, and the coating polymer is a group comprising cellulosic polymers, acrylic polymers, and mixtures thereof. Especially among the cellulosic polymers, ethylcellulose, hydroxypropylcellulose (HPC) and hydroxypropylmethylcellulose (HPMC), or mixtures thereof, are described as being suitable. Therefore, the content of this prior art does not suggest or imply the technical feature of the present invention that the core containing a water-soluble substance such as vitamin C of the present invention can form a stable coating by using a hydrophilic water-soluble substance such as xylitol or enzyme-treated stevia. . Korean Patent Application Publication No. 10-2011-0057480 is a mixture of L-ascorbic acid and L-ascorbate, preferably L-ascorbic acid and L-ascorbate sodium in a weight ratio of 1:085-2 A vitamin tablet prepared by processing a mixture of L-ascorbic acid (vitamin C) obtained by direct hitting is disclosed. This prior art does not understand what advantages the fine granule formulation of the present invention has compared to the tablets manufactured by the direct compression method, and does not imply the advantages of the zyritol or enzyme-treated stevia coating of the present invention. Meanwhile, Korean Patent Registration No. 10-1074271 discloses an oral fast-use film that effectively conceals an unpleasant taste. This prior art relates to an oral fast-use film that dissolves quickly in the oral cavity, and more specifically, a stevioside-based sweetener and a high-sweetener are contained in a ratio of 1:3~3:1 (w/w). , It is about an oral fast-use film that effectively shields the unpleasant taste of the drug and improves the tail that can be quickly dissolved and eaten in the oral cavity without water. In such prior art, hydroxypropylmethylcellulose, low viscosity hydroxypropylmethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, carboxymethylcellulose, polyvinyl alcohol, polyacrylic acid, methyl methacrylate copolymer, carboxyvinyl polymer, A water-soluble separator such as polyethylene glycol is used as an essential component. Therefore, in this prior art, the technical feature of the present invention, that is, a fine granule formulation in which a vitamin complex core is coated by using a sweetener such as xylitol or enzyme-treated stevia is not used as a binder resin such as a water-soluble polymer material, or Can't imply.

In order to overcome the problems and limitations of the prior art as described above, the present invention is a complex vitamin microgranules containing a coating layer surrounding a core containing vitamin C (C), wherein the coating layer is xylitol and/or enzyme It is a basic object to provide a complex vitamin microgranule, characterized in that it contains treated stevia.

In particular, in the present invention, in the complex vitamin microgranules containing a coating layer surrounding a core containing vitamin seed (C), the coating layer contains xylitol and or enzyme-treated stevia, but contains a substance derived from fat or butter. It is an object of the present invention to provide a multi-vitamin fine granule, characterized in that it does not contain.

In addition, the present invention uses a hydrophilic polymer material such as hydroxypropylmethylcellulose, polyvinylpyrrolidone, polyvinyl alcohol, vinylpyrrolidone-vinyl acetate copolymer, and polyethylene glycol in the coating layer surrounding the vitamin C complex granule formulation. Instead, it is an object of the present invention to provide a complex vitamin granule formulation using a coating material containing xylitol, which is a sweetening agent, and or enzyme-treated stevia.

In the prior art, in order to avoid the problem that the coating becomes unstable when the coating is composed of a water-soluble material due to moisture remaining in the core containing water-soluble vitamins such as vitamin C, vitamin B, and folic acid as an active ingredient, a fat-soluble substance such as butter This containing coating material was used.

As described above, in the prior art, a fat-soluble substance such as butter is contained in the coating, and thus, a fat-soluble substance used for coating a multivitamin taker must also be taken together with vitamins for a long time.

In order to solve the problems of the prior art, the present invention does not use a fat-derived substance such as butter, and a material capable of stably coating a core containing a water-soluble substance capable of containing water even when a water-soluble sweetener is used. Came to develop.

Due to the development of the complex vitamin fine granule formulation of the present invention, it is possible to solve various health problems caused by long-term taking of the complex vitamin granules according to the prior art using a coating containing butter.

In the present invention, unlike the prior arts, by forming a coating layer with a coating material made of a mixture containing xylitol and or enzyme-treated stevia and not containing any butter component, long-term consumption of butter can be avoided. Its basic purpose is to overcome the problems of people.

In addition, in the prior art, hydrophilic polymers such as hydroxypropylmethylcellulose, polyvinylpyrrolidone, polyvinyl alcohol, vinylpyrrolidone-vinyl acetate copolymer, polyethylene glycol, and the like have been used in the coating layer of the vitamin C complex granule formulation.

However, the use of these hydrophilic polymers has a problem in that the dosage is very high, the manufacturing time is long, and the manufacturing cost is increased.

Therefore, in the present invention, the use of these is completely excluded, and a complex vitamin granule formulation is provided using a coating containing only xylitol, which is a sweetener, and enzyme-treated stevia.

In order to coat the core with the composition for coating the core according to the present invention, various methods commonly applied in the art may be used, for example, top spray, bottom spray, tangential method in which centrifugal force is added, and the like can be used.

For the lower part, preferably, a bottom spray fluid bed granulator may be used. Specific methods such as spray rate, temperature, and spray pressure using a bottom spray fluid bed granulator may be all conventional methods known in the art.

In the manufacturing method of the complex vitamin fine granule formulation of the present invention, first, a uniform diameter of 1 mm or less, preferably 0.5 mm or less, more preferably 0.3 mm or less, using various types of granules manufacturing apparatus according to the prior art. The complex vitamin core with the first is manufactured.

Granulators according to the prior art of various structures can be used to manufacture complex vitamin granules of this size range, and use of a fluid bed granulator is suitable. The weight ratio of the coating to the core of the vitamin C complex granule formulation is preferably 5 to 20% by weight, more preferably 7 to 15% by weight, and most preferably 10 to 12% by weight.

The diameter including the coating of the complex vitamin granules of the present invention is preferably 1 mm or less in uniform diameter, more preferably 0.5 mm or less in diameter including the coating.

Compared to the case of a complex vitamin using butter as a coating material of the prior art, the fine granules of the present invention generally have a smaller diameter.

If the weight ratio of the coating layer to the core of the vitamin C complex granule formulation is less than 5% by weight, it is difficult to sufficiently achieve the taste masking effect, and when it exceeds 20% by weight, the total volume of the granules becomes too large and the coating layer becomes too thick, which causes the taste to deteriorate. There is.

The carrier acceptable for the formulation of the present invention may include a carrier (or diluent) that does not impair the biological activity and properties of the vitamin component. Ordinary additives such as flavors, sweeteners, and natural carbohydrates may be further included.

The core fine powder process may be performed in a food preparation mixer or dryer capable of liquid spraying, such as a fluid bed granulation dryer, a granulator, a coater, and the like. The mixing may be performed by a conventional solid-phase mixing method, such as fluidization, stirring, or the like.

In the core fine powder mixing process, the powder may be used to mean an average particle size in the range of 10 to 700 μm, and the granules in the range of 30 to 1000 μm).

Both the enzyme-treated stevia and xylitol used in the manufacture of the coating material are supplied in powder or granular form. Enzyme-treated stevia is supplied with an average particle size of about 200 to about 800 µm, and xylitol is supplied with an average particle size of 300 to 800 µm.

In the liquid spray coating process, xylitol or enzyme-treated stevia contained in a solution used for coating the core fine particles by liquid spraying may be 1 to 250% by weight based on the total weight of the final coating composition.

In one embodiment, the content of xylitol or enzyme-treated stevia contained in the coating solution may range from 10 to 40% by weight based on the content of xylitol or the content of enzyme-treated stevia in the final coating composition.

In addition, when coating with enzyme-treated stevia, the enzyme-treated stevia included in the coating solution may range from 5 to 50% by weight based on the total content of the enzyme-treated stevia included in the final coating composition.

The coating solution used in the liquid spray coating process may be a solution obtained by dissolving the xylitol or enzyme-treated stevia in at least one solvent selected from the group consisting of an appropriate solvent, purified water, ethanol, and the like.

The coating solution may also be prepared to have a concentration suitable for spray coating, and the solid content may be 10 to 50% by weight.

The liquid spray coating process may be performed by spraying a coating solution including the residual amount of xylitol or the residual amount of enzyme-treated stevia onto the core powder particles. In one embodiment, the spray coating process includes a process of stabilizing the granules by spraying a coating solution containing xylitol or enzyme-treated stevia onto the core powder particles.

The spray coating process may be performed at 40 to 70°C, 45 to 65°C, or 50 to 60°C. When the temperature of the liquid spray coating process is low, the moisture increases and intergranular bonds may appear, so that the size of the coated particles may be larger than the desired size.

If the temperature of the spray coating process is too high, the coating liquid is sprayed and moisture is evaporated at the same time, and thus, there may be a problem that the contact with the mixture and the coating are not well formed.

In the method for preparing the coating composition of the present invention, the enzyme-treated stevia and xylitol are coated on the solid mixture by weighing one component of enzyme-treated stevia or xylitol, mixing some of the remaining components in a solid state, and forming the remaining amount into a solution. By mixing this, it is possible to prepare a coating composition in which the enzyme-treated stevia and xylitol are contained in a solid state (powder and/or granular form), and the composition ratio of the enzyme-treated stevia and xylitol is uniformly distributed.

According to the present invention, a complex vitamin core containing vitamin C is coated with a substance containing xylitol and or enzyme-treated stevia to shield the acidity of vitamin C, and by granulating the vitamin, acidic stimulation to the stomach wall caused by tablets is prevented. By dispersing and excluding the use of fat components in the coating, the problem of complex vitamin tablets according to the prior art was overcome.

The complex vitamin granule formulation provided by the present invention may result from long-term administration of complex vitamin formulation users, who require long-term administration, inevitably taking animal fats such as butter components for a long time due to the butter component used for coating the formulation according to the prior art. It has the effect of allowing you to avoid various possible side effects.

Hereinafter, exemplary embodiments of the present invention will be described in detail with reference to examples, etc. to aid in understanding the present invention. However, the embodiments according to the present invention may be modified in various other forms, and the legal protection scope of the present invention should not be construed as being limited to the following examples. Embodiments of the present invention are provided to more completely describe the present invention to those of ordinary skill in the art.

After forming the fine granules containing vitamin C, the fine granules were coated with a coating material containing xylitol and/or enzyme-treated stevia. In the manufacturing method of the complex vitamin fine granule formulation of the present invention, first, a uniform diameter of 1 mm or less, preferably 0.5 mm or less, more preferably 0.3 mm or less, using various types of granules manufacturing apparatus according to the prior art. A complex vitamin core was prepared first. A fluid bed bed granulator was used to prepare the granules. The weight ratio of the coating to the core of the vitamin C complex granule formulation was adjusted to 10 to 12% by weight.

The diameter including the coating of the complex vitamin granules of the present invention was adjusted to be 0.5 mm or less, so that the fine granules of the present invention generally have the advantage of having a smaller diameter than the case of the complex vitamin using butter as a coating material of the prior art. .

If the weight ratio of the coating layer to the core of the vitamin C complex granule formulation is less than 5% by weight, it is difficult to sufficiently achieve the taste masking effect, and when it exceeds 20% by weight, the total volume of the granules becomes too large and the coating layer becomes too thick, which causes the taste to deteriorate. There was. In the present invention, xylitol and steviaside are used simultaneously as a coating material that replaces the hydrophobic coating that blocks moisture by covering a lipophilic material such as butter, that is, a hydrophilic material, or one of the two is used alone if necessary.

The carrier acceptable for the formulation of the present invention may include a carrier (or diluent) that does not impair the biological activity and properties of the vitamin component. Ordinary additives such as flavoring, sweetener, and natural carbohydrate were added.

Both the enzyme-treated stevia and xylitol used in the manufacture of the coating material are supplied in powder or granular form. In the case of enzyme-treated stevia, an average particle size of about 200 to about 800 µm, and for xylitol, an average particle size of 300 to 800 µm was supplied.

In the liquid spray coating process, the amount of xylitol or enzyme-treated stevia contained in the solution used for coating the core fine particles by liquid spraying was 1 to 250% by weight based on the total weight of the final coating composition. In one embodiment, the amount of xylitol or enzyme-treated stevia contained in the coating solution is in the range of 10 to 40% by weight based on the content of xylitol or the content of enzyme-treated stevia in the final coating composition.

In addition, in the case of coating with enzyme-treated stevia, the enzyme-treated stevia included in the coating solution is in the range of 5 to 50% by weight based on the total content of the enzyme-treated stevia included in the final coating composition.

The coating solution used in the liquid spray coating process is a solution obtained by dissolving the xylitol or enzyme-treated stevia in at least one solvent selected from the group consisting of an appropriate solvent, purified water, ethanol, and the like.

The coating solution can also be prepared to have a concentration suitable for spray coating and the solid content is 10 to 50% by weight.

The liquid spray coating process may be performed by spraying a coating solution including the residual amount of xylitol or the residual amount of enzyme-treated stevia onto the core powder particles. In one embodiment, the spray coating process includes a process of stabilizing the granules by spraying a coating solution containing xylitol or enzyme-treated stevia onto the core powder particles.

In the method for preparing the coating composition of the present invention, an enzyme-treated stevia and xylitol are prepared by weighing any one component of enzyme-treated stevia or xylitol, mixing some of the remaining components in a solid phase, and forming the remaining amount into a solution and covering the solid mixture. By mixing this, it is possible to prepare a coating composition in which the enzyme-treated stevia and xylitol are contained in a solid state (powder and/or granular form), and the composition ratio of the enzyme-treated stevia and xylitol is uniformly distributed.

According to the present invention, a lactic acid bacteria complex vitamin fine granule formulation containing lactic acid bacteria in the active ingredient was prepared as follows.

No Raw material name Mixing ratio (%) Content(mg) One Lactic Acid Bacteria Mixture Powder 5.5000% 110.0000 2 Enterococcus lactobacilli 1.0000% 20.0000 3 Vitamin B12 0.0090% 0.1800 4 Vitamin C 50.0000% 1,000.0000 5 Vitamin D3 0.5380% 10.7600 6 Folic acid 0.0010% 0.0200 7 Zinc oxide 0.0400% 0.8000 8 Xylitol 34.4000% 688.0000 9 Enzyme treatment stevia 4.0000 80.0000 10 Silicon dioxide 1.8120% 36.2400 11 Fructooligosaccharide 0.5000% 10.0000 12 Indigestible maltodextrin 0.2000% 4.0000 13 Lemon flavor powder 2.0000% 40.0000 system 100% 2000mg

The lactic acid bacteria mixture powder used in the granule formulation of this example is a lactic acid bacteria mixture powder marketed by Ildong Pharmaceutical of Korea, and details are described in detail in Korean Patent Registration No. 10-1280232. The Enterococcus fungus powder complexed with the vitamin core used in the granule formulation of this example is Enterococcus pecium sold by Cell Biotech Co., Ltd. of Korea.

The xylitol used for the coating of the granule formulation of this example was a 300 product commercially available from ROQUETTE FRERES, France, and the enzyme-treated Stevia was used as a Ribaten Premium product supplied by Daepoong Co., Ltd. of Korea.

Vitamin C was used as a medicinal vitamin marketed by Hebei Welcome Pharmaceutical Co., Ltd of China, and vitamin B12 was used as a medicinal vitamin supplied by BASF of Germany. For vitamin D, products supplied by DSM Mutritional Products Ltd of Switzerland were used, and excipients, trace amounts of food coloring and flavoring ingredients were used as products that passed the standard produced through the process in accordance with the Korean government's food or pharmaceutical production regulations.

The multi-vitamin microgranules according to the present example were stable in coating after 36 months in room temperature indoors, and the strong acidity of vitamin C was not felt when administered orally due to the strong sweetening effect.

The main ingredients, auxiliary ingredients, and coating ingredients used in Example 1 were used, but the content of each ingredient was adjusted as follows to prepare a male 3000mg complex vitamin fine granule formulation according to the present invention.

No Raw material name Mixing ratio (%) Content(mg) One Vitamin C 66.6665% 1,999.9950 2 Vitamin D3 mixture powder 0.3600% 10.8000 3 Vitamin B6 Hydrochloride 0.2341% 7.0230 4 Dry yeast 0.5300% 15.9000 5 Zinc oxide 0.3920% 11.7600 6 Xylitol 24.0000% 720.0000 7 Enzyme treatment stevia 6.0000% 180.0000 8 Rice bran extract powder 1.7674% 53.0220 9 Citrus extract 0.0500% 1.5000 system 100% 3000mg

The main ingredients, auxiliary ingredients, and coating ingredients used in Example 1 were used, but the content of each ingredient was adjusted as follows to prepare a female 3000mg complex vitamin fine granule formulation according to the present invention.

No Raw material name Mixing ratio (%) Content(mg) One Vitamin C 66.6665% 1,999.9950 2 Vitamin D3 0.3600% 10.8000 3 Vitamin B12 1.6000% 48.0000 4 Folic acid 0.0058% 0.1740 5 Zinc oxide 0.1330% 3.9900 6 Hyaluronic acid 0.7000% 21.0000 7 Xylitol 23.2000% 696.0000 8 Enzyme treatment stevia 4.9500% 148.5000 9 Rice bran extract powder 2.3347% 70.0410 10 Citrus extract 0.0500% 1.5000 system 100% 3000mg

The main ingredients, auxiliary ingredients, and coating ingredients used in Example 1 were used, but the content of each ingredient was adjusted as follows to prepare a 2500 mg complex vitamin fine granule formulation according to the present invention.

No Raw material name Mixing ratio (%) Content(mg) One Vitamin C 38.4600% 961.4000 2 Sodium L-ascorbate 8.0000% 200.0000 3 Vitamin D3 0.5340% 13.3500 4 Xylitol 30.0000% 750.0000 5 Lemon Flavor Powder 4.5000% 112.5000 6 Orange flavor powder 1.0000% 25.0000 7 Vitamin B2 0.0100% 0.2500 8 Enzyme treatment stevia 0.3000% 7.5000 9 Silicon dioxide 1.0000% 25.0000 10 Sucralose 0.2000% 5.0000 11 Crystalline glucose 16.0000% 400.0000 system 100% 2500mg

The main ingredients, auxiliary ingredients, and coating ingredients used in Example 1 were used, but the content of each ingredient was adjusted as follows, thereby preparing a 3000mg complex vitamin microgranule formulation for students according to the present invention.

No Raw material name Mixing ratio (%) Content(mg) One Vitamin C 66.6665% 1,999.9950 2 Vitamin D3 mixture powder 0.3600% 10.8000 3 Vitamin B6 Hydrochloride 0.6410% 19.2300 4 Vitamin B2 0.1180% 3.5400 5 Biotin 0.0144% 0.4320 6 Zinc oxide 0.3920% 11.7600 7 Xylitol 24.0000% 720.0000 8 Enzyme treatment stevia 5.5000% 165.0000 9 Rice bran extract powder 1.8081% 54.2430 10 Turmeric extract powder 0.0500% 1.5000 system 100% 3000mg

The main ingredients, auxiliary ingredients, and coating ingredients used in Example 1 were used, but each content was adjusted to prepare a 2400mg complex vitamin fine granule formulation according to the present invention as follows.

No. Raw material name Mixing ratio (%) Content(mg) One Vitamin C 83.3400% 2,000.1600 2 Vitamin D3 0.4500% 10.8000 3 Xylitol (300, France) 13.2 100% 317.0400 4 Enzyme Treatment Stevia (Levaten Premium) 3.0000% 72.0000 system 100% 2400mg

The main ingredients, auxiliary ingredients and coating ingredients used in Example 1 were used, but each content was adjusted as follows to prepare a 2000 mg complex vitamin fine granule formulation according to the present invention in which only xylitol was added to the coating material as shown in Table 7 below. I did.

No Raw material name Mixing ratio (%) Content (mg) One Ascorbic acid 26% 520 2 Vitamin B2 0.1% 2.0 3 Vitamin B6 0.25% 5.0 4 Xylitol (300 France)
fine powder 8.65% 173 5 Lactose hydrate 10% 200 6 Per minute
(sucrose fine powder) 40% 800 7 D-mannitol 15% 300 system 100% 2000mg

The 1900mg complex vitamin fine granule formulation according to the present invention, which is added to the enzyme-treated stevia alone coating material, using the main ingredients, auxiliary ingredients, and coating ingredients used in Example 1, but adjusting each content as follows, as shown in Table 8 below. It was prepared together.

No Raw material name Mixing ratio (%) Content (mg) One Ascorbic acid 27.37% 520 2 Vitamin B2 0.1% 2.0 3 Vitamin B6 0.26% 5.0 4 Enzyme treatment stevia 3.84% 73 5 Lactose hydrate 10.53% 200 6 Per minute
(sucrose fine powder) 42.1% 800 7 D-mannitol 15.79% 300 system 100% 1900mg

Claims (21)

A complex vitamin fine granule comprising a coating layer surrounding a core containing vitamin C (C), wherein the coating layer comprises xylitol and enzyme-treated stevia, or any one of them. . In the complex vitamin microgranules containing a coating layer surrounding a core containing vitamin seeds (C), the coating layer contains xylitol and enzyme-treated stevia or any one of them, but does not contain animal fat or butter. It is characterized in that, complex vitamin fine granules. The complex vitamin microgranules according to claim 1 or 2, wherein the core further comprises lactic acid bacteria powder. The complex vitamin microgranules according to claim 1 or 2, wherein the core further comprises vitamin B12. The complex vitamin microgranules according to claim 4, wherein the core further comprises vitamin D3. The complex vitamin fine granules of claim 5, wherein the core further comprises folic acid. [7] The complex vitamin microgranules according to claim 6, wherein the core further comprises zinc oxide. [8] The complex vitamin microgranules according to claim 7, wherein the core further comprises dilutealuronic acid. [8] The complex vitamin microgranules of claim 7, wherein the core further comprises dry yeast. The complex vitamin microgranules according to claim 7, wherein the core further comprises vitamin B2. [8] The complex vitamin microgranules according to claim 7, wherein the core further comprises batamine B6. The complex vitamin microgranules of claim 7, wherein the core further comprises a rice bran extract or a turmeric extract. The complex vitamin microgranules according to claim 7, wherein the core further comprises biotin. The complex vitamin microgranules according to claim 7, wherein the core further comprises sucralose or refined crystalline glucose. The complex vitamin microgranules according to claim 7, wherein the core further comprises fructooligosaccharide or indigestible maltodextrin. The complex vitamin fine granules according to claim 7, wherein the coating further comprises a lemon flavor powder, a citrus extract, or an orange flavor powder. The complex vitamin fine granules according to claim 3, wherein the lactic acid bacteria are Enterococcus fesium. The complex vitamin fine granules according to claim 1 or 2, wherein the weight ratio of enzyme-treated stevia and xylitol of the coating is 50 to 50. The complex vitamin fine granules according to claim 1 or 2, wherein the ratio of the core weight to the coating weight is in the range of 0.1 to 10. The complex vitamin fine granules according to claim 1 or 2, wherein the coating layer is coated by a bottom spray method. The multi-vitamin micro-granules according to claim 20, characterized in that the coating layer of the multi-vitamin microgranules is formed using a bottom spray fluid bed granulator.