KR20110057480A - Vitamin tablet comprising vitamin c mixture - Google Patents

Abstract

PURPOSE: A vitamin tablet containing vitamin C mixture is provided to stably maintain active ingredients of vitamin and to ensure excellent preference. CONSTITUTION: A vitamin tablet is prepared by processing a mixture of L-ascorbic acid and L-ascorbate in a weight ratio of 1:0.85-2. The L-ascorbate is sodium L-ascorbate, L-ascorbyl stearate, calcium ascorbate, or ascorbyl palmitate. The L-ascorbate is sodium L-ascorbate. The mixture additionally contains one or more selected from juice powder, binder, lubricant, excipient, and perfume.

Description

Vitamin tablet comprising Vitamin C mixture

The present invention relates to a vitamin C supplement tablet comprising a mixture of L-ascorbic acid and L-ascorbic acid salt. More specifically, the present invention relates to L-ascorbic acid and L-ascorbic acid salt, more preferably L-ascorbic acid and L-ascorbic acid in which L-ascorbic acid is mixed in a weight ratio of 1: 0.85-2. The present invention relates to a vitamin tablet prepared by processing a mixture of corbic acid and L-ascorbic acid by a direct stroke method.

Vitamin C is an essential vitamin that cannot be synthesized in the body and must be consumed in the form of food. Food sources of vitamin C include fresh vegetables and fruits, and vitamin C has a property of being easily oxidized and destroyed by storage, cooking, and processing methods. In the general diet, the average loss by cooking has been reported to be about 30%, and the loss due to oxidation from metal ion is considered to be the largest. For this reason, vitamin C is taken as a vitamin C supplement in tablet form, not as a regular food, and it is recognized as an intake method for supplying vitamin C to modern people who are prone to lack of vitamin C.

Vitamin C is used as a coenzyme of various enzymatic reactions in vivo, and is involved in the synthesis of collagen, a major protein that makes up connective tissues such as skin, skeleton, blood vessels, cartilage, etc., and the electron donating function of vitamin C is reactive oxygen species. It has antioxidant activity to remove free radicals such as oxygen species (ROS) and reactive nitrogen species (RNS). Vitamin C also has the ability to promote the absorption of vegetable iron that is not bound to hemoglobin by converting iron to the reduced form in the small intestine.

The average requirement for vitamin C in men and women is 75 mg / day and the recommended intake is 100 mg / day. Intake of high doses of vitamin C of 500 mg or more per day is known to enhance immune system by promoting the production and motility of immune cells. Especially, as the body ages, the vitamin C concentration and immunity of the body decreases. It is said to be possible. It is also recommended that smokers, those who use oral contraceptives, and those with tissue damage such as burns or surgery take up vitamins.

Insufficient vitamin C may inhibit collagen synthesis in connective tissues, causing scurvy symptoms, such as swelling of the gums due to gum swelling, bleeding, or capillary weakness. In addition, as a light deficiency, chronic fatigue, nosebleeds, shortness of breath, digestive disorders, depression, and the like, but can be easily cured through sufficient intake of vitamin C, various forms of vitamin C supplements have been prepared and marketed.

However, a problem with vitamin C supplements is that some people may experience symptoms of the gastrointestinal tract. L-ascorbic acid, the main ingredient of vitamin C, has strong acidity when it is dissolved in water, so if it is ingested at once, it can cause acidic irritation such as heartburn in the stomach. Patients with gastritis or gastric ulcers, especially those with gastrointestinal wounds or weak mucous membranes, may be more sensitive to these stimuli. In addition, high-dose vitamin C intake is required, such as children with weak immunity and elderly people who cannot swallow tablets.However, if you have difficulty ingestion due to problems such as acidity and the method of ingesting L-ascorbic acid, chew in an effort to solve this problem. Vitamin tablets are sometimes produced.

Chewable tablets are prepared by conventional wet granulation methods. Generally, when excipients such as lactose, cellulose, starch, and inorganic salts are used as excipients for the tableting process, the excipients and the main components are mixed and, if necessary, aqueous solutions or pharmaceuticals such as insoluble carboxymethyl cellulose, ethyl cellulose, starch, gelatin, etc. Conventional wet granules manufacturing method using a production process of mixing together a binder dissolved in an organic solvent acceptable to the industry, wherein the mixtures, associations and granules mixed together are dried, further mixed with lubricants and then compressed into tablets. Excellent tableting granules can be obtained. However, vitamin C may cause instability due to heat, moisture, metal, etc., and thus, there is a problem in safety due to the modification of the active ingredient.

In order to solve the above problems of the prior art, the present invention provides a mixture of L-ascorbic acid and L-ascorbic acid salt, preferably L-ascorbic acid and L-ascorbic acid, in an optimal ratio. To provide a high concentration of vitamin C preparation for the purpose of vitamin C supplementation, the vitamin C preparation according to the present invention to reduce the acidic stimulation caused by L- ascorbic acid to improve gastrointestinal disorders, but also has a good texture and preference Do.

 Another object of the present invention is to prepare a tablet using a tableting method to compress the compressive strength, the active ingredient of the vitamin C formulation can be kept stable, has an appropriate mechanical strength and is easy to ingest or melt in oral It is to provide vitamin C tablets.

Another object of the invention is a vitamin C comprising a mixture of L-ascorbic acid and L-ascorbic acid salts, preferably L-ascorbic acid and sodium L-ascorbic acid, which have good binding power without the addition of a binder. To provide tablets.

In the present invention, L-ascorbic acid and L-ascorbic acid salt, preferably L-ascorbic acid and L-ascorbic acid in a weight ratio of 1: 0.85 to 2, more preferably 1: 0.9 to 1.2 To provide a vitamin tablet prepared by processing a mixture of L- ascorbic acid and L- ascorbic acid mixed in a weight ratio of by a direct stroke method.

Vitamin tablet according to the present invention may further comprise at least one selected from juice powders, binders, lubricants, excipients, and fragrances in addition to L- ascorbic acid and L-ascorbic acid, L-ascorbic acid By using a mixture of vinic acid and L-ascorbate, it is possible to prepare a vitamin tablet without adding a binder.

In a preferred embodiment of the present invention, the vitamin tablet is 40-70% by weight of a mixture of L-ascorbic acid and L-ascorbic acid salt, preferably L-ascorbic acid and sodium L-ascorbic acid, juice powder 5 ~ 20% by weight, 0.1-5% by weight of lubricant, and residual amounts of additives, for example, juice powders, binders, lubricants, excipients, fragrances are mixed and processed by direct application, and are chewed or dissolved without adding binder. Vitamin tablets with a hardness suitable for ingestion can be obtained.

The vitamin tablet according to the present invention contains 100 to 1,000 mg, preferably 500 to 1,000 mg of L-ascorbic acid, based on L-ascorbic acid per tablet, and has a hardness suitable for chewing or dissolving.

Vitamin C tablets comprising a mixture of L-ascorbic acid and L-ascorbic acid salt according to the present invention reduce the acidic gastrointestinal disorders of conventional high concentration vitamin C tablets, improve the texture and improve palatability It is a high-concentration vitamin C tablet having a hardness suitable for chewing or melting by improving the physical property problem of stability reduction of the active ingredient that occurs during the conventional wet or dry granulation process and improving mechanical properties.

The present invention can all be achieved by the following description. The following description is to be understood as describing preferred embodiments of the invention, but the invention is not necessarily limited thereto. Hereinafter, the present invention will be described in more detail.

In the present specification, 'tablet' is made by tableting a drug raw material mixture, is suitable for chewing or ingested by saliva in the oral cavity, the color, shape and the like is not particularly limited.

In the present specification, 'high concentration' vitamin C is a vitamin C per tablet of vitamin C at a concentration of 100 to 1,000 mg, preferably 500 to 1,000 mg, which can reach 100 mg / day or more, which is the recommended intake of vitamin C in adults and men. It means vitamin C tablets containing vitamin C.

At least one L-ascorbic acid selected from L-ascorbic acid and L-ascorbic acid, L-ascorbic acid stearate, L-ascorbic acid, and L-ascorbic acid palmitate as the main source of vitamin C Use a mixture of corbates. Most preferred L-ascorbate is sodium L-ascorbate. Sodium L-ascorbic acid is prepared by applying sodium hydrogen carbonate to L-ascorbic acid and is in the form of a sodium salt having an acidity of pH 6.5 to 8.0 and having a salty taste in an aqueous solution. Sodium L-ascorbate has a mild reducing effect, preventing the color change caused by oxidation.

In the preparation of high concentration vitamin C tablets, L-ascorbic acid has a problem of gastrointestinal disorders such as heartburn caused by acidic stimulation as described above, and L-ascorbin such as sodium L-ascorbic acid, which can replace the same. Acid salts have a problem that cannot be used at high concentrations because of their unique salty taste. Therefore, the vitamin tablet according to the present invention is used by mixing L-ascorbic acid and L-ascorbic acid in an ideal ratio to lower the acidity in the aqueous solution form to improve the texture of the sour taste, and improve the peculiar salt taste You can get it.

In the present invention, a tableting method for directly tableting a drug raw material mixture is used instead of a conventional wet or dry granule manufacturing method in preparing tablets. As described above, the conventional wet granule manufacturing method used in the preparation of vitamin C tablets has a problem in that the safety of vitamin C is lowered during tableting. Therefore, in the present invention, L-ascorbic acid having low compressive strength has excellent compressive strength. Ascorbate is mixed at an appropriate ratio and compressed by compressive strength. Vitamin C tablets tableted by the direct hit method is superior in mechanical strength and prepared to be chewed or melted compared to the case prepared by the wet or dry granule manufacturing method.

In a preferred embodiment of the present invention, L-ascorbic acid and L-ascorbic acid are mixed in a weight ratio of 1: 0.85 to 2, more preferably in a weight ratio of 1: 0.9 to 1.2, and L- ascorbic acid and L It is to provide a vitamin tablet produced by processing the mixture of ascorbate in a direct method. When the ratio of L-ascorbic acid to L-ascorbic acid is lower than 0.85, the acidity of the manufactured vitamin tablets is high, and when the ratio of ascorbate exceeds 2, the salt is strong and excessive components such as sodium are excessive. There is a problem that can be ingested and there is a problem that the overall preference of the tablet is lowered. In the present invention, the optimum mixing ratio of L-ascorbic acid and L-ascorbic acid was found in consideration of the degree of preference of vitamin tablets and the intake of other components such as sodium. Therefore, the vitamin tablet according to the present invention has excellent palatability and mechanical strength suitable for vitamin C in the form of tablets chewed while being tasted.

The vitamin tablet according to the present invention may further include at least one selected from juice powders, binders, lubricants, excipients, and fragrances in addition to the mixture of L-ascorbic acid and L-ascorbic acid.

The juice powder is not particularly limited, but may be a powder of orange, strawberry, grape, peach, apple, lemon, vanilla, mango, or the like, or a mixture thereof, and preferably, mango juice powder.

The binder is used to enhance the binding property of the raw material and give plasticity, and may be a sugar solution such as gum, glucose, sorbitol, or sugar alcohol syrup, crystalline cellulose, or a mixture thereof, preferably sorbitol, gum, or a mixture thereof. . Although it is common to use binders in the manufacture of tablets, in the present invention, due to the binding force between L-ascorbic acid and L-ascorbic acid salts, the binder is conventionally used even if a separate binder is used or in a minimum amount. Tablets with hardness similar to those used by content can be prepared.

Glidants can be used as edible or pharmaceutically acceptable ingredients commonly used in the manufacture of tablets, preferably magnesium stearate, polyethylene glycol, sodium lauryl sulfate, magnesium lauryl sulfate, sodium benzoate, polyoxyethylene mono Stearates, magnesium stearate, zinc stearate, calcium stearate, stearic acid, talc, hardened vegetable oils, hard liquid paraffin or mixtures thereof, preferably magnesium stearate, zinc stearate, calcium stearate, stearic acid more preferably magnesium stearate Can be.

In addition, additives such as excipients and fragrances may be added lactose, mannitol, calcium dihydrogen phosphate, and the like. As described above, the vitamin tablet according to the present invention can minimize the amount of additives such as excipients due to the binding force between L-ascorbic acid and L-ascorbic acid.

In another preferred embodiment of the invention, the vitamin tablet is 40-70% by weight of a mixture of L-ascorbic acid and sodium L-ascorbic acid, 5-20% by weight of juice powder, 0.1-5% by weight of lubricant, and the balance It is prepared by mixing the additives and processing by the direct stroke method.

Vitamin tablets according to the present invention has a hardness that is suitable for chewing or dissolving in the oral cavity, preferably hardness is 7 ~ 10 kp / cm ² . If the hardness of the tablet is less than 7 kp / cm ² The form of the tablet is not maintained, if it is larger than 10 kp / cm ^{2 It} is too hard to chew ingestion.

Hereinafter, the configuration and effects of the present invention will be described in more detail with reference to specific examples and comparative examples in order to help understanding of the present invention. However, the following examples are merely illustrative in order to more clearly understand the present invention, and the scope of the present invention is not limited by the following examples.

Example

Test Example 1 Preparation and Evaluation of Mixed Powder of L-Ascorbic Acid and L-Ascorbic Acid

In order to prepare a vitamin tablet sample, a mixed powder of L-ascorbic acid and sodium L-ascorbic acid was used as a main raw material. L-ascorbic acid powder (DSM Nutritional Products (UK) Ltd.) and L-ascorbic acid powder (DSM Nutritional Products (UK) Ltd.) each contain 99% and 97% vitamin C content. Samples 1 to 23 were prepared by uniformly mixing the mixture in the weight ratio of Table 1 below. The pH of the mixture of L-ascorbic acid and sodium L-ascorbic acid was measured using a pH meter (Denver Instrument Company, USA), and sensory evaluation of the mixed powder samples 1 to 23 was performed in the food related field for more than 5 years. It was conducted by five sensory test personnel with experience in sensory testing. In sensory evaluation, the taste of the blended powder was evaluated by dividing it into six indicators of 'very sour, sour, good, good, salty, salty and irritating metal', and the results are shown in Table 1.

TABLE 1

Sample L-ascorbic acid:
Sodium L-ascorbate Weight Ratio pH Sensory evaluation One 1: 0 2.76 Very sour 2 1: 0.01 2.83 Very sour 3 1: 0.1 3.07 Sour taste 4 1: 0.25 3.45 Sour taste 5 1: 0.5 3.75 Sour taste 6 1: 0.75 3.90 Sour taste 7 1: 0.8 3.98 Sour taste 8 1: 0.85 4.01 Great 9 1: 0.9 4.04 Great 10 1: 0.95 4.05 Great 11 1: 1 4.12 Great 12 1: 1.05 4.15 Great 13 1: 1.1 4.16 Great 14 1: 1.15 4.18 Great 15 1: 1.2 4.19 Great 16 1: 1.25 4.20 Good 17 1: 1.5 4.33 Good 18 1: 1.75 4.36 Good 19 1: 2 4.37 Good 20 1: 2.5 4.55 Salty taste 21 1: 3 4.68 Salty taste 22 1: 4 4.82 Salty taste 23 0: 1 7.20 Salty and irritating metal taste

Sensory effect is due to the offset of the acidity of L-ascorbic acid and the salty or salty and irritating metal taste of L-ascorbic acid in samples 8 to 23, which showed pH 4 or more to reduce gastric irritation caused by strong acidity. As a result of the evaluation, the compound powder judged to have a good to excellent taste was found to be samples 8 to 19 in which L-ascorbic acid and sodium L-ascorbic acid were 1: 0.85-2 by weight ratio.

When the weight ratio of L-ascorbic acid to L-ascorbic acid is more than 2, not only salty results but also an increase in sodium intake content are not preferable. Therefore, the weight ratio of L-ascorbic acid and sodium L-ascorbic acid, which minimizes the intake of unnecessary sodium in the vitamin C supplement formulation and has the desired pH and good sensory evaluation results in the present invention, was found to be 1: 0.85-2.

As a result of sensory evaluation of Test Example 1, when a vitamin C formulation was prepared using a mixture of L-ascorbic acid and sodium L-ascorbic acid, the irritating acidity of L-ascorbic acid and the irritating sodium L-ascorbic acid It was found to have better palatability than phosphorus salty. In addition, due to the nature of the taste and chewable vitamin tablets, it has excellent palatability in vitamin C formulations with a mixture of L-ascorbic acid and sodium L-ascorbic acid with low irritant taste. The overall preference of vitamin C formulations using vitamin C mixed powders also showed excellent palatability. The results indicate that in vitamin C supplementation, irritating sourness and salty to metallic taste have a significant effect on the preference of chewable swallowing tablets, and the use of vitamin C mixtures reduces the irritation of taste to increase overall preference. The result was shown.

Test Example 2: Comparison of texture according to vitamin C content

In this test example, a combination powder of L-ascorbic acid and sodium L-ascorbic acid (Example 1), L-ascorbic acid powder (Comparative Example 1), and L-ascorbic acid sodium powder (Comparative Example 2) The texture of the vitamin C content was compared.

An aqueous solution containing Sample 10 (L-ascorbic acid: L-sodium ascorbate = 1: 0.95) in a sample confirmed as 'excellent' by the sensory evaluation of Test Example 1 was prepared. The aqueous sample was prepared to contain up to 1,000 mg of vitamin C by increasing the vitamin C content by 100 mg starting from at least 100 mg of the vitamin C content (Example 1).

In Comparative Examples 1 and 2, instead of the blended powder of L-ascorbic acid and sodium ascorbate of Example 1, L-ascorbic acid and L-ascorbic acid sodium powder were used as the vitamin C content of 100 to 1,000, respectively. An aqueous solution containing mg of vitamin C was prepared.

As in Test Example 1, the pH of the aqueous solution prepared according to Example 1 and Comparative Examples 1 and 2 was measured, and sensory evaluation was performed and the results are shown in Table 2.

TABLE 2

Vitamin C Content (mg) Example 1
(Mixed powder of L-ascorbic acid and sodium ascorbic acid) Comparative Example 1
(L-ascorbic acid) Comparative Example 2
(L-Sodium Ascorbate) evaluation pH Sensory evaluation pH Sensory evaluation pH Sensory evaluation 100 4.18 Great 3.20 Good 7.71 Good 200 4.15 Great 3.00 Good 7.72 Good 300 4.11 Great 2.89 Good 7.82 Good 400 4.10 Great 2.80 Sour taste 7.74 Good 500 4.09 Great 2.74 Sour taste 7.74 Good 600 4.10 Great 2.69 Sour taste 7.77 Irritating metal taste 700 4.10 Great 2.65 Very sour 7.75 Irritating metal taste 800 4.10 Good 2.61 Very sour 7.77 Irritating metal taste 900 4.10 Good 2.58 Very sour 7.74 Salty and irritating metal taste 1000 4.10 Good 2.55 Very sour 7.71 Salty and provocative
Metallic taste

As shown in Table 2, when the vitamin C supplement formulation of 100 to 1,000 mg of vitamin C content was prepared using a combination powder of L-ascorbic acid and sodium L-ascorbic acid as in Example 1, the pH of the product was increased. Sensory evaluation resulted in good or excellent because it did not show excessive sour taste.

However, when the same amount of vitamin C with L-ascorbic acid is to be replenished as in Comparative Example 1, a decrease in pH appears, and various efforts such as use of additives for masking gastrointestinal irritation and strong acidity are required. In addition, when supplementing the same amount of vitamin C with sodium L-ascorbate, as shown in Comparative Example 2, the pH range was shown to be neutral, but at a vitamin C content of 600 mg or more, an irritating metal taste was observed. Unintended sodium intake can be a problem.

In the case of Example 1 according to the present invention, it has a characteristic that does not significantly affect the pH of the product in the entire range containing 100 to 1,000 mg of vitamin C, and tastes like a chewable vitamin C formulation because it shows a good texture It can be applied to a variety of flavored and ingested vitamin C products. In particular, formulated powders may be usefully used in the preparation of commercially available high dose vitamin C supplements of 500 mg or more.

Test Example 3: Preparation of 500 mg vitamin C-containing tablet

In this test example, a combination powder of L-ascorbic acid and sodium L-ascorbic acid (Example 2), L-ascorbic acid powder (Comparative Example 3), and L-ascorbic acid powder (Comparative Example 4) To prepare a tablet containing 500mg vitamin C as the main raw material.

In Example 2, a tablet containing 500 mg of vitamin C content using the blended powder of Sample 10 of Test Example 1 was prepared by a direct stroke method. 61% vitamin C mixed powder (sample 10) by weight, and 10% mango juice powder for flavor, sorbitol 14.7%, acacia gum 7%, crystalline cellulose 7% and magnesium stearate 0.3% by weight The former, model TS232A), was compressed to have a diameter of 14π, a thickness of about 2.8mm, and 880 mg per tablet. The vitamin tablet according to Example 2 can sufficiently supplement the desired 500 mg of vitamin C with one tablet intake by minimizing the amount of unnecessary excipients.

In Comparative Examples 3 and 4, vitamin tablets were prepared in the same manner as in Example 2 using only L-ascorbic acid and sodium L-ascorbic acid, respectively, as vitamin C main ingredients instead of the vitamin C mixed powder.

The mechanical hardness of the vitamin tablets prepared in Example 2 and Comparative Examples 3 and 4 was measured (hardness tester ERWEKA® D-63150, Germany) and sensory evaluation was performed. The sensory test was performed by five sensory test personnel who had five years or more sensory test experience in the food-related field, and the palatability test using the 5-point item scale.The palatability test was characterized by the degree of sourness, salty taste, and chewing characteristics. Characteristics) and overall acceptability, and the results are shown in Table 3.

[Table 3]

Mechanical hardness
(kp / cm ² ) Sour taste
pepper Salty
pepper Chewing characteristics Full symbol Example 2
(Vitamin C mixed powder) 8.79 3.55 2.55 4.05 4.00 Comparative Example 3
(L-ascorbic acid) 6.50 2.55 3.05 2.50 2.75 Comparative Example 4
(L-Sodium Ascorbate) 16.45 1.00 1.00 1.00 1.00

Test Example 4: Crystalline Cellulose Vitamin C tablets without the use of binders

This test example was conducted to see if it is possible to minimize the use of additives such as binders in the preparation of tablets of vitamin C mixed powder.

In Example 3, Comparative Examples 5 and 6 was prepared in the same manner as in Example 2, Comparative Examples 3 and 4 except that the crystal cellulose was not added when preparing the tablet. The mechanical hardness of the prepared vitamin tablets was measured (hardness tester ERWEKA® D-63150, Germany), and the results are shown in Table 4.

 [Table 4]

Mechanical hardness (kp / cm ² ) Example 3 (vitamin C mixed powder) 8.69 Comparative Example 5 (L-ascorbic acid) 5.94 Comparative Example 6 (L-Sodium Ascorbate) 12.88

As shown in Table 4, when L-ascorbic acid is used as the main raw material, the mechanical hardness of the tablet is weak (Comparative Example 5), and when L-ascorbic acid is used as the main raw material, the mechanical hardness becomes too strong (Comparative Example). 6) was found. On the other hand, the use of vitamin C mixed powder of L-ascorbic acid and sodium ascorbate showed higher mechanical hardness than vitamin C supplements containing L-ascorbic acid as the main ingredient. This may be due to the binding force of sodium L-ascorbate.

In addition, even if vitamin tablets were prepared without the crystalline cellulose used as the binder, the vitamin tablet of Example 2 using the binder was not significantly different in terms of mechanical hardness, it was shown that the vitamin tablet can be prepared without the addition of the binder.

Claims (6)

1: A vitamin tablet prepared by processing L-ascorbic acid and L-ascorbic acid mixed in a weight ratio of 0.85 to 2 by a direct stroke method, wherein the L-ascorbic acid salt is sodium L-ascorbic acid, L Vitamin tablets, which are at least one salt selected from ascorbic acid stearate, calcium ascorbic acid, and L-ascorbic acid palmitate. The method of claim 1, wherein the mixture is L- ascorbic acid and L- ascorbic acid vitamin tablets in a weight ratio of 1: 0.9 to 1.2. The vitamin tablet of claim 1, wherein the L-ascorbic acid salt is sodium L-ascorbic acid. The vitamin tablet according to claim 1, wherein the mixture further comprises one or more selected from juice powders, binders, lubricants, excipients, and fragrances. 1: 40 to 70% by weight of a mixture of L-ascorbic acid and L-ascorbic acid in a weight ratio of 0.85 to 2, juice powder 5 to 20% by weight, lubricant 0.1 to 5% by weight, and juice powder, A vitamin tablet prepared by processing one or more additives selected from excipients and fragrances by a direct method, wherein the L-ascorbate is selected from sodium L-ascorbate, L-ascorbic acid stearate, and L-ascorbic acid At least one salt selected from calcium, and L-ascorbic acid palmitate, wherein said vitamin tablet does not comprise a binder. The vitamin tablet according to any one of claims 1 to 5, wherein the vitamin tablet contains 100 to 1,000 mg of L-ascorbic acid based on L-ascorbic acid per tablet.