CN108323762A - A kind of selenium-rich composition and preparation, preparation method and application - Google Patents
A kind of selenium-rich composition and preparation, preparation method and application Download PDFInfo
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- CN108323762A CN108323762A CN201810104156.2A CN201810104156A CN108323762A CN 108323762 A CN108323762 A CN 108323762A CN 201810104156 A CN201810104156 A CN 201810104156A CN 108323762 A CN108323762 A CN 108323762A
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- rich
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- 239000011669 selenium Substances 0.000 title claims abstract description 122
- 239000000203 mixture Substances 0.000 title claims abstract description 74
- 229910052711 selenium Inorganic materials 0.000 title claims abstract description 60
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 title claims abstract description 59
- 238000002360 preparation method Methods 0.000 title claims abstract description 47
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 76
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims abstract description 40
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 37
- 229930003268 Vitamin C Natural products 0.000 claims abstract description 37
- 235000019154 vitamin C Nutrition 0.000 claims abstract description 37
- 239000011718 vitamin C Substances 0.000 claims abstract description 37
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims abstract description 34
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims abstract description 29
- 239000008101 lactose Substances 0.000 claims abstract description 28
- 229920000881 Modified starch Polymers 0.000 claims abstract description 27
- 235000019359 magnesium stearate Nutrition 0.000 claims abstract description 16
- 238000010521 absorption reaction Methods 0.000 claims abstract description 11
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 11
- 239000000839 emulsion Substances 0.000 claims description 23
- 239000000843 powder Substances 0.000 claims description 15
- 239000003826 tablet Substances 0.000 claims description 14
- 239000000463 material Substances 0.000 claims description 12
- 229920002472 Starch Polymers 0.000 claims description 9
- 238000000227 grinding Methods 0.000 claims description 9
- 239000008107 starch Substances 0.000 claims description 9
- 235000019698 starch Nutrition 0.000 claims description 9
- 235000013305 food Nutrition 0.000 claims description 8
- 239000002002 slurry Substances 0.000 claims description 8
- 239000002775 capsule Substances 0.000 claims description 7
- 235000013402 health food Nutrition 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 239000006187 pill Substances 0.000 claims description 6
- 239000003814 drug Substances 0.000 claims description 5
- 239000008187 granular material Substances 0.000 claims description 4
- 239000007901 soft capsule Substances 0.000 claims description 4
- 239000007864 aqueous solution Substances 0.000 claims description 3
- 239000002131 composite material Substances 0.000 claims description 3
- 235000005911 diet Nutrition 0.000 claims description 3
- 230000037213 diet Effects 0.000 claims description 3
- 239000004615 ingredient Substances 0.000 claims description 3
- 229920006395 saturated elastomer Polymers 0.000 claims description 3
- 238000005516 engineering process Methods 0.000 claims description 2
- 230000001804 emulsifying effect Effects 0.000 claims 1
- 238000002474 experimental method Methods 0.000 abstract description 8
- 239000003963 antioxidant agent Substances 0.000 abstract description 5
- 235000006708 antioxidants Nutrition 0.000 abstract description 5
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 abstract description 3
- 239000002211 L-ascorbic acid Substances 0.000 abstract 1
- 235000000069 L-ascorbic acid Nutrition 0.000 abstract 1
- 229960005070 ascorbic acid Drugs 0.000 abstract 1
- 239000000523 sample Substances 0.000 description 52
- 238000012360 testing method Methods 0.000 description 20
- 230000000694 effects Effects 0.000 description 15
- 238000005303 weighing Methods 0.000 description 9
- 239000008280 blood Substances 0.000 description 8
- 210000004369 blood Anatomy 0.000 description 8
- 238000000034 method Methods 0.000 description 6
- 238000002156 mixing Methods 0.000 description 6
- 238000007254 oxidation reaction Methods 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- 230000003647 oxidation Effects 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 239000002994 raw material Substances 0.000 description 5
- 210000002966 serum Anatomy 0.000 description 5
- 230000036541 health Effects 0.000 description 4
- 210000004185 liver Anatomy 0.000 description 4
- 230000033001 locomotion Effects 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 241000700159 Rattus Species 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 238000003304 gavage Methods 0.000 description 3
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 3
- 235000015097 nutrients Nutrition 0.000 description 3
- 150000003254 radicals Chemical class 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- 206010057190 Respiratory tract infections Diseases 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000004945 emulsification Methods 0.000 description 2
- 235000019441 ethanol Nutrition 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 235000001497 healthy food Nutrition 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 238000004321 preservation Methods 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 239000012047 saturated solution Substances 0.000 description 2
- 239000011122 softwood Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000013112 stability test Methods 0.000 description 2
- DCXXMTOCNZCJGO-UHFFFAOYSA-N tristearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 150000003722 vitamin derivatives Chemical class 0.000 description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 1
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 244000249214 Chlorella pyrenoidosa Species 0.000 description 1
- 235000007091 Chlorella pyrenoidosa Nutrition 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 108010024636 Glutathione Proteins 0.000 description 1
- 108010068370 Glutens Proteins 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 238000012449 Kunming mouse Methods 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 206010047623 Vitamin C deficiency Diseases 0.000 description 1
- 229930003316 Vitamin D Natural products 0.000 description 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 239000005862 Whey Substances 0.000 description 1
- 102000007544 Whey Proteins Human genes 0.000 description 1
- 108010046377 Whey Proteins Proteins 0.000 description 1
- CANRESZKMUPMAE-UHFFFAOYSA-L Zinc lactate Chemical compound [Zn+2].CC(O)C([O-])=O.CC(O)C([O-])=O CANRESZKMUPMAE-UHFFFAOYSA-L 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- 239000012267 brine Substances 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 239000002826 coolant Substances 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 229960000913 crospovidone Drugs 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- 238000013524 data verification Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 229960003180 glutathione Drugs 0.000 description 1
- 235000021312 gluten Nutrition 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 239000008172 hydrogenated vegetable oil Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 239000006101 laboratory sample Substances 0.000 description 1
- 229960001375 lactose Drugs 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 238000007726 management method Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 230000004792 oxidative damage Effects 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 description 1
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 description 1
- 239000006041 probiotic Substances 0.000 description 1
- 235000018291 probiotics Nutrition 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 210000001533 respiratory mucosa Anatomy 0.000 description 1
- 238000010079 rubber tapping Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 208000010233 scurvy Diseases 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 239000007962 solid dispersion Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 229940032147 starch Drugs 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
- 229940050168 zinc lactate Drugs 0.000 description 1
- 239000011576 zinc lactate Substances 0.000 description 1
- 235000000193 zinc lactate Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/14—Yeasts or derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/064—Saccharomycetales, e.g. baker's yeast
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nutrition Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Inorganic Chemistry (AREA)
- Microbiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The invention discloses the selenium-rich compositions and preparation of a kind of stability and high efficiency.More particularly to the preparation method and application of Se-enriched yeast, vitamin C, lactose, pregelatinized starch, magnesium stearate compatible composition and its preparation.The composition is with the Se-enriched yeast of 16~71.45 parts of parts by weight, the vitamin C that 61~252.5 parts of parts by weight, the lactose that 61~146 parts of parts by weight, the pregelatinized starch that 115~274 parts of parts by weight, the magnesium stearate composition that 1~3 part of parts by weight.Wherein, Se-enriched yeast Se content (in terms of Se) is between 0.07%~0.2%；Vitamin C content (in terms of L ascorbic acid) >=99%.Experiments have shown that：Composition provided by the present invention each component before stability, absorption rate, anti-oxidant etc. are significantly better than combination.
Description
Technical field
The present invention relates to a kind of selenium-rich composition and preparation significantly improving stability, absorption rate, antioxidant activity,
More particularly to a kind of selenium-rich preparation of Se-enriched yeast, vitamin C, lactose, pregelatinized starch, magnesium stearate compatibility.
Technical background
Human body is because of factors such as the continuous contacts with the external world, including breathing (oxidation reaction), outside contamination, radioactive ray irradiation
Constantly generated free radicals in body.Studies have shown that cancer, aging or Other diseases mostly with the generation of excessive free radicals
It is related, it is anti-oxidant the most important functionality of one of main R＆D direction and market is classified as by health products, Management of Cosmetics Enterprises to tell
One of ask.
Nutrient prime replenisher raw material under Se-enriched yeast system healthy food material catalogue (one).Selenium is necessary to humans and animals
Trace element, closely related with the health of the mankind, selenium being capable of anti-oxidant, anti-aging；Se-enriched yeast is by biological concentration work
Skill makes inorganic selenium be enriched in yeast cells, it is made to exist in the form of Organic Selenium, has absorption rate compared with inorganic selenium
Feature high, toxicity is low.
Vitamin C (also known as L-AA) is the nutrient prime replenisher raw material under healthy food material catalogue (one).Most
It is well-known to be a lack of vitamin C and cause scurvy.In vivo, vitamin C is a kind of antioxidant, protects body
From the threat of free radical, physiological activity and the function such as supplement full diet vitamin insufficiency of intake.
Lactose system health food puts product on record can be with auxiliary material and its using available auxiliary material of regulation in regulation (tentative), by ox
It extracts and is made in whey, it is very extensive in foreign applications, it is linked by a molecule glucose and a molecule galactolipin, is to promote
Human intelligence development, the important substance that energy is provided, gastrointestinal tract probiotics balance is adjusted, minerals (calcium, selenium) is promoted to absorb.
Composition (the patent application publication number of oxidation resistance in a kind of raising human motion：201510665092.X) public
A kind of composition improving oxidation resistance in human motion is opened.The composition includes the raw material of following parts by weight：N- acetyl
0.5~8 part of base cysteine, 10~150 parts of A Sayi fruits, 1~20 part of malic acid, 5~50 parts of vitamin C, Se-enriched yeast
1.5~15 parts, 5~50 parts of vitamin E, 10~100 parts of gadol extract, 20~150 parts of oligomeric maltose, excipient is
The one or more of superfine silica gel powder, microcrystalline cellulose, crospovidone, lactose, starch, sodium carboxymethylcellulose, magnesium stearate.
Although the invention is mentioned through synergistic effect, significantly improve the oxidation resistant ability of body tissue during human motion, subtract
Oxidative damage caused by few movement, but there are many substance of its effect, can not know the substance and mechanism of its collaboration.
Health food (the patent application publication number of rate of respiratory infection after a kind of reduction strenuous exercise：
201510653921.2) disclose it is a kind of reduction strenuous exercise after rate of respiratory infection health food.The health food packet
Include the raw material of following parts by weight：20~90 parts of broken wall chlorella pyrenoidosa powder, 9~77 parts of wheat gluten, vitamin A 0.0024
~0.0075 part, 0.01~0.03 part of vitamin B2,0.3~2.0 part of vitamin C, vitamin D 0.000002~0.00001
Part, 0.2~0.8 part of zinc lactate, 0.3~0.87 part of Se-enriched yeast, excipient is lactose, and lubricant is magnesium stearate.The invention
Health food can play the resistance of enhancing respiratory mucosa, delay fatigue, the effect for promoting physical function to restore, with this hair
Bright application is far from each other.
Composition of the present invention with the Se-enriched yeast of 16~71.45 parts of parts by weight, 61~252.5 parts of parts by weight
Vitamin C, the lactose that 61~146 parts of parts by weight, the pregelatinized starch that 115~274 parts of parts by weight, 1~3 part of parts by weight
Magnesium stearate composition.Wherein, Se-enriched yeast Se content (in terms of Se) is between 0.07%~0.2%；Vitamin C content (with
L-AA meter) >=99%.Composition and preparation obtained by compatibility through the invention, technique and quality control, steady
Qualitative, absorption rate, antioxidant activity etc. achieve unexpected technique effect, have marked improvement and substance
Meaning.
Invention content
The first object of the present invention is to provide a kind of selenium-rich significantly improving stability, absorption rate and bioactivity
Composition and preparation.Second is designed to provide the preparation method and application of the selenium-rich composition and preparation.
The purpose of the present invention is what is realized using following technical scheme.
First, the present invention provides a kind of selenium-rich composition significantly improving stability, absorption rate, antioxidant activity.
The composition is by the Se-enriched yeast of 16~71.45 parts of parts by weight, the vitamin C that 61~252.5 parts of parts by weight, parts by weight
The lactose that 61~146 parts of number, the pregelatinized starch that 115~274 parts of parts by weight, the magnesium stearate group of 1~3 part of parts by weight
At.
Preferably, the composition is by the Se-enriched yeast of 25~63 parts of parts by weight, the dimension life that 74~201 parts of parts by weight
Plain C, the lactose that 81~138 parts of parts by weight, the pregelatinized starch that 153~259 parts of parts by weight, 1.5~2.8 parts of parts by weight
Magnesium stearate composition.
Further preferably, the composition by 34~55 parts of parts by weight Se-enriched yeast, 87~151 parts of parts by weight
Vitamin C, the lactose that 101~130 parts of parts by weight, the pregelatinized starch that 191~245 parts of parts by weight, parts by weight 2~
2.6 parts of magnesium stearate composition.
Most preferably, the composition is by the Se-enriched yeast of 43~46 parts of parts by weight, the dimension life that 98~101 parts of parts by weight
Plain C, the lactose that 121~123 parts of parts by weight, the pregelatinized starch that 228~231 parts of parts by weight, parts by weight 2.4~2.5
The magnesium stearate composition of part.
Secondly, the present invention provides the preparation method of the selenium-rich composition, the described method comprises the following steps：
Step 1：Lactose is placed in clean container, lactose is pressed in room temperature：Water (m:M)=11：50 add water system into container
Standby lactose saturated solution.Lactose saturated aqueous solution is heated to 60 DEG C, and pregelatinized starch is added under heat-retaining condition and is prepared containing pregelatinated
The starch slurry of starch 0.2%~1.0%.Preferably, pregelatinized starch mass percentage contained by starch slurry be 0.4%~
0.8%, more preferably 0.4%~0.6%.
Step 2：Pregelatinized starch slurry prepared by step 1 is moved in the types of RHJ-D60 × 4 grinding mulser, in 60 DEG C of guarantors
Se-enriched yeast is slowly added under the conditions of temperature, side edged is fully ground emulsification to be terminated to addition, is continued heat preservation grinding 2h, is down to room
Temperature obtains paste.Paste is dry in 60 DEG C or less, and ultramicro grinding crosses 850~1100 sieves, obtains selenium-rich emulsion Ultramicro-powder.Make
To be preferred, selenium-rich emulsion Ultramicro-powder grain size is 900~1050 mesh, more preferably 950~1000 mesh.After testing：Selenium-rich emulsifies
Se content is 0.018%~0.047% in object Ultramicro-powder.
Step 3：Selenium-rich emulsion Ultramicro-powder prepared by step 2 is set in clean mixing vessel, addition vitamin C, tristearin
Sour magnesium, remaining pregelatinized starch, are thoroughly mixed 30 minutes to get selenium-rich composition of the present invention.After testing：Selenium-rich composition
Middle Se content is 0.0062%~0.024%.
Thirdly, selenium-rich composition provided by the invention adds or does not add pharmaceutically acceptable auxiliary material, can be made into powder
The oral preparations such as agent, granule, capsule, tablet, soft capsule, capsule and pill, dripping pill.
Finally, selenium-rich composition and preparation provided by the invention, can be used for drug, health food, functional ordinary food,
Special medicine formula food, special diet food.
Compared with prior art：The present invention by composition composition ratio, preferably constitute ratio, special process and specific real
Test data verification, reach the technique effect for significantly improving stability, absorption rate, antioxidant activity, have marked improvement and
Substantive significance.
Specific implementation mode：
Below by specific embodiment, the invention will be further described, but is not limited in any way the present invention
System, be based on present invention teach that made by any change or replacement, belong to the scope of the present invention.
Embodiment 1：Combine the preparation of material
Se-enriched yeast：Health products nutrient prime replenisher raw material directly is purchased, Se content (in terms of Se) is 0.07% after testing.
Vitamin C：Food grade materials directly are purchased, Vitamin C content is (in terms of L-AA) after testing
99.79%.
Lactose, pregelatinized starch, magnesium stearate：Directly purchase food grade materials.
The preparation of 2 selenium-rich emulsion I of embodiment
Step 1：The lactose 21g for weighing the preparation of embodiment 1 is placed in clean container, by lactose：Water (m:M)=11：50 to
In container plus water prepares lactose saturated solution.Lactose saturated aqueous solution is heated to 60 DEG C, and heat-retaining condition calls the preparation of Example 1 in the following text
Pregelatinized starch 0.35g, be sufficiently stirred dissolving, the starch slurry containing pregelatinized starch 0.3% be made；
Step 2：Starch slurry prepared by step 1 is moved in the types of RHJ-D60 × 4 grinding mulser, in 60 DEG C of heat preservations.It weighs
(Se content is calculated as the Se-enriched yeast that embodiment 1 prepares with Se:0.2%) 6.6g is added slowly to grind under the conditions of being fully ground
Terminate to addition in mill mulser, continues grinding emulsification 2h, be down to room temperature, obtain paste.Paste is dry in 60 DEG C or less, surpasses
Crushing of Ultrafine crosses 900 mesh sieve, obtains selenium-rich emulsion I Ultramicro-powders 25g.After testing：Se content is 0.047%.
Embodiment 3：It is prepared by selenium-rich emulsion II
Lactose 367.5g, the pregelatinized starch 10.24g for weighing the preparation of embodiment 1 prepare 0.5% by 2 step 1 of embodiment
Pregelatinized starch is starched；Weighing the Se-enriched yeast that embodiment 1 prepares again, (Se content is in terms of Se:0.07%) 135g, by 2 step of embodiment
Rapid 2 prepare dry paste, and the rear ultramicro grinding that carries out crosses 1000 mesh sieve, obtains selenium-rich emulsion II 500g, after testing：Se content
It is 0.018%.
Embodiment 4：It is prepared by selenium-rich emulsion III
Lactose 55g, the pregelatinized starch 2.46g for weighing the preparation of embodiment 1 prepare 0.8% pre- glue by 2 step 1 of embodiment
Change starch slurry；Weighing the Se-enriched yeast that embodiment 1 prepares again, (Se content is in terms of Se:0.135%) 26g, by 2 step 2 of embodiment
Dry paste is prepared, the rear ultramicro grinding that carries out crosses 1100 mesh sieve, obtains selenium-rich emulsion III 80g, after testing：Se content is
0.042%.
Embodiment 5：It is prepared by composition I
The selenium-rich emulsion I Ultramicro-powder 18.6g for weighing the preparation of embodiment 2, set in dried and clean mixing vessel, weigh implementation
Vitamin C 35g, magnesium stearate 0.264g, the pregelatinized starch 45g of the preparation of example 1, richness is added slowly under the conditions of being sufficiently stirred
Terminate to addition in selenium emulsion I Ultramicro-powders, continues to be stirred 30 minutes to get composition I 90g.After testing：Composition I
Middle Se content is 0.0088%, Vitamin C content 35.33%.
Embodiment 6：It is prepared by composition II
The selenium-rich emulsion II Ultramicro-powder 342g for weighing the preparation of embodiment 3, set in dried and clean mixing vessel, weigh implementation
The vitamin C 200g that example 1 prepares, pregelatinized starch 453g, magnesium stearate 5g are added slowly to selenium-rich under the conditions of being sufficiently stirred
Terminate to addition in emulsion II Ultramicro-powders, continues to be stirred 30 minutes to get composition II 990g, after testing：Composition
Se content is 0.0062% in II, Vitamin C content 19.96%.
Embodiment 7：It is prepared by composition III
The selenium-rich emulsion III Ultramicro-powder 56g for weighing the preparation of embodiment 4, set in dried and clean mixing vessel, weigh implementation
The vitamin C 15g that example 1 prepares, pregelatinized starch 27g, magnesium stearate 0.75g are added slowly to selenium-rich under the conditions of being sufficiently stirred
Terminate to addition in emulsion III Ultramicro-powders, continues to be stirred 30 minutes to get composition III 90g, after testing：Combination
Se content is 0.024% in object III, Vitamin C content 15.16%.
Embodiment 8：It is prepared by tablet
The composition 450g for weighing the preparation of embodiment 6 is placed in mixing vessel, uses watering can to hold to mixing under agitation
70% ethyl alcohol is slowly sprayed in device, until softwood hand pinch it is agglomerating, tapping i.e. dissipate to get.The softwood of preparation is moved into clean granulator
Or in shaking screen, squeezed 20 mesh sieve, extracting screen underflow is laid in clean dried disk, thickness≤5mm to get.Wet granular moves to perseverance
Warm drying box, 1 hour dry in 50 DEG C or less, detection moisture obtains dry particl between 3-5%.Cross 20 mesh shaking screens, screenings
Forcing press is moved to, after adjusting pressure, tabletting speed to tablet appearance, hardness, tablet weight variation meet product quality requirement, booting pressure
Piece is to get tablet 440g.Se content is 0.0062% in tablet after testing, Vitamin C content 19.96%.
Embodiment 9：It is prepared by soft capsule
Composition prepared by Example 6 is prepared into soft capsule using gelatin, glycerol and water as capsule material.
Embodiment 10：The preparation of dripping pill
Composition prepared by Example 6 adds one in stearic acid, glycerin monostearate, beeswax, hydrogenated vegetable oil
Kind is several as matrix, and is prepared into dripping pill as cooling medium using water or different concentration ethanol.
Embodiment 11：The preparation of the solid orally ingestibles such as capsule, granule, pulvis
Composition prepared by Example 6 can be made by one or more of inclusion, microencapsulation, solid dispersion technology
At solid orally ingestibles such as capsule, granule, pulvis.
In order to further be illustrated to present composition technique effect, the present invention chooses group prepared by embodiment 6
Object is closed as test specimen, 6. number is.Choose selenium-rich prepared by the Se-enriched yeast, vitamin C, embodiment 3 of the preparation of embodiment 1
Emulsion, vitamin C+Se-enriched yeast (prepared by embodiment 1 Se-enriched yeast 2g, vitamin C 5g, be mixed), embodiment
1., 2., 3., 4., 5. tablet prepared by 8, number are followed successively by.Carry out accelerated stability, absorption rate, antioxidant activity etc.
Comparative test, it is as a result as follows：
1. accelerated stability test
Inspection target determines：Present composition component limits functional component content limit, for fully verification
The stability of functional component content under the conditions of accelerated test, this experiment also choose the preferred embodiment of the present invention preparation composition,
The tablet of preferred embodiment preparation and the functional component content corresponding to each component are as study on the stability index.
Grouping and experiment：It is each 200g of laboratory sample 1. 2. 5. 6. to take number respectively, is placed in clean vial, presses
Material medicine and preparation stability test direction principle (《Chinese Pharmacopoeia》2015 editions four are 9001), set temperature be 40 DEG C ± 2 DEG C,
It is placed 3 months under conditions of relative humidity 75% ± 5%, it is excellent to measure the present invention respectively at 0 month, 1 month, 2 months, 3 months
Select tablet and the corresponding functional component content of each component and decaying prepared by the composition of embodiment preparation, preferred embodiment
Rate.It the results are shown in Table 1 and table 2:
Table 1：Corresponding function component content
Table 2：Corresponding function ingredient attenuation rate (%)
Experiment conclusion：
It can be seen that from table 1, table 2：It is investigated through 3 months accelerated stabilities, 1., 2., 5., 6. functional component content is equal for sample
There is different degrees of decaying；Wherein sample 1., 5., 6. relatively stablize by middle selenium nature, the attenuation rate very little of functional component,
It is almost unchanged.There is different degrees of decaying in the vitamin C functional component content of sample 2., 5., 6., sample 2. in decaying compared with
To be apparent, 5., 6. middle attenuation rate significantly reduces sample, significantly improves its stability, and the attenuation rate of sample 5. is less than sample
6., i.e., 5. (tablet prepared by composition preferred embodiment of the present invention) stability significantly improves sample product.
2. absorption rate is tested
Experimental animal and equipment：Kunming mouse, half male and half female, 19~21g of weight；GSH：Reduced glutathione is
Domestic analysis is pure；Domestic 751 spectrophotometer and 960 fluophotometers.
Give sample dosage：Composition (test specimen is 6.) the 60kg adult prepared according to the preferred embodiment of the present invention gives sample agent
Amount is determined as 1g/ days, and it is daily 150mg/kg BW (wherein 13.5mg containing Se-enriched yeast, containing dimension to sample dosage to convert mouse accordingly
Raw element C 30mg)；According to etc. dosage to sample than principle determine the preferred embodiment of the present invention prepare tablet samples 5. daily to
Sample dosage is 150mg/kg BW (wherein 13.5mg containing Se-enriched yeast contains vitamin C 30mg), 3. sample is daily to sample dosage
51.3mg/kg BW (wherein contain Se-enriched yeast 13.5mg), according to etc. dosage to sample than principle, in conjunction with National Pharmacopeia or correlation
Professional standard recommends Se-enriched yeast highest day recommended dose to calculate, 1. it is 21.5mg/kg BW that sample gives sample dosage.
Modeling, grouping and experiment：50 mouse are randomly divided into 5 groups, every group of l0 only, half male and half female, respectively control group,
Se-enriched yeast group, selenium-rich emulsion group, composite preparation group, composition group.
Control group feeds physiological saline, test group by the Se-enriched yeast of weight difference gavage corresponding dosage, selenium-rich emulsion,
Composite preparation and composition, continuous gavage 30 days.Blood, liver selenium and blood GSH-Px activity are measured, the results are shown in Table 3.
Table 3：The comparison of bioavailability
Found out by table 3：1., 3., 5., 6. blood, liver selenium concentration and blood GSH-Px activity are aobvious compared with the control group for sample
It writes and increases (P<0.01)；5. sample is apparently higher than sample 1. (P with the Blood Se concentration of sample 6.<0.05), sample 5. with sample 6.
Liver selenium concentration and GSH-Px activity be significantly higher than sample 1. (P<0.01).
Test result：5. (tablet that i.e. prepared by composition preferred embodiment of the present invention) and sample be 6. (i.e. for sample
Invent composition prepared by the preferred embodiment) blood, liver selenium concentration and blood GSH-Px activity be significantly higher than other samples.
Illustrate that the composition prepared through the invention and tablet, functional component absorption rate relatively combine preceding each component and significantly carry
It is high.
3. anti-oxidant experiment
Experimental animal and equipment：SD rats, male, weight 150-180g；D- galactolipins；SOD, MDA, GSH-Px reagents
Box；DT1200 type electronic balances；MAX190 UV, visible light continuous spectrum microplate reader；Allegra X.22R refrigerated centrifuges
Give sample dosage：Composition (test specimen is 6.) the 60kg adult prepared according to the preferred embodiment of the present invention gives sample agent
Amount is determined as 1g/ days, and it is that (wherein 9.4mg containing Se-enriched yeast, contains 104.2mg/kg BW to convert daily rat accordingly to sample dosage
Vitamin C 20.8mg)；According to etc. dosage to sample than principle determine sample 4. daily give sample dosage be 30.2mg/kg BW (its
In 9.4mg containing Se-enriched yeast, contain vitamin C 20.8mg), according to etc. dosage to sample than principle, in conjunction with National Pharmacopeia or correlation
Professional standard recommends Se-enriched yeast highest day recommended dose to calculate, 1. it is 14.9mg/kg BW, sample that sample gives sample dosage daily
2. being daily 52.6mg/kg BW to sample dosage.
Modeling, grouping and experiment：The SD rats 60 for taking health, are randomly divided into 6 groups, every group 10, are set as control group, mould
Type group, Se-enriched yeast group, vitamin C group, Se-enriched yeast and vitamin C group and composition group.
In addition to Normal group, remaining 5 groups are injected intraperitoneally D- galactolipins (physiological saline are made into 30mg/ml, injection volume daily
For l ml/100g), successive administration 50d establishes aging model 1 time a day.
Modeling starts to be administered simultaneously, and 50d is administered in continuous gavage, and 1 time a day, model group, control group give isodose life
Manage brine.After last dose 1h, blood, 3500r/min is taken to centrifuge 10min, take upper serum.
The activity of SOD and GSH-Px and the content for measuring MDA in serum in serum are measured by each kit specification.Experiment
It the results are shown in Table 4.
Table 4：MDA contents, SOD activity, GSH-Px Activity determination results in serum
| Grouping | MDA(nmol/L) | SOD(U/L) | GSH-Px(U/L) |
| Control group | 191.6±32.1 | 47.9±7.3 | 598.5±13.8 |
| Model group | 283.9±47.3 | 32.1±5.7 | 537.4±20.3 |
| ① | 227.4±41.7 | 49.8±6.3 | 583.7±14.9 |
| ② | 215.4±49.8 | 57.1±4.2 | 590.3±12.4 |
| ④ | 204.7±37.4 | 59.2±7.1 | 594.2±11.3 |
| ⑥ | 196.8±39.1 | 60.8±3.4 | 597.9±12.3 |
Found out by table 4：Sample 1., 2., 4., 6. compared with MDA contents in model group serum, SOD activity, GSH-Px activity
There were significant differences (P<0.01).1. 4. sample is significantly reduced with the MDA contents of sample 2. compared with sample with the MDA contents of sample 6.
(p<0.01), and 6. 4. sample has notable difference (p with sample<0.01)；4. active, GSH-Px's sample lives with the SOD of sample 6.
Property compared with sample 1. with sample SOD activity 2., the active apparent increase (P of GSH-Px<0.05).
Conclusion (of pressure testing)：Sample 1., 2., 4., 6. have apparent oxidation resistance, and 6. (i.e. of the present invention group of sample
Close object) oxidation resistance be significantly stronger than sample 1., 2., 4..
Claims (9)
1. a kind of selenium-rich composition and preparation significantly improving stability, absorption rate, antioxidant activity.It is characterized in that：
The composition is by the Se-enriched yeast of 16~71.45 parts of parts by weight, the vitamin C that 61~252.5 parts of parts by weight, parts by weight
The lactose that 61~146 parts of number, the pregelatinized starch that 115~274 parts of parts by weight, the magnesium stearate group of 1~3 part of parts by weight
At.The Se-enriched yeast Se content (in terms of Se) is between 0.07%~0.2%, and preferably 0.07%~0.135%, more preferably
It is 0.07%~0.08%；Vitamin C content (in terms of L-AA) >=99%.
2. selenium-rich composition and preparation according to claim 1, it is characterised in that：The composition is by parts by weight 25~63
The Se-enriched yeast of part, the vitamin C that 74~201 parts of parts by weight, the lactose that 81~138 parts of parts by weight, parts by weight 153~
259 parts of pregelatinized starch, the magnesium stearate composition that 1.5~2.8 parts of parts by weight.
3. selenium-rich composition and preparation according to claim 1, it is characterised in that：The composition is by parts by weight 34~55
The Se-enriched yeast of part, the vitamin C that 87~151 parts of parts by weight, the lactose that 101~130 parts of parts by weight, parts by weight 191
~245 parts of pregelatinized starch, the magnesium stearate composition that 2~2.6 parts of parts by weight.
4. selenium-rich composition and preparation according to claim 1, it is characterised in that：The composition is by parts by weight 43~46
The Se-enriched yeast of part, the vitamin C that 98~101 parts of parts by weight, the lactose that 121~123 parts of parts by weight, parts by weight 228
~231 parts of pregelatinized starch, the magnesium stearate composition that 2.4~2.5 parts of parts by weight.
5. selenium-rich composition according to claims 1 to 4 and preparation, it is characterised in that：Using emulsifying technology by Se-enriched yeast,
Lactose, partially pregelatinized starch are mixed with selenium-rich emulsion；Selenium-rich emulsion is mixed with through ultramicro grinding and remaining ingredient
Composition；Composition, which adds or do not add pharmaceutically acceptable auxiliary material, prepares three processing steps of preparation.
6. according to claim 5 prepared by selenium-rich emulsion, it is characterised in that：Lactose room temperature adds water to prepare saturated aqueous solution,
Pregelatinized starch is added in 60 DEG C and prepares 0.2%~1.0% starch slurry, and selenium-rich is slowly added under the conditions of keeping the temperature, being fully ground
Yeast to addition terminates, continue grind 2h, be cooled to room temperature to get.Wherein, starch slurry concentration is preferably 0.4%~0.8%, more
Preferably 0.4%~0.6%.
7. selenium-rich composition according to claim 5, it is characterised in that：Selenium-rich emulsion is dry in 60 DEG C or less, Ultramicro-powder
Be broken to 850~1100 mesh, addition remaining ingredient be thoroughly mixed uniformly to get.Wherein, selenium-rich emulsion ultramicro grinding granularity
Preferably 900~1050 mesh sieve, more preferably 950~1000 mesh sieve.
8. selenium-rich composite preparation according to claim 5, it is characterised in that：Selenium-rich composition adds or does not add auxiliary material,
It can be made into the oral preparations such as pulvis, granule, tablet, capsule, soft capsule, capsule and pill, dripping pill.
9. selenium-rich composition according to claims 1 to 8 and preparation, it is characterised in that：Selenium-rich composition and preparation are in medicine
Application in product, health food, functional ordinary food, special medicine formula food, special diet food.
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| CN110946839A (en) * | 2019-12-31 | 2020-04-03 | 烟台万润药业有限公司 | Chewable tablet for supplementing selenium and vitamin C and preparation method thereof |
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