CN101679466A - 对包括fpps、ggpps和dpps在内的多靶点效力提高的二膦酸盐化合物及方法 - Google Patents

对包括fpps、ggpps和dpps在内的多靶点效力提高的二膦酸盐化合物及方法 Download PDF

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CN101679466A
CN101679466A CN200880019104A CN200880019104A CN101679466A CN 101679466 A CN101679466 A CN 101679466A CN 200880019104 A CN200880019104 A CN 200880019104A CN 200880019104 A CN200880019104 A CN 200880019104A CN 101679466 A CN101679466 A CN 101679466A
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E·奥德菲尔德
张永辉
殷锋霖
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University of Illinois System
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    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
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    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
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    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
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CN200880019104A 2007-04-12 2008-04-11 对包括fpps、ggpps和dpps在内的多靶点效力提高的二膦酸盐化合物及方法 Pending CN101679466A (zh)

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US91142607P 2007-04-12 2007-04-12
US60/911,426 2007-04-12
PCT/US2008/060051 WO2008128056A1 (en) 2004-10-08 2008-04-11 Bisphosphonate compounds and methods with enhanced potency for multiple targets including fpps, ggpps, and dpps

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EP (1) EP2203460A4 (enExample)
JP (1) JP2010523709A (enExample)
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Cited By (14)

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Publication number Priority date Publication date Assignee Title
CN102010905A (zh) * 2010-11-02 2011-04-13 山东省果树研究所 苹果fpps基因的三处突变及其鉴定方法
CN104822695A (zh) * 2012-07-05 2015-08-05 衣阿华大学研究基金会 治疗性双膦酸盐
CN108588023A (zh) * 2018-05-09 2018-09-28 河北森朗生物科技有限公司 一种生产嵌合抗原受体修饰的γδT细胞的方法
CN111569090A (zh) * 2016-01-15 2020-08-25 美国基因技术国际有限公司 用于活化γ-δ T细胞的方法和组合物
US11007209B2 (en) 2008-10-17 2021-05-18 American Gene Technologies International Inc. Safe lentiviral vectors for targeted delivery of multiple therapeutic molecules
US11090379B2 (en) 2016-07-08 2021-08-17 American Gene Technologies International Inc. HIV pre-immunization and immunotherapy
US11242527B1 (en) 2016-03-09 2022-02-08 American Gene Technologies International Inc. Combination vectors and methods for treating cancer
US11352646B2 (en) 2018-11-05 2022-06-07 American Gene Technologies International Inc. Vector system for expressing regulatory RNA
US11583562B2 (en) 2016-07-21 2023-02-21 American Gene Technologies International Inc. Viral vectors for treating Parkinson's disease
US11820999B2 (en) 2017-04-03 2023-11-21 American Gene Technologies International Inc. Compositions and methods for treating phenylketonuria
US11976292B2 (en) 2016-06-08 2024-05-07 American Gene Technologies International Inc. Non-integrating viral delivery system and methods related thereto
US11980663B2 (en) 2015-07-08 2024-05-14 American Gene Technologies International Inc. HIV pre-immunization and immunotherapy
US12090200B2 (en) 2016-02-08 2024-09-17 American Gene Technologies International Inc. Methods of producing cells resistant to HIV infection
US12403155B2 (en) 2016-01-15 2025-09-02 American Gene Technologies International Inc. Methods and compositions for the activation of gamma-delta T-cells

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FR2926081B1 (fr) * 2008-01-03 2010-02-19 Univ Nantes Derives d'acide hydroxy-bisphosphonique comme vecteur ciblant le tissu osseux
EP2922858A4 (en) * 2012-11-20 2016-06-15 Univ Mcgill THIENOPYRIMIDININHIBITORS OF FARNESYL AND / OR GERANYL GERANYL PYROPHOSPHATE SYNTHASE
US10532065B2 (en) 2014-12-19 2020-01-14 Nagasaki University Bisphosphonic acid derivative and application for same
JP6685047B2 (ja) * 2015-02-02 2020-04-22 国立大学法人 長崎大学 新規フッ素含有型ビスホスホン酸誘導体及びその用途

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Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11007209B2 (en) 2008-10-17 2021-05-18 American Gene Technologies International Inc. Safe lentiviral vectors for targeted delivery of multiple therapeutic molecules
CN102010905B (zh) * 2010-11-02 2013-05-01 山东省果树研究所 苹果fpps基因的三处突变及其鉴定方法
CN102010905A (zh) * 2010-11-02 2011-04-13 山东省果树研究所 苹果fpps基因的三处突变及其鉴定方法
CN104822695A (zh) * 2012-07-05 2015-08-05 衣阿华大学研究基金会 治疗性双膦酸盐
CN104822695B (zh) * 2012-07-05 2018-01-09 衣阿华大学研究基金会 治疗性双膦酸盐
US11980663B2 (en) 2015-07-08 2024-05-14 American Gene Technologies International Inc. HIV pre-immunization and immunotherapy
US11519006B2 (en) 2016-01-15 2022-12-06 American Gene Technologies International Inc. Methods and compositions for the activation of gamma-delta T-cells
US12410446B2 (en) 2016-01-15 2025-09-09 American Gene Technologies International Inc. Methods and compositions for the activation of gamma-delta T-cells
US12403155B2 (en) 2016-01-15 2025-09-02 American Gene Technologies International Inc. Methods and compositions for the activation of gamma-delta T-cells
CN111569090A (zh) * 2016-01-15 2020-08-25 美国基因技术国际有限公司 用于活化γ-δ T细胞的方法和组合物
US12090200B2 (en) 2016-02-08 2024-09-17 American Gene Technologies International Inc. Methods of producing cells resistant to HIV infection
US11242527B1 (en) 2016-03-09 2022-02-08 American Gene Technologies International Inc. Combination vectors and methods for treating cancer
US12359203B2 (en) 2016-03-09 2025-07-15 American Gene Technologies International Inc. Combination vectors and methods for treating cancer
US11976292B2 (en) 2016-06-08 2024-05-07 American Gene Technologies International Inc. Non-integrating viral delivery system and methods related thereto
US12370253B2 (en) 2016-07-08 2025-07-29 American Gene Technologies International Inc. Pre-immunization and immunotherapy
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