CN101678355B - 处理液体样品的装置 - Google Patents

处理液体样品的装置 Download PDF

Info

Publication number
CN101678355B
CN101678355B CN200880012452.4A CN200880012452A CN101678355B CN 101678355 B CN101678355 B CN 101678355B CN 200880012452 A CN200880012452 A CN 200880012452A CN 101678355 B CN101678355 B CN 101678355B
Authority
CN
China
Prior art keywords
fluid sample
sample
different
liquid
reagent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN200880012452.4A
Other languages
English (en)
Chinese (zh)
Other versions
CN101678355A (zh
Inventor
D·伯格曼
P·克鲁杰
D·朗霍尔姆
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
J Remsen International Assets LLC
J&J JSC
Original Assignee
Amic AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amic AB filed Critical Amic AB
Publication of CN101678355A publication Critical patent/CN101678355A/zh
Application granted granted Critical
Publication of CN101678355B publication Critical patent/CN101678355B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
    • F16K99/0017—Capillary or surface tension valves, e.g. using electro-wetting or electro-capillarity effects
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K2099/0082—Microvalves adapted for a particular use
    • F16K2099/0084—Chemistry or biology, e.g. "lab-on-a-chip" technology

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
CN200880012452.4A 2007-04-16 2008-04-15 处理液体样品的装置 Active CN101678355B (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US92379807P 2007-04-16 2007-04-16
SE0700930-1 2007-04-16
SE07009301 2007-04-16
US60/923,798 2007-04-16
SE0700930A SE529978C2 (sv) 2007-04-16 2007-04-16 Analysanordning för vätskeformiga prov
PCT/SE2008/050424 WO2008127191A1 (en) 2007-04-16 2008-04-15 Device for handling liquid samples

Publications (2)

Publication Number Publication Date
CN101678355A CN101678355A (zh) 2010-03-24
CN101678355B true CN101678355B (zh) 2012-11-14

Family

ID=38935813

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200880012452.4A Active CN101678355B (zh) 2007-04-16 2008-04-15 处理液体样品的装置

Country Status (6)

Country Link
EP (1) EP2134472A4 (de)
JP (1) JP5425757B2 (de)
CN (1) CN101678355B (de)
CA (1) CA2683920C (de)
SE (1) SE529978C2 (de)
WO (1) WO2008127191A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9216413B2 (en) 2009-07-07 2015-12-22 Boehringer Ingelheim Microparts Gmbh Plasma separation reservoir
EP2618153B1 (de) * 2012-01-20 2015-03-18 Ortho-Clinical Diagnostics, Inc. Steuerung des Fluidstroms durch eine Analysevorrichtung
US8895293B2 (en) * 2012-01-20 2014-11-25 Ortho-Clinical Diagnostics, Inc. Assay device having uniform flow around corners
JP6278772B2 (ja) * 2014-03-19 2018-02-14 テルモ株式会社 血糖値測定用チップ
CN107003329B (zh) * 2014-11-28 2019-05-31 东洋制罐集团控股株式会社 微细送液结构体、以及分析装置
CN107219170B (zh) * 2017-07-24 2023-09-19 苏州鼎实医疗科技有限公司 试剂片
WO2022058470A1 (en) * 2020-09-17 2022-03-24 Katholieke Universiteit Leuven Activation and pressure balancing mechanism
WO2024211341A2 (en) * 2023-04-03 2024-10-10 Burst Diagnostics Llc Chemiluminescence microfluidic immunoassay device and methods of use thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6296020B1 (en) * 1998-10-13 2001-10-02 Biomicro Systems, Inc. Fluid circuit components based upon passive fluid dynamics
CN1540335A (zh) * 2003-11-01 2004-10-27 浙江大学 集成微型电磁泵式毛细管电泳芯片
EP1525919A1 (de) * 2003-10-23 2005-04-27 F. Hoffmann-La Roche Ag Auslösedurchflussvorrichtung
GB2410086A (en) * 2004-01-14 2005-07-20 British Biocell Internat Ltd Assay devices having flow block(s) to determine flow of liquids
CN1933909A (zh) * 2004-03-24 2007-03-21 Amic公司 测定装置及方法
CN101010138A (zh) * 2004-06-02 2007-08-01 阿米克公司 控制流动的测定装置和方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0610900A (ja) * 1992-04-27 1994-01-21 Canon Inc 液体移動方法及び移動装置ならびにこれを利用した測定装置
US6156270A (en) * 1992-05-21 2000-12-05 Biosite Diagnostics, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membranes
JP3213566B2 (ja) * 1996-04-26 2001-10-02 アークレイ株式会社 検体分析用具およびそれを用いた検体分析方法並びに検体分析装置
US6571651B1 (en) * 2000-03-27 2003-06-03 Lifescan, Inc. Method of preventing short sampling of a capillary or wicking fill device
SE0201738D0 (sv) * 2002-06-07 2002-06-07 Aamic Ab Micro-fluid structures
KR100444751B1 (ko) * 2002-11-11 2004-08-16 한국전자통신연구원 표면장력에 의한 유체제어 소자
US20060043284A1 (en) * 2002-11-29 2006-03-02 Nec Corporation Micro chip, liquid feeding method using the micro chip, and mass analyzing system
DE10302720A1 (de) * 2003-01-23 2004-08-05 Steag Microparts Gmbh Mikrofluidischer Schalter zum Anhalten des Flüssigkeitsstroms während eines Zeitintervalls
EP1525916A1 (de) * 2003-10-23 2005-04-27 F. Hoffmann-La Roche Ag Auslösedurchflussvorrichtung
US20070160474A1 (en) * 2004-02-06 2007-07-12 Kazuhiro Iida Regulation structure, separation device and gradient forming device, and microchip using the same
US7682817B2 (en) * 2004-12-23 2010-03-23 Kimberly-Clark Worldwide, Inc. Microfluidic assay devices
CA2598513A1 (en) * 2005-02-25 2006-08-31 Inverness Medical Switzerland Gmbh Fluidic gating device
JPWO2006098370A1 (ja) * 2005-03-16 2008-08-28 日本電気株式会社 流路の実効的な通過時間の調整機構を具える遅延回路、マイクロチップ、およびその作製方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6296020B1 (en) * 1998-10-13 2001-10-02 Biomicro Systems, Inc. Fluid circuit components based upon passive fluid dynamics
EP1525919A1 (de) * 2003-10-23 2005-04-27 F. Hoffmann-La Roche Ag Auslösedurchflussvorrichtung
CN1540335A (zh) * 2003-11-01 2004-10-27 浙江大学 集成微型电磁泵式毛细管电泳芯片
GB2410086A (en) * 2004-01-14 2005-07-20 British Biocell Internat Ltd Assay devices having flow block(s) to determine flow of liquids
CN1933909A (zh) * 2004-03-24 2007-03-21 Amic公司 测定装置及方法
CN101010138A (zh) * 2004-06-02 2007-08-01 阿米克公司 控制流动的测定装置和方法

Also Published As

Publication number Publication date
SE0700930L (sv) 2008-01-22
JP5425757B2 (ja) 2014-02-26
CA2683920A1 (en) 2008-10-23
CA2683920C (en) 2016-05-31
EP2134472A4 (de) 2014-10-01
WO2008127191A1 (en) 2008-10-23
JP2010525319A (ja) 2010-07-22
SE529978C2 (sv) 2008-01-22
EP2134472A1 (de) 2009-12-23
CN101678355A (zh) 2010-03-24

Similar Documents

Publication Publication Date Title
CN101678355B (zh) 处理液体样品的装置
Gardeniers et al. Lab-on-a-chip systems for biomedical and environmental monitoring
US9421540B2 (en) Microfluidic device with auxiliary and bypass channels
US20010042712A1 (en) Microfluidic concentration gradient loop
Hansen et al. Nanoliter-scale electromembrane extraction and enrichment in a microfluidic chip
US11028690B2 (en) System and methodology for chemical constituent sensing and analysis
RU2019102399A (ru) Управление текучей средой
Kreutzer et al. Sample dispersion for segmented flow in microchannels with rectangular cross section
JP2006208388A (ja) 試料液を検査するための装置および方法
Cong et al. Electrokinetic sample preconcentration and hydrodynamic sample injection for microchip electrophoresis using a pneumatic microvalve
Greenwood et al. Sample manipulation in micro total analytical systems
Wells et al. High-throughput liquid–liquid extractions with nanoliter volumes
Forchelet et al. Separation of blood microsamples by exploiting sedimentation at the microscale
Eichhorn Microfluidic sorting of stereoisomers
Serra et al. Integrated droplet microfluidic device for magnetic particles handling: Application to DNA size selection in NGS libraries preparation
Ciceri et al. A study of molecular diffusion across a water/oil interface in a Y–Y shaped microfluidic device
Aota et al. Analysis of polychlorinated biphenyls in transformer oil by using liquid–liquid partitioning in a microfluidic device
US10976225B2 (en) DMF method and system for concentrating analyte from large volumes into smaller volumes using magnetic microparticles
JP2010525319A5 (de)
Montes et al. Transverse migration and microfluidic concentration of DNA using Newtonian buffers
Fukuyama et al. Kinetic switching of the concentration/separation behavior of microdroplets
Costin et al. Measuring the transverse concentration gradient between adjacent laminar flows in a microfluidic device by a laser-based refractive index gradient detector
Cai et al. A gravity driven micro flow injection wetting film extraction system on a polycarbonate chip
Mathur et al. Open Space Diffusive Filter for Simultaneous Species Retrieval and Separation
Maximiano et al. Simultaneous separation and electroanalysis in a single polydimethylsiloxane-based platform

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
TR01 Transfer of patent right
TR01 Transfer of patent right

Effective date of registration: 20180706

Address after: Delaware

Patentee after: J Remsen international assets LLC

Address before: Solna, Sweden

Patentee before: J&J JSC

Effective date of registration: 20180706

Address after: Solna, Sweden

Patentee after: J&J JSC

Address before: uppsala

Patentee before: AMIC AB