CN101678004A - 治疗生物膜形成的三唑化合物 - Google Patents

治疗生物膜形成的三唑化合物 Download PDF

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Publication number
CN101678004A
CN101678004A CN200880015539A CN200880015539A CN101678004A CN 101678004 A CN101678004 A CN 101678004A CN 200880015539 A CN200880015539 A CN 200880015539A CN 200880015539 A CN200880015539 A CN 200880015539A CN 101678004 A CN101678004 A CN 101678004A
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CN
China
Prior art keywords
alkyl group
lower alkyl
low alkyl
compound
low
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN200880015539A
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English (en)
Chinese (zh)
Inventor
D·里德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38534753&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN101678004(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis AG filed Critical Novartis AG
Publication of CN101678004A publication Critical patent/CN101678004A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN200880015539A 2007-05-22 2008-05-21 治疗生物膜形成的三唑化合物 Pending CN101678004A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07108650A EP1994930A1 (en) 2007-05-22 2007-05-22 Triazol compounds for treating biofilm formation
EP07108650.8 2007-05-22
PCT/EP2008/056231 WO2008142094A1 (en) 2007-05-22 2008-05-21 Triazol compounds for treating biofilm formation

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN2013103034363A Division CN103381271A (zh) 2007-05-22 2008-05-21 治疗生物膜形成的三唑化合物

Publications (1)

Publication Number Publication Date
CN101678004A true CN101678004A (zh) 2010-03-24

Family

ID=38534753

Family Applications (2)

Application Number Title Priority Date Filing Date
CN200880015539A Pending CN101678004A (zh) 2007-05-22 2008-05-21 治疗生物膜形成的三唑化合物
CN2013103034363A Pending CN103381271A (zh) 2007-05-22 2008-05-21 治疗生物膜形成的三唑化合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN2013103034363A Pending CN103381271A (zh) 2007-05-22 2008-05-21 治疗生物膜形成的三唑化合物

Country Status (18)

Country Link
US (2) US8309590B2 (https=)
EP (3) EP1994930A1 (https=)
JP (1) JP5470245B2 (https=)
KR (1) KR101519675B1 (https=)
CN (2) CN101678004A (https=)
AU (1) AU2008252964B2 (https=)
BR (1) BRPI0811103A2 (https=)
CA (1) CA2685112A1 (https=)
CL (1) CL2008001469A1 (https=)
IL (1) IL201832A (https=)
MA (1) MA31388B1 (https=)
MX (1) MX2009012628A (https=)
NZ (1) NZ580735A (https=)
RU (1) RU2478385C2 (https=)
TN (1) TN2009000487A1 (https=)
TW (1) TWI419690B (https=)
WO (1) WO2008142094A1 (https=)
ZA (1) ZA200907415B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107848980A (zh) * 2015-07-22 2018-03-27 俄亥俄州国家创新基金会 抑制多药耐受微生物生长的组合物和方法

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8829198B2 (en) 2007-10-31 2014-09-09 Proteotech Inc Compounds, compositions and methods for the treatment of beta-amyloid diseases and synucleinopathies
JP5548121B2 (ja) 2007-05-14 2014-07-16 リサーチ ファウンデーション オブ ステイト ユニバーシティ オブ ニューヨーク バイオフィルム中の細菌細胞における生理学的分散応答の誘導
EP1994930A1 (en) * 2007-05-22 2008-11-26 Novartis AG Triazol compounds for treating biofilm formation
WO2009111611A2 (en) 2008-03-05 2009-09-11 Proteotech Inc. Compounds, compositions and methods for the treatment of islet amyloid polypeptide (iapp) accumulation in diabetes
GB201021186D0 (en) * 2010-12-14 2011-01-26 Novabiotics Ltd Composition
TWI415572B (zh) 2011-06-17 2013-11-21 Univ Chang Gung 利用１，２，３，４，６－五－ｏ－沒食子醯基－ｄ－葡哌喃糖來抑制生物膜形成
RU2646488C2 (ru) * 2016-04-25 2018-03-05 Государственное бюджетное образовательное учреждение высшего профессионального образования "Оренбургский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ГБОУ ВПО ОрГМУ Минздрава России) Средство для селективного влияния на биопленкообразование микроорганизмами
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
CN110448693A (zh) * 2019-07-30 2019-11-15 华东理工大学 氟喹诺酮类药物作为多粘菌素类抗生素增敏剂的应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6004438A (en) * 1991-12-31 1999-12-21 3M Innovative Properties Company Biofilm reduction sterilizer
IL112778A0 (en) * 1994-03-04 1995-05-26 Merck & Co Inc Substituted heterocycles, their preparation and pharmaceutical compositions containing them
MY129541A (en) * 1996-06-25 2007-04-30 Novartis Ag Substituded 3,5-diphenyl-1,2,4-triazoles and their use as pharmaceutical metal chelators
AU3191597A (en) * 1996-06-26 1998-01-14 Sankyo Company Limited Novel medicinal compositions of hydropyridines
US6759040B1 (en) * 1997-09-12 2004-07-06 University Of Maryland, College Park Preparation and use of biofilm-degrading, multiple-specificity, hydrolytic enzyme mixtures
WO2001070213A2 (en) 2000-03-23 2001-09-27 Influx, Inc. Bactericidal antimicrobial methods and compositions for use in treating gram positive infections comprising an antibiotic potentiator having acyl hydrazide oxy amide or 8-hydroxy quinoline structure
US6861431B2 (en) * 2001-03-23 2005-03-01 The Board Of Trustees Of The University Of Illinois Compounds capable of modulating the activity of multidrug transporters and therapeutic use of the same
GB0126618D0 (en) * 2001-11-06 2002-01-02 Novartis Ag Organic compounds
GB0205593D0 (en) 2002-03-09 2002-04-24 Univ Nottingham Treatment of surfaces populated by bacteria
CN101134119A (zh) * 2002-05-24 2008-03-05 血管技术国际股份公司 用于涂覆医用植入物的组合物和方法
US7498292B2 (en) 2002-08-15 2009-03-03 The Research Foundation Of State University Of New York Combinatorial libraries of autoinducer analogs, autoinducer agonists and antagonists, and methods of use thereof
GB0223978D0 (en) 2002-10-15 2002-11-20 Novartis Ag Organic compound
EP1994930A1 (en) * 2007-05-22 2008-11-26 Novartis AG Triazol compounds for treating biofilm formation

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107848980A (zh) * 2015-07-22 2018-03-27 俄亥俄州国家创新基金会 抑制多药耐受微生物生长的组合物和方法

Also Published As

Publication number Publication date
WO2008142094A4 (en) 2009-01-29
KR20100017153A (ko) 2010-02-16
IL201832A (en) 2015-11-30
JP5470245B2 (ja) 2014-04-16
JP2010527960A (ja) 2010-08-19
AU2008252964A1 (en) 2008-11-27
AU2008252964B2 (en) 2011-12-01
RU2009147297A (ru) 2011-06-27
WO2008142094A1 (en) 2008-11-27
CA2685112A1 (en) 2008-11-27
US20100152101A1 (en) 2010-06-17
RU2478385C2 (ru) 2013-04-10
TW200913996A (en) 2009-04-01
EP1994930A1 (en) 2008-11-26
BRPI0811103A2 (pt) 2014-12-09
EP2162130A1 (en) 2010-03-17
NZ580735A (en) 2012-02-24
CL2008001469A1 (es) 2010-10-29
EP2253317A2 (en) 2010-11-24
EP2253317A3 (en) 2011-03-16
US8309590B2 (en) 2012-11-13
US8592473B2 (en) 2013-11-26
ZA200907415B (en) 2010-07-28
MA31388B1 (fr) 2010-05-03
TN2009000487A1 (en) 2011-03-31
KR101519675B1 (ko) 2015-05-12
IL201832A0 (en) 2010-06-16
CN103381271A (zh) 2013-11-06
MX2009012628A (es) 2009-12-07
TWI419690B (zh) 2013-12-21
US20120329746A1 (en) 2012-12-27

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Application publication date: 20100324