CN101669889A - Sunscreen lipstick with repair function and preparation method thereof - Google Patents
Sunscreen lipstick with repair function and preparation method thereof Download PDFInfo
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- CN101669889A CN101669889A CN200910024138A CN200910024138A CN101669889A CN 101669889 A CN101669889 A CN 101669889A CN 200910024138 A CN200910024138 A CN 200910024138A CN 200910024138 A CN200910024138 A CN 200910024138A CN 101669889 A CN101669889 A CN 101669889A
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Abstract
The invention discloses a sunscreen medicament lipstick with a repair function on the lip part and a preparation method thereof. The sunscreen medicament lipstick comprises the following components inpercentage by weight: 1-10 percent of medicament, 15-50 percent of wax, 35-50 percent of oil and the balance of additive. The preparation method comprises the following steps: weighing and adding zinc oxide and titanium dioxide into 95 percent of alcohol solution containing niacinamide; heating and grinding till the alcohol solution is completely volatilized; weighing beewax, carotene, ozocerite,vaseline, polyglycerol-2-triisostearate, liquid wax oil and castor oil with prescription content; heating, fusing and uniformly mixing; adding the mixed fine powder of the zinc oxide, the titanium dioxide and the niacinamide and continuously heating and stirring to obtain a uniform lipstick body; adding peppermint oil and uniformly mixing; cooling to 55 DEG C or so, injecting, demoulding and splitting to obtain the sunscreen medicament lipstick. The probability of cheilitis can be reduced, and the plateau cheilitis can be prevented.
Description
Technical field
The present invention relates to a kind of lip pomade and preparation thereof that contains medicine, particularly a kind of have lip damage is had lipblock of repair function and preparation method thereof.
Background technology
The lip disease is healthy and commonly encountered diseases, the frequently-occurring disease attractive in appearance of harm humans, and not only directly influence is taken food and communication, and it is attractive in appearance more to impair image.
The various physiological functions that the variation of climatic environment can cause body change, and cause human immune system's hypofunction;
Dry: along with the variation of Various Seasonal, particularly autumn and winter, dry whole skin and the mucosa of causing is dry unusually, and cheilitis takes place easily, shows as phenomenons such as chapped lip, lip drying.
Cold: cold external condition is shunk the lip blood capillary, causes lip blood supply deficiency, easily causes phenomenons such as chapped lip, decortication.
Ultraviolet: along with the continuous minimizing of global ozone amount, amount of ultraviolet irradiation is on the increase, and the ratio of sunburn, pigmentation, wrinkle, skin problems such as " photoaging " improves greatly.The lip mucosa is the anoderm mucosa, and long term exposure outside, and institute is undermined the most obvious, often develops into cheilitis, shows as decortication, redness etc.
The lip mucosa is as the unique long term exposure anoderm mucosa outside of whole body, resist ability that external environment changes a little less than, directly be subjected to the pessimal stimulation of various adverse circumstances after, institute is undermined the most obvious.In the most of crowd of China, all suffer from phenomenons such as in various degree chapped lip, drying, decortication.
At present, more thorny to the processing of cheilitis, still to adopt prevention at present and treat isolating method, treatment is normal adopts following three kinds:
1, microwave radiation is not easy to operate, and patient's compliance is poor;
2, it is unsatisfactory that whole body is used corticosteroid application curative effect, and side effect is big;
3, oral Chinese medicine preparation, medicine time is long, and produce effects is slow.
Common precautionary approach is mainly based on various lip pomades, and as commercially available products such as lipblock series, but this type of present lip pomade function singleness is damaged no repair function to the lip that has taken place.
Because cheilitis is mainly caused by environmental change, if can will combine treatment with prevention, both can reduce the incidence rate of cheilitis, the cheilitis that can quicken to have taken place heals as early as possible again, and can yet be regarded as is a kind of effective means.
Summary of the invention
The objective of the invention is to be, a kind of sun-proof medicine lip pomade with repair function and preparation method thereof is provided, this sun-proof medicine lip pomade has prophylactic function to cheilitis, can significantly reduce the incidence rate of cheilitis; The various infringements of lip that cheilitis take place and caused are had good therapeutical effect, can significantly shorten healing time.
The technical solution that realizes above-mentioned purpose is:
A kind of sun-proof medicine lip pomade with repair function is characterized in that the sun-proof medicine lip pomade of this that makes is made up of medicine, wax, oil and additive, and wherein, medicine shared percentage by weight in sun-proof medicine lip pomade is 1%～10%; Wax shared percentage by weight in sun-proof medicine lip pomade is 15%～50%; Oil shared percentage by weight in sun-proof medicine lip pomade is 35%～50%, and all the other are additive.
Described medicine is made of by weight percentage following prescription: nicotiamide: 20～40%, and zinc oxide: 20～40%, titanium dioxide: 20～40%;
Described wax is made of by weight percentage following prescription: polyglycereol-2-three isostearates: 5～20%, and ceresine: 5～35%, Cera Flava: 1～5%, alkene wax: 5～10%, vaseline: 30～50%;
Described oils and fats is made of by weight percentage following prescription: Oleum Ricini: 30～50%, and liquid paraffin: 50～70%;
Described additive is ethyl hydroxybenzoate and Oleum menthae.
The lipblock with repair function of the present invention's preparation, reasonable recipe, nicotiamide is called pellagra preventive factor or vitamin B again
3, be intracellular a kind of important coenzyme, it is safe to be used for cosmetics, the sun-proof result that skin is had antiinflammatory, anti-light radiation and repairs the damage that inductive DNA such as ultraviolet cause; Zinc oxide is nontoxic, harmless, nonirritant, has uvioresistant, convergence, moistens and appropriate special efficacies such as sterilization; The titanium dioxide stable in properties, effect such as ultra-violet radiation resisting, antibiotic, aging resistance; The lip pomade substrate that is become with line of oils by wax has the effect of preserving moisture.The lip damage that this sun-proof medicine lip pomade can be anti-drying in advance, cold, ultraviolet etc. causes, and have the damage of reparation, antibacterial action; Easy to use, safe, dosage form is advanced; Easy, the safety of its preparation method, low production cost, curative effect is outstanding, combines treatment with prevention, and has started the new method of cheilitis treatment.
The specific embodiment
The present invention is described in further detail for the embodiment that provides below in conjunction with the inventor and animal acute toxicity test, skin irritation test and sensitivity test, Pharmacodynamic test of active extract and clinical trial data.
Preparation embodiment 1:
1. the lipblock with repair function of present embodiment preparation, the weight percentage of its component and each component is as follows:
Nicotiamide 2%
Zinc oxide 2%
Titanium dioxide 1.5%
Cera Flava 2%
Ceresine 16%
Alkene wax 4%
Vaseline 16%
Polyglycereol-2-three isostearates 8%
Liquid paraffin 31%
Oleum Ricini 16%
Ethyl hydroxybenzoate 0.5%
Oleum menthae 1%
2. preparation method
The nicotiamide that takes by weighing formula ratio adds in an amount of 95% concentration (mass fraction) alcoholic solution, makes it to dissolve fully, and is standby;
Take by weighing zinc oxide and titanium dioxide and add in the alcoholic solution of 95% concentration (mass fraction) that contains nicotiamide, heating is ground and is volatilized fully until alcoholic solution, gets white homogeneous mixing fine powders;
Take by weighing recipe quantity Cera Flava, alkene wax, ceresine, vaseline, polyglycereol-2-three isostearates and saxol, Oleum Ricini, the heating and melting mixing, make lip pomade substrate, the mixing fine powders that in lip pomade substrate, adds zinc oxide, titanium dioxide and nicotiamide, continue heated and stirred and get the homogeneous mastic, adding additive is ethyl hydroxybenzoate and Oleum menthae, mixing; Be cooled to about 55 ℃, fill, the demoulding, packing are promptly.
3. using method and consumption:
External screws out about 3mm sun-proof medicine lip pomade, mastic evenly is applied to lips, every day 2～4 times.
Preparation embodiment 2:
Different is for present embodiment and embodiment 1, and the weight of prescription and percentage ratio is difference to some extent, and all the other are all with embodiment 1;
Nicotiamide 2.5%
Zinc oxide 3%
Titanium dioxide 3%
Cera Flava 2%
Ceresine 13%
Alkene wax 4%
Vaseline 18%
Polyglycereol-2-three isostearates 8%
Liquid paraffin 30%
Oleum Ricini 15%
Ethyl hydroxybenzoate 0.5%
Oleum menthae 1%
Preparation embodiment 3:
Different is for present embodiment and embodiment 1, and the weight of prescription and percentage ratio is difference to some extent, and all the other are all with embodiment 1;
Nicotiamide 1.5%
Zinc oxide 1.5%
Titanium dioxide 2%
Cera Flava 2%
Ceresine 15%
Alkene wax 4%
Vaseline 18%
Polyglycereol-2-three isostearates 9%
Liquid paraffin 30%
Oleum Ricini 15%
Ethyl hydroxybenzoate 1%
Oleum menthae 1%
Certainly, the foregoing description can also exclusive list, as space is limited, differs at this and one to enumerate, and adjusts a little in the scope that the present invention provides, and all can prepare qualified sun-proof medicine lip pomade.
The applicant has carried out animal acute toxicity test, skin irritation test and sensitivity test, Pharmacodynamic test of active extract and clinical trial to the prepared sun-proof medicine lip pomade of embodiment, specifically tests as follows:
First: animal acute toxicity test
Test objective: observe mouse stomach and give acute toxic reaction and the death condition that lip pomade produces.
Test method: according to the trial test result, get 40 mices, male and female half and half, be grouped into the 1st group (excipient) and the 2nd group (sun-proof medicine lip pomade) by body weight, overnight fasting be can't help water, can irritate stomach concentration gastric infusion with maximum, vehicle group is a substrate: Oleum Sesami=1: 2, lip pomade group are lip pomade: Oleum Sesami=1: 1.40ml/kg, administration is 3 times in 1 day, interval 4 hours.The normal granules material is raised after the administration, freely drink water, according to following table general activity situation and the survival condition of close observation 2 animals in week at once, record mice poisoning symptom and death condition were observed 14 continuously after the administration, weigh in the time of 7 days, put to death animal after weighing in 14th, animal and execution animal perform an autopsy on sb the pathological changes situation of perusal main organs to being poisoned to death, if ANOMALOUS VARIATIONS is arranged, carry out histopathology and observe.
Result of the test: after sun-proof medicine lip pomade medicated powder filling stomach gives the ICR mice, the part mice is movable to be reduced, have half mice that the diarrhoea phenomenon is arranged, do not have cry unusual, tremble, convulsions, sialorrhea, shed tears, phenomenons such as rhinorrhea, dyspnea, diarrhoea, constipation, intestinal tympanites take place.Administration and observing in 14 days, do not have 1 animal dead,, dissect by only putting to death mice, the perusal heart, liver, spleen, lung, kidney, adrenal gland, thymus, stomach, duodenum, colon, seminal vesicle, prostate, testis, ovary, each internal organs of bladder, all no abnormal discovery.The mice body weight is before the administration: vehicle group: female 20.9 ± 1.4g (n=10), male 21.3 ± 1.6g (n=10), after 7 days, claim to such an extent that body weight is female 24.4 ± 3.0g (n=10), male 26.1 ± 2.6g (n=10) after 14 days, claims to such an extent that body weight is female 25.9 ± 1.4g (n=10), male 26.7 ± 1.2g (n=10), lip pomade: female 20.9 ± 1.4g (n=10), male 21.3 ± 1.6g (n=10) is after 7 days, claim to such an extent that body weight is female 24.1 ± 1.8g (n=10), male 27.6 ± 3.2g (n=10) after 14 days, claims to such an extent that body weight is female 25.1 ± 2.5g (n=10), male 27.6 ± 3.0g (n=10), body weight gain.
Second portion: skin irritation test and sensitivity test
Test objective: observe sun-proof medicine lip pomade and repeatedly contact skin complete of rabbit and local skin irritant reaction and the anaphylaxis situation that damaged skin is produced.
1, irritant test
Test method:
(1) irritant test of intact skin: get 4 rabbit, 2.0-2.5kg, 24h cuts off tame rabbit back both sides fur 150cm before the test
2, unhairing district, back, left side is coated with excipient 1g/ and only compares group, sun-proof medicine lip pomade 1g/ smears only in unhairing district, back, right side, wraps up with clean gauze, fix 4 hours after, clean medicine-feeding part with warm water.Smear every day once, totally 7 times, remove behind the medicine 1h and observe before the coating once more and whether record erythema and edema, coating part have pigmentation, petechia, pachylosis or epidermatic atrophy situation and time of origin and regression time, and erythema and edema are marked each.Behind the last coating, 30～60min after removing medicine, 24h, 48h and 72h perusal and record are smeared the position and are had or not situations such as erythema, edema and pigmentation, petechia, skin softness.
(2) irritant test of damaged skin: get 4 rabbit, 2.0-2.5kg, 24h cuts off tame rabbit back both sides fur 150cm before the test
2, with the standardized gently groined type breakage of blade, degree of being is coated with lip pomade immediately with the oozing of blood, unhairing district, back, left side is coated with excipient 1g/ and only compares group, and lip pomade 1g/ only smears in unhairing district, back, right side, with clean gauze wrapping, after fixing 4 hours, after 4 hours, clean medicine-feeding part with warm water.Smear every day once, totally 7 times, remove behind the medicine 1h and observe before the coating once more and whether record erythema and edema, coating part have pigmentation, petechia, pachylosis or epidermatic atrophy situation and time of origin and regression time, and erythema and edema are marked each.Behind the last coating, 30～60min after removing medicine, 24h, 48h and 72h perusal and record are smeared the position and are had or not situations such as erythema, edema and pigmentation, petechia, skin softness.
Result of the test:
(1) irritant test of intact skin: sun-proof medicine lip pomade is to rabbit intact skin nonirritant.Histopathologic examination's result of the test: matched group and sun-proof medicine lip pomade administration group rabbit skin epithelial cell form no abnormality seen, corium and subcutaneous tissue are not seen vasodilation and cell infiltration and collagen fiber hypertrophy.
The sun-proof medicine lip pomade of table 1 group is to rabbit intact skin stimulation
(2) irritant test of damaged skin: 4 rabbit of lip pomade group do not have erythema, no edema, situations such as pigmentation.Histopathologic examination's result of the test: matched group and lip pomade administration group rabbit skin epithelial cell form show no obvious abnormalities, and corium and subcutaneous tissue are not seen vasodilation, do not see obvious collagen fiber hypertrophy, visible slight cell infiltration.Therefore lip pomade is to rabbit damaged skin nonirritant.
The sun-proof medicine lip pomade of table 2 group is to rabbit damaged skin stimulation
2, hypersensitive test
Test method: 18 of Cavia porcelluss are divided into 3 groups at random by the body weight sex, 6 every group: lip pomade group, vehicle group, 2,4-dinitro-chloro-benzene positive controls.Test and cut off guinea pig back left side hair 3 * 3cm in preceding 24 hours.1. lip pomade 1.0g/ only, 2. vehicle group 1.0g/ only, 3. 1%2,4-dinitro-chloro-benzene acetone soln 0.2ml/ only, last three groups respectively at the 1st, 3,5 day by above-mentioned dosage coating sensitization, weigh weekly 1 time, after behind the last coating 14 days right side cropping 3 * 3cm smear respectively lip pomade 1.0g/ only, vehicle group 1.0g/ only, 0.1%2,4-dinitro-chloro-benzene acetone soln 0.2ml/ only excites.Use the warm water flush away after 6 hours, at once, carried out the result in 24,48,72 hours and judge.After smearing, observation have useless pawl to scratch reactions such as nose, sneeze, perpendicular hair, tic, dyspnea, gatism, shock and death.
Result of the test: excipient excited on the 28th day, and guinea pig skin is normal, did not have any anaphylaxis and took place, and the 2.4-dinitro-chloro-benzene excited Cavia porcellus anaphylaxis to occur in the 28th day, anaphylaxis rate 100%.Lip pomade excited in 28 days does not all have any symptom, does not have irritated reaction.
The sun-proof medicine lip pomade of table 3 guinea pig skin anaphylaxis scoring
The sun-proof medicine lip pomade of table 4 is to the influence of Cavia porcellus body weight (X ± s)
Third part: the interactional test of multiple components drug effect in the compound preparation
Test objective: observe three kinds of composition anti-ultraviolet effects separately by the side of tearing open back, and with the effect of sun-proof medicine lip pomade relatively, with the reasonability of the compound medicine prescription that proves three kinds of compositions.
Test method:
Protective action to Cavia porcellus ultraviolet injury
Get the Cavia porcellus of 70 250-320g, with the about 9cm of the equal back depilation of 7% sodium sulfide
2, male and female half and half are divided into 7 groups: the 1st group: blank group (not smearing any excipient and medicine), and the 2nd group: model group is only smeared excipient 1g/, the 3rd group: the titanium dioxide group is coated with and only contains 1% titanium dioxide substrate 1g/; The 4th group: the nicotiamide group is smeared and is only contained 1% nicotiamide substrate 1g/; The 5th group: the zinc oxide group is smeared and is only contained 1% zinc oxide substrate 1g/; The 6th group: the lip pomade group is smeared lip pomade 1g/ only (content of dispersion 3%); The 7th group: plateau protective skin cream group is only smeared plateau protective skin cream 1g/, behind the 1h, the Cavia porcellus abdominal part is fixed to the next, with straight pipe type quartz ultraviolet germicidal lamp irradiation guinea pig back depilation district: light is apart from 8cm, and irradiation time 7min, record respectively organize after the Cavia porcellus irradiation immediately, 4h, the size of animal of erythema appears in 24h different time, irradiated site, observes the sun-proof result of respectively organizing Cavia porcellus.Use x
2The significance of inspection medicine.
Result of the test:
Sun-proof medicine lip pomade and modeling group are relatively, behind the ultraviolet radiation immediately, 4h, item has protective action to ultraviolet damage during 3 of 24h, behind the protective skin cream ultraviolet radiation of plateau immediately, item has protective action to ultraviolet damage during 2 of 4h, and sun-proof medicine lip pomade can prevent the ultraviolet injury of at least 21 times of MED.Containing titanium dioxide, zinc oxide, nicotiamide group separately has the trend of protective action to ultraviolet damage, but not statistically significant, the compound medicine group that contains three kinds of compositions has the effect of tangible anti-ultraviolet, illustrates that the compound medicine prescription of three kinds of compositions has certain reasonability.
The sun-proof medicine lip pomade of table 5 is to the effect (dosage is 1g/) of Cavia porcellus ultraviolet injury protection
Annotate: compare with model group
*P＜0.05,
*P＜0.01
The 4th part: Pharmacodynamic test of active extract
Test objective: observe lip pomade antiinflammatory, antibacterial and uvioresistant effect by pharmacological testing, for clinical application provides test basis.
Test method:
1. to the protective action of Cavia porcellus ultraviolet injury: test with third part.
2. to the bacteriostasis of mice injured skin
Get 72 of ICR mice 18-22g, male and female half and half are with the about 4cm of the equal back depilation of 6% sodium sulfide
2Be divided into 6 groups at random by the body weight sex, every group 12, aseptic wound group, vehicle group (model group), lip pomade big, in, little 3 dosage group: 0.2g/ are (content of dispersion 3%) only, and 0.2g/ is (content of dispersion 1.5%) only, 0.2g/ only (content of dispersion 0.75%), positive control drug group QUMIXIN emulsifiable paste: 0.2g/ are only.Each group mouse back is scratched " # " font respectively, and other each groups are dripped staphylococcus aureus (1 * 1010cpu/L) each 0.025ml respectively except that vehicle group.Smear respectively by each group and dosage and to be subjected to reagent or excipient in the back of mice, every day 2 times, single cage is raised, and continuous 8 days, observe the healing state of mice 4 days and 8 days back wounds after administration, judge the wound healing degree by following standard.The healing degree is divided into: deterioration, no change, improvement, four kinds of situations of recovery from illness.Worsen: the visible a large amount of puss in wound district, exudate, wound become big, fester, new granulation tissue is few, and tissue tension is bigger.No change: wound surface pus is arranged or ooze out, local swelling, it is big that wound does not become, and has newly to granulate, tissue tension is bigger.Take a turn for the better: as seen local desiccation, wound have newly and granulate, and wound diminishes, and local tension force is little.Recovery from illness: local desiccation, the wound closure, local tension force is little.
3. to the influence of mice ear
Get 60 of ICR mice 18-22g, male and female half and half, be divided into 5 groups at random by the body weight sex, every group 12, vehicle group, lip pomade big, in, little 3 dosage group: 0.1g/ are (content of dispersion 3%) only, only 0.1g/ (content of dispersion 1.5%), 0.1g/ is (content of dispersion 0.75%) only, and positive control drug group QUMIXIN emulsifiable paste: 0.1g/ only.Each group according to dosage is applied in the auricle of mice respectively, every day 2 times, single cage is raised, and continuous 7 days, fasting was 12 hours before the last administration, 45min behind the medicine, 20 μ l dimethylbenzene are applied in mouse right ear, after 20 minutes, cut left and right ear meticulously along auricle, with ten thousand/ balance claim the weight of two auricles, be auricle swelling degree with the difference of two auricle weight.
Result of the test:
1. to the protective action of Cavia porcellus ultraviolet injury: sun-proof medicine lip pomade and modeling group are relatively, behind the ultraviolet radiation immediately, 4h, ultraviolet relatively damage has protective action during 3 of 24h, behind the protective skin cream ultraviolet radiation of plateau immediately, ultraviolet relatively damage has protective action during 2 of 4h, and sun-proof medicine lip pomade can prevent the ultraviolet injury (the results are shown in Table 5) of at least 21 times of MED.
2. to the bacteriostasis of mice injured skin: model group and aseptic wound group relatively, the aseptic wound group significantly reduces than the traumatic infection degree of model group animal, illustrate that modeling is successfully.Sun-proof medicine lip pomade and modeling group relatively all had the healing effect of good promotion local infection wound in 4 days and 8 days.
The sun-proof medicine lip pomade of table 6 is to the bacteriostasis of mice injured skin
Annotate: with the statistical result of model group comparison scale preface value method
*P＜0.05,
*P＜0.01
3. heavy dose of group of lip pomade and QUMIXIN emulsifiable paste and vehicle group relatively can significantly suppress the ear thickness (P＜0.05) of mice caused by dimethylbenzene xylene.
The sun-proof medicine lip pomade of table 7 is to the inhibitory action of mice ear (X ± S)
Annotate: compare with the excipient matched group
*P＜0.05,
*P＜0.01,
* *P＜0.001
The 5th part: treatment and the clinical trial of prevention cheilitis
Test objective: this test is adopted at random, the parallel check experiment method, observes the effectiveness and the safety of lip pomade treatment and prevention cheilitis, for clinical practice provides foundation.
Test method:
1. treatment cheilitis clinical trial
Select age 18-35 year, the men and women does not limit, and suffers from through clinician's diagnosis that other are in a good state of health outside the slight cheilitis.Test the medicine of not using corticosteroids or other to influence immunologic function in preceding 3 months, treat after the cheilitis morbidity.The purpose of clear and definite this test of experimenter and requirement, and aspiration signature Informed Consent Form.Experimenter's totally 300 examples are included in design in, are divided into test group and matched group (each 150 example) at random.Test is adopted at random, the non-bad effect clinical trial design of parallel control.The experimenter who includes test group in uses and is subjected to the test preparation lip pomade, and the experimenter who includes matched group in uses the control formulation chlorotetracycline eye ointment.The clinical treatment time of each case is defined as 10 days.Medication: the lip pomade specification: 3.5g/ props up, and lip pomade is evenly coated the lip surface, and use every day 4 times (after the breakfast, lunch and dinner, sleep before).Chlorotetracycline eye ointment specification: 1g/ props up (content 0.5%), extrudes about 5mm at every turn, evenly coats the lip surface, and use every day 4 times (after the breakfast, lunch and dinner, sleep before).
2. prevention cheilitis clinical trial
Select age 18-35 year, the men and women does not limit, and diagnoses no cheilitis through the clinician, and other are in a good state of health.Testing in preceding 3 months did not use corticosteroids or other to influence the medicine of immunologic function.The purpose of clear and definite this test of experimenter and requirement, and aspiration signature Informed Consent Form.
Experimenter's totally 600 examples are included in design in, each 300 example of test group and matched group.Adopt at random, the parallel control clinical trial.The experimenter who includes test group in uses and is subjected to the test preparation lip pomade, and the experimenter who includes matched group in does not give medicine.The clinical treatment time of each case is defined as 20 days.
Medication: the lip pomade specification: 3.5g/ props up, and lip pomade is evenly coated the lip mucous membrane surface, and use every day 4 times (after the breakfast, lunch and dinner, sleep before).
Result of the test:
1. treatment cheilitis test: this research is actual to be gone into to organize 358 examples altogether, and the case that meets scheme has 350 examples, the lip pomade group: 177 examples, chlorotetracycline eye ointment group: 173 examples.
(1) sick damage face healing rate day by day: in the observation period after the medication of lip-stick group day by day healing rate by 0.00%～51.38% (FAS), 0.00%～52.54% (PPS), after the medication of chlorotetracycline eye ointment group day by day healing rate by 0.00%～26.55% (FAS), 0.00%～27.17% (PPS), through logrank check, between FAS demonstration group as a result after the medication day by day the healing rate difference statistical significance (x is arranged
2=24.88, P=0.0000), between PPS demonstration group as a result after the medication day by day the healing rate difference statistical significance (x is arranged
2=25.24, P=0.0000), prove that the clinical effectiveness of lip-stick treatment plateau cheilitis significantly is better than chlorotetracycline eye ointment.
(2) median healing stage: after the medication of lip-stick group meta day by day healing time be 9.00 days (FAS), 9.00 days (PPS), after the medication of chlorotetracycline eye ointment group meta day by day healing time greater than 10 days (FAS), greater than 10 days (PPS).
(3) vermilion border drying area: changing value before and after the treatment, through covariance analysis, difference not statistically significant between two groups (FAS:P=0.0960, PPS:P=0.0989); Test group is 0.03 (0.01,0.06) with contrast PPS result, the equal not statistically significant of difference between group.Changing value all has statistical significance before and after the group internal therapy, and gauged difference mean (95% credibility interval) FAS result is 0.53 (0.51,0.56) before and after the lip-stick treatment, and PPS result is 0.54 (0.52,0.57).Gauged difference mean (95% credibility interval) FAS result is 0.50 (0.48,0.53) before and after the chlorotetracycline eye ointment treatment, and PPS result is 0.51 (0.49,0.54).
(4) during vermilion border desquamation area baseline and when following up a case by regular visits at every turn, the equal not statistically significant of difference between group.
(5) during vermilion rhagades bar base line and when following up a case by regular visits at every turn, the equal not statistically significant of difference between group.
(6) satisfaction VAS score: changing value before and after the treatment, through covariance analysis, between two groups difference have statistical significance (FAS:P=0.0085, PPS:P=0.0082); Gauged difference mean (95% credibility interval) FAS result is 0.45 (0.12,0.78) between test group and matched group, and PPS result is 0.46 (0.12,0.80), and difference all has statistical significance between group, and the satisfaction of lip-stick is higher than chlorotetracycline eye ointment.Gauged difference mean (95% credibility interval) FAS result is 4.26 (4.03,4.50) before and after the lip-stick treatment, and PPS result is 4.29 (4.05,4.53), and difference all has statistical significance.Gauged difference mean (95% credibility interval) FAS result is 3.81 (3.58,4.05) before and after the chlorotetracycline eye ointment treatment, and PPS result is 3.83 (3.59,4.07), and difference all has statistical significance, shows that two groups of treatment front and back satisfactions all obviously improve.
2. prevention cheilitis test: group 732 examples (lip pomade group: 366 examples, matched group: 366 examples), all finish test, do not have case to come off is gone in this research altogether.Cheilitis incidence rate, lip-stick group are 0.27% (FAS), and 0.27% (PPS), the matched group that does not give medicine are 51.37% (FAS), 51.37% (PPS).The cheilitis incidence rate is through two-way unordered CHMx between two groups
2Check, FAS result shows that difference has statistical significance (x
2=249.080, P=0.0000), PPS display result as a result also has statistical significance (x
2=249.080, P=0.0000).Prove that sun-proof medicine lip pomade can significantly reduce the incidence rate of cheilitis, and draw the protective rate after the lip-stick medication, FAS and PPS result are 99%.
The above results shows that sun-proof medicine lip pomade of the present invention can significantly reduce the incidence rate of cheilitis, and the generation of prevention plateau cheilitis has very high protective effect.
Claims (2)
1, a kind of sun-proof medicine lip pomade with repair function is characterized in that, the sun-proof medicine lip pomade of this that makes is made up of medicine, wax, oil and additive, and wherein, medicine shared percentage by weight in sun-proof medicine lip pomade is 1%～10%; Wax shared percentage by weight in sun-proof medicine lip pomade is 15%～50%; Oil shared percentage by weight in sun-proof medicine lip pomade is 35%～50%, and all the other are additive;
Described medicine is made of by weight percentage following prescription: nicotiamide: 20～40%, and zinc oxide: 20～40%, titanium dioxide: 20～40%;
Described wax is made of by weight percentage following prescription: polyglycereol-2-three isostearates: 5～20%, and ceresine: 5～35%, Cera Flava: 1～5%, alkene wax: 5～10%, vaseline: 30～50%;
Described oils and fats is made of by weight percentage following prescription: Oleum Ricini: 30～50%, and liquid paraffin: 50～70%;
Described additive is ethyl hydroxybenzoate and Oleum menthae.
2, the described preparation method with sun-proof medicine lip pomade of repair function of claim 1 is characterized in that, comprises the following steps:
Step 1, the nicotiamide that takes by weighing formula ratio adds in the 95% an amount of alcoholic solution, makes it to dissolve fully, and is standby;
Step 2 takes by weighing the zinc oxide and the titanium dioxide of formula ratio, adds in the standby sample of step 1 gained, and heating is ground and volatilized fully until alcoholic solution, white homogeneous fine powder, standby;
Step 3 takes by weighing Cera Flava, alkene wax, ceresine, vaseline, polyglycereol-2-three isostearates and saxol, the Oleum Ricini of formula ratio, and the heating mixing is standby;
Step 4 with the standby sample of step 2 gained, adds in the fused mass of step 3, continues heating and grinds, and gets the homogeneous mastic, adds ethyl hydroxybenzoate and Oleum menthae as additive in mastic, mixing; Be cooled to about 55 ℃, fill, promptly.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2009100241384A CN101669889B (en) | 2009-09-29 | 2009-09-29 | Sunscreen lipstick with repair function and preparation method thereof |
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| CN2009100241384A CN101669889B (en) | 2009-09-29 | 2009-09-29 | Sunscreen lipstick with repair function and preparation method thereof |
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| CN101669889A true CN101669889A (en) | 2010-03-17 |
| CN101669889B CN101669889B (en) | 2011-07-20 |
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| CN2009100241384A Expired - Fee Related CN101669889B (en) | 2009-09-29 | 2009-09-29 | Sunscreen lipstick with repair function and preparation method thereof |
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| CN102697676A (en) * | 2012-07-05 | 2012-10-03 | 沈群华 | Jasmine-fragrance-type lipstick and preparation method thereof |
| CN102697700A (en) * | 2012-07-05 | 2012-10-03 | 沈群华 | Jasmine-fragrance-type lipstick and preparation method thereof |
| CN102935040A (en) * | 2012-11-15 | 2013-02-20 | 李贞� | Sunscreen lip care balm and preparation method thereof |
| CN104473851A (en) * | 2014-12-26 | 2015-04-01 | 武汉健民大鹏药业有限公司 | Lip cosmetics and preparation method thereof |
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| CN105963181A (en) * | 2016-05-25 | 2016-09-28 | 吴胜伟 | Lip balm with sunscreen moistening function |
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| CN114699342A (en) * | 2022-04-29 | 2022-07-05 | 中国人民解放军空军军医大学 | Lipstick with effects of moisturizing, repairing and preventing and treating desquamation and preparation method thereof |
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| CN104606120A (en) * | 2015-02-13 | 2015-05-13 | 南通蛇类治疗研究所 | Nanometer negative ion natural plant lipstick |
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| CN106074228B (en) * | 2016-08-24 | 2018-10-30 | 广州睿森生物科技有限公司 | A kind of lipstick and preparation method thereof |
| CN114699342A (en) * | 2022-04-29 | 2022-07-05 | 中国人民解放军空军军医大学 | Lipstick with effects of moisturizing, repairing and preventing and treating desquamation and preparation method thereof |
| CN117838610A (en) * | 2024-03-07 | 2024-04-09 | 天津科技大学 | High-permeability slow-release liposome lipstick for treating plateau cheilitis and preparation method thereof |
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