CN101669509A - Pesticide composition and application thereof - Google Patents
Pesticide composition and application thereof Download PDFInfo
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- CN101669509A CN101669509A CN200910167386A CN200910167386A CN101669509A CN 101669509 A CN101669509 A CN 101669509A CN 200910167386 A CN200910167386 A CN 200910167386A CN 200910167386 A CN200910167386 A CN 200910167386A CN 101669509 A CN101669509 A CN 101669509A
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Abstract
The invention discloses a pesticide composition and application thereof in agriculture. The effective components of the composition contain methoxyfenozide and organophosphorus pesticide, and the massratio of methoxyfenozide and organophosphorus pesticide is 100:1 to 1:100. The pesticide composition has the advantages of synergism, quick action and long effect, can reduce the use amount and savelabor, and is also good for delaying the development of resistance. The pesticide composition can be used for preventing and treating pests in plants, and is particularly suitable for preventing and treating lepidoptera pests such as spodoptera exigua, prodenia litura, cnaphalocrocis medinalis guenee, chilo suppressalis and cotton bollworm.
Description
Technical field
The present invention relates to a kind of composition pesticide and application thereof, be specially a kind of composition pesticide that contains methoxyfenozide, be applied to prevent and treat the insect on the plant.
Background technology
In pesticide, organophosphorous pesticide is an important class.This insecticides is because applied range, characteristics such as drug effect is better, the mode of action is various have been exactly one of main pesticide species classification since the sixties in last century.The long-term a large amount of of organic phosphor used, and brings drug resistance, person poultry poisoning, agricultural product residue of pesticide to exceed standard and a series of problems such as environmental pollution.But because its broad spectrum activity and the low advantage of price, organophosphorous pesticide still holds pride of place in China's agricultural chemicals usage amount at present.Progressively substituting or partly substitute organophosphorous pesticide is the some of the pesticide species structural adjustment of China.The Chinese government has stopped production and selling acephatemet, nuvacron, parathion, parathion-methyl, 5 high malicious organophosphorous pesticides of phosphamidon.
Organophosphorous pesticide can be prevented and treated various insect, and wherein multiple organic phosphor kind can be used for preventing and treating first class pest: lepidoptera pest.As the rice leaf roller on the paddy rice, striped rice borer; Leaf roller on the apple; Cotton bollworm on the cotton; Beet armyworm on the vegetables, prodenia litura or the like.Because the organophosphorous pesticide mechanism of action is identical, each interracial cross resistance is obvious.In recent years, organic phosphor had to strengthen dosage to lepidopterous control of insect worse and worse, sought to substitute medicament or seek reasonably composite dose.
Adopting the medicament and the organic phosphorous built of efficient, safety, the different mechanisms of action, is to tackle the effective ways commonly used that pest resistance to insecticide strengthens.After composite, be synergy, addition or antagonism, unpredictable.And, have only compound synergic well to fill a prescription, obviously improve actual control efficiency, when just can have both various effect characteristics, reduced the usage amount of organophosphorous pesticide, reduce producing resistance risk.
Summary of the invention
The object of the present invention is to provide a kind of composition pesticide, be characterized in higher, obvious synergistic effect is arranged, and itself be difficult for producing resistance the plant insect activity.Another object of the present invention is to provide the application of said composition on the control plant insect, the especially application on the control lepidoptera pest.
The present invention is achieved through the following technical solutions.
The present invention adopts methoxyfenozide and organophosphorus insecticides to carry out composite, the organophosphorus insecticides that relates to comprises chlopyrifos (chlorpyrifos), phoxim (phoxin), Hostathion (triazophos), Profenofos (profenophos), quinalphos (quinalphos), diazinon (diazinon), malathion (malathion), dichlorvos (dichlorvos), chlorophos (trichlorfon), though they there are differences on structure, activity level and effect characteristics, and the essentially identical mechanism of action is all arranged.
Technical scheme of the present invention is: a kind of composition pesticide, its active ingredient are methoxyfenozide and a kind of organophosphorus insecticides, and the mass ratio of methoxyfenozide and organophosphorus insecticides is 100: 1-1: 100; Described organophosphorus insecticides comprises chlopyrifos, phoxim, Hostathion, Profenofos, quinalphos, diazinon, malathion, dichlorvos and chlorophos etc.
The present composition is processed in actual applications and is fit to any dosage formulation that agricultural goes up use, and preferred dosage form is suspending agent, aqueous emulsion, microemulsion, water-dispersible granules, missible oil, wetting powder, micro-capsule suspension.
As a kind of improvement of the present invention, the mass ratio of methoxyfenozide and organophosphorus insecticides is preferably 20: 1-1: 20.
The present composition can be used for preventing and treating the insect on the plant, and it is higher to have activity simultaneously, and drug effect is rapid, reduces dosage, is difficult for producing the characteristics of resistance.Be particularly useful for preventing and treating lepidoptera pests such as beet armyworm, prodenia litura, lima bean pod borer, rice leaf roller, striped rice borer, cotton bollworm.
Composition pesticide of the present invention compared with prior art produces following beneficial effect: two kinds of active ingredients in (1) composition have synergistic effect, compare with single agent, have obviously improved control efficiency, reduce the organic phosphor dosage; (2) different effective ingredients have different effect characteristics, compare with single agent, have obviously improved quick-acting and lasting effect; (3) can reduce the field dosage, effectively reduce environmental pollution and residue of pesticide, reduce harm beneficial organism; (4) mechanism of action of both active ingredients is different in the composition, and the notable synergistic effect is arranged, and can delay the enhancing of insect to the medicament resistance.
Embodiment
In order to make purpose of the present invention, technical scheme and technological merit are clearer, below in conjunction with embodiment summary of the invention are described in further detail.Should be appreciated that described specific embodiment only is used to explain the present invention, and be not used in qualification the present invention.All any modifications of being made within the spirit and principles in the present invention, be equal to and replace and improvement etc., all should be included within protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Indoor virulence test implementation example 1-3
Embodiment 1: methoxyfenozide and chlopyrifos virulence test
Methoxyfenozide and chlorpyrifos mixture test, it is tested object that cotton bollworm is adopted in test.Concrete grammar is:
Cotton bollworm (Helicoverpa armigera Hubner): test former medicine methoxyfenozide from The Dow Agrosciences, LLC., the former medicine of chlopyrifos is from Nanjing HongTaiYang Co., Ltd.Former medicine is mixed with according to a conventional method the test medicine that needs.Examination worm worm kind is picked up from the Hubei peach of immortality, and indoor artificial feed are raised to third generation third-instar larvae and supplied to test.Test method is with reference to " the agricultural industry criteria NY/T1154.7-2006 of the People's Republic of China (PRC) " and " the agricultural industry criteria NY/T1154.14-2006 of the People's Republic of China (PRC) ".With size one to cabbage leaves in the soup under the series concentration, soaked medicine 5 seconds, take out and to put capable culture dish into after drying and preserve moisture, every ware inserts 10 of insects again, 5 wares of every processing, blank is soaked clear water.Each processing is provided with 6-7 concentration gradient.The culture dish of handling is put into 25 ℃, cultivate in the 12H/12H illumination box, check after 72 hours and calculate lethality by dead borer population.Carry out statistical analysis with the DPS data processing software, calculate the LC of each medicament
50, estimate the activity of reagent agent to the examination worm with this.
It is co-toxicity coefficient (CTC) method that the synergy mode adopts the abundant method of passing through toxicity index calculating mixture co-toxicity that waits nineteen sixty to propose of Sun Yun.The computing formula of co-toxicity coefficient is as follows:
Actual measurement toxicity index (ATI)=(standard medicament LC
50/ reagent agent LC
50) * 100
The percentage composition of B in percentage composition+B medicament ATI * mixture of A in theoretical toxicity index (TTI)=A medicament ATI * mixture
Co-toxicity coefficient (CTC)=[mixture actual measurement toxicity index (the ATI)/theoretical toxicity index (TTI) of mixture] * 100
When CTC≤80, then the composition performance is for antagonism, and when 80＜CTC＜120, then the composition performance is for summation action, and when CTC 〉=120, then the composition performance is synergistic effect.
Table 1 different disposal is to the cotton bollworm measurement result
| Handle | ??LC 50(mg/L) | ??AT1 | ??TTI | Co-toxicity coefficient CTC |
| Methoxyfenozide | ??2.56 | ??100.00 | ||
| Chlopyrifos | ??102.55 | ??2.50 | ||
| Methoxyfenozide 100+ chlopyrifos 1 | ??1.89 | ??135.45 | ??99.03 | ??136.77 |
| Methoxyfenozide 40+ chlopyrifos 1 | ??1.92 | ??133.33 | ??97.62 | ??136.58 |
| Methoxyfenozide 20+ chlopyrifos 1 | ??1.23 | ??208.13 | ??95.36 | ??218.26 |
| Methoxyfenozide 10+ chlopyrifos 1 | ??1.35 | ??189.63 | ??91.14 | ??208.07 |
| Methoxyfenozide 1+ chlopyrifos 1 | ??1.89 | ??135.45 | ??51.25 | ??264.30 |
| Methoxyfenozide 1+ chlopyrifos 10 | ??10.25 | ??24.98 | ??11.36 | ??219.85 |
| Methoxyfenozide 1+ chlopyrifos 20 | ??15.65 | ??16.36 | ??7.14 | ??229.12 |
| Methoxyfenozide 1+ chlopyrifos 40 | ??35.23 | ??7.27 | ??4.87 | ??149.07 |
| Methoxyfenozide 1+ chlopyrifos 100 | ??55.36 | ??4.62 | ??3.46 | ??133.58 |
As seen from Table 1, methoxyfenozide and chlorpyrifos mixture, mass ratio are 100: 1-1:, the CTC of cotton bollworm all greater than 120, is had synergistic effect at 100 o'clock.Be 20 with methoxyfenozide and chlopyrifos mass ratio again: 1-1: CTC was obviously higher in 20 o'clock, illustrated that synergy is more obvious under this proportioning.
Embodiment 2: methoxyfenozide and phoxim virulence test
Methoxyfenozide and phoxim compound synergism test, it is tested object that the beet armyworm on the vegetables is adopted in test.Concrete grammar is:
Beet armyworm (Laphygma exigua Hubner): test former medicine methoxyfenozide from The Dow Agrosciences, LLC., Phoxim original medicine is from Nanjing HongTaiYang Co., Ltd.Former medicine is mixed with according to a conventional method the test medicine that needs.Examination worm worm kind is picked up from Bao'an, Shenzhen Xixiang.Adopt artificial feed to raise the three generations, third-instar larvae is for test.Test method adopts leaf dipping method with reference to " the agricultural industry criteria NY/T1154.14-2008 of the People's Republic of China (PRC) " and " the agricultural industry criteria NY/T1154.7-2006 of the People's Republic of China (PRC) ".The Chinese cabbage leaf was soaked soup 5 seconds, take out dry after, to put into the culture dish processing of preserving moisture, beet armyworm is inserted in the culture dish, 10 in every ware, putting temperature and be 27 ℃, photoperiod is 12h: 12h (L: raise in incubator D).The clear water contrast, each concentration repeats 3 times.Check dead borer population after 72 hours, calculate lethality.Data processing and virulence evaluation method are with embodiment one.
Table 2 different disposal is to the toxicity test result of beet armyworm
| Handle | ??LC 50(mg/L) | ??AT1 | ??TTI | Co-toxicity coefficient CTC |
| Methoxyfenozide | ??1.56 | ??100 | ||
| Phoxim | ??62.55 | ??2.49 | ||
| Methoxyfenozide 100+ phoxim 1 | ??1.25 | ??124.80 | ??99.03 | ??126.02 |
| Methoxyfenozide 40+ phoxim 1 | ??1.30 | ??120.00 | ??97.62 | ??122.92 |
| Methoxyfenozide 20+ phoxim 1 | ??0.76 | ??205.26 | ??95.36 | ??215.26 |
| Methoxyfenozide 10+ phoxim 1 | ??0.78 | ??200.00 | ??91.14 | ??219.45 |
| Methoxyfenozide 1+ phoxim 1 | ??1.34 | ??116.42 | ??51.25 | ??227.17 |
| Methoxyfenozide 1+ phoxim 10 | ??6.30 | ??24.76 | ??11.36 | ??218.01 |
| Methoxyfenozide 1+ phoxim 20 | ??10.89 | ??14.33 | ??7.14 | ??200.71 |
| Methoxyfenozide 1+ phoxim 40 | ??23.65 | ??6.60 | ??4.87 | ??135.38 |
| Methoxyfenozide 1+ phoxim 100 | ??28.35 | ??5.50 | ??3.46 | ??159.06 |
As seen from Table 2, methoxyfenozide and phoxim compound, mass ratio are 100: 1-1:, the CTC of beet armyworm all greater than 120, is had synergistic effect at 100 o'clock.Be 20 with methoxyfenozide and phoxim mass ratio again wherein: 1-1: CTC was obviously higher in 20 o'clock, illustrated that synergy is more obvious under this proportioning.
Embodiment 3: methoxyfenozide and Hostathion virulence test
Methoxyfenozide and Triazoxide as built-up synergism test, it is tested object that striped rice borer (Chilo suppressalis) larva is adopted in test, concrete grammar is: test former medicine methoxyfenozide from The Dow Agrosciences, LLC., the former medicine of Hostathion is from Zhejiang Xinnong Chemical Co., Ltd.Former medicine is mixed with according to a conventional method the test medicine that needs.Test method adopts rice stem infusion process with reference to " the agricultural industry criteria NY/T1154.11-2008 of the People's Republic of China (PRC) " and " the agricultural industry criteria NY/T1154.7-2006 of the People's Republic of China (PRC) ".Adopt the rice stem of long 10cm to soak soup 5 seconds, clear water is soaked in contrast, puts into Boiling tube after taking-up is dried, and every Boiling tube inserts 5 striped rice borer third-instar larvaes.Fruit came to an end after 72 hours.Check result, data processing and virulence evaluation method are with embodiment one.
Table 3 different disposal is to the toxicity test result of striped rice borer
| Handle | ??LC 50(mg/L) | ??AT1 | ??TTI | Co-toxicity coefficient CTC |
| Methoxyfenozide | ??1.95 | ??100.00 | ||
| Hostathion | ??48.65 | ??4.01 | ||
| Methoxyfenozide 100+ Hostathion 1 | ??1.39 | ??140.29 | ??99.05 | ??141.63 |
| Methoxyfenozide 40+ Hostathion 1 | ??1.44 | ??135.42 | ??97.66 | ??138.66 |
| Methoxyfenozide 20+ Hostathion 1 | ??1.01 | ??193.07 | ??95.43 | ??202.32 |
| Methoxyfenozide 10+ Hostathion 1 | ??1.03 | ??189.32 | ??91.27 | ??207.42 |
| Methoxyfenozide 1+ Hostathion 1 | ??1.81 | ??107.73 | ??52.00 | ??207.17 |
| Methoxyfenozide 1+ Hostathion 10 | ??6.25 | ??31.20 | ??12.73 | ??245.00 |
| Methoxyfenozide 1+ Hostathion 20 | ??10.65 | ??18.31 | ??8.58 | ??213.42 |
| Methoxyfenozide 1+ Hostathion 40 | ??22.56 | ??8.64 | ??6.35 | ??136.13 |
| Methoxyfenozide 1+ Hostathion 100 | ??25.33 | ??7.70 | ??4.96 | ??155.25 |
As seen from Table 3, methoxyfenozide and Triazoxide as built-up, mass ratio are 100: 1-1:, the CTC of striped rice borer all greater than 120, is had synergistic effect at 100 o'clock.Be 20 with methoxyfenozide and Hostathion mass ratio again wherein: 1-1: CTC was obviously higher in 20 o'clock, illustrated that synergy is more obvious under this proportioning.
Embodiment 4: methoxyfenozide and chlorophos virulence test
Methoxyfenozide and the test of chlorophos compound synergic, it is tested object that rice leaf roller is adopted in test.Concrete grammar is:
Rice leaf roller test (Chaphalocrocis medina): the examination worm is picked up from Qingxin County, Guangdong.Test former medicine methoxyfenozide from The Dow Agrosciences, LLC., the former medicine of chlorophos is from Hubei Xianlong Chemical Industry Co., Ltd..Former medicine is mixed with according to a conventional method the test medicine that needs.Test method is with reference to " " the agricultural industry criteria NY/T1154.7-2006 of the People's Republic of China (PRC) " adopts the potter spray-on process.The culture dish of 9 centimetres of the diameters of paddy rice tender leaf (with agar processings of preserving moisture) adopt is put in test, and every processing connects 5 wares, sprays under 15PSI pressure with the potter spray tower, sprays a ware at every turn, 2 milliliters of every ware spraying liquids, and blank sprays the equivalent clear water.Each processing is provided with 6-7 concentration gradient.Every ware inserts 10 of third-instar larvaes, and the culture dish of handling is put into 25 ℃, cultivates in the 12H/12H illumination box, checks dead borer population after 72 hours.Result treatment is with embodiment one.
Table 4 different disposal is to the toxicity test result of rice leaf roller
| Handle | ??LC 50(mg/L) | ??AT1 | ??TTI | Co-toxicity coefficient CTC |
| Methoxyfenozide | ??4.12 | ??100 | ||
| Chlorophos | ??156.44 | ??2.63 | ||
| Methoxyfenozide 100+ chlorophos 1 | ??2.89 | ??142.56 | ??99.04 | ??143.95 |
| Methoxyfenozide 40+ chlorophos 1 | ??2.94 | ??140.14 | ??97.63 | ??143.54 |
| Methoxyfenozide 20+ chlorophos 1 | ??1.86 | ??221.51 | ??95.36 | ??232.27 |
| Methoxyfenozide 10+ chlorophos 1 | ??1.89 | ??217.99 | ??91.15 | ??239.16 |
| Methoxyfenozide 1+ chlorophos 1 | ??3.25 | ??126.77 | ??51.32 | ??247.03 |
| Methoxyfenozide 1+ chlorophos 10 | ??16.54 | ??24.91 | ??11.49 | ??216.88 |
| Methoxyfenozide 1+ chlorophos 20 | ??21.21 | ??19.42 | ??7.27 | ??267.19 |
| Methoxyfenozide 1+ chlorophos 40 | ??45.56 | ??9.04 | ??5.01 | ??180.56 |
| Methoxyfenozide 1+ chlorophos 100 | ??68.96 | ??5.97 | ??3.60 | ??166.07 |
As seen from Table 4, methoxyfenozide and chlorophos are composite, and mass ratio is 100: 1-1:, the CTC of rice leaf roller all greater than 120, is had synergistic effect at 100 o'clock.Be 20 with methoxyfenozide and chlorophos mass ratio again wherein: 1-1: CTC was obviously higher in 20 o'clock, illustrated that synergy is more obvious under this proportioning.
Example of formulations such as embodiment 5-14
Embodiment 5: methoxyfenozide and the preparation of chlorpyrifos mixture preparation
Former medicine 20.49 grams of 97.6% methoxyfenozide
Former medicine 0.22 gram of 90% chlopyrifos
Toluene (solvent) 15.8 grams
Dimethyl formamide (solvent) 15.2 grams
Triphenyl vinyl phenol polyoxyethylene poly-oxygen propylene aether (emulsifier) 4.5 grams
Calcium dodecyl benzene sulfonate (emulsifier) 3.6 grams
Water complements to 100 grams
With above component by the amount of prescription according to the processing that feeds intake of conventional aqueous emulsion processing method, after shear agitation is even, makes 100 and restrain 20.2% methoxyfenozide chlorpyrifos aqueous emulsions (mass ratio of methoxyfenozide and chlopyrifos is 100: 1).
Embodiment 6: methoxyfenozide and the preparation of phoxim compound preparation
Former medicine 10.33 grams of 97.6% methoxyfenozide
95% Phoxim original medicine, 1.1 grams
Ethylene glycol APEO 10.5 grams
Methyl naphthalene sulfonate formaldehyde condensate 4.9 grams
White carbon 5.0 grams
Xanthans 3.8 grams
Water adds to 100 grams
Earlier white carbon is mixed with Phoxim original medicine, make phoxim adsorb fully in the white carbon, mix with the amount of above other component then, after sand mill grinds, obtain 100 gram 11% methoxyfenozide phoxim suspending agents (mass ratio of methoxyfenozide and phoxim is 10: 1) by prescription.
Embodiment 7: methoxyfenozide and the preparation of diazinon complex preparation
Former medicine 1.03 grams of 97.6% methoxyfenozide
Former medicine 10.5 grams of 95% diazinon
Poly-naphthaldehyde sulfonate sodium 10.6 grams
Calcium dodecyl benzene sulfonate 4.6 grams
Dimethyl formamide 5.8 grams
Toluene adds to 100 grams
The amount of above component by prescription mixed, fully stir and obtain 100 gram 11% methoxyfenozide diazinon missible oil (mass ratio of methoxyfenozide and diazinon is 1: 10).
Embodiment 8: methoxyfenozide and chlorophos complex preparation
Former medicine 1.02 grams of 97.6% methoxyfenozide
Former medicine 84.21 grams of 95% chlorophos
Alkylaryl polyoxyethylene polyoxypropylene ether 2.1 grams
Poly-naphthaldehyde sulfonate sodium 2.1 grams
White carbon adds to 100 grams
The consumption of above component except that chlorophos by prescription mixed, become superfine powder through comminution by gas stream, chlorophos is become common fine powder with mechanical crushing, in mixer, two kinds of powders are mixed at last, obtain 81% methoxyfenozide chlorophos wetting powder (mass ratio between methoxyfenozide and the chlorophos is 1: 80).
Embodiment 9: methoxyfenozide and atgard mixed preparation
Former medicine 0.1 gram of 97.6% methoxyfenozide
Former medicine 10.52 grams of 95% dichlorvos
Sorbitol polyoxyethylene ether 10.8 grams
Dimethyl sulfoxide (DMSO) (cosolvent) 5.2 grams
Dimethylbenzene (solvent) 4.5 grams
Water complements to 100 grams
Former medicine, solvent, emulsifier are added together, make and be dissolved into even oil phase; With the mixed water that gets of water-soluble component, oily molten component and water; Under high-speed stirred, oil phase is mixed with water, make 11% methoxyfenozide dichlorvos microemulsion (mass ratio between methoxyfenozide and the dichlorvos is 1: 100).
Embodiment 10: methoxyfenozide and quinalphos complex preparation
Former medicine 1.02 grams of 97.6% methoxyfenozide
Former medicine 21.05 grams of 95% quinalphos
Sorbitol monooleate (emulsifier) 10.5 grams
Triphenyl vinyl phenol polyoxyethylene poly-oxygen propylene aether (emulsifier) 5 grams
Shitosan (cyst membrane agent) 10 grams
Dimethylbenzene (solvent) 12.5 grams
Dimethyl sulfoxide (DMSO) (cosolvent) 5.5 grams
Water complements to 100 grams
Former medicine, solvent, emulsifier etc. are added together, make and be dissolved into even oil phase; Under high-speed stirred, make 21% methoxyfenozide quinalphos micro-capsule suspension (mass ratio between methoxyfenozide and the quinalphos is 1: 20).
Embodiment 11: methoxyfenozide and chlorophos complex preparation
Former medicine 1.02 grams of 97.6% methoxyfenozide
Former medicine 21.05 grams of 95% chlorophos
Lauryl sodium sulfate 2.0 grams
Triphenyl vinyl phenol polyoxyethylene poly-oxygen propylene aether 5.2 grams
Starch 5.0 grams
Kaolin is supplied 100 grams
The consumption of above component except that chlorophos by prescription mixed, become superfine powder through comminution by gas stream, chlorophos is become common fine powder with mechanical crushing, in mixer, two kinds of powders are mixed at last, add 10-15% water again and be kneaded into wet feed, make 21% methoxyfenozide chlorophos water dispersible granules (mass ratio between methoxyfenozide and the chlorophos is 1: 20) through extruder grain, low temperature (30-40 ℃) oven dry and screening.
Embodiment 12: methoxyfenozide and the preparation of Profenofos complex preparation
Former medicine 1.03 grams of 97.6% methoxyfenozide
Former medicine 22.22 grams of 90% Profenofos
Lauryl sodium sulfate 8.6 grams
Dimethyl formamide 3.8 grams
Toluene adds to 100 grams
The amount of above component by prescription mixed, fully stir and obtain 100 gram 21% methoxyfenozide Profenofos missible oil (mass ratio of methoxyfenozide and Profenofos is 1: 20).
Embodiment 13: methoxyfenozide and the preparation of malathion complex preparation
Former medicine 10.25 grams of 97.6% methoxyfenozide
95% malathion active compound, 10.5 grams
Poly-naphthaldehyde sulfonate sodium (emulsifier) 10.6 grams
Toluene (solvent) 4.6 grams
Dimethyl formamide (solvent) 5.8 grams
Water adds to 100 grams
Former medicine, solvent, emulsifier are added together, make and be dissolved into even oil phase, under high-speed stirred that oil phase is mixed with water, obtain 100 gram 20% methoxyfenozide malathion microemulsions (mass ratio of methoxyfenozide and malathion is 1: 1).
Embodiment 14: methoxyfenozide and the preparation of chlorpyrifos mixture preparation
Former medicine 4.1 grams of 97.6% methoxyfenozide
Former medicine 22.3 grams of 90% chlopyrifos
Toluene (solvent) 15.8 grams
Dimethyl sulfoxide (DMSO) (cosolvent) 15.2 grams
Triphenyl vinyl phenol polyoxyethylene poly-oxygen propylene aether (emulsifier) 4.5 grams
Calcium dodecyl benzene sulfonate (emulsifier) 3.5 grams
Water complements to 100 grams
With above component by the amount of prescription according to the processing that feeds intake of conventional aqueous emulsion processing method, after shear agitation is even, makes 100 and restrain 24% methoxyfenozide chlorpyrifos aqueous emulsions (mass ratio of methoxyfenozide and chlopyrifos is 1: 5).
Embodiment 15-18 is seen in field trial and resistance research
Embodiment 15:
Test is controlled the rice leaf roller test standard with reference to " pesticide field efficacy medicine test criterion () insecticide " that China Standard Press publishes.Test medicine and concentration see Table 5, adopt workers and peasants-16 type atomizer spray, three repetitions of every processing, 20 square metres of every repetitions.Check the preceding radix of medicine, 1 day, 7 days and inspection in 21 days borer population alive behind the medicine.Calculate control efficiency.
21% methoxyfenozide Profenofos missible oil (mass ratio between methoxyfenozide and the Profenofos is 1: 20) of embodiment 12 preparations is to the field control effect of paddy rice rice leaf roller.See Table 5.
Table 5 methoxyfenozide, Profenofos and mixture thereof are to the field control effect of paddy rice rice leaf roller
Annotate: g a.i./ha represents per hectare effective ingredient medication gram number,
In the preventive effect a b c d represent to use the DMRT variance analysis in 5% the significance of difference, as follows.
Above result shows that 1 day effect is better than the agent of methoxyfenozide list behind the 21% methoxyfenozide Profenofos EC compound agent medicine, and control efficiency is better than two single agent after 7 days, and control efficiency also is better than two single agent after 21 days, obviously is better than Profenofos.Illustrate that composite dose of quick-acting is better than single agent, lasting effect also obviously is better than single agent, simultaneously, reduces the dosage of Profenofos, also reduces the drug cost of methoxyfenozide.
Embodiment 16:
Test is controlled the prodenia litura test standard with reference to " pesticide field efficacy medicine test criterion () insecticide " that China Standard Press publishes.Test medicine and concentration see Table 6, adopt workers and peasants-16 type atomizer spray, three repetitions of every processing, 20 square metres of every repetitions.Check the preceding radix of medicine, 1 day, 7 days and inspection in 21 days borer population alive behind the medicine.Calculate control efficiency.
20% methoxyfenozide malathion microemulsion (mass ratio between methoxyfenozide and the malathion is 1: 1) of embodiment 13 preparations is to the field control effect of brassicaceous vegetable prodenia litura.See Table 6.
Table 6 methoxyfenozide, malathion and mixture thereof are to the field control effect of prodenia litura
Above result shows that 1 day effect is better than the agent of methoxyfenozide list behind composite dose of medicine of 20% methoxyfenozide malathion microemulsion, and control efficiency is better than two single agent after 7 days, and control efficiency also is better than methoxyfenozide after 21 days, obviously is better than the malathion.Illustrate that composite dose of quick-acting is better than single agent, lasting effect also obviously is better than single agent, simultaneously, reduces the dosage of malathion, also reduces the drug cost of methoxyfenozide.
Duration of test finds that also composite dose also has positive effect to the brassicaceous vegetable phyllotreta striolata, and preventive effect reached 85% in 7 days, and the agent of methoxyfenozide list is invalid.Illustrate that composite dose can expanding prevention be composed.
Embodiment 17:
Test is controlled cowpea lima bean pod borer test standard with reference to " pesticide field efficacy medicine test criterion (two) insecticide " that China Standard Press publishes.Test medicine and concentration see Table 7, adopt workers and peasants-16 type atomizer spray, three repetitions of every processing, 20 square metres of every repetitions.Check the preceding radix of medicine, 1 day, 7 days and inspection in 21 days borer population alive behind the medicine.Calculate control efficiency.
The 24% methoxyfenozide chlorpyrifos aqueous emulsion (mass ratio between methoxyfenozide and the chlopyrifos is 1: 5) of embodiment 14 preparations is to the field control effect of cowpea lima bean pod borer.See Table 7.
Table 7 methoxyfenozide, chlopyrifos and mixture thereof are to the field control effect of lima bean pod borer
Above result shows that 1 day effect is better than the agent of methoxyfenozide list behind the 24% methoxyfenozide chlorpyrifos aqueous emulsion medicine, and control efficiency is better than two single agent after 7 days, and control efficiency also is better than methoxyfenozide after 21 days, obviously is better than chlopyrifos.Illustrate that composite dose of quick-acting is better than single agent, lasting effect also obviously is better than single agent, simultaneously, reduces the dosage of chlopyrifos, also reduces the drug cost of methoxyfenozide.
Embodiment 18: beet armyworm is to methoxyfenozide and the test of organic phosphates medicament monitoring for resistance
Beet armyworm (Laphygma exigua Hubner): test former medicine methoxyfenozide from The Dow Agrosciences, LLC., Phoxim original medicine is from Nanjing HongTaiYang Co., Ltd.Former medicine is mixed with according to a conventional method the test medicine that needs.Examination worm worm kind is picked up from Distributions in Liaocheng of Shandong Province.Screening adopts artificial feed to mix the medicine method, adopts medicament and dosage as described in Table 7, will be with the medicine feed to feed and raise beet armyworm, liquor strength is a population 50%-80% lethal dose, after 48 hours dead insect is chosen away, remaining insect continues indoor subculture to be raised, so repeated treatments 20 generations examination worm.If the blank of not dispenser.Room temperature keeps 25 ± 1 ℃, cultivates in the 12H/12H illumination box.Measure the 5th generation, 10 generations, 15 generations, 20 generations examination worm LC to each medicament
50(LC
50Assay method is with embodiment 2: the beet armyworm Toxicity Determination), and each time LC relatively
50The pesticide resistance to reagent agent of estimating the examination worm changes.
Can see obviously that according to following table 7 after the preparation of application methoxyfenozide and phoxim compound handled for 20 generations, test beet armyworm population was 3.59 times to the resistance development of methoxyfenozide phoxim compound agent, is in low-level resistance.Be starkly lower than methoxyfenozide and the agent of phoxim list and handle the resistance that 20 generations of beet armyworm produce 12.98 times and 52.43 times.Show that application methoxyfenozide and phoxim compound can effectively delay the generation of cotten aphid resistance.
Result of the test such as table 7 (following table):
| Chemicals treatment | Chemicals treatment dosage (mg/ L) | The 1st generation population LC 50??(mg/L) | The 5th generation population LC 50(mg/ ?L) | The 10th generation population LC 50(mg ??/L) | The 15th generation population LC 50(mg ??/L) | The 20th generation population LC 50(mg ??/L) |
| Methoxyfenozide | ??4 | ??1.26 | (1.94 1.51 times) | (2.25 1.79 times) | (6.25 4.96 times) | (16.35 12.98 times) |
| Phoxim | ??20 | ??23.58 | (435.35 5.74 times) | (425.65 18.05 times) | (689.38 29.24 times) | (1236.25 52.43 times) |
| Embodiment 2 (methoxyfenozide: phoxim=1: 1) | ??5 | ??2.05 | (2.35 1.15 times) | (3.65 1.78 times) | (4.56 2.22 times) | (7.36 3.59 times) |
Annotate: (* doubly) corresponding algebraically insect of expression is to the resistant multiple of each medicament
Claims (6)
1, a kind of composition pesticide, the effective ingredient that it is characterized in that it are methoxyfenozide and a kind of organophosphorus insecticides, and the mass ratio of methoxyfenozide and organophosphorus insecticides is 100: 1-1: 100.
2, composition pesticide according to claim 1 is characterized in that described organophosphorus insecticides is chlopyrifos, phoxim, Hostathion, Profenofos, quinalphos, diazinon, malathion, dichlorvos, chlorophos.
3, according to the described composition pesticide of claim 2, the mass ratio that it is characterized in that methoxyfenozide and organophosphorus insecticides is 20: 1-1: 20.
4,, it is characterized in that its formulation is suspending agent, aqueous emulsion, microemulsion, water-dispersible granules, missible oil, wetting powder, micro-capsule suspension according to each described composition pesticide of claim 1 to 3.
5, the described composition pesticide preparation of claim 4 is used to prevent and treat the insect on the plant.
6, the described composition pesticide preparation of claim 4 is used to prevent and treat beet armyworm, prodenia litura, lima bean pod borer, rice leaf roller, striped rice borer, cotton bollworm.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103300054A (en) * | 2012-03-12 | 2013-09-18 | 陕西韦尔奇作物保护有限公司 | Insecticidal composition containing chromafenozide and organic phosphorus |
| CN103563980A (en) * | 2012-08-05 | 2014-02-12 | 南京华洲药业有限公司 | Compound pesticidal composition containing chlorpyrifos and methoxyfenozide and application thereof |
| CN103563975A (en) * | 2012-08-05 | 2014-02-12 | 南京华洲药业有限公司 | Compound pesticidal composition containing methoxyfenozide and profenofos and application thereof |
| CN103651418A (en) * | 2013-12-30 | 2014-03-26 | 青岛崂乡茶制品有限公司 | Novel pesticide for tea trees |
| CN104542696A (en) * | 2015-01-28 | 2015-04-29 | 中国水稻研究所 | Methoxyfenozide and triazophos, pyridaphethione or fenitrothion compound pesticide |
| CN106912495A (en) * | 2017-03-14 | 2017-07-04 | 山东省联合农药工业有限公司 | A kind of plant vaccine of phosphorous worm prestige and methoxyfenozide and preparation method thereof |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103300054A (en) * | 2012-03-12 | 2013-09-18 | 陕西韦尔奇作物保护有限公司 | Insecticidal composition containing chromafenozide and organic phosphorus |
| CN103300054B (en) * | 2012-03-12 | 2015-09-09 | 陕西韦尔奇作物保护有限公司 | A kind of Pesticidal combination containing ring worm hydrazides and organic phosphates |
| CN103563980A (en) * | 2012-08-05 | 2014-02-12 | 南京华洲药业有限公司 | Compound pesticidal composition containing chlorpyrifos and methoxyfenozide and application thereof |
| CN103563975A (en) * | 2012-08-05 | 2014-02-12 | 南京华洲药业有限公司 | Compound pesticidal composition containing methoxyfenozide and profenofos and application thereof |
| CN103651418A (en) * | 2013-12-30 | 2014-03-26 | 青岛崂乡茶制品有限公司 | Novel pesticide for tea trees |
| CN104542696A (en) * | 2015-01-28 | 2015-04-29 | 中国水稻研究所 | Methoxyfenozide and triazophos, pyridaphethione or fenitrothion compound pesticide |
| CN104542696B (en) * | 2015-01-28 | 2016-08-17 | 中国水稻研究所 | Methoxyfenozide and triazophos, pyridaphethione or fenitrothion complex pesticide |
| CN106912495A (en) * | 2017-03-14 | 2017-07-04 | 山东省联合农药工业有限公司 | A kind of plant vaccine of phosphorous worm prestige and methoxyfenozide and preparation method thereof |
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