CN101657468B - 用作拮抗剂的抗促甲状腺激素受体的人单克隆抗体 - Google Patents

用作拮抗剂的抗促甲状腺激素受体的人单克隆抗体 Download PDF

Info

Publication number
CN101657468B
CN101657468B CN200880011577.5A CN200880011577A CN101657468B CN 101657468 B CN101657468 B CN 101657468B CN 200880011577 A CN200880011577 A CN 200880011577A CN 101657468 B CN101657468 B CN 101657468B
Authority
CN
China
Prior art keywords
tshr
tsh
antibody
thyroid
cyclic amp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN200880011577.5A
Other languages
English (en)
Chinese (zh)
Other versions
CN101657468A (zh
Inventor
B·瑞斯史密斯
J·福尔曼克
J·桑德斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RSR Ltd
Original Assignee
RSR Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0702990A external-priority patent/GB0702990D0/en
Priority claimed from GB0714036A external-priority patent/GB0714036D0/en
Application filed by RSR Ltd filed Critical RSR Ltd
Priority claimed from PCT/GB2008/000518 external-priority patent/WO2008099185A1/en
Publication of CN101657468A publication Critical patent/CN101657468A/zh
Application granted granted Critical
Publication of CN101657468B publication Critical patent/CN101657468B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Landscapes

  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN200880011577.5A 2007-02-15 2008-02-14 用作拮抗剂的抗促甲状腺激素受体的人单克隆抗体 Active CN101657468B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US90133207P 2007-02-15 2007-02-15
US60/901,332 2007-02-15
GB0702990A GB0702990D0 (en) 2007-02-15 2007-02-15 Products
GB0702990.3 2007-02-15
GB0714036.1 2007-07-18
GB0714036A GB0714036D0 (en) 2007-07-18 2007-07-18 Products
PCT/GB2008/000518 WO2008099185A1 (en) 2007-02-15 2008-02-14 Human monoclonal antibodies to the thyrotropin receptor which act as antagonists

Publications (2)

Publication Number Publication Date
CN101657468A CN101657468A (zh) 2010-02-24
CN101657468B true CN101657468B (zh) 2014-09-03

Family

ID=42352063

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200880011577.5A Active CN101657468B (zh) 2007-02-15 2008-02-14 用作拮抗剂的抗促甲状腺激素受体的人单克隆抗体

Country Status (2)

Country Link
JP (1) JP5345556B2 (https=)
CN (1) CN101657468B (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5997446B2 (ja) * 2011-02-03 2016-09-28 アークレイ株式会社 甲状腺ホルモン固定化担体の液体試薬およびその用途
JP7025041B2 (ja) * 2019-12-26 2022-02-24 ヤマサ醤油株式会社 変異が導入された甲状腺刺激ホルモン受容体
CN112269026A (zh) * 2020-09-04 2021-01-26 首都医科大学附属北京朝阳医院 一种适用于tsh粉末状国际标准物质浓度准确配制的方法
JP2025529812A (ja) * 2022-08-31 2025-09-09 シャンハイ シーゼン メディカル テクノロジー カンパニー リミテッド 甲状腺刺激ホルモン受容体に結合する抗体及びその使用
WO2025232704A1 (zh) * 2024-05-06 2025-11-13 橙帆生物医药公司 一种治疗性抗igf-1r和tshr的双特异性抗体及其应用
CN120230209A (zh) * 2024-08-07 2025-07-01 上海交通大学医学院附属第九人民医院 一组chk36同源簇全人源tsh受体阻断性单克隆抗体及其制备方法和应用
CN120230208A (zh) * 2024-08-07 2025-07-01 上海交通大学医学院附属第九人民医院 一组sh23同源簇全人源tsh受体阻断性单克隆抗体及其制备方法和应用
CN120230210A (zh) * 2024-08-07 2025-07-01 上海交通大学医学院附属第九人民医院 一组sh1同源簇全人源tsh受体阻断性单克隆抗体及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9909661D0 (en) * 1998-06-06 1999-06-23 Rsr Ltd Assays for TSH receptor autoantibodies
DE19907094C1 (de) * 1999-02-19 2000-04-13 Brahms Diagnostica Gmbh Verwendung von blockierenden Anti-TSH-Rezeptor-Antikörpern bei der Therapie von Hyperthyreosen sowie monoklonale Antikörper für eine solche Verwendung
US7084257B2 (en) * 2001-10-05 2006-08-01 Amgen Inc. Fully human antibody Fab fragments with human interferon-gamma neutralizing activity
EP2383296B1 (en) * 2002-11-29 2017-02-22 Rsr Limited Antibody for the thyrotropin receptor and uses thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KOHN L D.ET AL.characterization of monoclonal thyrotropin binding-inhibition autoantibodies from a hashimoto"s patient whose chindren ha inteauterine and neonatal throid disease..《THE JOURNAL OF CLINICAL EMDOCRINOLOGY AND METABOLISM》.1997,第82卷(第2期),3998-4009. *

Also Published As

Publication number Publication date
JP2010521139A (ja) 2010-06-24
JP5345556B2 (ja) 2013-11-20
CN101657468A (zh) 2010-02-24

Similar Documents

Publication Publication Date Title
CN101657468B (zh) 用作拮抗剂的抗促甲状腺激素受体的人单克隆抗体
JP7332627B2 (ja) 最適化された抗ｔｌ１ａ抗体
TWI674274B (zh) 抗體－飛諾莫接合物
EP2367850B1 (en) Human anti tshr antibodies
EP2121758B1 (en) Human monoclonal antibodies to the thyrotropin receptor which act as antagonists
CN108368177A (zh) 激活瘦素受体的抗原结合蛋白
EP3806959A1 (en) Il-11ra antibodies
BRPI0919853B1 (pt) anticorpo ou fragmento de ligação ao antígeno do mesmo que se liga especificamente ao receptor de interleucina-4 humano (hil-4r) e seus usos
PT2115003E (pt) Anticorpos humanos que se ligam ao ligando 4 semelhante ao ligando delta humano
CN110167965A (zh) 拮抗瘦素受体的抗原结合蛋白
AU2013269652B2 (en) TLR3 binding agents
WO2021018114A1 (zh) 抗人p40蛋白域抗体及其用途
WO2019238074A1 (zh) 一种高亲和力高生物活性的lag-3抗体及其应用
EP4397762A1 (en) Anti-growth hormone antibody
WO2026032069A1 (zh) 一组sh23同源簇全人源tsh受体阻断性单克隆抗体及其制备方法和应用
WO2025086801A1 (zh) 一种全人源tsh受体阻断性单克隆抗体及其制备和应用
WO2026032068A1 (zh) 一组chk36同源簇全人源tsh受体阻断性单克隆抗体及其制备方法和应用
HK40104653A (zh) 抗生长激素抗体
WO2026032067A1 (zh) 一组sh1同源簇全人源tsh受体阻断性单克隆抗体及其制备方法和应用
TW202409081A (zh) 抗促腎上腺皮質激素釋放激素抗體和多囊卵巢症候群
WO2023283211A2 (en) Cd21 antibodies and uses thereof
BR122020013670B1 (pt) Molécula de ácido nucléico que codifica um anticorpo ou fragmento de ligação ao antígeno do mesmo que se liga especificamente ao receptor de interleucina-4 humano (hil-4r), vetor e método de produção de um anticorpo ou fragmento de ligação ao antígeno do mesmo

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant