CN101657422A - 过渡金属催化的n-氨基吲哚的合成 - Google Patents

过渡金属催化的n-氨基吲哚的合成 Download PDF

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Publication number
CN101657422A
CN101657422A CN200880011689A CN200880011689A CN101657422A CN 101657422 A CN101657422 A CN 101657422A CN 200880011689 A CN200880011689 A CN 200880011689A CN 200880011689 A CN200880011689 A CN 200880011689A CN 101657422 A CN101657422 A CN 101657422A
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CN
China
Prior art keywords
unsubstituted
trisubstituted
alkyl
phenyl
independently mono
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CN200880011689A
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English (en)
Chinese (zh)
Inventor
N·哈兰
M·纳扎雷
A·林登施密德
O·勒克埃克
M·乌尔曼
J·阿朗索
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Sanofi SRL
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Sanofi Aventis SpA
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Publication of CN101657422A publication Critical patent/CN101657422A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN200880011689A 2007-04-13 2008-03-29 过渡金属催化的n-氨基吲哚的合成 Pending CN101657422A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07007585 2007-04-13
EP07007585.8 2007-04-13

Publications (1)

Publication Number Publication Date
CN101657422A true CN101657422A (zh) 2010-02-24

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CN200880011689A Pending CN101657422A (zh) 2007-04-13 2008-03-29 过渡金属催化的n-氨基吲哚的合成

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US (1) US8026375B2 (https=)
EP (1) EP2134682B1 (https=)
JP (1) JP5412422B2 (https=)
KR (1) KR20100015546A (https=)
CN (1) CN101657422A (https=)
AT (1) ATE537142T1 (https=)
AU (1) AU2008238379A1 (https=)
BR (1) BRPI0810199A2 (https=)
CA (1) CA2683578A1 (https=)
IL (1) IL201253A0 (https=)
MX (1) MX2009010536A (https=)
WO (1) WO2008125207A1 (https=)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102093334A (zh) * 2011-02-22 2011-06-15 郑州大学 一组稠环噻吩类化合物的合成方法
TWI646102B (zh) * 2016-12-30 2019-01-01 新加坡商沙特基礎工業愛思開奈克斯林恩私人有限公司 新穎環戊［Ｂ］苯硫基過渡金屬化合物、包含該化合物的過渡金屬催化劑組合物、以及使用該化合物製備乙烯均聚物或乙烯與α-烯烴的共聚物的方法
CN113286832A (zh) * 2018-12-21 2021-08-20 陶氏环球技术有限责任公司 用于烯烃聚合的基于杂环-杂环的iv族过渡金属催化剂
CN116813522A (zh) * 2023-05-04 2023-09-29 广州方中化工有限公司 一种含吲哚的苯磺酰脲类化合物的制备方法与应用
CN118638038A (zh) * 2024-06-05 2024-09-13 常州大学 一种n-n轴手性吲哚酰胺类化合物及其合成方法

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WO2007114926A2 (en) 2006-04-04 2007-10-11 The Regents Of The University Of California Kinase antagonists
GB2467670B (en) 2007-10-04 2012-08-01 Intellikine Inc Chemical entities and therapeutic uses thereof
EP3613743B1 (en) 2008-01-04 2022-03-16 Intellikine, LLC Processes for the preparation of 1h-pyrazolo[3,4-d]pyrimidin-4-amine derivatives
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
US8637542B2 (en) 2008-03-14 2014-01-28 Intellikine, Inc. Kinase inhibitors and methods of use
US8993580B2 (en) 2008-03-14 2015-03-31 Intellikine Llc Benzothiazole kinase inhibitors and methods of use
US20110224223A1 (en) 2008-07-08 2011-09-15 The Regents Of The University Of California, A California Corporation MTOR Modulators and Uses Thereof
JP5788316B2 (ja) 2008-07-08 2015-09-30 インテリカイン， エルエルシー キナーゼインヒビターおよび使用方法
US8703778B2 (en) 2008-09-26 2014-04-22 Intellikine Llc Heterocyclic kinase inhibitors
WO2010045542A2 (en) 2008-10-16 2010-04-22 The Regents Of The University Of California Fused ring heteroaryl kinase inhibitors
US8476431B2 (en) 2008-11-03 2013-07-02 Itellikine LLC Benzoxazole kinase inhibitors and methods of use
EP2427195B1 (en) 2009-05-07 2019-05-01 Intellikine, LLC Heterocyclic compounds and uses thereof
US8980899B2 (en) 2009-10-16 2015-03-17 The Regents Of The University Of California Methods of inhibiting Ire1
CA2799579A1 (en) 2010-05-21 2011-11-24 Intellikine, Inc. Chemical compounds, compositions and methods for kinase modulation
JP2013545749A (ja) 2010-11-10 2013-12-26 インフィニティー ファーマシューティカルズ， インコーポレイテッド 複素環化合物及びその使用
TWI674262B (zh) 2011-01-10 2019-10-11 美商英菲尼提製藥股份有限公司 製備異喹啉酮之方法及異喹啉酮之固體形式
US9295673B2 (en) 2011-02-23 2016-03-29 Intellikine Llc Combination of mTOR inhibitors and P13-kinase inhibitors, and uses thereof
WO2013012915A1 (en) 2011-07-19 2013-01-24 Infinity Pharmaceuticals Inc. Heterocyclic compounds and uses thereof
MX2014000648A (es) 2011-07-19 2014-09-25 Infinity Pharmaceuticals Inc Compuestos heterociclicos y sus usos.
KR20140075693A (ko) 2011-08-29 2014-06-19 인피니티 파마슈티칼스, 인코포레이티드 헤테로사이클릭 화합물 및 그의 용도
MX370814B (es) 2011-09-02 2020-01-08 Univ California Pirazolo[3,4-d]pirimidinas sustituidas y usos de las mismas.
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US8828998B2 (en) 2012-06-25 2014-09-09 Infinity Pharmaceuticals, Inc. Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
MX2015003874A (es) 2012-09-26 2015-12-16 Univ California Modulacion de ire1.
EP2914296B2 (en) 2012-11-01 2021-09-29 Infinity Pharmaceuticals, Inc. Treatment of cancers using pi3 kinase isoform modulators
US9481667B2 (en) 2013-03-15 2016-11-01 Infinity Pharmaceuticals, Inc. Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
MX2021012208A (es) 2013-10-04 2023-01-19 Infinity Pharmaceuticals Inc Compuestos heterocíclicos y usos de los mismos.
WO2015051241A1 (en) 2013-10-04 2015-04-09 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
CN103755621B (zh) * 2014-01-23 2015-08-05 清华大学 由芳基肼和炔烃制备多取代吲哚的方法
NZ724368A (en) 2014-03-19 2023-07-28 Infinity Pharmaceuticals Inc Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders
WO2015160975A2 (en) 2014-04-16 2015-10-22 Infinity Pharmaceuticals, Inc. Combination therapies
WO2016054491A1 (en) 2014-10-03 2016-04-07 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
WO2016069796A1 (en) * 2014-10-28 2016-05-06 Spectrum Spine Ip Holdings, Llc Expandable, adjustable inter-body fusion devices and methods
EP4585268A3 (en) 2015-09-14 2025-10-15 Twelve Therapeutics, Inc. Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same
US10759806B2 (en) 2016-03-17 2020-09-01 Infinity Pharmaceuticals, Inc. Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as PI3K kinase inhibitors
WO2017214269A1 (en) 2016-06-08 2017-12-14 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
RU2754507C2 (ru) 2016-06-24 2021-09-02 Инфинити Фармасьютикалз, Инк. Комбинированная терапия
ES2974634T3 (es) 2018-12-21 2024-06-28 Celgene Corp Inhibidores de tienopiridinas de RIPK2

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ATE115143T1 (de) * 1987-04-24 1994-12-15 Hoechst Roussel Pharma N-(pyridinyl)-1h-indol-1-amine, verfahren zu deren herstellung und ihre verwendung als arzneimittel.
US4983608A (en) 1989-09-05 1991-01-08 Hoechst-Roussell Pharmaceuticals, Inc. N-substituted-4-pyrimidinamines and pyrimidinediamines
DE60016068T2 (de) 1999-03-10 2005-11-03 Tosoh Corp., Shinnanyo Verfahren zur Herstellung Stickstoffheterocyclischer Verbindungen
FR2842196B1 (fr) * 2002-07-15 2006-01-13 Rhodia Polyamide Intermediates Procede de fabrication de composes nitriles a partir de composes a insaturation ethylenique
EP2119455A1 (en) 2004-04-08 2009-11-18 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Tripartite raftophilic structures and their use

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102093334A (zh) * 2011-02-22 2011-06-15 郑州大学 一组稠环噻吩类化合物的合成方法
CN102093334B (zh) * 2011-02-22 2013-05-08 郑州大学 一组稠环噻吩类化合物的合成方法
TWI646102B (zh) * 2016-12-30 2019-01-01 新加坡商沙特基礎工業愛思開奈克斯林恩私人有限公司 新穎環戊［Ｂ］苯硫基過渡金屬化合物、包含該化合物的過渡金屬催化劑組合物、以及使用該化合物製備乙烯均聚物或乙烯與α-烯烴的共聚物的方法
CN113286832A (zh) * 2018-12-21 2021-08-20 陶氏环球技术有限责任公司 用于烯烃聚合的基于杂环-杂环的iv族过渡金属催化剂
CN116813522A (zh) * 2023-05-04 2023-09-29 广州方中化工有限公司 一种含吲哚的苯磺酰脲类化合物的制备方法与应用
CN118638038A (zh) * 2024-06-05 2024-09-13 常州大学 一种n-n轴手性吲哚酰胺类化合物及其合成方法

Also Published As

Publication number Publication date
ATE537142T1 (de) 2011-12-15
WO2008125207A1 (en) 2008-10-23
AU2008238379A1 (en) 2008-10-23
KR20100015546A (ko) 2010-02-12
CA2683578A1 (en) 2008-10-23
US20100168429A1 (en) 2010-07-01
MX2009010536A (es) 2009-10-22
JP5412422B2 (ja) 2014-02-12
EP2134682B1 (en) 2011-12-14
JP2010523605A (ja) 2010-07-15
BRPI0810199A2 (pt) 2014-10-14
IL201253A0 (en) 2010-05-31
US8026375B2 (en) 2011-09-27
EP2134682A1 (en) 2009-12-23

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