CN101652470A - 骨髓细胞用于长期培养胰腺胰岛细胞的用途 - Google Patents

骨髓细胞用于长期培养胰腺胰岛细胞的用途 Download PDF

Info

Publication number
CN101652470A
CN101652470A CN200780049872A CN200780049872A CN101652470A CN 101652470 A CN101652470 A CN 101652470A CN 200780049872 A CN200780049872 A CN 200780049872A CN 200780049872 A CN200780049872 A CN 200780049872A CN 101652470 A CN101652470 A CN 101652470A
Authority
CN
China
Prior art keywords
islet
cell
cells
beta
bone marrow
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN200780049872A
Other languages
English (en)
Chinese (zh)
Inventor
罗履广
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roger Williams Medical Center
Original Assignee
Roger Williams Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roger Williams Medical Center filed Critical Roger Williams Medical Center
Publication of CN101652470A publication Critical patent/CN101652470A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1394—Bone marrow stromal cells; whole marrow

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
CN200780049872A 2006-11-21 2007-11-20 骨髓细胞用于长期培养胰腺胰岛细胞的用途 Pending CN101652470A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86063706P 2006-11-21 2006-11-21
US60/860,637 2006-11-21

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201410050889.4A Division CN103992982A (zh) 2006-11-21 2007-11-20 骨髓细胞用于长期培养胰腺胰岛细胞的用途

Publications (1)

Publication Number Publication Date
CN101652470A true CN101652470A (zh) 2010-02-17

Family

ID=39430369

Family Applications (2)

Application Number Title Priority Date Filing Date
CN200780049872A Pending CN101652470A (zh) 2006-11-21 2007-11-20 骨髓细胞用于长期培养胰腺胰岛细胞的用途
CN201410050889.4A Pending CN103992982A (zh) 2006-11-21 2007-11-20 骨髓细胞用于长期培养胰腺胰岛细胞的用途

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201410050889.4A Pending CN103992982A (zh) 2006-11-21 2007-11-20 骨髓细胞用于长期培养胰腺胰岛细胞的用途

Country Status (7)

Country Link
US (1) US20100143306A1 (https=)
EP (1) EP2092057B1 (https=)
JP (1) JP5474559B2 (https=)
CN (2) CN101652470A (https=)
AU (1) AU2007321983B2 (https=)
CA (1) CA2670289A1 (https=)
WO (1) WO2008063640A2 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8852934B2 (en) 2010-03-17 2014-10-07 Kyoto University Method of culturing pancreatic islet-like tissues by a tissue complex of pancreas-derived non-endocrinal epithelial cells and vascular endothelial cells
MX2020014242A (es) * 2018-06-25 2021-05-27 Imagine Pharma Llc Composiciones y métodos para propagar las células de islotes productoras de insulina y usos terapéuticos de las mismas.
AU2022217790A1 (en) * 2021-02-03 2023-09-07 Symbiocelltech, Llc Cell clusters comprising stem and islet cells, methods of making, and treatment of diabetes mellitus therewith

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6001647A (en) * 1994-04-28 1999-12-14 Ixion Biotechnology, Inc. In vitro growth of functional islets of Langerhans and in vivo uses thereof
US20050208029A1 (en) * 2002-04-17 2005-09-22 Akihiro Umezawa Method of forming pancreatic beta cells from mesenchymal cells

Also Published As

Publication number Publication date
JP2010509936A (ja) 2010-04-02
AU2007321983A1 (en) 2008-05-29
WO2008063640A3 (en) 2008-12-18
EP2092057B1 (en) 2014-10-15
EP2092057A2 (en) 2009-08-26
CN103992982A (zh) 2014-08-20
WO2008063640A2 (en) 2008-05-29
AU2007321983B2 (en) 2014-05-29
CA2670289A1 (en) 2008-05-29
EP2092057A4 (en) 2011-04-20
JP5474559B2 (ja) 2014-04-16
US20100143306A1 (en) 2010-06-10

Similar Documents

Publication Publication Date Title
Gamble et al. Improved islet recovery and efficacy through co-culture and co-transplantation of islets with human adipose-derived mesenchymal stem cells
US6703017B1 (en) Reversal of insulin-dependent diabetes by islet-producing stem cells, islet progenitor cells and islet-like structures
US20080274090A1 (en) Reversal of insulin-dependent diabetes by islet-producing stem cells, islet progenitor cells and islet-like structures
US20190367883A1 (en) Regulating stem cells
US10874698B2 (en) Therapy using cardiac stem cells and mesenchymal stem cells
JP2014159477A (ja) ヒト多能性幹細胞由来膵臓細胞のカプセル化
JP2021054869A (ja) 膵島移植のための改善された方法
Yang et al. The cytoprotection of chitosan based hydrogels in xenogeneic islet transplantation: An in vivo study in streptozotocin-induced diabetic mouse
Luo et al. Allogeneic bone marrow supports human islet β cell survival and function over six months
JP5263756B2 (ja) 細胞の培養方法および細胞培養物
AU2007321983B2 (en) Use of bone marrow cells for long term culture of pancreatic islet cells
JP2004533234A (ja) カプセル化細胞インジケータシステム
Forster et al. A prevascularized tissue engineering chamber supports growth and function of islets and progenitor cells in diabetic mice
Hirt-Burri et al. Human muscular fetal cells: a potential cell source for muscular therapies
Maloy et al. In vivo differentiation of stem cell-derived human pancreatic progenitors to treat type 1 diabetes
Vishwakarma et al. TiO2 Nanoflowers on Conducting Substrates Ameliorate Effective Transdifferentiation of Human Hepatic Progenitor Cells for Long‐Term Hyperglycemia Reversal in Diabetic Mice
AU2014218470A1 (en) Use of bone marrow cells for long term culture of pancreatic islet cells.
Skuk Cell transplantation and “stem cell therapy” in the treatment of myopathies: many promises in mice, few realities in humans
TR201902008A2 (tr) Otoi̇mmun ataklardan kaçinabi̇len ve i̇nsüli̇n salgilayan yeni̇ nesi̇l pankreati̇k doku ve üreti̇m yöntemi̇
Wang et al. α-Cell loss from islet impairs its insulin secretion in vitro and in vivo
Higa et al. Regenerative Therapy
WO2007075956A2 (en) Methods for producing and using pancreatic endocrine cells
Bara Tissue engineering a pancreatic substitute based on recombinant intestinal endocrine cells
Reisner Growing organs for transplantation from embryonic precursor tissues
KR20250008585A (ko) Mbp-성장인자 고정 매트릭스 기반 플랫폼

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C12 Rejection of a patent application after its publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20100217