CN101652374B - 无水晶状的长春氟宁盐、其制备方法和作为药物的用途和长春氟宁纯化的方法 - Google Patents

无水晶状的长春氟宁盐、其制备方法和作为药物的用途和长春氟宁纯化的方法 Download PDF

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Publication number
CN101652374B
CN101652374B CN2008800082409A CN200880008240A CN101652374B CN 101652374 B CN101652374 B CN 101652374B CN 2008800082409 A CN2008800082409 A CN 2008800082409A CN 200880008240 A CN200880008240 A CN 200880008240A CN 101652374 B CN101652374 B CN 101652374B
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China
Prior art keywords
vinflunine
solvent
preparation
salt
ether
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Expired - Fee Related
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CN2008800082409A
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English (en)
Chinese (zh)
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CN101652374A (zh
Inventor
J-L·莫雷尔
R·贝纳
J-P·里贝
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Pierre Fabre Medicament SA
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Pierre Fabre Medicament SA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN2008800082409A 2007-02-13 2008-02-13 无水晶状的长春氟宁盐、其制备方法和作为药物的用途和长春氟宁纯化的方法 Expired - Fee Related CN101652374B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
FR0753211 2007-02-13
FR0753211A FR2912406B1 (fr) 2007-02-13 2007-02-13 Sels cristalins anhydres de vinflunine, procede de preparation et utilisation en tant que medicament et moyen de purification de la vinflunine.
US89412707P 2007-03-09 2007-03-09
US60/894,127 2007-03-09
PCT/EP2008/051755 WO2008098970A1 (en) 2007-02-13 2008-02-13 Anhydrous crystalline vinflunine salts, method of preparation and use thereof as a drug and means of vinflunine purification

Publications (2)

Publication Number Publication Date
CN101652374A CN101652374A (zh) 2010-02-17
CN101652374B true CN101652374B (zh) 2013-06-19

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ID=38577387

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CN2008800082409A Expired - Fee Related CN101652374B (zh) 2007-02-13 2008-02-13 无水晶状的长春氟宁盐、其制备方法和作为药物的用途和长春氟宁纯化的方法

Country Status (8)

Country Link
US (1) US8343991B2 (enExample)
EP (1) EP2121708A1 (enExample)
JP (1) JP2010518145A (enExample)
CN (1) CN101652374B (enExample)
CA (1) CA2677269C (enExample)
FR (1) FR2912406B1 (enExample)
RU (1) RU2456291C2 (enExample)
WO (1) WO2008098970A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101607968A (zh) * 2008-06-17 2009-12-23 江苏豪森药业股份有限公司 长春氟宁盐、其制备方法及其药物组合物
BR112013026352A2 (pt) * 2011-04-12 2016-07-26 Endocyte Inc composição farmacêutica sólida
CN105121447B (zh) * 2013-04-19 2018-02-02 暨南大学 长春碱类衍生物及其制备方法和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5620985A (en) * 1993-07-21 1997-04-15 Pierre Fabre Medicament Antimitotic binary alkaloid derivatives from catharanthus roseus
US6127377A (en) * 1997-04-10 2000-10-03 Adir Et Compagnie Vinca alkaloid antimitotic halogenated derivatives

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL4066C (enExample) 1920-04-02
AR024852A1 (es) * 2000-01-12 2002-10-30 Eriochem Sa Procedimiento para la produccion de ditartrato de 5'-nor-anhidrovinblastina a partir de especies vegetales del genero catharanthus y procedimiento a escala industrial.
FR2863891B1 (fr) * 2003-12-23 2006-03-24 Pf Medicament Composition pharmaceutique de vinflunine destinee a une administration parentale, procede de preparation et utilisation
FR2894966B1 (fr) * 2005-12-20 2008-03-14 Pierre Fabre Medicament Sa Nouvelle forme cristalline de la vinflunine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5620985A (en) * 1993-07-21 1997-04-15 Pierre Fabre Medicament Antimitotic binary alkaloid derivatives from catharanthus roseus
US6127377A (en) * 1997-04-10 2000-10-03 Adir Et Compagnie Vinca alkaloid antimitotic halogenated derivatives

Also Published As

Publication number Publication date
CA2677269C (en) 2016-07-05
CA2677269A1 (en) 2008-08-21
US20100029703A1 (en) 2010-02-04
RU2456291C2 (ru) 2012-07-20
EP2121708A1 (en) 2009-11-25
JP2010518145A (ja) 2010-05-27
FR2912406A1 (fr) 2008-08-15
CN101652374A (zh) 2010-02-17
US8343991B2 (en) 2013-01-01
RU2009133244A (ru) 2011-03-20
WO2008098970A1 (en) 2008-08-21
FR2912406B1 (fr) 2009-05-08

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C06 Publication
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C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
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GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20130619

Termination date: 20170213