FR2912406B1 - Sels cristalins anhydres de vinflunine, procede de preparation et utilisation en tant que medicament et moyen de purification de la vinflunine. - Google Patents

Sels cristalins anhydres de vinflunine, procede de preparation et utilisation en tant que medicament et moyen de purification de la vinflunine.

Info

Publication number
FR2912406B1
FR2912406B1 FR0753211A FR0753211A FR2912406B1 FR 2912406 B1 FR2912406 B1 FR 2912406B1 FR 0753211 A FR0753211 A FR 0753211A FR 0753211 A FR0753211 A FR 0753211A FR 2912406 B1 FR2912406 B1 FR 2912406B1
Authority
FR
France
Prior art keywords
vinflunin
medicament
purifying
preparation
anhydrous crystal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR0753211A
Other languages
English (en)
French (fr)
Other versions
FR2912406A1 (fr
Inventor
Jean Louis Maurel
Richard Pena
Jean Paul Ribet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre Medicament SA
Original Assignee
Pierre Fabre Medicament SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0753211A priority Critical patent/FR2912406B1/fr
Application filed by Pierre Fabre Medicament SA filed Critical Pierre Fabre Medicament SA
Priority to CA2677269A priority patent/CA2677269C/en
Priority to US12/524,898 priority patent/US8343991B2/en
Priority to PCT/EP2008/051755 priority patent/WO2008098970A1/en
Priority to RU2009133244/04A priority patent/RU2456291C2/ru
Priority to JP2009549413A priority patent/JP2010518145A/ja
Priority to EP08716836A priority patent/EP2121708A1/en
Priority to CN2008800082409A priority patent/CN101652374B/zh
Publication of FR2912406A1 publication Critical patent/FR2912406A1/fr
Application granted granted Critical
Publication of FR2912406B1 publication Critical patent/FR2912406B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
FR0753211A 2007-02-13 2007-02-13 Sels cristalins anhydres de vinflunine, procede de preparation et utilisation en tant que medicament et moyen de purification de la vinflunine. Active FR2912406B1 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
FR0753211A FR2912406B1 (fr) 2007-02-13 2007-02-13 Sels cristalins anhydres de vinflunine, procede de preparation et utilisation en tant que medicament et moyen de purification de la vinflunine.
US12/524,898 US8343991B2 (en) 2007-02-13 2008-02-13 Anhydrous crystalline vinflunine salts, method of preparation and use thereof as a drug and means of vinflunine purification
PCT/EP2008/051755 WO2008098970A1 (en) 2007-02-13 2008-02-13 Anhydrous crystalline vinflunine salts, method of preparation and use thereof as a drug and means of vinflunine purification
RU2009133244/04A RU2456291C2 (ru) 2007-02-13 2008-02-13 Безводные кристаллические соли винфлунина, способ их получения и их применение в качестве лекарства, и способ очистки винфлунина
CA2677269A CA2677269C (en) 2007-02-13 2008-02-13 Anhydrous crystalline vinflunine salts, method of preparation and use thereof as a drug and means of vinflunine purification
JP2009549413A JP2010518145A (ja) 2007-02-13 2008-02-13 無水結晶ビンフルニン塩、その製造方法ならびに薬物およびビンフルニン精製手段としてのその使用
EP08716836A EP2121708A1 (en) 2007-02-13 2008-02-13 Anhydrous crystalline vinflunine salts, method of preparation and use thereof as a drug and means of vinflunine purification
CN2008800082409A CN101652374B (zh) 2007-02-13 2008-02-13 无水晶状的长春氟宁盐、其制备方法和作为药物的用途和长春氟宁纯化的方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0753211A FR2912406B1 (fr) 2007-02-13 2007-02-13 Sels cristalins anhydres de vinflunine, procede de preparation et utilisation en tant que medicament et moyen de purification de la vinflunine.

Publications (2)

Publication Number Publication Date
FR2912406A1 FR2912406A1 (fr) 2008-08-15
FR2912406B1 true FR2912406B1 (fr) 2009-05-08

Family

ID=38577387

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0753211A Active FR2912406B1 (fr) 2007-02-13 2007-02-13 Sels cristalins anhydres de vinflunine, procede de preparation et utilisation en tant que medicament et moyen de purification de la vinflunine.

Country Status (8)

Country Link
US (1) US8343991B2 (enExample)
EP (1) EP2121708A1 (enExample)
JP (1) JP2010518145A (enExample)
CN (1) CN101652374B (enExample)
CA (1) CA2677269C (enExample)
FR (1) FR2912406B1 (enExample)
RU (1) RU2456291C2 (enExample)
WO (1) WO2008098970A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101607968A (zh) * 2008-06-17 2009-12-23 江苏豪森药业股份有限公司 长春氟宁盐、其制备方法及其药物组合物
CN103607891A (zh) * 2011-04-12 2014-02-26 恩多塞特公司 固体药用组合物
CN105121447B (zh) * 2013-04-19 2018-02-02 暨南大学 长春碱类衍生物及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL4066C (enExample) 1920-04-02
FR2707988B1 (fr) * 1993-07-21 1995-10-13 Pf Medicament Nouveaux dérivés antimitotiques des alcaloïdes binaires du catharantus rosesus, leur procédé de préparation et les compositions pharmaceutiques les comprenant.
FR2761990B1 (fr) * 1997-04-10 1999-06-25 Pf Medicament Derives halogenes antimitotiques d'alcaloides de vinca
AR024852A1 (es) * 2000-01-12 2002-10-30 Eriochem Sa Procedimiento para la produccion de ditartrato de 5'-nor-anhidrovinblastina a partir de especies vegetales del genero catharanthus y procedimiento a escala industrial.
FR2863891B1 (fr) * 2003-12-23 2006-03-24 Pf Medicament Composition pharmaceutique de vinflunine destinee a une administration parentale, procede de preparation et utilisation
FR2894966B1 (fr) * 2005-12-20 2008-03-14 Pierre Fabre Medicament Sa Nouvelle forme cristalline de la vinflunine

Also Published As

Publication number Publication date
FR2912406A1 (fr) 2008-08-15
EP2121708A1 (en) 2009-11-25
JP2010518145A (ja) 2010-05-27
RU2456291C2 (ru) 2012-07-20
CN101652374B (zh) 2013-06-19
CN101652374A (zh) 2010-02-17
US20100029703A1 (en) 2010-02-04
CA2677269C (en) 2016-07-05
US8343991B2 (en) 2013-01-01
CA2677269A1 (en) 2008-08-21
WO2008098970A1 (en) 2008-08-21
RU2009133244A (ru) 2011-03-20

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