CN101647996A - Chinese medicine composition for treating grice enteritidis and preparation method thereof - Google Patents

Abstract

The invention provides a Chinese medicine composition for treating grice enteritidis and a preparation method thereof. The Chinese medicine composition comprises the following components in parts by weight: 10-30 parts of rhizoma atractylodis, 5-15 parts of Tuckahoe, 5-16 parts of cinnamon, 5-15 parts of rhizoma zingiberis, 3-12 parts of magnolia officinalis, 3-12 parts of radix aucklandiae, 3-12parts of amomum villosum, 4-10 parts of tuber pinellia, 4-10 parts of umbellate pore furgus, 4-10 parts of alisma orientale, 5-15 parts of dried orange peel, 5-12 parts of liquorice and 2-7 parts of date. The preparation method comprises the following steps: adding water and decocting components to obtain concentrated filtrate; adding ethylparaben, ethanol, propanediol and sodium benzoate in the concentrated filtrate; and sufficiently mixing the concentrated filtrate until the components are dissolved. The Chinese medicine composition has low toxicity and can effectively treat grice enteritidis and increase organism degeneration-resistant capability; and the preparation method is simple and meets the requirements of large-scale industrial production.

Description

A kind of Chinese medicine composition for the treatment of grice enteritidis and preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicine composition and preparation method thereof, especially a kind of Chinese medicine composition for the treatment of grice enteritidis and preparation method thereof.

Background technology

Grice enteritidis is a kind of common frdquently encountered disease of pig, contain foreign body in how poor, the feedstuff because of feeding quality or by mould contamination, change feedstuff, flu, heatstroke etc. suddenly and cause, piglet is in the easiest generation of growth stage, mortality rate is the highest, cause heavy losses for the production of raising pigs, therefore researching and developing a kind of medicine that can effectively treat grice enteritidis is a problem that needs to be resolved hurrily present stage.

Summary of the invention

Technical problem to be solved by this invention is to provide a kind of Chinese medicine composition for the treatment of grice enteritidis.

Another technical problem to be solved by this invention is to provide the preparation method of the Chinese medicine composition of above-mentioned treatment grice enteritidis.

For solving the problems of the technologies described above, technical scheme of the present invention is:

A kind of Chinese medicine composition for the treatment of grice enteritidis, comprise Rhizoma Atractylodis, Poria, Cortex Cinnamomi, Rhizoma Zingiberis, Cortex Magnoliae Officinalis, the Radix Aucklandiae, Fructus Amomi, the Rhizoma Pinelliae, Polyporus, Rhizoma Alismatis, Pericarpium Citri Reticulatae, Radix Glycyrrhizae and Fructus Jujubae, by its parts by weight Rhizoma Atractylodis 10-30 part, Poria 5-15 part, Cortex Cinnamomi 5-15 part, Rhizoma Zingiberis 5-15 part, Cortex Magnoliae Officinalis 3-12 part, Radix Aucklandiae 3-12 part, Fructus Amomi 3-12 part, Rhizoma Pinelliae 4-10 part, Polyporus 4-10 part, Rhizoma Alismatis 4-10 part, Pericarpium Citri Reticulatae 5-15 part, Radix Glycyrrhizae 5-15 part, Fructus Jujubae 2-7 part.

Preferably, the Chinese medicine composition of above-mentioned treatment grice enteritidis is by 20 parts of its parts by weight Rhizoma Atractylodis, 10 parts in Poria, 10 parts of Cortex Cinnamomis, 10 parts of Rhizoma Zingiberiss, 8 parts of Cortex Magnoliae Officinalis, 7 parts of the Radix Aucklandiae, 8 parts of Fructus Amomis, 6 parts of the Rhizoma Pinelliaes, 7 parts of Polyporus, 6 parts of Rhizoma Alismatis, 10 parts of Pericarpium Citri Reticulataes, 10 parts in Radix Glycyrrhizae, 4 parts in Fructus Jujubae.

Preferably, the Chinese medicine composition of above-mentioned treatment grice enteritidis is by 10 parts of its parts by weight Rhizoma Atractylodis, 15 parts in Poria, 5 parts of Cortex Cinnamomis, 5 parts of Rhizoma Zingiberiss, 12 parts of Cortex Magnoliae Officinalis, 3 parts of the Radix Aucklandiae, 3 parts of Fructus Amomis, 10 parts of the Rhizoma Pinelliaes, 4 parts of Polyporus, 10 parts of Rhizoma Alismatis, 5 parts of Pericarpium Citri Reticulataes, 15 parts in Radix Glycyrrhizae, 2 parts in Fructus Jujubae.

Preferably, the Chinese medicine composition of above-mentioned treatment grice enteritidis is by 30 parts of its parts by weight Rhizoma Atractylodis, 5 parts in Poria, 15 parts of Cortex Cinnamomis, 15 parts of Rhizoma Zingiberiss, 3 parts of Cortex Magnoliae Officinalis, 12 parts of the Radix Aucklandiae, 12 parts of Fructus Amomis, 4 parts of the Rhizoma Pinelliaes, 10 parts of Polyporus, 4 parts of Rhizoma Alismatis, 15 parts of Pericarpium Citri Reticulataes, 5 parts in Radix Glycyrrhizae, 7 parts in Fructus Jujubae.

Preferably, the Chinese medicine composition of above-mentioned treatment grice enteritidis is by 25 parts of its parts by weight Rhizoma Atractylodis, 7 parts in Poria, 10 parts of Cortex Cinnamomis, 7 parts of Rhizoma Zingiberiss, 10 parts of Cortex Magnoliae Officinalis, 5 parts of the Radix Aucklandiae, 10 parts of Fructus Amomis, 6 parts of the Rhizoma Pinelliaes, 6 parts of Polyporus, 8 parts of Rhizoma Alismatis, 7 parts of Pericarpium Citri Reticulataes, 10 parts in Radix Glycyrrhizae, 5 parts in Fructus Jujubae.

Preferably, the Chinese medicine composition of above-mentioned treatment grice enteritidis is by 30 parts of its parts by weight Rhizoma Atractylodis, 10 parts in Poria, 8 parts of Cortex Cinnamomis, 10 parts of Rhizoma Zingiberiss, 5 parts of Cortex Magnoliae Officinalis, 10 parts of the Radix Aucklandiae, 4 parts of Fructus Amomis, 8 parts of the Rhizoma Pinelliaes, 8 parts of Polyporus, 9 parts of Rhizoma Alismatis, 13 parts of Pericarpium Citri Reticulataes, 6 parts in Radix Glycyrrhizae, 7 parts in Fructus Jujubae.

Preferably, the Chinese medicine composition of above-mentioned treatment grice enteritidis is by 17 parts of its parts by weight Rhizoma Atractylodis, 13 parts in Poria, 7 parts of Cortex Cinnamomis, 13 parts of Rhizoma Zingiberiss, 7 parts of Cortex Magnoliae Officinalis, 8 parts of the Radix Aucklandiae, 8 parts of Fructus Amomis, 7 parts of the Rhizoma Pinelliaes, 7 parts of Polyporus, 10 parts of Rhizoma Alismatis, 10 parts of Pericarpium Citri Reticulataes, 8 parts in Radix Glycyrrhizae, 3 parts in Fructus Jujubae.

Preferably, the Chinese medicine composition of above-mentioned treatment grice enteritidis is by 15 parts of its parts by weight Rhizoma Atractylodis, 10 parts in Poria, 12 parts of Cortex Cinnamomis, 7 parts of Rhizoma Zingiberiss, 8 parts of Cortex Magnoliae Officinalis, 6 parts of the Radix Aucklandiae, 10 parts of Fructus Amomis, 10 parts of the Rhizoma Pinelliaes, 9 parts of Polyporus, 7 parts of Rhizoma Alismatis, 15 parts of Pericarpium Citri Reticulataes, 13 parts in Radix Glycyrrhizae, 6 parts in Fructus Jujubae.

The Chinese medicine composition of above-mentioned treatment grice enteritidis is brown liquid, abnormal smells from the patient perfume (or spice), and it is sweet to distinguish the flavor of.

The preparation method of the Chinese medicine composition of above-mentioned treatment grice enteritidis, concrete preparation process is as follows:

(1) getting Rhizoma Atractylodis, Poria, Cortex Cinnamomi, Rhizoma Zingiberis, Cortex Magnoliae Officinalis, the Radix Aucklandiae, Fructus Amomi, the Rhizoma Pinelliae, Polyporus, Rhizoma Alismatis, Pericarpium Citri Reticulatae, Radix Glycyrrhizae and Fructus Jujubae by above-mentioned parts by weight is raw material;

(2) decocting that described Rhizoma Atractylodis, Poria, Cortex Cinnamomi, Rhizoma Zingiberis, Cortex Magnoliae Officinalis, the Radix Aucklandiae, Fructus Amomi, the Rhizoma Pinelliae, Polyporus, Rhizoma Alismatis, Pericarpium Citri Reticulatae, Radix Glycyrrhizae and Fructus Jujubae is added 5～12 times of its gross weights boils, boiled 30～60 minutes, get filtrate, residue adds 5～10 times water boil 30～50 minutes again, get filtrate, leave standstill and be concentrated into relative density 1.0～1.3 after getting supernatant, put into ethanol water afterwards, the concentration expressed in percentage by volume of described ethanol water is 50%～80%, left standstill 24 hours, and got filtrate recycling ethanol and be concentrated into relative density 1-1.3;

(3) the every 110-130ml taking ethylparaben of concentrated filtrate 0.5～2g in the eucalyptus globulus step (2), with ethanol 5～15ml dissolving, add propylene glycol 5～10ml and stir, add sodium benzoate 0.2～0.6g again and be stirred well to dissolving, add in the described concentrated filtrate, promptly.

Preferably, the preparation method of the Chinese medicine composition of above-mentioned treatment grice enteritidis, the dosage form of the Chinese medicine composition that described step (3) is made is a solution.

Use the Chinese medicine composition of the treatment grice enteritidis that above-mentioned preparation method makes, when being used for the treatment of grice enteritidis, 1-4ml gavages by the every kg body weight of pig every day, and usual amounts is for to gavage by the every kg body weight of pig every day 2ml, and logotype 3～5 days was a course of treatment.

Beneficial effect of the present invention:

(1) Chinese medicine composition toxicity of the present invention is little, and cost is lower, can effectively play the therapeutical effect to grice enteritidis, goes back the anti-adversity ability of enhancing body simultaneously;

(2) simple to operate, easy to use, a people can operate;

(3) preparation method of the present invention is simple, is fit to requirements of large-scale industrial production.

The specific embodiment

Below in conjunction with specific embodiment technical scheme of the present invention is further described.

Embodiment 1

A kind of Chinese medicine composition for the treatment of grice enteritidis comprises Rhizoma Atractylodis, Poria, Cortex Cinnamomi, Rhizoma Zingiberis, Cortex Magnoliae Officinalis, the Radix Aucklandiae, Fructus Amomi, the Rhizoma Pinelliae, Polyporus, Rhizoma Alismatis, Pericarpium Citri Reticulatae, Radix Glycyrrhizae and Fructus Jujubae, and concrete preparation method is as follows:

(1) gets 20 parts of Rhizoma Atractylodis, 10 parts in Poria, 10 parts of Cortex Cinnamomis, 10 parts of Rhizoma Zingiberiss, 8 parts of Cortex Magnoliae Officinalis, 7 parts of the Radix Aucklandiae, 8 parts of Fructus Amomis, 6 parts of the Rhizoma Pinelliaes, 7 parts of Polyporus, 6 parts of Rhizoma Alismatis, 10 parts of Pericarpium Citri Reticulataes, 10 parts in Radix Glycyrrhizae, Fructus Jujubae by weight and be raw material for 4 parts;

(2) decocting that described Rhizoma Atractylodis, Poria, Cortex Cinnamomi, Rhizoma Zingiberis, Cortex Magnoliae Officinalis, the Radix Aucklandiae, Fructus Amomi, the Rhizoma Pinelliae, Polyporus, Rhizoma Alismatis, Pericarpium Citri Reticulatae, Radix Glycyrrhizae and Fructus Jujubae is added 8 times of its gross weights boils, boiled 45 minutes, get filtrate, residue adds 6 times water boil 30 minutes again, gets filtrate, leaves standstill to be concentrated into relative density 1.1 after getting supernatant, put into ethanol water afterwards, the concentration expressed in percentage by volume of described ethanol water is 60%, leaves standstill 24 hours, gets filtrate recycling ethanol and is concentrated into relative density 1.05;

(3) the every 120ml taking ethylparaben of concentrated filtrate 0.6g in the eucalyptus globulus step (2) with ethanol 7ml dissolving, adds propylene glycol 5ml and stirs, and adds sodium benzoate 0.5g again and is stirred well to dissolving, adds in the described concentrated filtrate, makes solution.

Embodiment 2

A kind of Chinese medicine composition for the treatment of grice enteritidis comprises Rhizoma Atractylodis, Poria, Cortex Cinnamomi, Rhizoma Zingiberis, Cortex Magnoliae Officinalis, the Radix Aucklandiae, Fructus Amomi, the Rhizoma Pinelliae, Polyporus, Rhizoma Alismatis, Pericarpium Citri Reticulatae, Radix Glycyrrhizae and Fructus Jujubae, and concrete preparation method is as follows:

(1) gets 10 parts of Rhizoma Atractylodis, 15 parts in Poria, 5 parts of Cortex Cinnamomis, 5 parts of Rhizoma Zingiberiss, 12 parts of Cortex Magnoliae Officinalis, 3 parts of the Radix Aucklandiae, 3 parts of Fructus Amomis, 10 parts of the Rhizoma Pinelliaes, 4 parts of Polyporus, 10 parts of Rhizoma Alismatis, 5 parts of Pericarpium Citri Reticulataes, 15 parts in Radix Glycyrrhizae, Fructus Jujubae by weight and be raw material for 2 parts;

(2) decocting that described Rhizoma Atractylodis, Poria, Cortex Cinnamomi, Rhizoma Zingiberis, Cortex Magnoliae Officinalis, the Radix Aucklandiae, Fructus Amomi, the Rhizoma Pinelliae, Polyporus, Rhizoma Alismatis, Pericarpium Citri Reticulatae, Radix Glycyrrhizae and Fructus Jujubae is added 8 times of its gross weights boils, boiled 50 minutes, get filtrate, residue adds 8 times water boil 40 minutes again, gets filtrate, leaves standstill to be concentrated into relative density 1.0 after getting supernatant, put into ethanol water afterwards, the concentration expressed in percentage by volume of described ethanol water is 80%, leaves standstill 24 hours, gets filtrate recycling ethanol and is concentrated into relative density 1.1;

(3) the every 110ml taking ethylparaben of concentrated filtrate 0.5g in the eucalyptus globulus step (2) with ethanol 5ml dissolving, adds propylene glycol 10ml and stirs, and adds sodium benzoate 0.6g again and is stirred well to dissolving, adds in the described concentrated filtrate, promptly gets product.

Embodiment 3

A kind of Chinese medicine composition for the treatment of grice enteritidis comprises Rhizoma Atractylodis, Poria, Cortex Cinnamomi, Rhizoma Zingiberis, Cortex Magnoliae Officinalis, the Radix Aucklandiae, Fructus Amomi, the Rhizoma Pinelliae, Polyporus, Rhizoma Alismatis, Pericarpium Citri Reticulatae, Radix Glycyrrhizae and Fructus Jujubae, and concrete preparation method is as follows:

(1) gets 30 parts of Rhizoma Atractylodis, 5 parts in Poria, 15 parts of Cortex Cinnamomis, 15 parts of Rhizoma Zingiberiss, 3 parts of Cortex Magnoliae Officinalis, 12 parts of the Radix Aucklandiae, 12 parts of Fructus Amomis, 4 parts of the Rhizoma Pinelliaes, 10 parts of Polyporus, 4 parts of Rhizoma Alismatis, 15 parts of Pericarpium Citri Reticulataes, 5 parts in Radix Glycyrrhizae, Fructus Jujubae by weight and be raw material for 7 parts;

(2) decocting that described Rhizoma Atractylodis, Poria, Cortex Cinnamomi, Rhizoma Zingiberis, Cortex Magnoliae Officinalis, the Radix Aucklandiae, Fructus Amomi, the Rhizoma Pinelliae, Polyporus, Rhizoma Alismatis, Pericarpium Citri Reticulatae, Radix Glycyrrhizae and Fructus Jujubae is added 12 times of its gross weights boils, boiled 30 minutes, get filtrate, residue adds 5 times water boil 50 minutes again, gets filtrate, leaves standstill to be concentrated into relative density 1.2 after getting supernatant, put into ethanol water afterwards, the concentration expressed in percentage by volume of described ethanol water is 50%, leaves standstill 24 hours, gets filtrate recycling ethanol and is concentrated into relative density 1.3;

(3) the every 130ml taking ethylparaben of concentrated filtrate 2g in the eucalyptus globulus step (2) with ethanol 15ml dissolving, adds propylene glycol 8ml and stirs, and adds sodium benzoate 0.4g again and is stirred well to dissolving, adds in the described concentrated filtrate, promptly gets product.

Embodiment 4

A kind of Chinese medicine composition for the treatment of grice enteritidis comprises Rhizoma Atractylodis, Poria, Cortex Cinnamomi, Rhizoma Zingiberis, Cortex Magnoliae Officinalis, the Radix Aucklandiae, Fructus Amomi, the Rhizoma Pinelliae, Polyporus, Rhizoma Alismatis, Pericarpium Citri Reticulatae, Radix Glycyrrhizae and Fructus Jujubae, and concrete preparation method is as follows:

(1) gets 25 parts of Rhizoma Atractylodis, 7 parts in Poria, 10 parts of Cortex Cinnamomis, 7 parts of Rhizoma Zingiberiss, 10 parts of Cortex Magnoliae Officinalis, 5 parts of the Radix Aucklandiae, 10 parts of Fructus Amomis, 6 parts of the Rhizoma Pinelliaes, 6 parts of Polyporus, 8 parts of Rhizoma Alismatis, 7 parts of Pericarpium Citri Reticulataes, 10 parts in Radix Glycyrrhizae, Fructus Jujubae by weight and be raw material for 5 parts;

(2) decocting that described Rhizoma Atractylodis, Poria, Cortex Cinnamomi, Rhizoma Zingiberis, Cortex Magnoliae Officinalis, the Radix Aucklandiae, Fructus Amomi, the Rhizoma Pinelliae, Polyporus, Rhizoma Alismatis, Pericarpium Citri Reticulatae, Radix Glycyrrhizae and Fructus Jujubae is added 5 times of its gross weights boils, boiled 60 minutes, get filtrate, residue adds 7 times water boil 50 minutes again, gets filtrate, leaves standstill to be concentrated into relative density 1.3 after getting supernatant, put into ethanol water afterwards, the concentration expressed in percentage by volume of described ethanol water is 80%, leaves standstill 24 hours, gets filtrate recycling ethanol and is concentrated into relative density 1.0;

(3) the every 125ml taking ethylparaben of concentrated filtrate 1g in the eucalyptus globulus step (2) with ethanol 10ml dissolving, adds propylene glycol 7ml and stirs, and adds sodium benzoate 0.2g again and is stirred well to dissolving, adds in the described concentrated filtrate, makes solution.

Embodiment 5

A kind of Chinese medicine composition for the treatment of grice enteritidis comprises Rhizoma Atractylodis, Poria, Cortex Cinnamomi, Rhizoma Zingiberis, Cortex Magnoliae Officinalis, the Radix Aucklandiae, Fructus Amomi, the Rhizoma Pinelliae, Polyporus, Rhizoma Alismatis, Pericarpium Citri Reticulatae, Radix Glycyrrhizae and Fructus Jujubae, and concrete preparation method is as follows:

(1) gets 30 parts of Rhizoma Atractylodis, 10 parts in Poria, 8 parts of Cortex Cinnamomis, 10 parts of Rhizoma Zingiberiss, 5 parts of Cortex Magnoliae Officinalis, 10 parts of the Radix Aucklandiae, 4 parts of Fructus Amomis, 8 parts of the Rhizoma Pinelliaes, 8 parts of Polyporus, 9 parts of Rhizoma Alismatis, 13 parts of Pericarpium Citri Reticulataes, 6 parts in Radix Glycyrrhizae, Fructus Jujubae by weight and be raw material for 7 parts;

(2) decocting that described Rhizoma Atractylodis, Poria, Cortex Cinnamomi, Rhizoma Zingiberis, Cortex Magnoliae Officinalis, the Radix Aucklandiae, Fructus Amomi, the Rhizoma Pinelliae, Polyporus, Rhizoma Alismatis, Pericarpium Citri Reticulatae, Radix Glycyrrhizae and Fructus Jujubae is added 10 times of its gross weights boils, boiled 40 minutes, get filtrate, residue adds 10 times water boil 45 minutes again, gets filtrate, leaves standstill to be concentrated into relative density 1.3 after getting supernatant, put into ethanol water afterwards, the concentration expressed in percentage by volume of described ethanol water is 70%, leaves standstill 24 hours, gets filtrate recycling ethanol and is concentrated into relative density 1.2;

(3) the every 115ml taking ethylparaben of concentrated filtrate 1.6g in the eucalyptus globulus step (2) with ethanol 13ml dissolving, adds propylene glycol 6ml and stirs, and adds sodium benzoate 0.3g again and is stirred well to dissolving, adds in the described concentrated filtrate, promptly gets product.

Embodiment 6

A kind of Chinese medicine composition for the treatment of grice enteritidis comprises Rhizoma Atractylodis, Poria, Cortex Cinnamomi, Rhizoma Zingiberis, Cortex Magnoliae Officinalis, the Radix Aucklandiae, Fructus Amomi, the Rhizoma Pinelliae, Polyporus, Rhizoma Alismatis, Pericarpium Citri Reticulatae, Radix Glycyrrhizae and Fructus Jujubae, and concrete preparation method is as follows:

(1) gets 17 parts of Rhizoma Atractylodis, 13 parts in Poria, 7 parts of Cortex Cinnamomis, 13 parts of Rhizoma Zingiberiss, 7 parts of Cortex Magnoliae Officinalis, 8 parts of the Radix Aucklandiae, 8 parts of Fructus Amomis, 7 parts of the Rhizoma Pinelliaes, 7 parts of Polyporus, 10 parts of Rhizoma Alismatis, 10 parts of Pericarpium Citri Reticulataes, 8 parts in Radix Glycyrrhizae, Fructus Jujubae by weight and be raw material for 3 parts;

(2) decocting that described Rhizoma Atractylodis, Poria, Cortex Cinnamomi, Rhizoma Zingiberis, Cortex Magnoliae Officinalis, the Radix Aucklandiae, Fructus Amomi, the Rhizoma Pinelliae, Polyporus, Rhizoma Alismatis, Pericarpium Citri Reticulatae, Radix Glycyrrhizae and Fructus Jujubae is added 8 times of its gross weights boils, boiled 45 minutes, get filtrate, residue adds 6 times water boil 30 minutes again, gets filtrate, leaves standstill to be concentrated into relative density 1.1 after getting supernatant, put into ethanol water afterwards, the concentration expressed in percentage by volume of described ethanol water is 60%, leaves standstill 24 hours, gets filtrate recycling ethanol and is concentrated into relative density 1.05;

(3) the every 120ml taking ethylparaben of concentrated filtrate 0.6g in the eucalyptus globulus step (2) with ethanol 7ml dissolving, adds propylene glycol 5ml and stirs, and adds sodium benzoate 0.5g again and is stirred well to dissolving, adds in the described concentrated filtrate, makes solution.

Embodiment 7

A kind of Chinese medicine composition for the treatment of grice enteritidis comprises Rhizoma Atractylodis, Poria, Cortex Cinnamomi, Rhizoma Zingiberis, Cortex Magnoliae Officinalis, the Radix Aucklandiae, Fructus Amomi, the Rhizoma Pinelliae, Polyporus, Rhizoma Alismatis, Pericarpium Citri Reticulatae, Radix Glycyrrhizae and Fructus Jujubae, and concrete preparation method is as follows:

(1) gets 15 parts of Rhizoma Atractylodis, 10 parts in Poria, 12 parts of Cortex Cinnamomis, 7 parts of Rhizoma Zingiberiss, 8 parts of Cortex Magnoliae Officinalis, 6 parts of the Radix Aucklandiae, 10 parts of Fructus Amomis, 10 parts of the Rhizoma Pinelliaes, 9 parts of Polyporus, 7 parts of Rhizoma Alismatis, 15 parts of Pericarpium Citri Reticulataes, 13 parts in Radix Glycyrrhizae, Fructus Jujubae by weight and be raw material for 6 parts;

(2) decocting that described Rhizoma Atractylodis, Poria, Cortex Cinnamomi, Rhizoma Zingiberis, Cortex Magnoliae Officinalis, the Radix Aucklandiae, Fructus Amomi, the Rhizoma Pinelliae, Polyporus, Rhizoma Alismatis, Pericarpium Citri Reticulatae, Radix Glycyrrhizae and Fructus Jujubae is added 5 times of its gross weights boils, boiled 60 minutes, get filtrate, residue adds 7 times water boil 50 minutes again, gets filtrate, leaves standstill to be concentrated into relative density 1.3 after getting supernatant, put into ethanol water afterwards, the concentration expressed in percentage by volume of described ethanol water is 80%, leaves standstill 24 hours, gets filtrate recycling ethanol and is concentrated into relative density 1.0;

(3) the every 125ml taking ethylparaben of concentrated filtrate 1g in the eucalyptus globulus step (2) with ethanol 10ml dissolving, adds propylene glycol 7ml and stirs, and adds sodium benzoate 0.2g again and is stirred well to dissolving, adds in the described concentrated filtrate, makes solution.

In the Chinese medicine composition of above-mentioned treatment grice enteritidis, Rhizoma Atractylodis, Poria, Cortex Cinnamomi, Rhizoma Zingiberis, Cortex Magnoliae Officinalis, the Radix Aucklandiae, Fructus Amomi, the Rhizoma Pinelliae, Polyporus, Rhizoma Alismatis, Pericarpium Citri Reticulatae, Radix Glycyrrhizae and Fructus Jujubae all meet the relevant regulations in " Chinese veterinary drug allusion quotation ".

Rhizoma Atractylodis, the Poria invigorating the spleen and regulating the stomach of making a show of power in the Chinese medicine composition of above-mentioned treatment grice enteritidis; Cortex Cinnamomi, Rhizoma Zingiberis, Fructus Amomi warming spleen and stomach for dispelling cold, warming the stomach spleen invigorating; Join Pericarpium Citri Reticulatae, Radix Aucklandiae spleen invigorating is regulated the flow of vital energy, stomach warming and in; The Cortex Magnoliae Officinalis warming the middle warmer and descending qi, the dampness expectorant; Polyporus, Rhizoma Alismatis eliminating dampness and diuresis; Rhizoma Pinelliae drying dampness to eliminate phlegm; The Fructus Jujubae invigorating the spleen and replenishing QI; The Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription makes whole prescription mend, support, control in one, and coordinative role makes therapeutical effect strengthen greatly mutually, and the anti-adversity ability of enhancing body is effectively treated grice enteritidis simultaneously.

Grice enteritidis is modal a kind of disease in the livestock culturing, various pathogens and stressors all can cause grice enteritidis, cause feed conversion rate reduction, emaciated physique, prolong marketing time, bring very big loss, all can take place throughout the year to the raiser, for inquiring into the effective way of control grice enteritidis, the selection medication of science, the medicine of selecting to have warming spleen and stomach for dispelling cold, warming the stomach spleen invigorating, drying dampness to eliminate phlegm, invigorating the spleen and replenishing QI carries out prescription, and clinical trial is as follows:

Clinical trial 1

Before the Tianjin in 2008 Bi Zhuan raiser Wang raising 2 the monthly age piglet vomit, faecal incontinence, disease is seen: spirit is depressed, emaciated physique, disorderly thick by hair, and happiness is crouched, vomiting and diarrhoea, fervescence.

Treatment: Application Example 1 described Chinese medicine composition is treated, and calculates according to its consumption, presses the 60-80ml/ head during treatment, once gavages logotype 3 days, cure rate 95% in 1 day.

Clinical trial 2

In March, 2007, the 4 monthly ages piglet morbidity that Mare Tranquillitatis, Tianjin Zhang raises, main suit: suffer from pig and do not eat, vomit a couple of days, once with the intramuscular injection of piglet help pin, and oral ciprofloxacin is invalid, check generally and find: more than the fervescence to 40 ℃, about 133 times/minute of heart beating is breathed about 37 times/minute, and vomitus is the bile sample, asoscope is dry and cracked, spirit is depressed, and thick disorderly unglazed by hair, vomiting is violent.

Treatment: Application Example 1 described Chinese medicine composition is treated, and calculates according to its consumption, presses the 100ml-140ml/ head during treatment, once gavages in 1 day, cooperate sugar-salt-water 250～500ml simultaneously, VC10～20ml, mixed venous injection, 1 day 1 time, logotype 5 days, cure rate 93%.

As seen, Chinese medicine composition of the present invention is by the collaborative regulating action of each Chinese medicinal components, stomach warming and in, invigorating the spleen and replenishing QI, invigorating the spleen and regulating the stomach, effective enhancing body anti-adversity ability, simultaneously eliminating dampness and diuresis, drying dampness to eliminate phlegm make full use of the theory of tcm treatment according to syndrome differentiation, make whole prescription mend, support, control in one, each component complements each other, and grice enteritidis is played notable therapeutic effect.

Above-mentioned detailed description of this a kind of Chinese medicine composition for the treatment of grice enteritidis and preparation method thereof being carried out with reference to embodiment; be illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.

Claims (10)

1. Chinese medicine composition for the treatment of grice enteritidis, it is characterized in that: comprise Rhizoma Atractylodis, Poria, Cortex Cinnamomi, Rhizoma Zingiberis, Cortex Magnoliae Officinalis, the Radix Aucklandiae, Fructus Amomi, the Rhizoma Pinelliae, Polyporus, Rhizoma Alismatis, Pericarpium Citri Reticulatae, Radix Glycyrrhizae and Fructus Jujubae, by its parts by weight Rhizoma Atractylodis 10-30 part, Poria 5-15 part, Cortex Cinnamomi 5-15 part, Rhizoma Zingiberis 5-15 part, Cortex Magnoliae Officinalis 3-12 part, Radix Aucklandiae 3-12 part, Fructus Amomi 3-12 part, Rhizoma Pinelliae 4-10 part, Polyporus 4-10 part, Rhizoma Alismatis 4-10 part, Pericarpium Citri Reticulatae 5-15 part, Radix Glycyrrhizae 5-15 part, Fructus Jujubae 2-7 part.

2. a kind of Chinese medicine composition for the treatment of grice enteritidis according to claim 1 is characterized in that: by 20 parts of its parts by weight Rhizoma Atractylodis, 10 parts in Poria, 10 parts of Cortex Cinnamomis, 10 parts of Rhizoma Zingiberiss, 8 parts of Cortex Magnoliae Officinalis, 7 parts of the Radix Aucklandiae, 8 parts of Fructus Amomis, 6 parts of the Rhizoma Pinelliaes, 7 parts of Polyporus, 6 parts of Rhizoma Alismatis, 10 parts of Pericarpium Citri Reticulataes, 10 parts in Radix Glycyrrhizae, 4 parts in Fructus Jujubae.

3. a kind of Chinese medicine composition for the treatment of grice enteritidis according to claim 1 is characterized in that: by 10 parts of its parts by weight Rhizoma Atractylodis, 15 parts in Poria, 5 parts of Cortex Cinnamomis, 5 parts of Rhizoma Zingiberiss, 12 parts of Cortex Magnoliae Officinalis, 3 parts of the Radix Aucklandiae, 3 parts of Fructus Amomis, 10 parts of the Rhizoma Pinelliaes, 4 parts of Polyporus, 10 parts of Rhizoma Alismatis, 5 parts of Pericarpium Citri Reticulataes, 15 parts in Radix Glycyrrhizae, 2 parts in Fructus Jujubae.

4. a kind of Chinese medicine composition for the treatment of grice enteritidis according to claim 1 is characterized in that: by 30 parts of its parts by weight Rhizoma Atractylodis, 5 parts in Poria, 15 parts of Cortex Cinnamomis, 15 parts of Rhizoma Zingiberiss, 3 parts of Cortex Magnoliae Officinalis, 12 parts of the Radix Aucklandiae, 12 parts of Fructus Amomis, 4 parts of the Rhizoma Pinelliaes, 10 parts of Polyporus, 4 parts of Rhizoma Alismatis, 15 parts of Pericarpium Citri Reticulataes, 5 parts in Radix Glycyrrhizae, 7 parts in Fructus Jujubae.

5. a kind of Chinese medicine composition for the treatment of grice enteritidis according to claim 1 is characterized in that: by 25 parts of its parts by weight Rhizoma Atractylodis, 7 parts in Poria, 10 parts of Cortex Cinnamomis, 7 parts of Rhizoma Zingiberiss, 10 parts of Cortex Magnoliae Officinalis, 5 parts of the Radix Aucklandiae, 10 parts of Fructus Amomis, 6 parts of the Rhizoma Pinelliaes, 6 parts of Polyporus, 8 parts of Rhizoma Alismatis, 7 parts of Pericarpium Citri Reticulataes, 10 parts in Radix Glycyrrhizae, 5 parts in Fructus Jujubae.

6. a kind of Chinese medicine composition for the treatment of grice enteritidis according to claim 1 is characterized in that: by 30 parts of its parts by weight Rhizoma Atractylodis, 10 parts in Poria, 8 parts of Cortex Cinnamomis, 10 parts of Rhizoma Zingiberiss, 5 parts of Cortex Magnoliae Officinalis, 10 parts of the Radix Aucklandiae, 4 parts of Fructus Amomis, 8 parts of the Rhizoma Pinelliaes, 8 parts of Polyporus, 9 parts of Rhizoma Alismatis, 13 parts of Pericarpium Citri Reticulataes, 6 parts in Radix Glycyrrhizae, 7 parts in Fructus Jujubae.

7. a kind of Chinese medicine composition for the treatment of grice enteritidis according to claim 1 is characterized in that: by 17 parts of its parts by weight Rhizoma Atractylodis, 13 parts in Poria, 7 parts of Cortex Cinnamomis, 13 parts of Rhizoma Zingiberiss, 7 parts of Cortex Magnoliae Officinalis, 8 parts of the Radix Aucklandiae, 8 parts of Fructus Amomis, 7 parts of the Rhizoma Pinelliaes, 7 parts of Polyporus, 10 parts of Rhizoma Alismatis, 10 parts of Pericarpium Citri Reticulataes, 8 parts in Radix Glycyrrhizae, 3 parts in Fructus Jujubae.

8. a kind of Chinese medicine composition for the treatment of grice enteritidis according to claim 1 is characterized in that: by 15 parts of its parts by weight Rhizoma Atractylodis, 10 parts in Poria, 12 parts of Cortex Cinnamomis, 7 parts of Rhizoma Zingiberiss, 8 parts of Cortex Magnoliae Officinalis, 6 parts of the Radix Aucklandiae, 10 parts of Fructus Amomis, 10 parts of the Rhizoma Pinelliaes, 9 parts of Polyporus, 7 parts of Rhizoma Alismatis, 15 parts of Pericarpium Citri Reticulataes, 13 parts in Radix Glycyrrhizae, 6 parts in Fructus Jujubae.

9. according to the described a kind of Chinese medicine composition for the treatment of grice enteritidis of one of claim 1-8, it is characterized in that: be brown liquid, abnormal smells from the patient perfume (or spice), it is sweet to distinguish the flavor of.

10. the preparation method of the Chinese medicine composition of the described treatment grice enteritidis of claim 1-9 is characterized in that: concrete preparation process is as follows:

(1) getting Rhizoma Atractylodis, Poria, Cortex Cinnamomi, Rhizoma Zingiberis, Cortex Magnoliae Officinalis, the Radix Aucklandiae, Fructus Amomi, the Rhizoma Pinelliae, Polyporus, Rhizoma Alismatis, Pericarpium Citri Reticulatae, Radix Glycyrrhizae and Fructus Jujubae by above-mentioned parts by weight is raw material;

(2) decocting that described Rhizoma Atractylodis, Poria, Cortex Cinnamomi, Rhizoma Zingiberis, Cortex Magnoliae Officinalis, the Radix Aucklandiae, Fructus Amomi, the Rhizoma Pinelliae, Polyporus, Rhizoma Alismatis, Pericarpium Citri Reticulatae, Radix Glycyrrhizae and Fructus Jujubae is added 5～12 times of its gross weights boils, boiled 30～60 minutes, get filtrate, residue adds 5～10 times water boil 30～50 minutes again, get filtrate, leave standstill and be concentrated into relative density 1.0～1.3 after getting supernatant, put into ethanol water afterwards, the concentration expressed in percentage by volume of described ethanol water is 50%～80%, left standstill 24 hours, and got filtrate recycling ethanol and be concentrated into relative density 1-1.3;

(3) the every 110-130ml taking ethylparaben of concentrated filtrate 0.5～2g in the eucalyptus globulus step (2), with ethanol 5～15ml dissolving, add propylene glycol 5～10ml and stir, add sodium benzoate 0.2～0.6g again and be stirred well to dissolving, add in the described concentrated filtrate, promptly.