CN101647875B - Plant extract for treating bradycardia - Google Patents
Plant extract for treating bradycardia Download PDFInfo
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- CN101647875B CN101647875B CN2009101449233A CN200910144923A CN101647875B CN 101647875 B CN101647875 B CN 101647875B CN 2009101449233 A CN2009101449233 A CN 2009101449233A CN 200910144923 A CN200910144923 A CN 200910144923A CN 101647875 B CN101647875 B CN 101647875B
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- extract
- heart rate
- bradycardia
- amiodarone
- radix aconiti
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Abstract
The invention relates to a plant extract for treating bradycardia, which is an oral preparation prepared from the extract of radix aconitilateralis preparata as the raw material, wherein the extract of radix aconitilateralis preparata is obtained by water extraction and alcohol deposition treatment. Pharmacodynamic tests and clinical practice of many kinds of chronic heart rate models prove that the extract can obviously raise the heart rate of bradycardia, and especially raise the heart rate of bradycardia caused by amiodarone. The total effective rate can reach more than 90%, the average heart rate increases 5-15 times/minute, the lasting period is long, and the extract can be repeatedly used without obvious adverse reaction.
Description
One, technical field
The present invention relates to the bradycardic orally taken plant extract of a kind of treatment, definite to say so with the Radix Aconiti Lateralis Preparata be the bradycardic plant extract of treatment of feedstock production.
Two, background technology
What bradycardia was that a multi-pathogenesis causes is main systemic disease with the heart change, in the majority with the old people.When heart rate slowed to a certain degree, symptom such as minimizing in various degree appears in each important organ blood supply, and clinical manifestation is dizzy, uncomfortable in chest, weak often needed the installation artificial cardiac pacemaker.Because the latter costs an arm and a leg, and brings the pressure of body and mind to make it and can not popularize to the patient.Therefore patient's universal demand makes medicament improve heart rate.Clinical practice atropic category medicine, rapid-action, effect is obvious, but it is of short duration to hold time, and have xerostomia, fever sensation of the face, elderly men untoward reaction such as dysuria often to occur.Therefore, the pure galenical of exploitation determined curative effect and few side effects has great importance.
Amiodarone is clinical anti-arrhythmic commonly used, but many patients are in using the amiodarone process, and heart rate is obviously slowed down bradycardia that amiodarone causes is not found efficacious therapy medicine (atropine is invalid) so far in the world as yet.Therefore, must stop using.Abroad,, use heavy dose of amiodarone arrhythmia, when serious bradycardia occurring, often must implant a pacemaker especially in the U.S..And for example, original heart rate is after the patient takes cardiac tonic such as digoxin relatively slowly, and heart rate further reduces, often compelled drug withdrawal.
Three, summary of the invention
The present invention aims to provide the bradycardic Chinese medicine of a kind of treatment, but the bradycardia that causes of antagonism amiodarone, digoxin particularly, and technical problem to be solved is the active component of selecting in the Chinese herbal medicine.
The alleged plant extract of the present invention is meant by Radix Aconiti Lateralis Preparata through extract that water is carried, precipitate with ethanol obtains after handling and the oral formulations that obtains as raw material processing.Described oral formulations is any peroral dosage form that allows on the pharmaceutics, like decoction, granule, tablet, electuary, capsule etc.
With Radix Aconiti Lateralis Preparata, add 10 times of water gagings and decoct secondary, each 2 hours, collecting decoction filtered; Filtrate decompression is condensed into extractum, adds ethanol, stirs, and leaves standstill 24 hours; Get supernatant, decompression recycling ethanol is concentrated into thick paste, at this moment can add adjuvant mix homogeneously post-treatment and obtain corresponding dosage forms; Perhaps with after the thick paste drying again with adjuvant mix homogeneously post-treatment corresponding dosage forms.
The raw medicinal material Radix Aconiti Lateralis Preparata is for " one one of Chinese pharmacopoeia version in 2005 is recorded kind.Nature and flavor are hot, sweet, hot, poisonous.GUIXIN, kidney, spleen channel.The recuperating depleted YANG and rescuing the patient from collapse of merit tool, supporing yang benefit fire, dispersing cold for relieving pain.Be suitable for the YANG-depletion collapse, cold extremities faint pulse, trusted subordinate's cold type of pain, diseases such as YIN-cold edema.Can on help heart-yang, middle warming the spleen sun, following kidney-replenishing is " the recuperating depleted YANG and rescuing the patient from collapse first article medicine ".It is hot sweet warm, high complement sun is arranged, the effect of boosting source of fire for eliminating abundance of yin.
Research shows: Radix Aconiti Lateralis Preparata extract has heart tonifying; Coronary blood flow increasing, blood vessel dilating; Arrhythmia; Enhance immunity; Antiinflammatory; Effects such as analgesia.Can clinically be used to treat bradyarrhythmia, the bradyarrhythmia that different reasons such as coronary heart disease, myocarditis, cardiomyopathy are caused comprises sick sinus syndrome; Sinus bradycardia, the atrioventricular block patient, the rhythm of the heart is accelerated; Hear sounds strengthens; Conducting system of heart is also had a significant effect, can make a sino atrial block and a part disappear or weaken, can improve and improve the endogenous sinus node function in the atrioventricular block in interface.
The applicant has carried out the pharmacodynamics test and the clinical practice of system respectively to Radix Aconiti Lateralis Preparata extract, and the result is following:
1. pharmacodynamics test:
Adopt two kinds of bradyarrhythmia models of rat amiodarone and propranolol respectively, three kinds of dosage of ig extractum 0.32,0.16,0.08g extractum/kg (amounting to crude drug 2,1,0.5g/kg) treat 2 week and 3 weeks of propranolol model of rat amiodarone model respectively.The result shows, these article are high, in can obviously the raise heart rate of amiodarone bradycardia rat of two kinds of dosage, and its blood pressure do not had obvious influence, also can obviously the raise heart rate of propranolol bradycardia rat model of these article high dose.
This extract also can obviously increase the heart rate of rabbit hole model, strengthens the strong conduction function of antrum, improves the self-disciplining of sinuatrial node.
This extract does not have obvious influence basically to normal rat serum hydromechanics index; Dosage big or middle changes caused the caused hemodynamics of Acute Myocardial Ischemia in Rats by pituitrin, has the better protect effect.
The effect that this extract is significantly improved to the heart rate of the work model of hypofunction, but less to normal work model heart rate influence.These article can make coronary flow, aorta flow and cardiac output that increase is in various degree arranged, and point out this extract can improve heart blood supply, cardiac function enhancing.
2. clinical practice:
In clinical practice, use the decreased heart rate that this extract for treating bradyarrhythmia, especially amiodarone cause; About 245 examples; Total effective rate reaches more than 90%, on average can heart rate be improved 5-15 time/minute, and curative effect can be kept 3-6 month after the drug withdrawal; And medication repeatedly, and do not see obvious adverse reaction.The result shows, this extract is for the treatment of slow arrhythmia and prevent safe and effective.
More than research shows: Radix Aconiti Lateralis Preparata extract has effect comparatively significantly for the treatment of slow arrhythmia, the bradycardic treatment that particularly caused by amiodarone; And take for a long time safely, have no side effect.
Four, the specific embodiment
Existing is example with the capsule, and non-limiting examples is narrated as follows.
1. get 666 parts of Radix Aconiti Lateralis Preparatas, add 10 times of water gagings and decoct secondary, each 2 hours, collecting decoction filtered; Filtrate decompression is condensed into clear paste, adds ethanol, stirs, and leaves standstill 24 hours, gets supernatant; Decompression recycling ethanol is concentrated into thick paste, gets thick paste and adds an amount of dextrin and starch, and drying is pulverized; Granulate, incapsulate, process 1000, promptly get.
Specification: every dress 0.21g.Oral, one time 3,3 times on the one.
2. get 600 parts of Radix Aconiti Lateralis Preparatas, processing is with embodiment 1.
3. get 500 parts of Radix Aconiti Lateralis Preparatas, processing is with embodiment 1.
4. get 400 parts of Radix Aconiti Lateralis Preparatas, processing is with embodiment 1.
Claims (2)
1. the purposes of a Radix Aconiti Lateralis Preparata extract is characterized in that: treat application in the bradycardia oral drugs that by amiodarone caused through the extract that water is carried, precipitate with ethanol obtains after handling in preparation by Radix Aconiti Lateralis Preparata.
2. the purposes of Radix Aconiti Lateralis Preparata extract according to claim 1, it is characterized in that: described oral drugs are capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009101449233A CN101647875B (en) | 2009-09-11 | 2009-09-11 | Plant extract for treating bradycardia |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009101449233A CN101647875B (en) | 2009-09-11 | 2009-09-11 | Plant extract for treating bradycardia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101647875A CN101647875A (en) | 2010-02-17 |
| CN101647875B true CN101647875B (en) | 2012-07-04 |
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ID=41670273
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009101449233A Expired - Fee Related CN101647875B (en) | 2009-09-11 | 2009-09-11 | Plant extract for treating bradycardia |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101647875B (en) |
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2009
- 2009-09-11 CN CN2009101449233A patent/CN101647875B/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN101647875A (en) | 2010-02-17 |
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| C14 | Grant of patent or utility model | ||
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Owner name: ANHUI HEALSTAR PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: HEFEI HENGXING INSTITUTE OF MATERIA MEDICA Effective date: 20120615 |
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Effective date of registration: 20120615 Address after: Five road 230051 Anhui city in Hefei Province, Baohe Industrial District No. 15 weft Patentee after: Anhui Heal Star Pharmaceutical Co.,Ltd. Address before: Five road 230051 Anhui city in Hefei Province, Baohe Industrial District No. 15 weft Patentee before: Hefei Hengxing Institute of Materia Medica |
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| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120704 Termination date: 20140911 |
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