CN101631850B - 增加和转移造血干细胞的方法 - Google Patents

增加和转移造血干细胞的方法 Download PDF

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CN101631850B
CN101631850B CN2008800077612A CN200880007761A CN101631850B CN 101631850 B CN101631850 B CN 101631850B CN 2008800077612 A CN2008800077612 A CN 2008800077612A CN 200880007761 A CN200880007761 A CN 200880007761A CN 101631850 B CN101631850 B CN 101631850B
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cell
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CN101631850A (zh
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亚历山大·沙科夫
埃夫格尼亚·斯特罗姆
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Statera Biopharma Inc
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    • A61K38/00—Medicinal preparations containing peptides
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    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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CN2008800077612A 2007-01-09 2008-01-09 增加和转移造血干细胞的方法 Expired - Fee Related CN101631850B (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US88416207P 2007-01-09 2007-01-09
US60/884,162 2007-01-09
US88989307P 2007-02-14 2007-02-14
US60/889,893 2007-02-14
US93856407P 2007-05-17 2007-05-17
US60/938,564 2007-05-17
US1324307P 2007-12-12 2007-12-12
US61/013,243 2007-12-12
PCT/US2008/050644 WO2008086426A2 (en) 2007-01-09 2008-01-09 Methods for increasing and mobilizing hematopoietic stem cells

Publications (2)

Publication Number Publication Date
CN101631850A CN101631850A (zh) 2010-01-20
CN101631850B true CN101631850B (zh) 2013-12-04

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CN2008800077612A Expired - Fee Related CN101631850B (zh) 2007-01-09 2008-01-09 增加和转移造血干细胞的方法

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US (3) US20100055077A1 (enExample)
EP (1) EP2115124B1 (enExample)
JP (1) JP5389666B2 (enExample)
KR (1) KR101493474B1 (enExample)
CN (1) CN101631850B (enExample)
BR (1) BRPI0806557A2 (enExample)
CA (1) CA2675032A1 (enExample)
EA (1) EA018983B1 (enExample)
IL (1) IL199766A (enExample)
MX (1) MX2009007391A (enExample)
NZ (2) NZ603805A (enExample)
SG (1) SG177959A1 (enExample)
WO (1) WO2008086426A2 (enExample)
ZA (1) ZA200905378B (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8008260B2 (en) 2005-06-13 2011-08-30 Cleveland Clinic Foundation Methods of protecting against apoptosis using lipopeptides
CA2655933C (en) * 2006-06-23 2014-09-09 Alethia Biotherapeutics Inc. Polynucleotides and polypeptide sequences involved in cancer
CN104829714A (zh) 2008-11-03 2015-08-12 阿莱斯亚生物疗法股份有限公司 特异性地阻滞肿瘤抗原的生物活性的抗体
EP2493295A4 (en) * 2009-10-28 2013-05-08 Ford Henry Health System METHOD FOR MINIMIZING LESIONS DUE TO RADIATION EXPOSURE
EP2338521A1 (en) * 2009-12-28 2011-06-29 Helmholtz-Zentrum für Infektionsforschung GmbH Lipopeptide- and lipoprotein-conjugates and its use
US20130230580A1 (en) * 2010-09-14 2013-09-05 Paul S. Frenette Administration of SNS Neuroprotective Agents to Promote Hematopoietic Regeneration
CA2893376A1 (en) 2011-03-31 2012-10-04 Alethia Biotherapeutics Inc. Antibodies against kidney associated antigen 1 and antigen binding fragemnts thereof
AU2013209234B2 (en) 2012-01-09 2017-11-09 Adc Therapeutics Sa Method for treating breast cancer
WO2013149064A1 (en) * 2012-03-30 2013-10-03 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Uridine diphosphate compounds as mobilizers of hematopoietic progenitor cells
CA2882853C (en) 2012-04-20 2021-11-23 Vineet Gupta Compounds and methods for regulating integrins
CN104027791B (zh) * 2013-03-06 2016-08-10 浙江海正药业股份有限公司 药物组合物
JP2016518415A (ja) * 2013-10-21 2016-06-23 アドバンスド ニューロリジェネレイティブ セラピーズ エルエルシー 加齢と疾患免疫機能障害と細胞老化とをリンパ球系幹細胞で修復する方法、及び治療使用のためのそれらの再適用する方法
CN104744563B (zh) * 2013-12-27 2019-02-26 中国人民解放军军事医学科学院毒物药物研究所 端基具有亲脂性结构的线性脂肽、其制备方法及用途
WO2016073733A1 (en) * 2014-11-06 2016-05-12 Cleveland Biolabs, Inc. Methods of treating cancer using lipopeptides
WO2020047236A1 (en) * 2018-08-30 2020-03-05 The Regents Of The University Of California Mobilization and collection of peripheral blood hematopoietic stem cells from deceased donors
CN112851755B (zh) * 2021-01-13 2023-09-01 中国人民解放军军事科学院军事医学研究院 一种线性脂肽化合物及其制备方法与应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4554101A (en) 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
US5192553A (en) * 1987-11-12 1993-03-09 Biocyte Corporation Isolation and preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood and methods of therapeutic use
DE19822820A1 (de) * 1998-05-20 1999-11-25 Biotechnolog Forschung Gmbh Pharmazeutisches Präparat zur Wundbehandlung
US8008260B2 (en) * 2005-06-13 2011-08-30 Cleveland Clinic Foundation Methods of protecting against apoptosis using lipopeptides
MX2009001445A (es) * 2006-08-07 2009-02-18 Genzyme Corp Terapia de combinacion.

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
胡晶等.当归多糖对小鼠外周血造血干细胞动员作用的研究.《中草药》.2006,第37卷(第12期),摘要. *

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Publication number Publication date
WO2008086426A3 (en) 2008-12-18
EA200900806A1 (ru) 2010-08-30
SG177959A1 (en) 2012-02-28
MX2009007391A (es) 2009-08-13
NZ603805A (en) 2014-03-28
JP2010515748A (ja) 2010-05-13
IL199766A (en) 2015-01-29
WO2008086426A8 (en) 2009-07-30
AU2008204836A1 (en) 2008-07-17
US20140045747A1 (en) 2014-02-13
CN101631850A (zh) 2010-01-20
WO2008086426A2 (en) 2008-07-17
HK1134835A1 (en) 2010-05-14
EP2115124A4 (en) 2012-05-30
US20100055077A1 (en) 2010-03-04
KR20090108703A (ko) 2009-10-16
BRPI0806557A2 (pt) 2014-04-15
JP5389666B2 (ja) 2014-01-15
EP2115124A2 (en) 2009-11-11
KR101493474B1 (ko) 2015-02-16
NZ578928A (en) 2013-03-28
EP2115124B1 (en) 2016-03-16
EA018983B1 (ru) 2013-12-30
US20150174195A1 (en) 2015-06-25
ZA200905378B (en) 2010-05-26
CA2675032A1 (en) 2008-07-17

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