CN101618044B - Capsule containing ginseng saponin, radix notoginseng saponin and amino acids and preparation method thereof - Google Patents
Capsule containing ginseng saponin, radix notoginseng saponin and amino acids and preparation method thereof Download PDFInfo
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- CN101618044B CN101618044B CN 200810132954 CN200810132954A CN101618044B CN 101618044 B CN101618044 B CN 101618044B CN 200810132954 CN200810132954 CN 200810132954 CN 200810132954 A CN200810132954 A CN 200810132954A CN 101618044 B CN101618044 B CN 101618044B
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Abstract
The invention provides a compound capsule containing ginseng saponin Rb1, ginseng saponin Re, radix notoginseng saponin R1, tryptophan, threonine, leucine, valine, methionine, isoleucine, phenylalanine and lysine hydrochloride, wherein the compound capsule can also contain arginine hydrochloride and/or histidine hydrochloride. The preparation method of the capsule comprises the step of preparing various amino acids and saponin into coating micro-pills respectively. The capsule has stable quality, convenient transportation, storage and use and good absorbing effect. An advanced micro-pill coating preparation technique is adopted, the amino acids, the pseudo-ginseng saponin and the ginseng saponin are respectively prepared into the coating micro-pills with various colors, the quality is more stable by respective packaging, and the absorption of an organism is further promoted, thereby retaining the high potency of the capsule. The capsule has definite curative effect and wide adaptive disease, and clinical observation shows that the capsule can effectively enhance the immunity of the organism, can quicken the healing of wounds and has a very good curative effect on various leukopenia and gastrointestinal tract malabsorption diseases.
Description
Technical field
The present invention relates to a kind of compound capsule and preparation method thereof, be specifically related to a kind of ginsenoside of containing, arasaponin and amino acid whose compound capsule and preparation method thereof.
Background technology
The Tianshen Anjisuan capsule is that 10 kinds of needed by human of a kind of employing and semi-dispensable amino acid are base stock; Be equipped with the compound capsule that the extract of rare medicinal herbs Radix Ginseng, Radix Notoginseng is processed, wherein 8 seed amino acids all be needed by human body but can not synthetic in vivo essential amino acids; Radix Ginseng has the effect of strongly invigorating primordial QI, unimpeded blood vessels; Radix Notoginseng has the effect of removing stasis to stop bleeding, removing obstruction in the collateral to relieve pain.Therefore, this capsule can increase the synthetic of body protein (particularly albumin), thus enhancing human body immunity power.But the aminoacid in the existing Tianshen Anjisuan capsule is very easily rotten under the situation of the moisture absorption and illumination, cause property of drug to change and can not use, and the assimilation effect of active component is also undesirable.
Summary of the invention
The present invention is through discover in a large number, and the Radix Notoginseng in the Tianshen Anjisuan capsule, the mineral in the Radix Ginseng extract are the main causes that influences aminoacid stability.In addition, owing to Radix Ginseng, Radix Notoginseng extract ingredient complicacy, therefore can have influence on effective absorption of active component in the capsule.
Therefore, the object of the present invention is to provide a kind of steady quality and help absorption of human body contain ginsenoside, arasaponin and amino acid whose compound capsule and preparation method thereof.
Above-mentioned purpose of the present invention realizes through following technical scheme:
A kind of compound capsule wherein comprises ginsenoside Rb1, ginsenoside Re, arasaponin R1, tryptophan, threonine, leucine, valine, methionine, isoleucine, phenylalanine and lysine hydrochloride.Wherein, Count by weight, said capsule comprises 0.001-0.3 part ginsenoside Rb1,0.001-0.2 part ginsenoside Re, 0.001-0.5 part arasaponin R1,1-30 part tryptophan, 1-10 part threonine, 1-30 part leucine, 1-10 part valine, 1-30 part methionine, 1-10 part isoleucine, 1-30 part phenylalanine and 1-70 part lysine hydrochloride.
Above-mentioned capsule can also comprise arginine hydrochloride and/or histidine monohydrochloride.Wherein, count by weight, said capsule comprises 1-15 part arginine hydrochloride and/or 1-10 part histidine monohydrochloride.
Above-mentioned capsule can also comprise acceptable accessories.Said adjuvant is preferably starch, Pulvis Talci, silicon dioxide and magnesium stearate.Specifically, count by weight, said capsule comprises 0.5-15 part starch, 1-10 part Pulvis Talci, 1-50 part silicon dioxide and 0.1-5 part magnesium stearate.
Each seed amino acid in the above-mentioned capsule and various saponin can be processed coated micropill respectively.
A kind of method for preparing of above-mentioned compound capsule is comprising the step of said each seed amino acid and various saponin being processed coated micropill respectively.
Capsule quality of the present invention is stable, is convenient to transportation, storage and uses good absorbing effect.Adopt advanced micropill coating preparation technology; Each seed amino acid and Radix Notoginseng, ginsenoside are processed micropill of all kinds respectively; Packing has been eliminated the influence each other of various compositions respectively, makes the more stable quality of these article, and has further promoted the absorption of body; Thereby keep capsular efficient, clinical trial shows that this capsular gastrointestinal absorption rate reaches more than 90%.
Capsule determined curative effect of the present invention, indication is wide, and clinical observation shows this capsule human body immunity improving power effectively; Strengthen normal human's non-specific immunity, promote the metabolism of body, blood fat reducing and cholesterol; Coronary blood flow increasing and microcirculation improvement; And have good hemostasis and analgesic activity, can accelerating wound, pancytopenia and gastrointestinal absorption disorder disease are all had better curative effect.
In addition, capsule of the present invention also all has treatment and auxiliary treatment effect to hypertension, cardiac muscular dystrophy, coronary heart disease, angina pectoris, cerebral arteriosclerosis, diabetes, chronic renal failure etc.Take for a long time and do not see toxic and side effects (toxicity test: these article can not detect half lethal dose).
The specific embodiment
Embodiment 1
1. the system micropill is write out a prescription:
| Raw material or adjuvant title | Specification | Per 1000 materials amounts |
| Tryptophan | Medicinal | 26.5g |
| Threonine | Medicinal | 15g |
| Leucine | Medicinal | 30g |
| Valine | Medicinal | 15g |
| Methionine | Medicinal | 25g |
| Isoleucine | Medicinal | 15g |
| Phenylalanine | Medicinal | 30g |
| Arginine hydrochloride | Medicinal | 20g |
| Histidine monohydrochloride | Medicinal | 12g |
| Lysine hydrochloride | Medicinal | 63g |
| The ginsenoside Rb1 | Medicinal | 25mg |
| The ginsenoside Re | Medicinal | 18mg |
| Arasaponin R1 | Medicinal | 50mg |
| Starch | Medicinal | 10g |
| Pulvis Talci | Medicinal | 15g |
| Silicon dioxide | Medicinal | 50g |
| Magnesium stearate | Medicinal | 2.8g |
2. method for making:
Radix Ginseng extract method for making: get the Radix Ginseng coarse powder, add 75% soak with ethanol of 5 times of crude drug amounts, heating and refluxing extraction 2 hours; Again according to 4 times of amounts for the second time, 3 times of amounts for the third time, the 4th time 3 times of amounts add 75% ethanol, second and third, four each reflux, extract, 1 hour; Merge extractive liquid, filters, and collects filtrating, reclaims ethanol and be concentrated into thick paste, and vacuum drying promptly gets ginsenoside Rb1 and ginsenoside Re.
Radix Notoginseng extract method for making: get the Radix Notoginseng coarse powder, add 90% above alcohol heating reflux and extract three times.Wherein for the first time: 3 times of amounts, 3 hours; For the second time: 1.5 times of amounts, 2 hours; For the third time: 1.5 times of amounts, 2 hours.Merge extractive liquid, adds medicinal carbon decoloring, filters carbon removal, reclaims ethanol and is concentrated into and do not have the alcohol flavor; Use n-butanol extraction, n-butanol layer reclaims n-butyl alcohol, is concentrated into the thick paste shape, and vacuum drying promptly gets arasaponin R1.
Starch, silicon dioxide, Pulvis Talci, magnesium stearate and Radix Notoginseng and Radix Ginseng extract pulverize separately are sieved.Accurately take by weighing Radix Notoginseng and Radix Ginseng extract, starch, silicon dioxide, Pulvis Talci by above-mentioned recipe quantity, crushing screening again behind the mix homogeneously.Again various aminoacid are mixed evenly crushing screening.
Two groups of mixture are processed micropill through molding, increasing, round as a ball, coating, drying respectively, and aminoacid group micropill packet package clothing color is processed yellow, orange, white ball, and saponin group coating becomes brown ball.Each organizes the painted after drying of coating, each group micropill is always mixed again, and adds magnesium stearate when always mixing, and divides encapsulatedly, promptly gets.
Embodiment 2
1. pharmacological activity test
(1) human body immunity improving power.Capsule of the present invention is applied to the various diseases that 226 examples are caused by all kinds of immunologic hypofunctions as adjuvant therapy medicaments; Clinical observation shows this capsule human body immunity improving power effectively; Strengthen normal human's non-specific immunity; Promote the metabolism of body, total effective rate reaches 88%.And it also has total fat of obvious reduction and cholesterol, the effect of coronary blood flow increasing and microcirculation improvement.
(2) all kinds of perioperative clinical practices.Use capsule for treating 50 routine all kinds of surgical patients of the present invention, find that this capsule has good hemostasis and analgesic activity, can promote the human body protein metabolism, thereby correct the effect of negative nitrogen balance performance accelerating wound.
(3) treatment leukopenia.Adopt capsule for treating leukopenia patient of the present invention, reduce disease patient 110 examples comprising the leukocyte count that the leukocyte count after tumor radiotherapy, the chemotherapy reduces and other reasons causes, effect sees the following form:
Annotate: produce effects: leukocyte count raises 3.0 * 10
9/ L; Take a turn for the better: leukocyte count rising (0.5-1.0) * 10
9/ L;
Invalid: leukocyte＜0.5 * 10
9/ L.
(4) to malnourished clinical practice.With suffering from juvenile camp's gastrointestinal absorption impaired patients that anemia, malnutrition and liver pancreas disease cause of nourishing one's nature 147 routine 2-12 years of capsule for treating of the present invention.The result shows this capsule to treating the evident in efficacy of gastrointestinal absorption disorder disease, and effective percentage reaches 94.4%; Nutritional anemia, malnutrition I-II ° curative effect is preferably arranged also for treatment, effective percentage reaches 81.8% and 86.6% respectively.
Claims (7)
1. compound capsule; Wherein comprise the ginsenoside Rb1; The ginsenoside Re; Arasaponin R1; Tryptophan; Threonine; Leucine; Valine; Methionine; Isoleucine; Phenylalanine and lysine hydrochloride; Per 1000 of said capsule comprises the 25mg ginsenoside Rb1; The 18mg ginsenoside Re; The 50mg arasaponin R1; 26.5g tryptophan; The 15g threonine; The 30g leucine; The 15g valine; The 25g methionine; The 15g isoleucine; 30g phenylalanine and 63g lysine hydrochloride; Wherein
Ginsenoside Rb1 and ginsenoside Re's method for making is: get the Radix Ginseng coarse powder, add 75% soak with ethanol of 5 times of crude drug amounts, heating and refluxing extraction 2 hours; Again according to 4 times of amounts for the second time, 3 times of amounts for the third time, the 4th time 3 times of amounts add 75% ethanol, second and third, four each reflux, extract, 1 hour; Merge extractive liquid, filters, and collects filtrating, reclaims ethanol and be concentrated into thick paste, and vacuum drying promptly gets ginsenoside Rb1 and ginsenoside Re;
The method for making of arasaponin R1 is: get the Radix Notoginseng coarse powder, add 90% above alcohol heating reflux and extract three times, for the first time: 3 times of amounts, 3 hours; For the second time: 1.5 times of amounts, 2 hours; For the third time: 1.5 times of amounts, 2 hours; Merge extractive liquid, adds medicinal carbon decoloring, filters carbon removal, reclaims ethanol and is concentrated into and do not have the alcohol flavor; Use n-butanol extraction, n-butanol layer reclaims n-butyl alcohol, is concentrated into the thick paste shape, and vacuum drying promptly gets arasaponin R1.
2. capsule according to claim 1 is characterized in that said capsule also comprises arginine hydrochloride and/or histidine monohydrochloride.
3. capsule according to claim 1 is characterized in that, per 1000 of said capsule also comprises 20g arginine hydrochloride and/or 12g histidine monohydrochloride.
4. according to each described capsule in the claim 1 to 3, it is characterized in that said capsule also comprises acceptable accessories.
5. capsule according to claim 4 is characterized in that, per 1000 of said capsule also comprises 10g starch, 15g Pulvis Talci, 50g silicon dioxide and 2.8g magnesium stearate.
6. according to each described capsule in the claim 1 to 3, it is characterized in that said each seed amino acid and various saponin are processed coated micropill respectively.
7. method for preparing according to each described compound capsule in the claim 1 to 6 comprises the step of said each seed amino acid and various saponin being processed coated micropill respectively, and wherein this method also comprises:
Ginsenoside Rb1 and ginsenoside Re's method for making: get the Radix Ginseng coarse powder, add 75% soak with ethanol of 5 times of crude drug amounts, heating and refluxing extraction 2 hours; Again according to 4 times of amounts for the second time, 3 times of amounts for the third time, the 4th time 3 times of amounts add 75% ethanol, second and third, four each reflux, extract, 1 hour; Merge extractive liquid, filters, and collects filtrating, reclaims ethanol and be concentrated into thick paste, and vacuum drying promptly gets ginsenoside Rb1 and ginsenoside Re;
The method for making of arasaponin R1: get the Radix Notoginseng coarse powder, add 90% above alcohol heating reflux and extract three times, for the first time: 3 times of amounts, 3 hours; For the second time: 1.5 times of amounts, 2 hours; For the third time: 1.5 times of amounts, 2 hours; Merge extractive liquid, adds medicinal carbon decoloring, filters carbon removal, reclaims ethanol and is concentrated into and do not have the alcohol flavor; Use n-butanol extraction, n-butanol layer reclaims n-butyl alcohol, is concentrated into the thick paste shape, and vacuum drying promptly gets arasaponin R1.
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| CN 200810132954 CN101618044B (en) | 2008-07-02 | 2008-07-02 | Capsule containing ginseng saponin, radix notoginseng saponin and amino acids and preparation method thereof |
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| CN 200810132954 CN101618044B (en) | 2008-07-02 | 2008-07-02 | Capsule containing ginseng saponin, radix notoginseng saponin and amino acids and preparation method thereof |
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| CN101618044A CN101618044A (en) | 2010-01-06 |
| CN101618044B true CN101618044B (en) | 2012-08-22 |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103006730B (en) * | 2012-12-31 | 2014-06-18 | 扬州丁家宜农业科技有限公司 | Composition containing arginine and panax notoginseng extract for promoting nitric oxide generation and preventing and protecting cardiovascular disease |
| CN104758304B (en) * | 2014-01-03 | 2019-12-13 | 上海中医药大学 | Medical application of notoginsenoside R1 |
| CN103989692B (en) * | 2014-06-09 | 2017-05-24 | 吉林农业大学 | Method for preparing compound amino acid and ginseng saponin capsule |
| CN113016967A (en) * | 2021-04-15 | 2021-06-25 | 深圳仙草生物科技股份有限公司 | Specific immunity-inducing composition and specific immunity-inducing beverage |
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2008
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Non-Patent Citations (4)
| Title |
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| 化学药品地标升国标.田参氨基酸胶囊.《国家药品西药标准》.2002,第9卷WS-10001-(HD-0801)-2002. * |
| 林新广.田参氨基酸胶囊对慢性肾衰竭患者低白蛋白血症的治疗作用.《中国中西医结合肾病杂志》.2002,第3卷(第7期),第402-404页. * |
| 陈华.AccQ-Tag法测定田参氨基酸胶囊中的氨基酸含量.《广东药学院学报》.1998,第14卷(第2期),第119-123页. * |
| 陈松.高效液相色谱法测定田参氨基酸胶囊中三七皂甙R1的含量.《广东药学》.2000,第10卷(第1期),第18-19页. * |
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