CN113016967A - Specific immunity-inducing composition and specific immunity-inducing beverage - Google Patents

Specific immunity-inducing composition and specific immunity-inducing beverage Download PDF

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CN113016967A
CN113016967A CN202110406649.3A CN202110406649A CN113016967A CN 113016967 A CN113016967 A CN 113016967A CN 202110406649 A CN202110406649 A CN 202110406649A CN 113016967 A CN113016967 A CN 113016967A
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parts
ginseng
beverage
specific immune
composition
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杨光伟
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Guangzhou Institute Of Respiratory Health
Rare Xiancao Shenzhen Culture Media Co ltd
Shenzhen Xiancao Biotechnology Co Ltd
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Guangzhou Institute Of Respiratory Health
Rare Xiancao Shenzhen Culture Media Co ltd
Shenzhen Xiancao Biotechnology Co Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/38—Other non-alcoholic beverages
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/18—Peptides; Protein hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Abstract

The invention relates to a specific immune induction composition and a specific immune induction beverage, wherein the specific immune induction composition comprises, by mass, 0.01-0.4 part of panaxan, 0.05-0.2 part of ginseng polypeptide, 15-25 parts of total ginsenoside and 0.035-0.07 part of amino acid. Compared with the prior art, the invention has the following beneficial effects: the beverage prepared by the composition can inhibit the release of inflammatory factors, promote the proliferation of macrophages and enhance the macrophage bacteria removing capacity. In addition, the drink of the invention can promote the biosynthesis of nucleic acid and protein of serum, liver and bone marrow.

Description

Specific immunity-inducing composition and specific immunity-inducing beverage
Technical Field
The invention relates to the technical field of functional beverages, and particularly relates to a specific immune induction composition and a specific immune induction beverage.
Background
The Chinese herbal medicine ginseng is the root of ginseng (dry root of ginseng) of the family Araliaceae, and is grown in dense forest, the main root is big, the meat is big, and the shape is cylindrical, and the Chinese herbal medicine ginseng is divided into several types: the root branch is commonly called "Ling Fang" or "Traverse"; the lower part of the branch is commonly called as "stupid body" or "cis body"; long root, many small warts; there are stem marks on the rootstock, sometimes several adventitious roots. In traditional Chinese medicine, ginseng can greatly tonify primordial qi, consolidate and promote fluid production, calm the nerves, and treat consumptive disease, anorexia, lassitude, regurgitation and vomiting, diarrhea, deficiency cough and dyspnea, spontaneous perspiration and sudden death, palpitation due to fright, amnesia, dizziness and headache, impotence, frequent micturition, diabetes, metrorrhagia and metrostaxis of women, infantile chronic convulsion, chronic deficiency and body fluid deficiency and all the symptoms of deficiency of qi, blood and body fluid.
The Ginseng radix extract is prepared by extracting root, stem and leaf of Panax ginseng C.A. Meyer of Araliaceae, dissolving in 80 deg.C water, and dissolving in ethanol easily. The Ginseng radix extract is mainly suitable for coronary heart disease, angina pectoris, bradycardia, tachycardia, ventricular premature beat, blood pressure disorder, neurasthenia, climacteric syndrome, fatigue, asthenia after illness, parturition and operation. In addition, the ginseng extract can prolong life and enhance physical strength after long-term administration, and can be used for treating low immune function and other symptoms of cancer patients caused by radiotherapy and chemotherapy. In addition, the Ginseng radix extract has effects of resisting cold and heat stress, enhancing activity of human surface cell, and inhibiting aging.
Traditional studies on ginseng extracts: for example, the composition for resisting anoxia is prepared by matching ginseng extract containing ginsenoside, ginseng polysaccharide, volatile oil, amino acid, polypeptide or combination thereof with coriander root or extract thereof; for example, the nanometer SOD extracted from Ginseng radix containing ginsenoside, ginseng polysaccharide, ginseng polypeptide, and ginseng hemiterpene can be used for treating cardiovascular system diseases, stomach and liver diseases, diabetes, psychosis, etc.; for example, Ginsenoside Rb2(Ginsenoside Rb2) is used for preparing a medicament for preventing and/or treating atherosclerosis, and the expression level of TNF-alpha is reduced (P <0.05) after the intervention of Ginsenoside Rb 2; for example, the method for separating ginseng monomeric polysaccharide with immunological activity and anti-tumor property comprises the following steps: (1) extracting ginseng polysaccharide with water as extractant by microwave extraction method to obtain ginseng crude polysaccharide, and measuring the content and extraction rate of the ginseng crude polysaccharide by phenol-sulfuric acid method after extraction; (2) purifying the crude ginseng polysaccharide by adopting pretreated cotton-shaped DEAE cellulose to obtain purified ginseng polysaccharide; (3) separating purified ginseng polysaccharide by using DEAE-52 cellulose, and sequentially eluting with distilled water, 0.1mol/L, 0.2mol/L and 0.3mol/L NaCl aqueous solution at the flow rate of 1mL/min to obtain ginseng monomer polysaccharide; and proves that the separated polysaccharide has certain promotion effect on the proliferation of RAW264.7 cells.
Disclosure of Invention
Based on this, the main object of the present invention is to provide a specific immunity-inducing composition and a specific immunity-inducing beverage.
The technical scheme of the invention is as follows:
a specific immune induction composition comprises, by mass, 0.01-0.4 parts of ginseng polysaccharide, 0.05-0.2 parts of ginseng polypeptide, 15-25 parts of total ginsenoside and 0.035-0.07 parts of amino acid.
In one embodiment, the specific immune induction composition comprises 0.02 to 0.36 parts of ginseng polysaccharide, 0.08 to 0.16 parts of ginseng polypeptide, 18 to 24.5 parts of total ginsenoside and 0.06 to 0.07 part of amino acid by mass.
In one embodiment, the amino acid comprises at least one of aspartic acid, threonine, serine, glutamic acid, glycine, valine, lysine, arginine, methionine, isoleucine, leucine, tyrosine, phenylalanine, histidine, proline, and alanine.
In one embodiment, the amino acid comprises aspartic acid, threonine, serine, glutamic acid, glycine, valine, lysine, arginine, methionine, isoleucine, leucine, tyrosine, phenylalanine, histidine, proline and alanine.
In one embodiment, the amino acids include, by mass, 0.003 to 0.0042 parts of aspartic acid, 0.0008 to 0.0009 parts of threonine, 0.001 to 0.0015 parts of serine, 0.01 to 0.02 parts of glutamic acid, 0.001 to 0.002 parts of glycine, 0.0006 to 0.0007 parts of valine, 0.0008 to 0.0009 parts of lysine, 0.03 to 0.04 parts of arginine, 0.0001 to 0.0009 parts of methionine, 0.0001 to 0.0005 parts of isoleucine, 0.0001 to 0.0014 parts of leucine, 0.0001 to 0.0011 parts of tyrosine, 0.0001 to 0.00099 parts of phenylalanine, 0.0001 to 0.00079 parts of histidine, 0.001 to 0.0035 parts of proline, and 0.001 to 0.0039 parts of alanine.
Use of a specific immune-inducing composition as described above in the preparation of a composition for promoting macrophage proliferation.
Use of a specific immune-inducing composition as described above in the preparation of a composition for inhibiting the release of macrophage inflammatory factor.
In one embodiment, the inflammatory factor is IL-6 or/and TNF-a.
A specific immune-inducing beverage comprising a specific immune-inducing composition as described above and a beverage base.
In one embodiment, the beverage base is water.
In one embodiment, the specific immunity induction beverage package comprises, by mass, 70 to 100 parts of the water, 0.01 to 0.4 part of the ginseng polysaccharide, 0.05 to 0.2 part of the ginseng polypeptide, 15 to 25 parts of the ginseng total saponin, and 0.035 to 0.07 part of the amino acid.
Compared with the prior art, the invention has the following beneficial effects:
the invention matches proper amounts of ginseng polysaccharide, ginseng polypeptide, ginseng total saponin and amino acid to form a composition with a specific formula, and the beverage prepared by the composition can inhibit the release of inflammatory factors, promote the proliferation of macrophages and enhance the bacterial removal capacity of the macrophages. In addition, the drink of the invention can promote the biosynthesis of nucleic acid and protein of serum, liver and bone marrow.
Detailed Description
In order that the invention may be more fully understood, reference will now be made to the following description. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention.
The embodiment of the invention provides a specific immune induction composition, which comprises, by mass, 0.01-0.4 part of panaxan, 0.05-0.2 part of ginseng polypeptide, 15-25 parts of total ginsenoside and 0.035-0.07 part of amino acid.
In the embodiment of the invention, a proper amount of ginseng polysaccharide, ginseng polypeptide, ginseng total saponin and amino acid are matched to form a composition with a specific formula, and a beverage (such as a beverage formed by water) prepared by using the composition can inhibit the release of inflammatory factors (the release of macrophage IL-6 and TNF-a inflammatory factors generated in the presence of bacterial LPS (lipid-producing substances) is obviously inhibited, and the inhibition effect is enhanced along with the dosage under the dosage of 0.5-2.0 mg/ml) and the proliferation of macrophages is promoted, so that the inductive defense effect of the macrophages is enhanced. Moreover, after the consumers drink the beverage provided by the embodiment of the invention, the biosynthesis of nucleic acid and protein of serum, liver and bone marrow can be promoted. In addition, the beverage provided by the embodiment of the invention has double effects of enhancing macrophage bacteria removing capacity and controlling inflammatory factor release, and has wide application value in prevention and treatment of bacterial infectious diseases such as pneumonia.
The ginseng total saponin, also called ginseng total saponin, is the main component of ginseng extract, the lixivium of ginseng can be slowly absorbed by skin, has no any adverse stimulation to skin, can expand skin capillary vessels, promote skin blood circulation, increase skin nutrition, regulate water-oil balance of skin, prevent skin dehydration, hardening and wrinkling, and can enhance skin elasticity and regenerate cells by using the product containing ginseng for a long time.
Ginseng polypeptide, which mainly controls the growth, development, immunoregulation and metabolism of human body, is in a balanced state in human body, and if the active peptide is reduced, the function of human body is changed significantly. For example: for children, the growth and development of the children become slow and even stop due to the lack of active peptides, and the dwarfism is formed after the children grow for a long time; for adults or the elderly, after the active peptide is lacked, the immunity of the adults or the elderly is reduced, the metabolism is disordered, the endocrine is disordered, and various diseases are caused.
The antiviral mechanism of panaxan is to inhibit the adsorption of virus to cells, which is probably due to the fact that the panaxan macromolecule is mechanically or chemically bound to Gp120 molecule of HW-I, and the binding sites of virus and cells are covered, so that the virus infection cells are blocked competitively.
The ginseng in the ginseng polysaccharide, ginseng polypeptide and ginseng total saponin provided by the embodiment of the invention can be selected from wild ginseng, red ginseng, white ginseng, Korean ginseng, garden ginseng, pansy, sugared ginseng, American ginseng or a combination thereof.
In one example, the specific immunity inducing composition includes, in parts by mass, 0.02 to 0.36 parts of ginseng polysaccharide, 0.08 to 0.16 parts of ginseng polypeptide, 18 to 24.5 parts of ginseng total saponin, and 0.06 to 0.07 parts of amino acid.
In one example, the amino acid comprises at least one of aspartic acid, threonine, serine, glutamic acid, glycine, valine, lysine, arginine, methionine, isoleucine, leucine, tyrosine, phenylalanine, histidine, proline, and alanine.
In one example, the amino acid comprises aspartic acid, threonine, serine, glutamic acid, glycine, valine, lysine, arginine, methionine, isoleucine, leucine, tyrosine, phenylalanine, histidine, proline, and alanine.
In one example, the amino acids include, by mass, 0.003 to 0.0042 parts of aspartic acid, 0.0008 to 0.0009 parts of threonine, 0.001 to 0.0015 parts of serine, 0.01 to 0.02 parts of glutamic acid, 0.001 to 0.002 parts of glycine, 0.0006 to 0.0007 parts of valine, 0.0008 to 0.0009 parts of lysine, 0.03 to 0.04 parts of arginine, 0.0001 to 0.0009 parts of methionine, 0.0001 to 0.0005 parts of isoleucine, 0.0001 to 0.0014 parts of leucine, 0.0001 to 0.0011 parts of tyrosine, 0.0001 to 0.00099 parts of phenylalanine, 0.0001 to 0.00079 parts of histidine, 0.001 to 0.0035 parts of proline, and 0.0039 parts of alanine.
The embodiments of the present invention relate to the use of a specific immune-inducing composition as described above for the preparation of a composition for promoting macrophage proliferation.
The embodiment of the invention relates to the application of the specific immune induction composition in preparing the composition for inhibiting the release of macrophage inflammatory factor.
In the composition for promoting macrophage proliferation and the composition for inhibiting macrophage inflammatory factor release, the composition can be medicines, health-care food, functional drinks and the like.
The "release of macrophage inflammatory factor" according to the embodiment of the present invention may be release of macrophage inflammatory factor induced by LPS (Lipopolysaccharide). LPS (Lipopolysaccharide) is an important virulence factor for gram-negative bacteria such as escherichia coli, pseudomonas aeruginosa, klebsiella pneumoniae and the like, and has a close relationship with the onset and progression of common respiratory diseases such as pneumonia, chronic obstructive pulmonary disease acute exacerbation, bronchiectasis and the like. During bacterial infection, airway and alveolar macrophages play an important first defense line through their phagocytic function.
In one example, the inflammatory factor includes, but is not limited to, IL-6, TNF-a, and the like.
The embodiment of the invention relates to a specific immunity induction beverage, which comprises the specific immunity induction composition and a beverage matrix.
It is understood that the beverage of the present invention may be a solid beverage or a liquid beverage, and that the beverage base may be water in the case of a liquid beverage.
The beverage provided by the embodiment of the invention can be a functional beverage, and the functional beverage is a beverage for regulating the functions of a human body to a certain extent by adjusting the components and content ratio of nutrients in the beverage. The functional beverage contains electrolytes such as potassium, sodium, calcium, magnesium and the like, has similar components with body fluid of a human body, can be absorbed by the human body more quickly after being drunk, and can supplement water and electrolytes lost by the human body due to sweat generated by a large amount of exercise in time to enable the body fluid to reach a balanced state.
It will be appreciated that the skilled person can select a corresponding beverage base according to the actual need, including but not limited to diluents, lubricants, disintegrants, flavouring agents, stabilisers, preservatives, etc.
Examples of preferred diluents may include: lactose, glucose, sucrose, corn starch, soybean oil, microcrystalline cellulose, sorbitol, xylitol, and mannitol.
Examples of preferred lubricants may include: examples of magnesium stearate and talc, preferred binders, may include: polyvinylpyrrolidone or hydroxypropyl cellulose.
Examples of preferred disintegrants may include: calcium carboxymethylcellulose, sodium carboxymethyl starch, potassium polyacrylate or crospovidone.
Examples of preferred stabilizers may include: sodium carboxymethylcellulose, beta-cyclodextrin, beeswax, and xanthan gum.
Examples of preferred preservatives may include: methyl paraben, propyl paraben and potassium sorbate.
In addition to these ingredients, known flavoring agents for improving taste may be included, such as: natural flavoring agents (such as plum, lemon, pineapple or herb flavors), natural fruit juices, natural dyes (such as chlorophyllin or flavonoids), sweetening ingredients (such as fructose, honey, sugar alcohols or sugar), or acidulants (such as citric acid or sodium citrate).
In one example, the specific immunity-inducing beverage includes, by mass, 70 to 100 parts of the water, 0.01 to 0.4 parts of the ginseng polysaccharide, 0.05 to 0.2 parts of the ginseng polypeptide, 15 to 25 parts of the ginseng total saponin, and 0.035 to 0.07 parts of the amino acid.
Example 1
The embodiment provides a ginseng element beverage for improving the induction specificity defense effect of macrophages, which comprises water, ginseng polysaccharide, ginseng polypeptide, sixteen kinds of amino acids and ginseng total saponin.
The ginseng element beverage of the embodiment comprises (mass part unit: g):
Figure BDA0003022544710000081
Figure BDA0003022544710000091
example 2
The embodiment provides a ginseng element beverage formula for improving the induction specificity defense effect of macrophages, which comprises water, ginseng polysaccharide, ginseng polypeptide, sixteen kinds of amino acids and ginseng total saponin.
The ginseng element beverage of the embodiment comprises (mass part unit: g):
Figure BDA0003022544710000092
Figure BDA0003022544710000101
example 3
The embodiment provides a ginseng element beverage formula for improving the induction specificity defense effect of macrophages, which comprises water, ginseng polysaccharide, ginseng polypeptide, sixteen kinds of amino acids and ginseng total saponin.
The ginseng element beverage of the embodiment comprises (mass part unit: g):
Figure BDA0003022544710000102
Figure BDA0003022544710000111
example 4
The embodiment provides a ginseng element beverage formula for improving the induction specificity defense effect of macrophages, which comprises water, ginseng polysaccharide, ginseng polypeptide, sixteen kinds of amino acids and ginseng total saponin.
The ginseng element beverage of the embodiment comprises (mass part unit: g):
Figure BDA0003022544710000112
Figure BDA0003022544710000121
example 5
The embodiment provides a ginseng element beverage formula for improving the induction specificity defense effect of macrophages, which comprises water, ginseng polysaccharide, ginseng polypeptide, sixteen kinds of amino acids and ginseng total saponin.
The ginseng element beverage of the embodiment comprises (mass part unit: g):
Figure BDA0003022544710000122
Figure BDA0003022544710000131
TABLE 1, EXAMPLES 1 TO 5A summary of the ginseng element beverage formulations (unit: parts)
Figure BDA0003022544710000132
Figure BDA0003022544710000141
Comparative example 1
The comparative example is that of example 1, and the ginseng element beverage provided by the comparative example comprises water, ginseng polysaccharide, ginseng polypeptide, sixteen amino acids and ginseng total saponin, and the main difference relative to example 1 is that the dosage of ginseng polysaccharide is excessive.
Specifically, the ginseng element beverage of the present comparative example comprises (mass part unit: g):
Figure BDA0003022544710000142
Figure BDA0003022544710000151
comparative example 2
The comparative example is that of example 1, the ginseng element beverage of the comparative example includes water, ginseng polysaccharide, ginseng polypeptide, sixteen amino acids and ginseng total saponin, and the main difference with respect to example 1 is that the amount of ginseng polypeptide is excessive.
Specifically, the ginseng element beverage of the present comparative example comprises (mass part unit: g):
Figure BDA0003022544710000152
Figure BDA0003022544710000161
comparative example 3
The comparative example is the comparative example of example 1, the ginseng element beverage of the comparative example comprises water, ginseng polysaccharide, ginseng polypeptide, ginseng total saponin and amino acid, and the main difference relative to example 1 is that the dosage of the ginseng total saponin is excessive.
Specifically, the ginseng element beverage of the present comparative example comprises (mass part unit: g):
Figure BDA0003022544710000162
Figure BDA0003022544710000171
comparative example 4
The comparative example is the comparative example of example 1, the ginseng element beverage of the comparative example comprises water, ginseng polysaccharide, ginseng polypeptide, ginseng total saponin and amino acid, and the main difference with respect to example 1 is that the dosage of the amino acid is excessive. Specifically, the ginseng element beverage of the present comparative example comprises (mass part unit: g):
Figure BDA0003022544710000172
Figure BDA0003022544710000181
the ginseng element beverage provided in example 1 above was tested for functionality, and the test results were as follows:
(1) anti-inflammatory function test results
TNF-a levels in cell culture supernatants were significantly increased (P <0.0001) 6 hours after LPS stimulation of RAW264.7 macrophages; the ginseng element beverage has no significant influence on the L-6 release level stimulated by LPS at the concentration of 0.25 mg/ml; adding ginseng element beverage (0.5 mg/ml-2.0 mg/ml) to obviously inhibit TNF-a expression induced by LPS (P < 0.05); the inhibiting effect of the ginseng element beverage is related to dosage under the concentration of 0.5mg/ml and 1.0mg/ml >2.0mg/ml, and the inhibiting effect reaches the maximum under the dosage of 2.0 mg/ml.
(2) Macrophage proliferation promoting function
After RAW264.7 macrophage LPS and ginseng element beverages with different concentrations are stimulated for 6 hours, the number of living cells is detected, and LPS has no obvious influence on the number of macrophages; compared with LPS only group, the ginseng element beverage has remarkable promotion effect on macrophage proliferation (P <0.05) under the dosage of 0.5mg/ml and 1.0 mg/ml.
The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.

Claims (12)

1. The specific immune induction composition is characterized by comprising, by mass, 0.01-0.4 part of panaxan, 0.05-0.2 part of ginseng polypeptide, 15-25 parts of total ginsenoside and 0.035-0.07 part of amino acid.
2. The specific immune induction composition according to claim 1, wherein the specific immune induction composition comprises 0.02 to 0.36 parts by mass of panaxan, 0.08 to 0.16 parts by mass of ginseng polypeptide, 18 to 24.5 parts by mass of total ginsenoside and 0.06 to 0.07 parts by mass of amino acid.
3. The specific immune inducing composition of claim 1 or 2, wherein the amino acid comprises at least one of aspartic acid, threonine, serine, glutamic acid, glycine, valine, lysine, arginine, methionine, isoleucine, leucine, tyrosine, phenylalanine, histidine, proline and alanine.
4. The specific immunity inducing composition of claim 3, wherein said amino acids comprise aspartic acid, threonine, serine, glutamic acid, glycine, valine, lysine, arginine, methionine, isoleucine, leucine, tyrosine, phenylalanine, histidine, proline and alanine.
5. The specific immune induction composition according to any one of claims 1, 2 and 4, wherein the amino acids comprise, by mass, 0.003 to 0.0042 parts of aspartic acid, 0.0008 to 0.0009 parts of threonine, 0.001 to 0.0015 parts of serine, 0.01 to 0.02 parts of glutamic acid, 0.001 to 0.002 parts of glycine, 0.0006 to 0.0007 parts of valine, 0.0008 to 0.0009 parts of lysine, 0.03 to 0.04 parts of arginine, 0.0001 to 0.0009 parts of methionine, 0.0001 to 0.0001 parts of isoleucine, 0.0001 to 0.0014 parts of leucine, 0.0001 to 0.0011 parts of tyrosine, 0.0001 to 0.00099 parts of phenylalanine, 0.0001 to 0.00079 parts of histidine, 0.001 to 0.0035 parts of proline and 0.0039 parts of alanine.
6. Use of a specific immune-inducing composition according to any of claims 1 to 5 in the preparation of a composition for promoting macrophage proliferation.
7. Use of a specific immune-inducing composition according to any of claims 1 to 5 in the preparation of a composition for inhibiting the release of macrophage inflammatory factor.
8. The use according to claim 7, wherein the inflammatory factor is IL-6.
9. The use according to claim 7, wherein the inflammatory factor is TNF-a.
10. A specific immunity-inducing beverage comprising the specific immunity-inducing composition according to any one of claims 1 to 5 and a beverage base.
11. The specific immune-derived beverage of claim 10, wherein the beverage base is water.
12. The specific immune induction beverage according to claim 11, characterized by comprising, by mass, 70 to 100 parts of the water, 0.01 to 0.4 part of the ginseng polysaccharide, 0.05 to 0.2 part of the ginseng polypeptide, 15 to 25 parts of the total ginsenoside, and 0.035 to 0.07 part of the amino acid.
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