CN101616910A - 作为白细胞介素-1受体相关激酶调节剂的吲唑衍生物 - Google Patents

作为白细胞介素-1受体相关激酶调节剂的吲唑衍生物 Download PDF

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CN101616910A
CN101616910A CN200780041379A CN200780041379A CN101616910A CN 101616910 A CN101616910 A CN 101616910A CN 200780041379 A CN200780041379 A CN 200780041379A CN 200780041379 A CN200780041379 A CN 200780041379A CN 101616910 A CN101616910 A CN 101616910A
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凯文·古基安
查尔斯·朱厄尔
帕特里克·康兰
林盈翔
蒂莫西·钱
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Biogen MA Inc
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Biogen Idec MA Inc
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
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  • Hematology (AREA)
  • Obesity (AREA)
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  • Cardiology (AREA)
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  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Dermatology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN200780041379A 2006-09-07 2007-09-07 作为白细胞介素-1受体相关激酶调节剂的吲唑衍生物 Pending CN101616910A (zh)

Applications Claiming Priority (2)

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US84280106P 2006-09-07 2006-09-07
US60/842,801 2006-09-07

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CN101616910A true CN101616910A (zh) 2009-12-30

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CN200780041379A Pending CN101616910A (zh) 2006-09-07 2007-09-07 作为白细胞介素-1受体相关激酶调节剂的吲唑衍生物

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US (1) US8293923B2 (https=)
EP (1) EP2061786A2 (https=)
JP (1) JP2010502717A (https=)
KR (1) KR20090049076A (https=)
CN (1) CN101616910A (https=)
AU (1) AU2007292929A1 (https=)
BR (1) BRPI0716549A2 (https=)
CA (1) CA2663100A1 (https=)
IL (1) IL197274A0 (https=)
MX (1) MX2009002377A (https=)
NO (1) NO20091326L (https=)
NZ (1) NZ575410A (https=)
RU (1) RU2459821C2 (https=)
WO (1) WO2008030584A2 (https=)
ZA (1) ZA200901529B (https=)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106170486A (zh) * 2013-12-19 2016-11-30 拜耳医药股份有限公司 新吲唑甲酰胺、其制备方法、包含其的药物制剂及其用于制备药物的用途
CN106222183A (zh) * 2016-07-25 2016-12-14 南通大学 靶向人irak1基因的小干扰rna及其应用
CN106458982A (zh) * 2014-01-10 2017-02-22 奥列基因发现技术有限公司 作为irak4抑制剂的吲唑化合物
CN108864151A (zh) * 2010-11-19 2018-11-23 利亘制药公司 杂环胺及其用途
CN110305109A (zh) * 2014-11-26 2019-10-08 拜耳医药股份有限公司 新型取代的吲唑、其制备方法、包含其的药物制剂及其用于制备药物的用途
CN114585609A (zh) * 2019-06-27 2022-06-03 比奥根Ma公司 2h-吲唑衍生物及其在疾病治疗中的用途
CN115710253A (zh) * 2021-08-23 2023-02-24 上海交通大学 一类含有氨基苯并咪唑类衍生物及其制备和用途

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WO2014058685A1 (en) 2012-10-08 2014-04-17 Merck Sharp & Dohme Corp. Inhibitors of irak4 activity
WO2014058691A1 (en) 2012-10-08 2014-04-17 Merck Sharp & Dohme Corp. Inhibitors of irak4 activity
EP2746260A1 (en) 2012-12-21 2014-06-25 Basf Se Substituted [1,2,4]triazole and imidazole compounds
EP2746259A1 (en) 2012-12-21 2014-06-25 Basf Se Substituted [1,2,4]triazole and imidazole compounds
LT2953952T (lt) * 2013-02-07 2017-08-25 Merck Patent Gmbh Makrocikliniai piridazinono dariniai
EP2953944B1 (en) * 2013-02-07 2017-04-26 Merck Patent GmbH Pyridazinone-amides derivatives
EP3019171B1 (en) 2013-07-11 2018-09-05 Merck Sharp & Dohme Corp. Substituted amidopyrazole inhibitors of interleukin receptor-associated kinases (irak-4)
FI3805233T3 (fi) 2014-01-13 2024-04-17 Aurigene Oncology Ltd N-(5-(3-hydroksipyrrolidin-1-yyli)-2-morfolinooksatsolo[4,5-b]pyridin-6-yyli)-2-(2-metylipyridin-4-yyli)okatsoli-karboksamidin (r)- (s)-enantiomeerit irak4-estäjänä syövän hoitoon
JP2017518348A (ja) * 2014-06-20 2017-07-06 オーリジーン ディスカバリー テクノロジーズ リミテッドＡｕｒｉｇｅｎｅ Ｄｉｓｃｏｖｅｒｙ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｌｉｍｉｔｅｄ Ｉｒａｋ４阻害剤としての置換インダゾール化合物
TW201702218A (zh) 2014-12-12 2017-01-16 美國杰克森實驗室 關於治療癌症、自體免疫疾病及神經退化性疾病之組合物及方法
US10807983B2 (en) 2015-03-16 2020-10-20 Ligand Pharmaceuticals, Inc. Imidazo-fused heterocycles and uses thereof
EP3195865A1 (de) 2016-01-25 2017-07-26 Bayer Pharma Aktiengesellschaft Kombinationen von irak4 inhibitoren und btk inhibitoren
UY36660A (es) 2015-04-30 2016-11-30 Bayer Pharma AG Combinaciones de inhibidores de irak4
EP3423446B1 (de) 2016-03-03 2020-09-16 Bayer Pharma Aktiengesellschaft Neue 2-substituierte indazole, verfahren zu ihrer herstellung, pharmazeutische präparate die diese enthalten, sowie deren verwendung zur herstellung von arzneimitteln
EP3219329A1 (en) 2016-03-17 2017-09-20 Bayer Pharma Aktiengesellschaft Combinations of copanlisib
KR102409105B1 (ko) 2016-04-29 2022-06-16 바이엘 파마 악티엔게젤샤프트 인다졸의 합성
UA123169C2 (uk) 2016-04-29 2021-02-24 Байєр Фарма Акцієнгезелльшафт Поліморфна форма n-{6-(2-гідроксипропан-2-іл)-2-[2-(метилсульфоніл)етил]-2н-індазол-5-іл}-6-(трифторметил)піридин-2-карбоксаміду
MY199070A (en) 2016-06-01 2023-10-12 Bayer Pharma AG Substituted indazoles useful for treatment and prevention of allergic and/or inflammatory diseaes in animals
TW202340194A (zh) 2017-02-16 2023-10-16 美商基利科學股份有限公司 吡咯并[1,2-b]嗒𠯤衍生物
DK3600270T3 (da) 2017-03-31 2023-07-10 Aurigene Oncology Ltd Forbindelser og sammensætninger til behandling af hæmatologiske lidelser
CA3079292A1 (en) 2017-10-19 2019-04-25 Bayer Animal Health Gmbh Use of fused heteroaromatic pyrrolidones for treatment and prevention of diseases in animals
CA3079628A1 (en) 2017-10-31 2019-05-09 Curis, Inc. Compounds and compositions for treating hematological disorders
WO2019111218A1 (en) 2017-12-08 2019-06-13 Cadila Healthcare Limited Novel heterocyclic compounds as irak4 inhibitors
TWI842978B (zh) * 2018-07-13 2024-05-21 美商基利科學股份有限公司 衍生物
WO2020097398A1 (en) 2018-11-07 2020-05-14 Dana-Farber Cancer Institute, Inc. Benzothiazole derivatives and 7-aza-benzothiazole derivatives as janus kinase 2 inhibitors and uses thereof
WO2020097396A1 (en) 2018-11-07 2020-05-14 Dana-Farber Cancer Institute, Inc. Benzimidazole derivatives and aza-benzimidazole derivatives as janus kinase 2 inhibitors and uses thereof
EP3877371A4 (en) 2018-11-07 2022-07-27 Dana-Farber Cancer Institute, Inc. IMIDAZOPYRIDINE DERIVATIVES AND AZA-IMIDAZOPYRIDINE DERIVATIVES AS JANUS KINASE 2 INHIBITORS AND USES THEREOF
CA3181537A1 (en) 2020-05-06 2021-11-11 Ajax Therapeutics, Inc. 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors
EP4267574B1 (en) 2020-12-23 2025-04-23 Ajax Therapeutics, Inc. 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors
KR20240004476A (ko) 2021-04-08 2024-01-11 쿠리스 인코퍼레이션 암 치료를 위한 병용 요법
JP7782035B2 (ja) 2021-11-09 2025-12-08 エイジャックス セラピューティクス， インコーポレイテッド Ｊａｋ２阻害剤としての６－ヘテロアリールオキシベンゾイミダゾール及びアザベンゾイミダゾール
TW202325289A (zh) 2021-11-09 2023-07-01 美商雅捷可斯治療公司 Ｊａｋ２抑制劑之形式及組合物

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Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108864151A (zh) * 2010-11-19 2018-11-23 利亘制药公司 杂环胺及其用途
CN106170486A (zh) * 2013-12-19 2016-11-30 拜耳医药股份有限公司 新吲唑甲酰胺、其制备方法、包含其的药物制剂及其用于制备药物的用途
CN106170486B (zh) * 2013-12-19 2019-01-15 拜耳医药股份有限公司 新吲唑甲酰胺、其制备方法、包含其的药物制剂及其用于制备药物的用途
CN106458982A (zh) * 2014-01-10 2017-02-22 奥列基因发现技术有限公司 作为irak4抑制剂的吲唑化合物
CN110305109A (zh) * 2014-11-26 2019-10-08 拜耳医药股份有限公司 新型取代的吲唑、其制备方法、包含其的药物制剂及其用于制备药物的用途
CN110305109B (zh) * 2014-11-26 2022-04-08 拜耳医药股份有限公司 新型取代的吲唑、其制备方法、包含其的药物制剂及其用于制备药物的用途
CN106222183A (zh) * 2016-07-25 2016-12-14 南通大学 靶向人irak1基因的小干扰rna及其应用
CN106222183B (zh) * 2016-07-25 2019-11-08 南通大学 靶向人irak1基因的小干扰rna及其应用
CN114585609A (zh) * 2019-06-27 2022-06-03 比奥根Ma公司 2h-吲唑衍生物及其在疾病治疗中的用途
CN115710253A (zh) * 2021-08-23 2023-02-24 上海交通大学 一类含有氨基苯并咪唑类衍生物及其制备和用途
CN115710253B (zh) * 2021-08-23 2024-07-02 上海交通大学 一类含有氨基苯并咪唑类衍生物及其制备和用途

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CA2663100A1 (en) 2008-03-13
ZA200901529B (en) 2009-11-25
US8293923B2 (en) 2012-10-23
KR20090049076A (ko) 2009-05-15
NO20091326L (no) 2009-04-01
RU2009112598A (ru) 2010-10-20
JP2010502717A (ja) 2010-01-28
US20110152260A1 (en) 2011-06-23
RU2459821C2 (ru) 2012-08-27
NZ575410A (en) 2012-03-30
IL197274A0 (en) 2009-12-24
EP2061786A2 (en) 2009-05-27
AU2007292929A1 (en) 2008-03-13
WO2008030584A3 (en) 2008-07-17
WO2008030584A2 (en) 2008-03-13
BRPI0716549A2 (pt) 2013-09-24
MX2009002377A (es) 2009-03-13

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