CN101616679A - The compositions that is used for the treatment of skin disorder - Google Patents

The compositions that is used for the treatment of skin disorder Download PDF

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Publication number
CN101616679A
CN101616679A CN200780048639A CN200780048639A CN101616679A CN 101616679 A CN101616679 A CN 101616679A CN 200780048639 A CN200780048639 A CN 200780048639A CN 200780048639 A CN200780048639 A CN 200780048639A CN 101616679 A CN101616679 A CN 101616679A
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China
Prior art keywords
compositions
mollusca
broken shell
solution
carrier
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Pending
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CN200780048639A
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F·门罗
R·莱布朗克
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SCALLOP SHELL POLLUTION SOLUTI
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SCALLOP SHELL POLLUTION SOLUTI
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    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D17/00—Detergent materials or soaps characterised by their shape or physical properties
    • C11D17/0008—Detergent materials or soaps characterised by their shape or physical properties aqueous liquid non soap compositions
    • C11D17/0013—Liquid compositions with insoluble particles in suspension
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/965—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of inanimate origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/18—Antioxidants, e.g. antiradicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D39/00—Filtering material for liquid or gaseous fluids
    • B01D39/02—Loose filtering material, e.g. loose fibres
    • B01D39/04—Organic material, e.g. cellulose, cotton
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D39/00—Filtering material for liquid or gaseous fluids
    • B01D39/02—Loose filtering material, e.g. loose fibres
    • B01D39/06—Inorganic material, e.g. asbestos fibres, glass beads or fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
    • B01J20/0203—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising compounds of metals not provided for in B01J20/04
    • B01J20/0225—Compounds of Fe, Ru, Os, Co, Rh, Ir, Ni, Pd, Pt
    • B01J20/0229—Compounds of Fe
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
    • B01J20/06—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising oxides or hydroxides of metals not provided for in group B01J20/04
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/24—Naturally occurring macromolecular compounds, e.g. humic acids or their derivatives
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • C—CHEMISTRY; METALLURGY
    • C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F1/00—Treatment of water, waste water, or sewage
    • C02F1/28—Treatment of water, waste water, or sewage by sorption
    • C—CHEMISTRY; METALLURGY
    • C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F1/00—Treatment of water, waste water, or sewage
    • C02F1/28—Treatment of water, waste water, or sewage by sorption
    • C02F1/281—Treatment of water, waste water, or sewage by sorption using inorganic sorbents
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/384—Animal products
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
    • C11D7/22—Organic compounds
    • C11D7/40—Products in which the composition is not well defined
    • C11D7/46—Animal products
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00—Aspects relating to sorbent materials
    • B01J2220/40—Aspects relating to the composition of sorbent or filter aid materials
    • B01J2220/48—Sorbents characterised by the starting material used for their preparation
    • B01J2220/4875—Sorbents characterised by the starting material used for their preparation the starting material being a waste, residue or of undefined composition
    • B01J2220/4881—Residues from shells, e.g. eggshells, mollusk shells
    • C—CHEMISTRY; METALLURGY
    • C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F1/00—Treatment of water, waste water, or sewage
    • C02F1/28—Treatment of water, waste water, or sewage by sorption
    • C02F1/288—Treatment of water, waste water, or sewage by sorption using composite sorbents, e.g. coated, impregnated, multi-layered
    • C—CHEMISTRY; METALLURGY
    • C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F1/00—Treatment of water, waste water, or sewage
    • C02F1/50—Treatment of water, waste water, or sewage by addition or application of a germicide or by oligodynamic treatment
    • C—CHEMISTRY; METALLURGY
    • C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F1/00—Treatment of water, waste water, or sewage
    • C02F1/66—Treatment of water, waste water, or sewage by neutralisation; pH adjustment
    • C—CHEMISTRY; METALLURGY
    • C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F1/00—Treatment of water, waste water, or sewage
    • C02F1/68—Treatment of water, waste water, or sewage by addition of specified substances, e.g. trace elements, for ameliorating potable water
    • C—CHEMISTRY; METALLURGY
    • C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F1/00—Treatment of water, waste water, or sewage
    • C02F1/68—Treatment of water, waste water, or sewage by addition of specified substances, e.g. trace elements, for ameliorating potable water
    • C02F1/685—Devices for dosing the additives
    • C02F1/688—Devices in which the water progressively dissolves a solid compound
    • C—CHEMISTRY; METALLURGY
    • C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
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    • C02F2101/103—Arsenic compounds
    • C—CHEMISTRY; METALLURGY
    • C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
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    • C02F2101/20—Heavy metals or heavy metal compounds
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    • C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
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    • C02F2103/02—Non-contaminated water, e.g. for industrial water supply
    • C02F2103/026—Treating water for medical or cosmetic purposes
    • C—CHEMISTRY; METALLURGY
    • C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
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    • C02F2209/00—Controlling or monitoring parameters in water treatment
    • C02F2209/11—Turbidity

Abstract

A kind of compositions that is used for the treatment of various skin disorders is provided, and wherein said compositions comprises the solution that once-through at least contains the solid post of being made up of the broken shell of the Mollusca of at least a particle diameter of filling.Then this solution is mixed with pharmaceutically acceptable carrier.Said composition can effectively be used as cleaning agent and disinfectant, finds that also the treatment for skin and other body illnesses is useful.In addition, housing can be pulverized, as the active component in the ointment formulation that is fit to therapeutic treatment.

Description

The compositions that is used for the treatment of skin disorder
Invention field
The present invention relates generally to comprise the topical composition with the blended living solution of pharmaceutically acceptable carrier, wherein said solution makes liquid prepare to filter by the broken shell particulate filtration/extraction column of Mollusca is housed repeatedly.Described compositions can be used for treating various skin disorders.
Background of invention
The present invention is a Canadian patent application 2,566,562 improvement, and this patent has disclosed a kind of preparation method of the solution that uses in the skin disorder treatment.Further research has disclosed the application summary of above-mentioned solution in the preparation new compositions.For ease of understanding solution itself and manufacture method thereof, the reader can be with reference to Canadian patent application 2,556,562.
Being derived from molluscan housing is the industrial waste that global fishery produces.Conventional way is to pour these housing waste materials into sea.Yet housing can be used for obtaining antibacterial and is used for purified water effectively as the calcium source.Show that obtain powder from scallop, Concha Ostreae, clam and other molluscan housings, the solution that perhaps contains these powder has antibiotic and antiviral properties, and can be used as water scavengine agent.Also find when above-mentioned powder is used for sterilization as deodorizer, to have useful properties during as antiseptic and the medical applications that is used to select.
Verified and tested Mollusca housing powder and extract medical character.For example, european patent application 1676583 has disclosed a kind of periodontal disease therapeutic agent of adopting the preparation of scallop shell material, and it has the antimicrobial acivity of antagonism periodontal disease inductivity antibacterial.Specifically, with the capsid crushing, at high temperature baking is calcined then, makes the calcium carbonate in the original capsid be converted into calcium oxide.Then with new lime powder that forms and original and calcium carbonate powder formation aqueous solution.
Application No. 2004/0028748 has disclosed a kind of treatment scheme of tinea, and the aqueous dispersion that the capsid that has a crystal structure by grinding forms product and forms product obtains treatment.Specifically, surpass 1000 ℃ of housings of calcining through grinding, and adopt the housing of original grinding and form aqueous solution through incinerating housing by granule is heated to.
Japanese patent application 2004/256785 has disclosed a kind of soap with adjuvant treatment effect, can the alleviation pruritus relevant with atopic dermatitis and psoriasis.Main active in the soap is the fine powder of high temperature calcining preparations such as scallop shell, Concha Ostreae, Concha Meretricis Seu Cyclinae.
United States Patent (USP) 6,627,229 have disclosed a kind of Anti-virus agent, and this reagent applies 700-1200 ℃ heat treatment by the ground powder to the calcareous material (for example shell of Concha Meretricis Seu Cyclinae, crustacean, bone, Corallium Japonicum Kishinouye and Margarita) of animal origin and is prepared from.
The United States Patent (USP) 6,365,193 and 6,488,978 of Sasaki etc. discloses, and fired housing can be used as antibacterial and water scavengine agent.Sasaki etc. are disclosed in the inert gas atmosphere heat treated housing and fire housing.Specifically, in inert gas atmosphere the burning clam shell powder and obtain antibacterial.This powder is soluble in water, can be used as antiseptic solution.
The extensive use field that utilizes housing character has been described in the above-mentioned application of housing.Thirst for and need the further research of the new purposes of guide housings material, with control and the annual a large amount of housing waste material that produces of minimizing.
Most of application requirements mentioned above use broken shell or the powder that obtains from the Mollusca housing, in all cases, adopt high-temperature heat treatment, to realize the particulate calcining of housing.Therefore, all these methods require expensive equipment and complicated assignment procedure to realize these high temperature, and in fact, calcining may not be the essential step that represents the intrinsic medical character of housing granule.
And most of therapeutic agent that physician's prescription and/or recommendation are used for skin disorder comprises irritating chemical substance, for example rudimentary MHA, i.e. ethanol and isopropyl alcohol.Yet, the plentiful xerosis cutis and the stimulation that usually causes on the administering therapeutic agent zone of these alcohol in the therapeutic agent.The disappearance of these and other additives will farthest reduce the side effect relevant with these chemical substances among the present invention.
Summary of the invention
One of purpose of the present invention provides a kind of compositions, and it comprises the extract of Mollusca housing, and main component is a calcium, the safe in utilization and environmental friendliness of human body.And said composition has kept antibiotic, the antiviral and the auxiliary character of curing of housing, can be effective to the treatment of skin disorder as mentioned above.In addition, wish that said composition can not cause any tangible xerosis cutis or stimulation.
And compositions of the present invention and preparation method are simple, thereby economic aspect is useful.Therefore, the general public can obtain compositions of the present invention with the price of affording.
According to an aspect of the present invention, provide a kind of topical composition, it comprises and the blended living solution of pharmaceutically acceptable carrier, and wherein said solution is by filtering liquid repeatedly by the broken shell particulate filtration of Mollusca/extraction column preparation is housed.
According to a further aspect in the invention, provide a kind of topical composition, it comprises and the broken shell fine grained of the blended Mollusca of pharmaceutically acceptable carrier.
According to another aspect of the invention, provide a kind of topical composition, comprised the broken shell fine grained of smart Mollusca is dissolved in the solution.
Brief Description Of Drawings
By accompanying drawing, above-mentioned and other features of the present invention will become more apparent.
Fig. 1 has shown the sectional view of the extraction column that comprises import, outlet and casing component;
Fig. 2 a is the amplification sectional view of extraction column the first half, has shown the void column setting;
Fig. 2 b is the amplification sectional view of extraction column the latter half, has shown with loading the post that member is filled;
Fig. 3 is the amplification sectional view of extract the latter half, has shown the void column setting;
Fig. 4 has shown the sectional view of the equipment of the extraction column that comprises two arranged in series;
Fig. 5 has shown the turbidity of living solution mensuration and the curve of time of contact;
Fig. 6 has shown the increase of the calcium amount of measuring in the living solution and the curve of time of contact;
Fig. 7 has shown the variation of living solution pH and the curve of time of contact, has also compared the influence to pH of the housing granule that adopts different ratios and solvent;
Fig. 8 has shown the variation of living solution electric conductivity and the curve of time of contact, has also compared the influence to electric conductivity of the housing granule of different ratios and solvent;
Fig. 9 has shown the variation of the calcium amount that reclaims in the living solution and the curve of time of contact, has also compared the influence to calcium of the housing granule of different ratios and solvent.
Detailed Description Of The Invention
An ingredient of embodiment of the present invention is and the blended living solution of pharmaceutically acceptable carrier.The process of preparation living solution is similar to the method that discloses in the application's priority text, and promptly Canadian patent application 2,556,562, will describe with reference to the accompanying drawings here.
Fig. 1 shows filtration/extraction column (10), comprises import (11), outlet (13), two screen clothes (14) and a casing component (12).Casing component (12) limits the passage (12a) that can load the broken shell of Mollusca.
Fig. 2 a shows the enlarged drawing of filtration/extraction column (10) the first half, comprises top attachment part (16), spiral cover (15) and is arranged in the outlet (13) of spiral cover (15).Screen cloth (14) can be arranged in the top of casing component (12) so that the broken shell of Mollusca is contained in filtration/extraction column (10).Connector in top attachment part (16) and the lip spare (17) is complementary so that screen cloth (14) is attached to casing component.Interchangeable sealing member (18) is used for the seepage of suppressed column as silicon.
Fig. 2 b shows the enlarged drawing of extraction column the latter half, comprises bottom connector (16), lid (15) and is arranged in the import (11) of lid (15).The bottom connector also with lip spare (17) in connector be complementary so that screen cloth (14) is attached to casing component (12), and the broken shell of Mollusca is contained in filtration/extraction column.Import (11) is designed to be connected to plastic valve and the pump that is used for the solvent displacement pile.Interchangeable silicon sealing member (18) is used to avoid the seepage of post.
Fig. 3 shows filtration/extraction column (10), comprises import (11), outlet (13), top screen cloth (14) and the casing component (12) identical with the bottom.Casing component (12) holds the broken shell granule of the identical or different Mollusca of particle diameter.In an embodiment shown in Figure 3, casing component contains the broken shell granule (20) of diameter between 0.5 to 1 millimeter in the bottom, contains the broken shell granule (21) of diameter between 3 to 4 millimeters on top.Yet the broken shell of Mollusca can be made of the granule along the equally distributed about same particle size of passage in one or more zones according to filtration/extraction needs.Zone definitions is the broken shell granule that contains roughly the same diameter.The filling that contains the particulate post of broken shell can be according to the regular distribution of required gradient and/or irregular distribution.
Fig. 4 shows the sectional view according to equipment of the present invention (1), and this equipment comprises at least two filtration/extraction columns (2,3) of arranged in series.In this twin columns equipment (1), filtration/extraction column is linear to be provided with, and makes the outlet (13) of the post of winning (2) be connected to the import (11) of second post (3) by connection tube (23).The casing component (12) of first post (2) can contain the broken shell granule (20) of diameter between 0.5 to 1 millimeter in its bottom, is the broken shell granule (21) of diameter between 3 to 4 millimeters then.The casing component (12) of second post (3) can contain the broken shell granule of useful iron oxides or bloodstone (24) coating.It is believed that with iron oxides or bloodstone to apply broken shell granule, can significantly improve the purification character of filtration/extraction column by reducing solution metal content by equipment (1).Water by filtration/extraction column equipment (1) the analysis showed that the content of aluminum and arsenic is close to zero in the living solution.
In the practice of the inventive method of preparation living solution, from the direct assembling supporting member of fishing boat and place tote box to be transported to maker.With electric drill and wire brush cleaning housing, water thoroughly cleans to guarantee effective cleaning under the high pressure then.Behind cleaning and the cleaning step can be cooling step, housing is placed that maintenance is enough to make housing to be cooled to the time of ambient temperature on the steel wire rack in cooling step.Next step by any method known in the art (for example boil and toast), is heat-treated housing, makes housing reach about 100-300 ℃ temperature.Heat treated main purpose is to remove any residual Mollusca tissue, forces the intrinsic hole of capsid to be opened, and further by eliminating protective layer the housing internal layer is exposed.Heat treatment makes that the internal layer that contains most active component is easier to when using leach in the said equipment.
At this moment, by any way well known by persons skilled in the art whole housings are crushed.Then by using devices such as screen cloth, filter that the gained granule is separated according to particle diameter and sieving.The preferred scallop shell granule of selecting the about 1-6 millimeter of diameter, the more preferably about 2-5 millimeter of diameter, the about 3-4 millimeter of most preferred diameters.Though also can use diameter to arrive about 25 millimeters granule for about 10 microns, still fall within the scope of the invention.These granules can be introduced filtration/extraction column then.Perhaps, can use approximately identical granule or the different particulate mixture of diameter of diameter in the present invention's filtration/extraction column.
Living solution with and the effectiveness of compositions will and form some factors of particle diameter that extraction column loads the broken shell of member by the pH that comprises solvent for use and determine.Preferably, solvent is a water.More preferably, solvent is distilled water or reverse osmosis purified water.By allowing water flow through filtration/extraction column (10), can control the character such as turbidity, pH, calcium content, electric conductivity and suspended solid of living solution.The ratio regular meeting decision living solution that filters broken shell in the flow velocity of number of times, water and water and the post with and the character of compositions.Show that the particle diameter of broken shell and the effectiveness of compositions relatively are inversely proportional to.For example, preferred broken capsomere footpath is between 1 to 6 millimeter, more preferably between 2 to 5 millimeters, most preferably between 3 to 4 millimeters, to become the living solution of effective topical composition after preparation and the acceptable carrier combination.
Fig. 5 shows determined turbidity and the relation of time of contact among the embodiment 1 of following detailed description.The turbidity of the living solution that obviously, records reduces with its increase with the time of contact of filtration/extraction column.Each solvent streams is measured turbidity after crossing extraction column.After being 12 hours time of contact, the turbidity of the living solution that records is about 2.2NTU.Above-mentioned turbidity measurements is associated with each solid content measuring value that suspends in the living solution of back of filtering.Therefore, shown in the table 1 of embodiment 1, as time goes by, the 6mg/L of the amount of suspended solid after solvent flows through filtration/extraction column for the first time is reduced to the 0mg/L after 12 hours.
Fig. 6 illustrates each water and flows through the calcium content that records after the extraction column and the relation of time of contact.The calcium that final living solution comprises is higher about 121 times than raw material solvent.Preferably, the calcium content of living solution is higher than 14mg/L, more preferably is higher than 20mg/L.Other factors that influence living solution and compositions effectiveness are pH and turbidity of living solution.In order to optimize the effectiveness of living solution, keeping the endurable while of external, the pH of living solution is preferably 6.0-10.0, more preferably 6.5-9.0, most preferably 7.0-8.0.Turbidity should be less than 6 NTU units.
According to the embodiment of the present invention, living solution mixes the back and forms compositions with pharmaceutically acceptable carrier, wherein living solution filters liquid repeatedly by the broken shell particulate filtration of Mollusca/extraction column preparation is housed, and has reached all required character by described filtering technique.With living solution and blended concrete grammar of pharmaceutically acceptable carrier and process and unrestricted, adopt any mixed method of any known mixing apparatus all to fall within the scope of the invention.
Living solution and the blended method for optimizing of acceptable carrier are comprised the kitchen mixing apparatus that adopts routine.When mixing beginning, whole living solution increments joined in half the acceptable carrier that accounts for gross weight.After thoroughly mixing, add remaining carrier and combination formation compositions.The advantage of this method is, the generation of bubble significantly reduces and helps to guarantee constant product denseness in the compositions.
The pharmaceutically acceptable carrier of the present invention can be but be not limited to: emulsifiable paste, lotion, gel, ointment and paste.Preferably, carrier is vaseline, substrate emulsifying ointment (base emulsifying ointment) or eucerin TM(Eucerin TM).More preferably, carrier is substrate emulsifying ointment or eucerin TMIn the optional embodiment of the present invention, carrier can comprise the combination in any of above-claimed cpd.
According to an embodiment of the invention, when acceptable carrier is an eucerin TMThe time, living solution and eucerin TMThe mixed weight ratio be about 1: 1 to about 7: 1.Preferably, living solution and eucerin TMWeight ratio be 7: 1.The upper limit of these ratios is mixed eucerin by living solution TMIn ability limit.In the upper limit of described ratio, promptly 7: 1, eucerin TMSaturated, continue to add living solution blending again.Therefore, can make living solution at eucerin TMIn oversaturated any living solution and eucerin TMRatio all fall within the scope of the invention.These ratios produce the emulsifiable paste that is easy on the paint skin.
According to the embodiment of the present invention, when acceptable carrier was substrate emulsifying ointment, living solution was about 0.5: 1 to about 7: 1 with the mixed weight ratio of substrate emulsifying ointment.Preferably, the weight ratio of living solution and substrate emulsifying ointment is 5: 1.The upper limit of these ratios is limited by the ability of living solution doped matrix emulsifying ointment.In the upper limit of described ratio, promptly 7: 1, substrate emulsifying ointment was saturated, continued to add living solution blending again.Therefore, living solution ratio of oversaturated any living solution and substrate emulsifying ointment in substrate emulsifying ointment is all fallen within the scope of the invention.The emulsifiable paste that these ratios produce is smooth, on the easy paint skin, and absorbs by the skin duct easily.
Form compositions when according to another implementation of the invention, the broken shell particulate of Mollusca being added pharmaceutically acceptable carrier.In the present invention, " the broken shell particulate of Mollusca " is defined as the broken shell granule of Mollusca that diameter is less than or equal to 250 μ m.More preferably, the diameter of the broken shell particulate of Mollusca is less than or equal to 150 μ m.Pharmaceutically acceptable carrier as mentioned above.
The broken shell particulate of the broken shell preparation of granules of Mollusca according to the present invention Mollusca.In other words, thoroughly clean after the housing, housing is heat-treated, for example boil or bake, make housing reach about 100-300 ℃ temperature by any way well known by persons skilled in the art.Then by any way crushing housing well known by persons skilled in the art.The gained granule is separated according to the size of used screen cloth, filter etc. and sieve.During this screening step, differentiate the broken shell particulate of Mollusca.Then the broken shell particulate of these Molluscas is mixed in the compositions that contains pharmaceutically acceptable carrier.Preferably, the percentage by weight of particulate with about 0.01-0.5% mixed in the compositions.More preferably, particulate mixes in the compositions with about 0.03% percentage by weight.About particulate being added being limited in the compositions, even particulate, they remain granulous fully in nature.Therefore,, find that the use of compositions is limited, because compositions becomes excessively coarse and has the overwhelming trend that makes the skin serious dehydration of using if particulate is mixed compositions with the percentage by weight that is higher than above-mentioned scope.
According to preferred implementation of the present invention, living solution of the present invention is mixed the back form compositions with pharmaceutically acceptable carrier, wherein the broken shell particulate of Mollusca is added in the said composition.Be similar to above-mentioned parameter, when carrier is an eucerin TMThe time, the weight ratio of living solution and carrier is about 1: 1 to about 7: 1.Preferably, living solution and eucerin TMWeight ratio be 7: 1.When carrier was substrate emulsifying ointment, the weight ratio of living solution and carrier was about 0.5: 1 to about 7: 1.Preferably, the weight ratio of living solution and substrate emulsifying ointment is 5: 1.Particulate is identical with above-mentioned particulate.Preferably, the percentage by weight of particulate with about 0.01-0.5% mixed in the present composition.More preferably, particulate is mixed in the compositions with about 0.03% percentage by weight.About particulate being added being limited in the compositions, even particulate, they remain granulous fully in nature.Therefore, if particulate is mixed in the compositions with the percentage by weight that is higher than above-mentioned scope, find that the use of compositions is limited, compositions becomes excessively coarse and has the overwhelming trend that makes the skin serious dehydration of using.
Another embodiment of the invention is the application of any above-mentioned topical composition.Preferably, the application of any present composition is in order to treat at least a skin disorder.More preferably, the application of the present composition is in order to treat at least a skin disorder, described at least a skin disorder is selected from: psoriasis, acne, herpes zoster, dermatosis, insect bite, the insecticide relevant with banded chickenpox virus bite thorn, vesicle, xeroderma, burn, sunburn, erythra, tinea pedis, eczema and dermatitis, comprise contact dermatitis and atopic dermatitis.
According to another implementation of the invention, the broken shell particulate of Mollusca is dissolved in the aqueous solution.Preferably, particulate mixes in the solution with the percentage by weight of about 5-20%.Aqueous solution can be any solution that can dissolve the broken shell particulate of Mollusca of above-mentioned amount, as long as its external safety.Preferably, aqueous solution is water or living solution.Embodiments of the present invention consider that the solution that contains the broken shell particulate of dissolved Mollusca can be used for treating at least a skin disorder.Preferably, at least a skin disorder is selected from hyperhidrosis or pitted keratolysis.
According to another implementation of the invention, handle living solution with sodium hydroxide (NaOH).Preferably, NaOH is introduced in the living solution with the percentage by weight of about 0.1-4%.Preferably, the calcium concentration in the living solution is about 30mg/L to 〉=1000mg/L.After composition is dispersed in the solution, the adding of NaOH will cause the pH of solution to raise, and follow the precipitation of some calcium.The living solution that comprises sedimentary calcium can exchange use with the described any living solution of the present composition.
Embodiment 1
As shown in Figure 1, with 6 inches of diameters, the pvc pipe of long 4 chis makes up extraction column (10), and its two ends have two connectors (16).Top attachment part (16) has 90 ° of bend pipes, be threaded 3/4 inch plastic tube of bend pipe.Top attachment part (16) and the plastic tube that connects thereof form outlet of the present invention (13).
The bottom connector (16) that makes up has the straight-through adapter that is spun on the connector lid, and this straight-through adapter connects plastic tube, forms import of the present invention (11).The pump of one 12V, 360 gallons per hours is connected in the import of post (10), is used for the distilled water pumping by post (10).Design the top and the bottom of post (10) in an identical manner, just bottom connector (16) has 3/4 joint and 3/4 plastic tube that connects plastic valve and 12V pump.As shown in Figure 1, be retained in the passage (12a) with the scallop shell of two screen clothes (14) crushing.
Broken shell compositions is by the scallop shell granulometric composition of diameter 0.5 and 1 millimeter.The quality of smaller particles is about 10kg, is filled within two inches of screen cloth (14) belows of upper link of post (10).The remainder filling particle diameter 3 of post (10) and 4 millimeters bigger granule.
After first distilled water passed through, living solution had high suspended sediment concentration.Find that this suspended sediment concentration is with disappearing time of contact.Table 1 shows the suspended sediment concentration in the solution that is recorded by the DR-2400 of Hach company spectrophotometer.The method that records suspended solid is simple directly measurement, does not need the filtration of gravimetric analysis method or lights/weigh step.Though USEPA has stipulated the gravimetry that solid is measured, this method usually is used for the inside plants checking process.Measure test result at 810nm.This method is recorded in Hach water analysis handbook, in 8006, the 963 pages of the methods.
To measure the accuracy and the Hach water analysis handbook of the spectrophotography of suspended sediment concentration, the gravimetry shown in the method 8271, the 947 compares.Quality with Scientech 120 analytical balances measurement aluminum dish is accurate to 1 milligram.Obtain 100 ml samples from the solution original position, be placed in the aluminum dish.The aluminum dish that will contain sample placed the baking oven of preheating, about 6 hours of 103-105 ℃ of evaporation.From baking oven, take out aluminum dish then, make it in exsiccator, be cooled to room temperature.From exsiccator, take out the aluminum dish that contains sample then, carry out quality determination, be accurate to 0.1 milligram with Scientech 120 analytical balances.This is the first quality determination result of sample.Aluminum dish and sample are put into the baking oven 1 hour of preheating once more, carry out quality determination and be no more than 0.4 milligram up to result difference.Carry out the quality determination second time as mentioned above in an identical manner.Following table 2 shows the suspended sediment concentration in the solution of measuring by gravimetry.
Total solid analysis
Table 2
Initial pallet weight (B) Dry weight (g) for the first time Dry weight (g) (A) for the second time The first time and secondary weight difference＜0.4mg Total solid mg/L
Pallet
1 ??8.1982 ??8.2109 ??8.2106 ??0.0003 ??0.124
Pallet 2 ??8.2245 ??8.2395 ??8.2393 ??0.0002 ??0.147
Pallet 3 ??8.31 ??8.3253 ??8.3250 ??0.0003 ??0.15
Pallet 4 ??8.2486 ??8.2620 ??8.2620 ??0.0000 ??0.144
Pallet 5 ??8.2659 ??8.2805 ??8.2806 ??0.0001 ??0.147
Total solid is calculated
Equation: the mg/L total solid= (A-B) X1000
Sample volume ml
In the formula:
The weight of A=sample+pallet (mg)
B=pallet weight (mg)
The % error result
The % error=( Dh-D1)X100= (0.15mg-0.124mg)The x100=0.5% error
Data point # 5
In the formula:
The maximum data result that Dh=obtains
The minimum data result that Dl=obtains
Embodiment 2
As two extraction columns of structure (10) (referring to Fig. 4) as described in the embodiment 1.This two posts (10) arranged in series, the outlet of first post (10) directly is connected with the import of second post (10).The pump of one 12V, 360 gallons per hours is connected in the import of first pillar (10), is used for the distilled water pumping by first and second posts (10).
The filling member of first post (10) is made of 0.5 and 1 millimeter less scallop shell granule of diameter.The quality of smaller particles is about 10kg, should be filled to two inches places, screen cloth (14) below of packed column middle and upper part connector (16).The remainder filling diameter 3 of post (10) and 4 millimeters bigger granule are as described in embodiment 1.
The filling member of second post (10) is by with iron oxides or bloodstone (Fe 2O 3) the broken shell granule of scallop that applies constitutes.Applying broken shell granule with iron oxides can realize by any method known to those skilled in the art.In the present invention, by housing being impregnated in iron oxides or the bloodstone 4 hours, 200 ℃ of baking housings and solution 4 hours, finish the coating of scallop shell then.Use the distilled water wash housing then, and in 200 ℃ baking oven dry 3 hours.
Make contaminated water by comprising the equipment of the extraction column that two series connection are provided with high-load aluminum and arsenic.Find in the practice that the content of aluminum and arsenic is reduced to 0mg/L in the gained living solution.
Embodiment 3
Use diameter 5.08cm, the clean propylene acid tube of long 79cm makes up extraction column (10), has two connectors (16) near the two ends of post, as described in Figure 1.Top attachment part (16) has 90 ° of bend pipes, and bend pipe is threaded with 3/4 inch plastic tube.According to the present invention, top attachment part (16) and the plastic tube that connects thereof form outlet (13).
The bottom connector (16) that makes up has the straight-through adapter that is spun on connector (16) lid, and this straight-through adapter connects plastic tube, forms import of the present invention (11).The pump of one 12V, 360 gallons per hours is connected in the import of post (10), is used for distilled water or the water pump that is derived from reverse osmosis are sent by post (10).Design the top and the bottom of post (10) in an identical manner, just bottom connector (16) has 3/4 joint and 3/4 plastic tube that connects plastic valve and 12V pump.As shown in Figure 1, be retained in the passage (12a) with the scallop shell of two screen clothes (14) crushing.
With distilled water wash and cleaning scallop shell, dry then, make housing reach 100 ℃ temperature.Then with housing crushing, after sieving based on particle diameter, composition therefor is made of the scallop shell granulate mixture of diameter 3 and 4 millimeters.The volume and the type that are loaded into the solvent on the post (10) are 1 premium on currency.
In the test of carrying out two kinds of different situations aspect the broken shell amount to optimize service condition.The amount of used housing is A) about 0.35 pound, the ratio of water and scallop shell is about 1: 0.35 (w/w), or B) about 1 pound, the ratio of water and scallop shell is about 1: 1 (w/w).Be filled in the packed column within two inches of screen cloth (14) belows of top connector (16).Allow water continuous-flow pass through post then.In both cases, solvent flows out and is about 2.16 liters/minute.
When analyzing the gained living solution, according to the ratio of used scallop shell and water, there is some variation in measurement parameter.As seen from Figure 7, the pH value of solution is quite approaching.
With reference now to Fig. 8,, shown the electric conductivity of above-mentioned situation, represent with little Siemens.Adopt the latter event (B) of larger proportion housing to produce higher electric conductivity.The maximum conductivity that realize in the framework whole observing time under two kinds of situations be (A) 58.9 μ s/cm and (B) 95.8 μ s/cm.
In order to understand the relation between two kinds of different situations and the electric conductivity, measured calcium concentration.As seen from Figure 9, (B) contains the calcium concentration that is significantly higher than the previous case (A) under the latter event.Last batch of situation A flow of solution is crossed after the post, and the content of calcium is higher 20.83 times than initial soln in the solution, and the flow of solution of last batch of situation B is crossed post (10) afterwards, and the content of calcium is higher 32.5 times than initial soln in the solution.
With reference now to Figure 10,, shown the turbidity of above-mentioned two kinds of situations, with the NTU unit representation.When comparing between the solution that will be prepared by the housing granule and the solvent of different proportion, measured turbidity totally reduces in time, but if any, difference is very little.Either way can realize value less than a NTU unit.
These embodiment show, according to the increase of broken shell granule and solvent ratios, extract calcium from broken shell granule and become more effective.Should be understood that broken shell granule and the ratio of solvent except that above-mentioned all fall within the scope of the invention, should be based on the required character of gained living solution.
Embodiments of the present invention described herein are exemplary, think that many improvement, variant and rearrangement can easily realize suitable basically result, and all these comprises within the spirit and scope of the present invention.
Industrial usability
The invention provides and be used for the treatment of various dermopathic topical compositions, wherein said living solution is that liquid is filtered filtration by the broken shell particle of mollusk is housed/extraction column preparation repeatedly, then mixes with pharmaceutically acceptable carrier. Resulting composition has numerous characteristics. Specifically, said composition can be used as the plethoric effective means for the treatment of skin related disease. And, the invention provides a large amount of industrial wastes that global fishery produces, i.e. the application of mollusk shell believes that this is that finance and environment are useful, is conducive to the public's purposes to realize these reject products.

Claims (49)

1. topical composition that comprises with the blended living solution of pharmaceutically acceptable carrier, wherein, described solution filters liquid repeatedly by the broken shell particulate filtration of Mollusca/extraction column preparation is housed.
2. compositions as claimed in claim 1 is characterized in that described liquid is water.
3. compositions as claimed in claim 2 is characterized in that, described water is distilled water or reverse osmosis purified water.
4. as each described compositions among the claim 1-3, it is characterized in that, the broken shell of Mollusca is boiled under at least about 100 ℃ temperature boil about 15 minutes, be crushed to granule then and place filtration/extraction column.
5. as each described compositions among the claim 1-4, it is characterized in that, the broken shell of described Mollusca was toasted about 15 minutes under at least about 300 ℃ temperature, be crushed to granule then and place filtration/extraction column.
6. as each described compositions among the claim 1-5, it is characterized in that, the broken shell granule of described Mollusca is boiled under at least about 100 ℃ temperature boil about 15 minutes, place filtration/extraction column then.
7. as each described compositions among the claim 1-6, it is characterized in that, the broken shell granule of described Mollusca was toasted about 15 minutes under at least about 300 ℃ temperature, place filtration/extraction column then.
8. as each described compositions among the claim 1-7, it is characterized in that the concentration of calcium is greater than 14mg/L in the described living solution.
9. as each described compositions among the claim 1-8, it is characterized in that the concentration of calcium is greater than 20mg/L in the described living solution.
10. as each described compositions among the claim 1-9, it is characterized in that the pH of described living solution is between 6 to 10.
11., it is characterized in that the pH of described living solution is between 6.5 to 9.0 as each described compositions among the claim 1-10.
12., it is characterized in that the pH of described living solution is between 7.0 to 8.0 as each described compositions among the claim 1-11.
13., it is characterized in that the turbidity of described living solution is less than 6NTU as each described compositions among the claim 1-10.
14., it is characterized in that described compositions also comprises the broken shell granule of Mollusca as each described compositions among the claim 1-13.
15. compositions as claimed in claim 14 is characterized in that, the particle diameter of the broken shell particulate of described Mollusca≤250 μ M.
16. compositions as claimed in claim 15 is characterized in that, described particle diameter≤150 μ M.
17., it is characterized in that the broken shell particulate of described Mollusca boils about 15 minutes boiling at least about 100 ℃ temperature before in adding described compositions as each described compositions among the claim 14-16.
18., it is characterized in that the broken shell particulate of described Mollusca was toasting at least about 300 ℃ temperature about 15 minutes before in adding described compositions as each described compositions among the claim 14-17.
19. as each described compositions among the claim 1-18, it is characterized in that, described living solution with handle with the sodium hydroxide that accounts for the about 0.1-4% of solution weight percentage ratio before described carrier mixes.
20., it is characterized in that described carrier is an emulsifiable paste as each described compositions among the claim 1-19.
21., it is characterized in that described carrier is a lotion as each described compositions among the claim 1-19.
22., it is characterized in that described carrier is an ointment as each described compositions among the claim 1-19.
23., it is characterized in that described carrier is a paste as each described compositions among the claim 1-19.
24., it is characterized in that described carrier is a gel as each described compositions among the claim 1-19.
25., it is characterized in that described carrier is a vaseline as each described compositions among the claim 1-19.
26., it is characterized in that described carrier is a substrate emulsifying ointment as each described compositions among the claim 1-19.
27. compositions as claimed in claim 26 is characterized in that, described living solution mixed with described substrate emulsifying ointment to about 7: 1 weight ratio with about 0.5: 1.
28. compositions as claimed in claim 27 is characterized in that, described ratio was from about 5: 1 to about 6: 1.
29., it is characterized in that described carrier is an eucerin as each described compositions among the claim 1-19 TM
30. compositions as claimed in claim 29 is characterized in that, described living solution mixed with eucerin to about 7: 1 weight ratio with about 1: 1.
31. compositions as claimed in claim 30 is characterized in that, described ratio was from about 6: 1 to about 7: 1.
32. a topical composition, it comprises and the broken shell particulate of the blended Mollusca of pharmaceutically acceptable carrier.
33. compositions as claimed in claim 32 is characterized in that, the particle diameter of the broken shell particulate of described Mollusca≤250 μ M.
34. compositions as claimed in claim 33 is characterized in that, described particle diameter≤150 μ M.
35. as each described compositions among the claim 32-34, it is characterized in that, the broken shell particulate of described Mollusca with boiling at least about 100 ℃ temperature about 15 minutes before described pharmaceutically acceptable carrier mixes.
36. as each described compositions among the claim 32-35, it is characterized in that, the broken shell particulate of described Mollusca with toasting at least about 300 ℃ temperature about 15 minutes before described pharmaceutically acceptable carrier mixes.
37., it is characterized in that described pharmaceutically acceptable carrier is selected from down group as each described compositions among the claim 32-36: emulsifiable paste, lotion, paste, gel, eucerin, vaseline and substrate emulsifying ointment.
38., it is characterized in that the broken shell particulate of described Mollusca mixes with carrier with the weight ratio of about 0.01-0.5% as each described compositions among the claim 32-37.
39., it is characterized in that the broken shell particulate of described Mollusca mixes with carrier with about 0.03% ratio as each described compositions among the claim 32-38.
40. as the application of each described compositions among the claim 1-39 at least a skin disorder of treatment.
41. application as claimed in claim 40, it is characterized in that described at least a skin disorder is selected from down group: psoriasis, acne, herpes zoster, dermatosis, insect bite, the insecticide relevant with banded chickenpox virus bite thorn, burn, sunburn, vesicle, erythra, xeroderma, tinea pedis and dermatitis.
42. a topical composition, it comprises the broken shell particulate of the Mollusca that is dissolved in the solution.
43. compositions as claimed in claim 42 is characterized in that, described solution is water.
44., it is characterized in that the broken shell grain diameter of described Mollusca≤250 μ m as claim 42 or 43 described compositionss.
45. compositions as claimed in claim 44 is characterized in that, described particle diameter≤150 μ M.
46., it is characterized in that the broken shell particulate of described Mollusca was boiling at least about 100 ℃ temperature about 15 minutes before in being dissolved into described solution as each described compositions among the claim 42-45.
47., it is characterized in that the broken shell particulate of described Mollusca was toasting at least about 300 ℃ temperature about 15 minutes before in being dissolved into described solution as each described compositions among the claim 42-46.
48. as the application of each described compositions among the claim 42-47 at least a skin disorder of treatment.
49. the application of compositions as claimed in claim 48 is characterized in that, described at least a skin disorder is selected from down group: hyperhidrosis and pitted keratolysis.
CN200780048639A 2006-10-31 2007-10-29 The compositions that is used for the treatment of skin disorder Pending CN101616679A (en)

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CN117652551A (en) * 2024-02-02 2024-03-08 烟台福晟机械设备有限公司 Scallop processing production line

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