CN101612273A - A kind of pharmaceutical composition that is used for the treatment of hemiplegia and cerebral thrombosis - Google Patents
A kind of pharmaceutical composition that is used for the treatment of hemiplegia and cerebral thrombosis Download PDFInfo
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Abstract
The present invention relates to a kind of pharmaceutical composition that is used for the treatment of hemiplegia and cerebral thrombosis, belong to Chinese medicine.Include following active substance: Radix Astragali total flavones, each 10～20 parts of Rhizoma Acori Graminei quintessence oils, the Radix Ginseng Rubra total glycosides, Radix Angelicae Sinensis volatile oil, Radix Paeoniae Rubra total glycosides, gastrodin, Rhizoma Atractylodis Macrocephalae volatile oil, the Radix Scrophulariae total glycosides, the Rhizoma Alismatis total glycosides, arasaponin, carthamin, the Herba Agrimoniae glycoside, the Arisaema Cum Bile triterpenoid saponin, berberine, the Rhizoma Chuanxiong ferulic acid, the Radix Polygoni Multiflori Preparata emodin, the Rhizoma Typhonii saponin, the Pheretima lumbricin, menispermine, Concha Haliotidis gallbladder element, the Flos Sophorae glycoside, Radix Puerariae total flavones, the Fructus Forsythiae general glycoside, the Fructus Lycii ethanol extract, each 1～5 part of Semen Cassiae polysaccharide, Scorpio, Bombyx Batryticatus is short cast off a skin 0.1～3 part of sterol, the Lignum Aquilariae Resinatum resin, Radix Aucklandiae total saponins, Borneolum Syntheticum, Herba Asari volatile oil, the Fructus Gleditsiae Abnormalis Saponin, each 0.1～5 part of Radix Et Rhizoma Rhei volatile oil, 5～15 parts of general icariins, 3～15 parts of amygdalins, 1～3 part of Margarita calcium carbonate is used for the treatment of obnubilation, the tone is not smoothgoing puckery, contracture of the limbs, hemiplegia, cerebral thrombosis and sequela thereof.
Description
Technical field
The invention belongs to a kind of Chinese medicine, refer in particular to and be used for the treatment of not smoothgoing puckery, the contracture of the limbs of obnubilation, the tone, hemiplegia, cerebral thrombosis and sequela thereof, have the refreshment of reducing phlegm, the function of expelling wind and heat network.
Background technology
Because cerebrovascular disease serious harm public health, in China's disease cause of death, cerebrovascular disease has surpassed cancer and has occupied first.Economically developed countries and regions such as American-European-Japanese, public's disease cause of death central vessel is sick to occupy first, and cerebrovascular occupies second.At present the more of chemicals used in the treatment of above-mentioned cerebrovascular disease, but because of problems such as end-of-dose failure and toxic and side effects, the development toxic and side effects of still needing further is little or have no side effect, and can take for a long time, reduces the desirable medicine of recurrence.
Summary of the invention
The invention provides a kind of pharmaceutical composition that is used for the treatment of hemiplegia and cerebral thrombosis, have the refreshment of reducing phlegm, the function of expelling wind and heat network is used for the treatment of not smoothgoing puckery, the contracture of the limbs of obnubilation, the tone, hemiplegia, cerebral thrombosis and sequela thereof.The technical scheme that the present invention takes is: include the active substance by following ratio of weight and number:
10～20 parts of Radix Astragali total flavoness, 1～5 part of Radix Ginseng Rubra total glycosides, 1～5 part of Radix Angelicae Sinensis volatile oil, 1～5 part of Radix Paeoniae Rubra total glycosides, 1～5 part of gastrodin, 1～5 part of Rhizoma Atractylodis Macrocephalae volatile oil, 1～5 part of Radix Scrophulariae total glycosides, 1～5 part of Rhizoma Alismatis total glycosides, 0.1～3 part of Scorpio, 0.1～5 part of Lignum Aquilariae Resinatum resin, 0.1～5 part of Radix Aucklandiae total saponins, 0.1～5 part of Borneolum Syntheticum, 5～15 parts of general icariins, 1～5 part of arasaponin, 1～5 part of carthamin, 3～15 parts of amygdalins, 1～5 part of Herba Agrimoniae glycoside, 1～5 part of Arisaema Cum Bile triterpenoid saponin, 1～5 part of berberine, 1～5 part of Rhizoma Chuanxiong ferulic acid, 1～5 part of Radix Polygoni Multiflori Preparata emodin, 1～5 part of Rhizoma Typhonii saponin, Bombyx Batryticatus is short cast off a skin 0.1～3 part of sterol, 1～3 part of Margarita calcium carbonate, 10～20 parts of Rhizoma Acori Graminei quintessence oils, 1～5 part of Pheretima lumbricin, 1～5 part of coculine, 1～5 part of Concha Haliotidis gallbladder element, 1～5 part of Flos Sophorae glycoside, 1～5 part of Radix Puerariae total flavones, 1～5 part of Fructus Forsythiae general glycoside, 1～5 part of Fructus Lycii ethanol extract, 1～5 part of Semen Cassiae polysaccharide, 0.1～5 part of Herba Asari volatile oil, 0.1～5 part of Fructus Gleditsiae Abnormalis Saponin, 0.1～5 part of Radix Et Rhizoma Rhei volatile oil.
Be preferably:
15 parts of Radix Astragali total flavoness, 3 parts of Radix Ginseng Rubra total glycosides, 3 parts of Radix Angelicae Sinensis volatile oils, 3 parts of Radix Paeoniae Rubra total glycosidess, 3 parts of gastrodins, 3 parts of Rhizoma Atractylodis Macrocephalae volatile oils, 3 parts of Radix Scrophulariae total glycosides, 3 parts of Rhizoma Alismatis total glycosides, 1.5 parts of Scorpios, 2.5 parts of Lignum Aquilariae Resinatum resins, 2.5 parts of Radix Aucklandiae total saponins, 2.5 parts of Borneolum Syntheticums, 10 parts of general icariins, 3 parts of arasaponins, 3 parts of carthamins, 9 parts of amygdalins, 3 parts of Herba Agrimoniae glycosides, 3 parts of Arisaema Cum Bile triterpenoid saponin, 3 parts of berberines, 3 parts of Rhizoma Chuanxiong ferulic acids, 3 parts of Radix Polygoni Multiflori Preparata emodins, 3 parts of Rhizoma Typhonii saponin, Bombyx Batryticatus is short cast off a skin 1.5 parts of sterols, 2 parts of Margarita calcium carbonate, 15 parts of Rhizoma Acori Graminei quintessence oils, 3 parts of Pheretima lumbricins, 3 parts of coculines, plain 3 parts of Concha Haliotidis gallbladder, 3 parts of Flos Sophorae glycosides, 3 parts of Radix Puerariae total flavoness, 3 parts of Fructus Forsythiae general glycosides, 3 parts of Fructus Lycii ethanol extract, 3 parts of Semen Cassiae polysaccharide, 2.5 parts of Herba Asari volatile oils, 2.5 parts of Fructus Gleditsiae Abnormalis Saponins, 2.5 parts of Radix Et Rhizoma Rhei volatile oil.
Above-mentioned various extracts among the present invention can be by extracting method acquisition arbitrarily in the prior art. are preferably:
Radix Astragali total flavones: it is an amount of to take by weighing raw material, with 50%-90% alcohol reflux 1-3 hour, adds 6-16 times of decocting at every turn and boils 0.5-3 hour, filters, and merging filtrate concentrates.
The Radix Ginseng Rubra total glycosides: it is an amount of to take by weighing raw material, adds 5-14 times of ethanol and decocts 0.5-3 hour with 50%-90% alcohol reflux 1-3 time is each, filter, and merging filtrate, concentrated.
Radix Angelicae Sinensis volatile oil: it is an amount of to take by weighing raw material, and water decocts 1-3 time, adds 5-15 times of decocting at every turn and boils 0.5-3 hour, filter, and merging filtrate, concentrated.
Radix Paeoniae Rubra total glycosides: it is an amount of to take by weighing raw material, with 50%-90% alcohol reflux 1-3 time, adds 5-14 times of ethanol at every turn and decocts 0.5-3 hour, filter, and merging filtrate, concentrated.
Gastrodin: it is an amount of to take by weighing raw material, with 50%-90% alcohol reflux 1-3 time, adds 5-14 times of ethanol at every turn and decocts 0.5-3 hour, filter, and merging filtrate, concentrated.
Rhizoma Atractylodis Macrocephalae volatile oil: it is an amount of to take by weighing raw material, and water decocts 1-3 time, adds 6-17 times of decocting at every turn and boils 0.5-3 hour, filter, and merging filtrate, concentrated.
The Radix Scrophulariae total glycosides: it is an amount of to take by weighing raw material, and water decocts 1-3 time, adds 5-15 times of decocting at every turn and boils 0.5-3 hour, filter, and merging filtrate, concentrated.
The Rhizoma Alismatis total glycosides: it is an amount of to take by weighing raw material, and water decocts 1-3 time, adds 5-17 times of decocting at every turn and boils 0.5-3 hour, filter, and merging filtrate, concentrated.
The Lignum Aquilariae Resinatum resin: it is an amount of to take by weighing raw material, with 50%-90% alcohol reflux 1-3 time, adds 5-14 times of ethanol at every turn and decocts 0.5-3 hour, filter, and merging filtrate, concentrated.
Radix Aucklandiae total saponins: it is an amount of to take by weighing raw material, and water decocts 1-3 time, adds 5-17 times of decocting at every turn and boils 0.5-3 hour, filter, and merging filtrate, concentrated.
General icariin: it is an amount of to take by weighing raw material, with distilled water reflux, extract, 1-3 time, adds 7-15 times of distilled water at every turn and boils 1-3 hour, filter, and merging filtrate, concentrated.
Arasaponin: it is an amount of to take by weighing raw material, with 50%-90% alcohol reflux 1-3 time, adds 5-14 times of ethanol at every turn and decocts 0.5-3 hour, filter, and merging filtrate, concentrated.
Carthamin: it is an amount of to take by weighing raw material, with distilled water reflux, extract, 1-3 time, adds 7-15 times of distilled water at every turn and boils 1-3 hour, filter, and merging filtrate, concentrated.
Amygdalin: it is an amount of to take by weighing the raw material Semen Persicae, with distilled water reflux, extract, 1-3 time, adds 7-15 times of distilled water at every turn and boils 1-3 hour, filter, and merging filtrate, concentrated.
The Herba Agrimoniae glycoside: it is an amount of to take by weighing raw material, with distilled water reflux, extract, 1-3 time, adds 7-15 times of distilled water at every turn and boils 1-3 hour, filter, and merging filtrate, concentrated.
The Arisaema Cum Bile triterpenoid saponin: it is an amount of to take by weighing raw material, with distilled water reflux, extract, 1-3 time, adds 7-15 times of distilled water at every turn and boils 1-3 hour, filter, and merging filtrate, concentrated.
Berberine: it is an amount of to take by weighing raw material, and 50%-90% alcohol reflux 1-3 time adds 5-14 times of ethanol at every turn and decocted 0.5-3 hour, filters, and merging filtrate concentrates.
The Rhizoma Chuanxiong ferulic acid: it is an amount of to take by weighing raw material, and with distilled water reflux, extract, 1-3 time, add 7-15 times of distilled water at every turn and boil filtration in 1-3 hour, merging filtrate, concentrated.
The Radix Polygoni Multiflori Preparata emodin: it is an amount of to take by weighing raw material, and with distilled water reflux, extract, 1-3 time, add 7-15 times of distilled water at every turn and boil filtration in 1-3 hour, merging filtrate, concentrated.
The Rhizoma Typhonii saponin: it is an amount of to take by weighing raw material, with distilled water reflux, extract, 1-3 time, adds 7-15 times of distilled water at every turn and boils 1-3 hour, filter, and merging filtrate, concentrated.
The short sterol of casting off a skin of Bombyx Batryticatus: it is an amount of to take by weighing raw material, with 50%-90% alcohol reflux 1-3 hour, adds 6-16 times of ethanol at every turn and decocts 0.5-3 hour, filters, and merging filtrate concentrates.
The Margarita calcium carbonate: it is an amount of to take by weighing raw material, and with distilled water reflux, extract, 1-3 time, add 7-15 times of distilled water at every turn and boil filtration in 1-3 hour, merging filtrate, concentrated.
The Rhizoma Acori Graminei quintessence oil: it is an amount of to take by weighing raw material, with distilled water reflux, extract, 1-3 time, adds 7-15 times of distilled water at every turn and boils 1-3 hour, filter, and merging filtrate, concentrated.
The Pheretima lumbricin: it is an amount of to take by weighing raw material, and with distilled water reflux, extract, 1-3 time, add 7-15 times of distilled water at every turn and boil filtration in 1-3 hour, merging filtrate, concentrated.
Coculine: it is an amount of to take by weighing raw material, with distilled water reflux, extract, 1-3 time, adds 7-15 times of distilled water at every turn and boils 1-3 hour, filter, and merging filtrate, concentrated.
Concha Haliotidis gallbladder element: it is an amount of to take by weighing raw material, with distilled water reflux, extract, 1-3 time, adds 7-15 times of distilled water at every turn and boils 1-3 hour, filter, and merging filtrate, concentrated.
The Flos Sophorae glycoside: it is an amount of to take by weighing raw material, with distilled water reflux, extract, 1-3 time, adds 7-15 times of distilled water at every turn and boils 1-3 hour, filter, and merging filtrate, concentrated.
Radix Puerariae total flavones: it is an amount of to take by weighing raw material, with distilled water reflux, extract, 1-3 time, adds 7-15 times of distilled water at every turn and boils 1-3 hour, filter, and merging filtrate, concentrated.
The Fructus Forsythiae general glycoside: it is an amount of to take by weighing raw material, and with distilled water reflux, extract, 1-3 time, add 7-15 times of distilled water at every turn and boil filtration in 1-3 hour, merging filtrate, concentrated.
The Fructus Lycii ethanol extract: it is an amount of to take by weighing raw material, with distilled water reflux, extract, 1-3 time, adds 7-15 times of distilled water at every turn and boils 1-3 hour, filter, and merging filtrate, concentrated.
The Semen Cassiae polysaccharide: it is an amount of to take by weighing raw material, and with distilled water reflux, extract, 1-3 time, add 7-15 times of distilled water at every turn and boil filtration in 1-3 hour, merging filtrate, concentrated.
Herba Asari volatile oil: it is an amount of to take by weighing raw material, with 50%-90% alcohol reflux 1-3 hour, adds 6-16 times of ethanol at every turn and decocts 0.5-3 hour, filters, and merging filtrate concentrates.
The Fructus Gleditsiae Abnormalis Saponin: it is an amount of to take by weighing raw material, with 50%-90% alcohol reflux 1-3 hour, adds 6-16 times of ethanol at every turn and decocts 0.5-3 hour, filters, and merging filtrate concentrates.
Radix Et Rhizoma Rhei volatile oil: it is an amount of to take by weighing raw material, and with distilled water reflux, extract, 1-3 time, add 7-15 times of distilled water at every turn and boil filtration in 1-3 hour, merging filtrate, concentrated.
The present invention can be mixed with medicament with one or more pharmaceutically acceptable carriers or adjuvant.
Above-mentioned pharmaceutically acceptable carrier is meant the pharmaceutical carrier or the adjuvant of pharmaceutical field routine, for example: diluent, excipient and water etc., filler such as starch, dextrin, sucrose, mannitol, lactose, microcrystalline Cellulose etc.; Binding agent such as cellulose derivative, alginate, gelatin and polyvinylpyrrolidone; Wetting agent such as glycerol: disintegrating agent such as methyl starch sodium, hyprolose, cross-linked carboxymethyl cellulose, agar, calcium carbonate and sodium bicarbonate; Absorption enhancer such as quaternary ammonium compound; Surfactant such as hexadecanol, Tween 80, sodium lauryl sulphate; Alms bowl such as Kaolin and soap clay are carried in absorption; Lubricant such as Pulvis Talci, calcium stearate and magnesium, micropowder silica gel and Polyethylene Glycol etc.In medicament, can also contain other adjuvant such as flavouring agent, sweeting agent etc. in addition.
The medicament that the present invention makes can be applied to the patient by the mode of oral, rectum or parenteral.Be used for when oral, can be made into conventional solid preparation such as tablet, capsule, powder, granule etc., make other liquid preparation of liquid preparation such as water or oil-suspending agent such as syrup, mixture, elixir etc.; When being used for parenteral, can be made into solution, powder pin, water or the oiliness suspending agent etc. of injection.The preferred form of the present invention is oral liquid, tablet, coated tablet, capsule, granule.
The present invention is used for the treatment of not smoothgoing puckery, the contracture of the limbs of obnubilation, the tone, hemiplegia, cerebral thrombosis and sequela thereof, has the refreshment of reducing phlegm, the function of expelling wind and heat network.Have taking convenience, the course of treatment is shorter, characteristics evident in efficacy.The amount of application of the present invention and medicament thereof can be according to variations such as the type of route of administration, patient age, body weight, the disease of being treated and the orders of severity, 4 of oral doses one time, 2 times on the one.
The specific embodiment
Further verify the present invention below by Pharmacodynamic test of active extract.
Experiment material
Medicine medicine of the present invention, hereinafter to be referred as the refreshment reworking capsule, the prosperous Pharmaceutical of purple limited company provides by Tonghua, lot number: 081005, remove capsule during experiment, getting its content is mixed with 10%, 5% and 2.5% suspension with distilled water and puts 4 ℃ of refrigerators and preserve standby, xingnao zaizao pill records in Drug Standard of Ministry of Public Health of the Peoples Republic of China Chinese traditional patent formulation preparation (the 4th) WS3-B-0867-91, produce by Changchun people pharmaceutical factory, lot number 080609, it is standby to make 97% suspension with distilled water before the experiment.
Animal: Kunming mouse, outbreeding system closed colony, body weight 18～22g, male and female half and half.Wistar kind rat, body weight 180～260g, male and female are usefulness all, and every batch of experiment weight range is not more than 30g, provides by laboratory animal room of Jilin University.
Method and result
Influence to cerebral lesion due to the ligation rat brain medium-sized artery
48 of rats, five equilibrium is 6 groups at random, presses the gastric infusion of dosage shown in the table 1, every day 1 time, after administration on the 5th 1 hour, with urethane anesthesia (1g/kg), adopts the method for middle cerebral artery blocking blood flow to make the pathological model of ischemic encephalopathy rat.Under suitable right eye of rat right side temples and auris dextra, observe and expose the middle cerebral artery initial part, with SD-A type bipolar electrocoagulator blocking-up middle cerebral artery, layering suture tissue then, and continued gastric infusion 2, in postoperative 48 hours, separate right carotid and inject fixedly brain of 10% neutral formalin, get brain reuse 10% neutral formalin then and fix.Full brain is taken out in the fully fixing back of the cerebral tissue of waiting, with the optic chiasma is standard, to the forward and backward coronal section of respectively making 2 millimeters thick, respectively cut the embedding of dewatering routinely of (comprising positions such as frontal lobe, substrate leaf, top, a hippocampal gyrus) cerebral tissue, ComonShi special staining dyeing with hematoxylin Yihong and improvement, carrying out histopathology under optical microscope observes, and through the area of CIMA-400 type medical images analysis-e/or determining right side brain and infarction kitchen range, Sham-operated control group is not except that blocking the brain medium-sized artery, and all the other processing are all the same.Sham-operated control group cerebral tissue neurocyte is all normal as a result, and 8 animals of model group, wherein see that in the brain back of the body outside cortical areas ischemic region infarction kitchen range that differs in size is arranged for 7, the most of degeneration necrosis of cell in the kitchen range, what have only has a profile, and nerve fiber is the sponge shape, axon and myelin cracking, disappearance, neurocyte swelling around the infarction kitchen range, degeneration, acidophilia strengthen, and seeing of having has band shape or lamellar hemorrhage, glial cells hyperplasia.Refreshment reworking capsule and xingnao zaizao pill agent group and model group relatively, pathological change is lighter, and it is less the number of animals of pathological changes to occur, infarct size is also less, sees Table 1, as seen, refreshment reworking capsule and xingnao zaizao pill agent all have tangible treating cerebral ischemia.
Influence (n=8, the X ± SD) of cerebral infarction kitchen range appears in table 1 pair rat
Annotate: compare with model group,
*P＜0.05
Influence to artery thrombosis in the rat body
50 of rats, five equilibrium is 5 groups at random, presses the gastric infusion of dosage shown in the table 2, matched group is given equal-volume water, every day 1 time, continuous 6 days, after the last administration 1 hour, with pentobarbital sodium anesthesia, separate a side common carotid artery, the stimulating electrode and the temperature sensor that the experimental thrombus in vivo of BT87-2 type are formed analyzer are colluded respectively on tremulous pulse, continue to stimulate blood vessel wall 3 minutes with the 2mA unidirectional current, observe variations in temperature, the record blood vessel blockage time (T), the results are shown in Table 2.By table 2 as seen, refreshment reworking capsule or its pill be obvious experimental artery thrombosis time of prolong rats all, suppresses artery thrombosis.
The influence of artery thrombosis in the table 2 pair rat body (n=10, X ± SD)
Annotate: compare * P＜0.05 with matched group; * P＜0.01; * * P＜0.001 (following table together)
To the adherent influence of rat platelet
Adopt glass ball method, 45 of rats, five equilibrium is 5 groups at random, press the gastric infusion of dosage shown in the table 3, matched group is given equal-volume water, every day 1 time, continuous 6 days, after the last administration 1 hour, with the 5ml plastic injector in abdominal aortic blood 1.8ml, add and to contain in the 3.8% sodium citrate 0.2ml silication test tube mixing immediately, get blood 1ml from test tube, the adding capacity is in the long-neck garden pin of 8ml, place on formation of XSN-R type external thrombus and the platelet adhesion double-purpose instrument rotating disk, 37 ℃ of constant temperature with 3.7r/min rotation 15 minutes, are measured respectively and are rotated forward and backward platelet count.Platelet adhesion rate %=(ball adheres to thromboblast number-ball and adheres to the back platelet count)/adhere to the thromboblast number the results are shown in Table 3.As known from Table 3, refreshment reworking capsule and pill thereof all have significant inhibitory effect to platelet adhering function.
The influence of table 3 pair rat platelet adhesion function (n=9, X ± SD)
Influence to rat platelet aggregation
50 of rats, five equilibrium is 5 groups at random, presses the gastric infusion of dosage shown in the table 4, every day 1 time, continuous 6 days, matched group was given equal-volume water, after the last administration 1 hour, with the pentobarbital sodium anesthetized rat, with 5ml plastic injector abdominal aortic blood (pressing anticoagulant in 1: 9) with 3.8% sodium citrate, be derivant with ADP, use the multi-functional platelet aggregation instrument of SPA-4 type, measure platelet aggregation rate, result such as table 4.By table 4 as seen, big or middle dosage group of refreshment reworking capsule and pill group thereof all have the obvious suppression effect to platelet aggregation.
The influence of table 4 pair rat platelet aggregation function (n=10, X ± SD)
Influence to hemorheology of rat
50 of rats, five equilibrium is 5 groups at random, presses the gastric infusion of dosage shown in the table 5, every day 1 time, continuous 6 days, after the last administration 1 hour, pentobarbital sodium anesthetized rat, abdominal aortic blood, anticoagulant heparin is measured whole blood contrast viscosity, plasma viscosity, packed cell volume and erythrocyte sedimentation rate, the results are shown in Table 5.As seen the big or middle dosage group of refreshment reworking capsule all can obviously reduce whole blood contrast viscosity and plasma viscosity, but packed cell volume and erythrocyte sedimentation rate are not then had obvious influence.
The influence of table 5 pair hemorheology of rat (n=10, X ± SD)
Influence to clotting time of mice
Adopt slide method.50 of mices, five equilibrium is 5 groups at random, presses the gastric infusion of dosage shown in the table 6, every day 1 time, continuous 6 days, after the last administration 1 hour, extract eyeball of mouse, discard the 1st earlier and bleed, get 2 and bleed in microscope slide, every 30S with dry syringe needle provoke on the microscope slide blood once, another does contrast, till seeing fiber protein yarn, it is clotting time that autoblood flows out to the time that fiber protein yarn occurs, the results are shown in Table 6.As seen from Table 6, the refreshment reworking capsule can obviously prolong clotting time.
The influence of table 6 pair clotting time of mice (n=10, X ± SD)
Above-mentioned experimental result shows that medicine of the present invention has significant protective effect to the Ischemia Injury pathological changes, can reduce the cerebral infarction number of animals, and infarct size is obviously dwindled; Can reduce platelet adhesion rate to antiplatelet aggregation, obviously the experimental artery thrombosis time of prolong rats, suppress artery thrombosis; Significantly reduce whole blood contrast viscosity and plasma viscosity, improve hemorheological property, and can the significant prolongation clotting time of mice.Xingnao zaizao pill also has above-mentioned pharmacological action, and under identical clinical multiple dosage condition, medicine of the present invention is better than xingnao zaizao pill.This shows that the refreshment reworking capsule has the refreshment of reducing phlegm, dispelling, collateral-activating function, for treating obnubilation clinically, the tone is not smoothgoing puckery, contracture of the limbs, and hemiplegia, cerebral thrombosis and sequela thereof provide the pharmacology foundation.
The preparation of embodiment 1 tablet of the present invention
Radix Astragali total flavones 10g, Radix Ginseng Rubra total glycosides 1g, Radix Angelicae Sinensis volatile oil 1g, Radix Paeoniae Rubra total glycosides 1g, gastrodin 1g, Rhizoma Atractylodis Macrocephalae volatile oil 1g, Radix Scrophulariae total glycosides 1g, Rhizoma Alismatis total glycosides 1g, Scorpio 0.1g, Lignum Aquilariae Resinatum resin 0.1g, Radix Aucklandiae total saponins 0.1g, Borneolum Syntheticum 0.1g, general icariin 5g, arasaponin 1g, carthamin 1g, amygdalin 3g, Herba Agrimoniae glycoside 1g, Arisaema Cum Bile triterpenoid saponin 1g, berberine 1g, Rhizoma Chuanxiong ferulic acid 1g, Radix Polygoni Multiflori Preparata emodin 1g, Rhizoma Typhonii saponin 1g, the short sterol 0.1g of casting off a skin of Bombyx Batryticatus, Margarita calcium carbonate 1g, Rhizoma Acori Graminei quintessence oil 10g, Pheretima lumbricin 1g, coculine 1g, the plain 1g of Concha Haliotidis gallbladder, Flos Sophorae glycoside 1g, Radix Puerariae total flavones 1g, Fructus Forsythiae general glycoside 1g, Fructus Lycii ethanol extract 1g, Semen Cassiae polysaccharide 1g, Herba Asari volatile oil 0.1g, Fructus Gleditsiae Abnormalis Saponin 0.1g, Radix Et Rhizoma Rhei volatile oil 0.1g.
Add the conventional adjuvant of preparation tablet, make tablet.
Above-mentioned various extracts among the present invention can be by extracting method acquisition arbitrarily in the prior art. are preferably:
Radix Astragali total flavones: it is an amount of to take by weighing raw material, with 50%-90% alcohol reflux 1-3 hour, adds 6-16 times of decocting at every turn and boils 0.5-3 hour, filters, and merging filtrate concentrates.
The Radix Ginseng Rubra total glycosides: it is an amount of to take by weighing raw material, adds 5-14 times of ethanol and decocts 0.5-3 hour with 50%-90% alcohol reflux 1-3 time is each, filter, and merging filtrate, concentrated.
Radix Angelicae Sinensis volatile oil: it is an amount of to take by weighing raw material, and water decocts 1-3 time, adds 5-15 times of decocting at every turn and boils 0.5-3 hour, filter, and merging filtrate, concentrated.
Radix Paeoniae Rubra total glycosides: it is an amount of to take by weighing raw material, with 50%-90% alcohol reflux 1-3 time, adds 5-14 times of ethanol at every turn and decocts 0.5-3 hour, filter, and merging filtrate, concentrated.
Gastrodin: it is an amount of to take by weighing raw material, with 50%-90% alcohol reflux 1-3 time, adds 5-14 times of ethanol at every turn and decocts 0.5-3 hour, filter, and merging filtrate, concentrated.
Rhizoma Atractylodis Macrocephalae volatile oil: it is an amount of to take by weighing raw material, and water decocts 1-3 time, adds 6-17 times of decocting at every turn and boils 0.5-3 hour, filter, and merging filtrate, concentrated.
The Radix Scrophulariae total glycosides: it is an amount of to take by weighing raw material, and water decocts 1-3 time, adds 5-15 times of decocting at every turn and boils 0.5-3 hour, filter, and merging filtrate, concentrated.
The Rhizoma Alismatis total glycosides: it is an amount of to take by weighing raw material, and water decocts 1-3 time, adds 5-17 times of decocting at every turn and boils 0.5-3 hour, filter, and merging filtrate, concentrated.
The Lignum Aquilariae Resinatum resin: it is an amount of to take by weighing raw material, with 50%-90% alcohol reflux 1-3 time, adds 5-14 times of ethanol at every turn and decocts 0.5-3 hour, filter, and merging filtrate, concentrated.
Radix Aucklandiae total saponins: it is an amount of to take by weighing raw material, and water decocts 1-3 time, adds 5-17 times of decocting at every turn and boils 0.5-3 hour, filter, and merging filtrate, concentrated.
General icariin: it is an amount of to take by weighing raw material, with distilled water reflux, extract, 1-3 time, adds 7-15 times of distilled water at every turn and boils 1-3 hour, filter, and merging filtrate, concentrated.
Arasaponin: it is an amount of to take by weighing raw material, with 50%-90% alcohol reflux 1-3 time, adds 5-14 times of ethanol at every turn and decocts 0.5-3 hour, filter, and merging filtrate, concentrated.
Carthamin: it is an amount of to take by weighing raw material, with distilled water reflux, extract, 1-3 time, adds 7-15 times of distilled water at every turn and boils 1-3 hour, filter, and merging filtrate, concentrated.
Amygdalin: it is an amount of to take by weighing the raw material Semen Persicae, with distilled water reflux, extract, 1-3 time, adds 7-15 times of distilled water at every turn and boils 1-3 hour, filter, and merging filtrate, concentrated.
The Herba Agrimoniae glycoside: it is an amount of to take by weighing raw material, with distilled water reflux, extract, 1-3 time, adds 7-15 times of distilled water at every turn and boils 1-3 hour, filter, and merging filtrate, concentrated.
The Arisaema Cum Bile triterpenoid saponin: it is an amount of to take by weighing raw material, with distilled water reflux, extract, 1-3 time, adds 7-15 times of distilled water at every turn and boils 1-3 hour, filter, and merging filtrate, concentrated.
Berberine: it is an amount of to take by weighing raw material, and 50%-90% alcohol reflux 1-3 time adds 5-14 times of ethanol at every turn and decocted 0.5-3 hour, filters, and merging filtrate concentrates.
The Rhizoma Chuanxiong ferulic acid: it is an amount of to take by weighing raw material, and with distilled water reflux, extract, 1-3 time, add 7-15 times of distilled water at every turn and boil filtration in 1-3 hour, merging filtrate, concentrated.
The Radix Polygoni Multiflori Preparata emodin: it is an amount of to take by weighing raw material, and with distilled water reflux, extract, 1-3 time, add 7-15 times of distilled water at every turn and boil filtration in 1-3 hour, merging filtrate, concentrated.
The Rhizoma Typhonii saponin: it is an amount of to take by weighing raw material, with distilled water reflux, extract, 1-3 time, adds 7-15 times of distilled water at every turn and boils 1-3 hour, filter, and merging filtrate, concentrated.
The short sterol of casting off a skin of Bombyx Batryticatus: it is an amount of to take by weighing raw material, with 50%-90% alcohol reflux 1-3 hour, adds 6-16 times of ethanol at every turn and decocts 0.5-3 hour, filters, and merging filtrate concentrates.
The Margarita calcium carbonate: it is an amount of to take by weighing raw material, and with distilled water reflux, extract, 1-3 time, add 7-15 times of distilled water at every turn and boil filtration in 1-3 hour, merging filtrate, concentrated.
The Rhizoma Acori Graminei quintessence oil: it is an amount of to take by weighing raw material, with distilled water reflux, extract, 1-3 time, adds 7-15 times of distilled water at every turn and boils 1-3 hour, filter, and merging filtrate, concentrated.
The Pheretima lumbricin: it is an amount of to take by weighing raw material, and with distilled water reflux, extract, 1-3 time, add 7-15 times of distilled water at every turn and boil filtration in 1-3 hour, merging filtrate, concentrated.
Coculine: it is an amount of to take by weighing raw material, with distilled water reflux, extract, 1-3 time, adds 7-15 times of distilled water at every turn and boils 1-3 hour, filter, and merging filtrate, concentrated.
Concha Haliotidis gallbladder element: it is an amount of to take by weighing raw material, with distilled water reflux, extract, 1-3 time, adds 7-15 times of distilled water at every turn and boils 1-3 hour, filter, and merging filtrate, concentrated.
The Flos Sophorae glycoside: it is an amount of to take by weighing raw material, with distilled water reflux, extract, 1-3 time, adds 7-15 times of distilled water at every turn and boils 1-3 hour, filter, and merging filtrate, concentrated.
Radix Puerariae total flavones: it is an amount of to take by weighing raw material, with distilled water reflux, extract, 1-3 time, adds 7-15 times of distilled water at every turn and boils 1-3 hour, filter, and merging filtrate, concentrated.
The Fructus Forsythiae general glycoside: it is an amount of to take by weighing raw material, and with distilled water reflux, extract, 1-3 time, add 7-15 times of distilled water at every turn and boil filtration in 1-3 hour, merging filtrate, concentrated.
The Fructus Lycii ethanol extract: it is an amount of to take by weighing raw material, with distilled water reflux, extract, 1-3 time, adds 7-15 times of distilled water at every turn and boils 1-3 hour, filter, and merging filtrate, concentrated.
The Semen Cassiae polysaccharide: it is an amount of to take by weighing raw material, and with distilled water reflux, extract, 1-3 time, add 7-15 times of distilled water at every turn and boil filtration in 1-3 hour, merging filtrate, concentrated.
Herba Asari volatile oil: it is an amount of to take by weighing raw material, with 50%-90% alcohol reflux 1-3 hour, adds 6-16 times of ethanol at every turn and decocts 0.5-3 hour, filters, and merging filtrate concentrates.
The Fructus Gleditsiae Abnormalis Saponin: it is an amount of to take by weighing raw material, with 50%-90% alcohol reflux 1-3 hour, adds 6-16 times of ethanol at every turn and decocts 0.5-3 hour, filters, and merging filtrate concentrates.
Radix Et Rhizoma Rhei volatile oil: it is an amount of to take by weighing raw material, and with distilled water reflux, extract, 1-3 time, add 7-15 times of distilled water at every turn and boil filtration in 1-3 hour, merging filtrate, concentrated.
The preparation of embodiment 2 capsules of the present invention
Radix Astragali total flavones 15g, Radix Ginseng Rubra total glycosides 3g, Radix Angelicae Sinensis volatile oil 3g, Radix Paeoniae Rubra total glycosides 3g, gastrodin 3g, Rhizoma Atractylodis Macrocephalae volatile oil 3g, Radix Scrophulariae total glycosides 3g, Rhizoma Alismatis total glycosides 3g, Scorpio 1.5g, Lignum Aquilariae Resinatum resin 2.5g, Radix Aucklandiae total saponins 2.5g, Borneolum Syntheticum 2.5g, general icariin 10g, arasaponin 3g, carthamin 3g, amygdalin 9g, Herba Agrimoniae glycoside 3g, Arisaema Cum Bile triterpenoid saponin 3g, berberine 3g, Rhizoma Chuanxiong ferulic acid 3g, Radix Polygoni Multiflori Preparata emodin 3g, Rhizoma Typhonii saponin 3g, the short sterol 1.5g of casting off a skin of Bombyx Batryticatus, Margarita calcium carbonate 2g, Rhizoma Acori Graminei quintessence oil 15g, Pheretima lumbricin 3g, menispermine 3g, the plain 3g of Concha Haliotidis gallbladder, Flos Sophorae glycoside 3g, Radix Puerariae total flavones 3g, Fructus Forsythiae general glycoside 3g, Fructus Lycii ethanol extract 3g, Semen Cassiae polysaccharide 3g, Herba Asari volatile oil 2.5g, Fructus Gleditsiae Abnormalis Saponin 2.5g, Radix Et Rhizoma Rhei volatile oil 2.5g.
Add the conventional adjuvant of preparation capsule, make 1000, every material 0.3g.
The preparation of embodiment 3 granules of the present invention
Radix Astragali total flavones 20g, Radix Ginseng Rubra total glycosides 5g, Radix Angelicae Sinensis volatile oil 5g, Radix Paeoniae Rubra total glycosides 5g, gastrodin 5g, Rhizoma Atractylodis Macrocephalae volatile oil 5g, Radix Scrophulariae total glycosides 5g, Rhizoma Alismatis total glycosides 5g, Scorpio 3g, Lignum Aquilariae Resinatum resin 5g, Radix Aucklandiae total saponins 5g, Borneolum Syntheticum 5g, general icariin 15g, arasaponin 5g, carthamin 5g, amygdalin 15g, Herba Agrimoniae glycoside 5g, Arisaema Cum Bile triterpenoid saponin 5g, berberine 5g, Rhizoma Chuanxiong ferulic acid 5g, Radix Polygoni Multiflori Preparata emodin 5g, Rhizoma Typhonii saponin 5g, the short sterol 3g of casting off a skin of Bombyx Batryticatus, Margarita calcium carbonate 3g, Rhizoma Acori Graminei quintessence oil 20g, Pheretima lumbricin 5g, coculine 5g, the plain 5g of Concha Haliotidis gallbladder, Flos Sophorae glycoside 5g, Radix Puerariae total flavones 5g, Fructus Forsythiae general glycoside 5g, Fructus Lycii ethanol extract 5g, Semen Cassiae polysaccharide 5g, Herba Asari volatile oil 5g, Fructus Gleditsiae Abnormalis Saponin 5g, Radix Et Rhizoma Rhei volatile oil 5g.
Add the conventional adjuvant of preparation granule, make granule.
Claims (2)
1, a kind of pharmaceutical composition that is used for the treatment of hemiplegia and cerebral thrombosis is characterized in that, includes the active substance by following ratio of weight and number:
10～20 parts of Radix Astragali total flavoness, 1～5 part of Radix Ginseng Rubra total glycosides, 1～5 part of Radix Angelicae Sinensis volatile oil, 1～5 part of Radix Paeoniae Rubra total glycosides, 1～5 part of gastrodin, 1～5 part of Rhizoma Atractylodis Macrocephalae volatile oil, 1～5 part of Radix Scrophulariae total glycosides, 1～5 part of Rhizoma Alismatis total glycosides, 0.1～3 part of Scorpio, 0.1～5 part of Lignum Aquilariae Resinatum resin, 0.1～5 part of Radix Aucklandiae total saponins, 0.1～5 part of Borneolum Syntheticum, 5～15 parts of general icariins, 1～5 part of arasaponin, 1～5 part of carthamin, 3～15 parts of amygdalins, 1～5 part of Herba Agrimoniae glycoside, 1～5 part of Arisaema Cum Bile triterpenoid saponin, 1～5 part of berberine, 1～5 part of Rhizoma Chuanxiong ferulic acid, 1～5 part of Radix Polygoni Multiflori Preparata emodin, 1～5 part of Rhizoma Typhonii saponin, Bombyx Batryticatus is short cast off a skin 0.1～3 part of sterol, 1～3 part of Margarita calcium carbonate, 10～20 parts of Rhizoma Acori Graminei quintessence oils, 1～5 part of Pheretima lumbricin, 1～5 part of menispermine, 1～5 part of Concha Haliotidis gallbladder element, 1～5 part of Flos Sophorae glycoside, 1～5 part of Radix Puerariae total flavones, 1～5 part of Fructus Forsythiae general glycoside, 1～5 part of Fructus Lycii ethanol extract, 1～5 part of Semen Cassiae polysaccharide, 0.1～5 part of Herba Asari volatile oil, 0.1～5 part of Fructus Gleditsiae Abnormalis Saponin, 0.1～5 part of Radix Et Rhizoma Rhei volatile oil.
2, the pharmaceutical composition that is used for the treatment of hemiplegia and cerebral thrombosis according to claim 1 is characterized in that, includes the active substance by following ratio of weight and number:
15 parts of Radix Astragali total flavoness, 3 parts of Radix Ginseng Rubra total glycosides, 3 parts of Radix Angelicae Sinensis volatile oils, 3 parts of Radix Paeoniae Rubra total glycosidess, 3 parts of gastrodins, 3 parts of Rhizoma Atractylodis Macrocephalae volatile oils, 3 parts of Radix Scrophulariae total glycosides, 3 parts of Rhizoma Alismatis total glycosides, 1.5 parts of Scorpios, 2.5 parts of Lignum Aquilariae Resinatum resins, 2.5 parts of Radix Aucklandiae total saponins, 2.5 parts of Borneolum Syntheticums, 10 parts of general icariins, 3 parts of arasaponins, 3 parts of carthamins, 9 parts of amygdalins, 3 parts of Herba Agrimoniae glycosides, 3 parts of Arisaema Cum Bile triterpenoid saponin, 3 parts of berberines, 3 parts of Rhizoma Chuanxiong ferulic acids, 3 parts of Radix Polygoni Multiflori Preparata emodins, 3 parts of Rhizoma Typhonii saponin, Bombyx Batryticatus is short cast off a skin 1.5 parts of sterols, 2 parts of Margarita calcium carbonate, 15 parts of Rhizoma Acori Graminei quintessence oils, 3 parts of Pheretima lumbricins, 3 parts of menispermines, plain 3 parts of Concha Haliotidis gallbladder, 3 parts of Flos Sophorae glycosides, 3 parts of Radix Puerariae total flavoness, 3 parts of Fructus Forsythiae general glycosides, 3 parts of Fructus Lycii ethanol extract, 3 parts of Semen Cassiae polysaccharide, 2.5 parts of Herba Asari volatile oils, 2.5 parts of Fructus Gleditsiae Abnormalis Saponins, 2.5 parts of Radix Et Rhizoma Rhei volatile oil.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102008591A (en) * | 2010-12-10 | 2011-04-13 | 冯学安 | Traditional Chinese medicine capsule for treating hypertension |
| CN113559067A (en) * | 2020-06-29 | 2021-10-29 | 内蒙古工业大学 | Emodin-calcium carbonate composite particles and preparation method thereof |
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| CN1634250A (en) * | 2004-10-18 | 2005-07-06 | 四川乐山三民药物科技开发有限公司 | Compound injectio of Chinese angelica and astragalus root and its preparing process |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102008591A (en) * | 2010-12-10 | 2011-04-13 | 冯学安 | Traditional Chinese medicine capsule for treating hypertension |
| CN102008591B (en) * | 2010-12-10 | 2012-07-25 | 冯学安 | Traditional Chinese medicine capsule for treating hypertension |
| CN113559067A (en) * | 2020-06-29 | 2021-10-29 | 内蒙古工业大学 | Emodin-calcium carbonate composite particles and preparation method thereof |
| CN113559067B (en) * | 2020-06-29 | 2023-03-14 | 内蒙古工业大学 | Emodin-calcium carbonate composite particles and preparation method thereof |
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Denomination of invention: Medicine composition used for treating hemiplegia and cerebral thrombus Effective date of registration: 20190318 Granted publication date: 20110511 Pledgee: Jilin rural commercial bank and Limited by Share Ltd Pledgor: Jilin Zixin Pharmaceutical Co., Ltd. Registration number: 2019220000006 |
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