CN101606966A - A kind of medicine for the treatment of hepatitis B and other hepatitis - Google Patents
A kind of medicine for the treatment of hepatitis B and other hepatitis Download PDFInfo
- Publication number
- CN101606966A CN101606966A CNA2009101581970A CN200910158197A CN101606966A CN 101606966 A CN101606966 A CN 101606966A CN A2009101581970 A CNA2009101581970 A CN A2009101581970A CN 200910158197 A CN200910158197 A CN 200910158197A CN 101606966 A CN101606966 A CN 101606966A
- Authority
- CN
- China
- Prior art keywords
- extractum
- radix astragali
- medicine
- herba haleniae
- haleniae corniculatae
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
The invention belongs to field of pharmaceutical technology, particularly a kind of medicine for the treatment of hepatitis B and other hepatitis.This medicine feature is that the composition of raw materials mass percent is a Herba Haleniae Corniculatae: the Radix Astragali: Radix Glycyrrhizae extractum=40～60%: 38～58%: 1～5%; Processing technique places in the extraction pot respectively for the raw material Herba Haleniae Corniculatae and the Radix Astragali after will preparing burden, extract respectively 2～5 times, extract is made Herba Haleniae Corniculatae extractum or Herba Haleniae Corniculatae extract powder, Radix Astragali extractum or Radix Astragali extractum powder respectively, at last Herba Haleniae Corniculatae extractum or Herba Haleniae Corniculatae extract powder, Radix Astragali extractum or Radix Astragali extractum powder, three kinds of raw materials of raw material Radix Glycyrrhizae extractum are made solid dosage forms or liquid dosage form or further refining after make the injection type medicine.The clinical effective rate of this medicine reaches 92%, and the normalization rate of ALT reaches 60～82%, and HBeAg is cloudy, and to change the treatment group be 38%, also obviously is better than having now medicine, no side effects aspect the elimination of, hepatomegaly painful at poor appetite, weak, nauseating, abdominal distention, liver.
Description
One, technical field:
The invention belongs to field of pharmaceutical technology, particularly a kind of medicine for the treatment of hepatitis B and other hepatitis.
Two, technical background:
Hepatitis B and other hepatitis are one of persistent ailments of harm humans health at present, especially hepatitis B, it had both had stronger infectiousness, sickness rate height, very big to human body harm, and there is not specific medicament to effect a radical cure again, particularly chronic hepatitis B is all the more so, and many liver cirrhosis, the liver cancer patients of China all are from the continuous development of early stage hepatitis B and next.Current medicine aspect the treatment hepatitis B is a lot, but its curative effect is all undesirable.Therefore, the medicine of the treatment hepatitis B of exploitation and development better efficacy also is extremely urgent, also is the important topic of pendulum in face of people.
Three, summary of the invention:
The objective of the invention is at the prior art above shortcomings, and develop a kind of medicine for the treatment of hepatitis B and other hepatitis, this medicine reaches 92% through the clinical research total effective rate, the normalization rate of ALT reaches 60～82%, the cloudy commentaries on classics of HBeAg treatment group is 37.5%, and matched group only is 18.2%, the cloudy treatment group of changeing of HBV-DNA reaches 38%, more than these data all be better than the curative effect of existing medicine, in addition this medicine aspect the common signs symptom as poor appetite, weak, wait the elimination aspect not see notable difference though feel sick with existing medicine, this medicine is many early to be removed after medication in 4～8 weeks but use, especially in abdominal distention, liver is painful, elimination aspect treatment groups such as hepatomegaly obviously are better than existing medicine, the no abnormal variation of routine blood test during treating, and patient also has no adverse reaction, its no side effects is a safety, effective medicine.
Technical scheme is: the medicine feature of this treatment hepatitis B and other hepatitis is that the composition of raw materials mass percent is a Herba Haleniae Corniculatae: the Radix Astragali: Radix Glycyrrhizae extractum=40～60%: 38～58%: 1～5%; Process recipes is: with Herba Haleniae Corniculatae alcohol reflux 2～5 times, extracting solution is made Herba Haleniae Corniculatae extractum or Herba Haleniae Corniculatae extract powder; The Radix Astragali is made Radix Astragali extractum or Radix Astragali extractum powder to extracting solution with water extraction 2～5 times, and Herba Haleniae Corniculatae extractum or Herba Haleniae Corniculatae extract powder, Radix Astragali extractum or Radix Astragali extractum powder, three kinds of raw materials of Radix Glycyrrhizae extractum are made solid dosage forms, liquid dosage form or injection type.Herba Haleniae Corniculatae is the Tibetan medical herbs of Qinghai-Tibet Platean; be Gentianaceae Herba Haleniae Corniculatae platymiscium; the nature and flavor bitter cold; function clearing away heat-damp and promoting diuresis, suppressing the hyperactive liver function of gallbladder promoting; the main effective ingredient of treatment hepatitis is a haleniaside, and through pharmacology test, damage has the better protect effect to rats'liver; can increase glycogen and ribonucleic acid in the hepatocyte, promote liver cell regeneration.Because Herba Haleniae Corniculatae nature and flavor bitter cold, for a long time with imapirment of the spleen and stomach probably, so, strengthen adjusting immunologic function and hepatoprotective effect with the Radix Astragali, the Radix Glycyrrhizae medicine of air making-up and spleen enlivening.The raw material Radix Astragali is a kind of clean Chinese herbal medicine that is used as medicine, and the raw material Radix Glycyrrhizae extractum is that water or ethanol are made the extractum that makes after extractant extracts the Radix Glycyrrhizae medical herbs.Solid dosage medicine of the present invention has granule, hard capsule, soft capsule, drop pill, tablet, pill etc.; The liquid dosage form medicine has oral liquid, syrup; Also has injection in addition.The preparation method of solid dosage medicine, liquid dosage form medicine and injection type medicine is prior art, no longer here stating more.What deserves to be mentioned is, tablet can be made into two kinds of tablets of A, B, best results, and the A sheet is the tablet that Herba Haleniae Corniculatae extractum or Herba Haleniae Corniculatae dry powder are made, the B sheet is the tablet that makes behind Radix Astragali extractum or Radix Astragali dry powder and the Radix Glycyrrhizae extractum mixing, and A sheet and B sheet are according to dosage taken simultaneously and got final product when taking.
The dose of this medicine is the dosage of 100 gram raw material Herba Haleniae Corniculatae medical herbs for being grown up 7～10 days, takes every day 2～3 times, by that analogy.Whenever take 10 days to two weeks be a course of treatment, generally take a course of treatment with regard to visual effects, take visible big effect the 2～4 courses of treatment.
Four, the specific embodiment:
Embodiment 1:
Take by weighing raw material by following weight proportion:
Herba Haleniae Corniculatae 400g Radix Astragali 580g Radix Glycyrrhizae extractum 20g
Preparation method is as follows:
1, get Herba Haleniae Corniculatae and place in the extraction pot, make the extractant reflux, extract, 2 times with ethanol, merge extractive liquid, filters, and reclaims ethanol, concentrates, and drying is made extract powder, and is standby;
2, Radix Astragali water extraction 5 times, merge extractive liquid, filters, and concentrates, and drying is made extract powder, and is standby;
3, above-mentioned Herba Haleniae Corniculatae extract powder adds proper auxiliary materials adjusting total amount, uses alcohol granulation, drying, and the adding lubricant is an amount of, mixing, tabletting, coating (film-coat, enteric coating) is made the A sheet; Radix Astragali extractum powder and Radix Glycyrrhizae extractum powder add proper auxiliary materials and regulate total amount, use alcohol granulation, drying, and the adding lubricant is an amount of, mixing, tabletting, coating (film-coat, enteric coating) is made the B sheet, promptly gets two kinds of tablets of A, B.A, B sheet are taken simultaneously, and each each 2 ~ 4, every day 2 ~ 3 times.
Embodiment 2:
Take by weighing raw material by following weight proportion:
The Herba Haleniae Corniculatae 600 gram Radixs Astragali 380 gram Radix Glycyrrhizae extractum 20 grams
Preparation method is as follows:
1, get Herba Haleniae Corniculatae and place in the extraction pot, make the extractant reflux, extract, 5 times with ethanol, merge extractive liquid, filters, and reclaims ethanol, concentrates, and drying is made extract powder, and is standby;
2, Radix Astragali water extraction 2 times, merge extractive liquid, filters, and concentrates, and drying is made extract powder, and is standby;
3, above-mentioned Herba Haleniae Corniculatae extract powder, Radix Astragali extractum powder, Radix Glycyrrhizae extractum powder uniform mixing add an amount of adjuvant and regulate total amount, use alcohol granulation, drying, and granulate makes granule.Above-mentioned extract powder or granule are made acceptable granule, hard capsule, soft capsule, drop pill, tablet, pill on the pharmaceutics.Concrete preparation method is as follows:
1, with above-mentioned granule packing, get granule, take 5 ~ 15g, every day 2 ~ 3 times at every turn.
2 or with above-mentioned extract powder filled capsules, make oral capsule (hard capsule, enteric coated capsule).Take 2 ~ 4, every day 2 ~ 3 times at every turn.
3, above-mentioned dry extract is made suspension or pastel with suitable disperse medium, fully mixing is pressed into soft capsule, takes the 1--2 grain, every day 2 ~ 3 times at every turn.Disperse medium vegetable oil (as edible oil, Oleum Glycines, Semen arachidis hypogaeae wet goods), also available aqueous polyvinylidene or liquid paraffin etc.
4, the thick extractum after maybe will concentrating is added in the suitable fusion substrate, and mixing splashes in the not miscible condensed fluid, and condensation is shaped, and the flush away condensed fluid makes drop pill.Take 4 ~ 6, every day 2 ~ 3 times at every turn.
5 or in above-mentioned granule, add lubricant, mixing, tabletting, coating (film-coat, enteric coating) makes tablet.Take 2 ~ 4, every day 2 ~ 3 times at every turn.
6 or above-mentioned extract powder added the abundant mixing of proper auxiliary materials, make pill.Each 5 ~ 10g, every day 2 ~ 3 times.
Embodiment 3:
Take by weighing raw material by following weight proportion:
The Herba Haleniae Corniculatae 450 gram Radixs Astragali 500 gram Radix Glycyrrhizae extractum 50 grams
Preparation method is as follows:
1, get Herba Haleniae Corniculatae and place in the extraction pot, make the extractant reflux, extract, 3 times with ethanol, merge extractive liquid, filters, and reclaims ethanol, is condensed into extractum, and is standby;
2, Radix Astragali water extraction 4 times, merge extractive liquid, filters, and filtrate is condensed into extractum, and is standby;
3, above-mentioned Herba Haleniae Corniculatae extractum, Radix Astragali extractum, Radix Glycyrrhizae extractum uniform mixing add an amount of adjuvant, make acceptable oral liquid, syrup on the pharmaceutics.Preparation method is as follows in detail:
1, above-mentioned extractum is mixed, add correctives acesulfame-K or cyclamate, citric acid, essence is an amount of, adds pure water and regulates total amount, mixing filters, and is distributed into every bottle of 10ml, and sterilization promptly gets oral solutions.Take 1～2 bottle, every day 2 ~ 3 times at every turn.
2, above-mentioned extractum is mixed, add simple syrup, make cane sugar content be not less than 45%, add preservative benzoic acid or sodium benzoate, essence, add water and regulate total amount, packing, sterilization makes syrup.Take 10～20ml, every day 2 ~ 3 times at every turn.
Embodiment 4:
Take by weighing raw material by following weight proportion:
The Herba Haleniae Corniculatae 480 gram Radixs Astragali 510 gram Radix Glycyrrhizae extractum 10 grams
Preparation method is as follows:
Get Herba Haleniae Corniculatae and place in the extraction pot, make to extract solvent refluxing with ethanol and extract 4 times, merge backflow and reclaim ethanol, standby; Radix Astragali water extraction 3 times, merge extractive liquid,, refinement treatment gets the injection extract, and is standby; Above-mentioned two parts of extracts mixing can be added suitable additives such as chlorobutanol, sodium thiosulfate or sodium hydrogen phosphate, regulate total amount with water for injection, sterilization, cold preservation, fine straining concentrates, and powder is made in lyophilizing, and packing promptly gets injection.
Claims (2)
1, a kind of medicine for the treatment of hepatitis B and other hepatitis.This medicine feature is that the composition of raw materials mass percent is a Herba Haleniae Corniculatae: the Radix Astragali: Radix Glycyrrhizae extractum=40～60%: 38～58%: 1～5%; Processing technique places in the extraction pot for the raw material Herba Haleniae Corniculatae after will preparing burden, and makes the extractant reflux, extract, 2～5 times with ethanol, and extract is made Herba Haleniae Corniculatae extractum or Herba Haleniae Corniculatae extract powder; The raw material Radix Astragali after the batching is placed in the extraction pot, using water as extractant extracts 2～5 times, extract is made Radix Astragali extractum or Radix Astragali extractum powder, at last Herba Haleniae Corniculatae extractum or Herba Haleniae Corniculatae extract powder, Radix Astragali extractum or Radix Astragali extractum powder, three kinds of raw materials of raw material Radix Glycyrrhizae extractum are made acceptable solid dosage forms granule, hard capsule, soft capsule, drop pill, tablet, pill on the pharmaceutics; Liquid dosage form oral liquid, syrup; Or make the injection type medicine after further refining.
2, according to the medicine of claim 1 described treatment hepatitis B and other hepatitis, the tablet that it is characterized in that one of solid dosage forms is two kinds of tablets of A, B, the A sheet is the tablet that Herba Haleniae Corniculatae extractum or Herba Haleniae Corniculatae extract powder are made, the B sheet is the tablet that makes behind Radix Astragali extractum or Radix Astragali extractum powder and the Radix Glycyrrhizae extractum mixing, and A sheet and B sheet are taken simultaneously.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2009101581970A CN101606966A (en) | 2009-07-15 | 2009-07-15 | A kind of medicine for the treatment of hepatitis B and other hepatitis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2009101581970A CN101606966A (en) | 2009-07-15 | 2009-07-15 | A kind of medicine for the treatment of hepatitis B and other hepatitis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101606966A true CN101606966A (en) | 2009-12-23 |
Family
ID=41480976
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2009101581970A Pending CN101606966A (en) | 2009-07-15 | 2009-07-15 | A kind of medicine for the treatment of hepatitis B and other hepatitis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101606966A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103316074A (en) * | 2013-07-08 | 2013-09-25 | 三普药业股份有限公司 | Medicine composite of halenia corni extract, astragalus extract and liquorice extract as well as preparation and application of medicine composite |
-
2009
- 2009-07-15 CN CNA2009101581970A patent/CN101606966A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103316074A (en) * | 2013-07-08 | 2013-09-25 | 三普药业股份有限公司 | Medicine composite of halenia corni extract, astragalus extract and liquorice extract as well as preparation and application of medicine composite |
| CN103316074B (en) * | 2013-07-08 | 2015-04-22 | 三普药业有限公司 | Medicine composite of halenia corni extract, astragalus extract and liquorice extract as well as preparation and application of medicine composite |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101491611B (en) | Preparation method of serissa extract and use thereof | |
| CN104906406B (en) | A kind of natural drug composition and preparation method for preventing and treating alcoholic liver injury | |
| CN102058632B (en) | Application of medicinal composition to preparation of medicament for preventing and treating alcoholic liver damage and fatty liver and lowering blood fat | |
| CN104083727A (en) | Traditional Chinese medicine composition for nourishing and protecting liver | |
| WO2013155995A1 (en) | Red yeast and kudzu root pharmaceutical composition for regulating blood lipids and preparation method therefor | |
| CN103705578B (en) | There is blood fat reducing and Chinese medicine preparation suppressing blood glucose rising effect and preparation method thereof | |
| CN106074810A (en) | A kind of three wonderful capsules and preparation method thereof | |
| CN105999058B (en) | Bidens bipinnata lipid-lowering tablet | |
| CN101690775A (en) | Medicament having qi-supplementing, blood-nourishing, kidney-boosting, yang-reinforcing and anti-cancer effects | |
| CN101695562B (en) | Chinese medicinal composition for treating viral hepatitis and preparation method thereof | |
| CN101606966A (en) | A kind of medicine for the treatment of hepatitis B and other hepatitis | |
| CN104547026B (en) | Preparation method and application of salvia miltiorrhiza leave pseudo-ginseng extract | |
| CN102302545A (en) | Dai medicine extract with blood-sugar reducing activity, preparation method, composition and application | |
| CN101816708B (en) | Chinese medicinal composition for curing rheumatism and preparation method thereof | |
| CN1215876C (en) | Antigout medicinal composition and its preparing method | |
| CN101301356B (en) | Use of Schisandra chinensis extract in treating alcohol liver | |
| CN1899574A (en) | Chinese medicine composition for preventing and controlling liver cancer and its use | |
| CN1795901B (en) | Medication for removing toxic heat, eliminating wetness and treating jaundice | |
| CN104547027B (en) | Preparation method and application of salvia miltiorrhiza leave and panax notoginseng leaf extract | |
| CN104510857B (en) | A kind of Chinese medicinal effective-part composition for blood fat reducing and preparation thereof | |
| CN106309522A (en) | Chaifei Qingning capsule and preparing method thereof | |
| CN106377651A (en) | Preparation method for extracting pharmaceutical monomer for preventing and treating hyperuricemia and gout from rhizoma smilacis glabrae | |
| CN105641168A (en) | Medicine for treating viral hepatitis B and viral hepatitis C and preparation method of medicine | |
| CN1814250A (en) | Chinese medicine composition for treating liver cirrhosis ascites and use thereof | |
| CN102475778B (en) | Preparation method for traditional Chinese medicinal composition used for treating essential hypertension |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20091223 |