CN101606841B

CN101606841B - MRI locating measurement method for human body optic tract shape

Info

Publication number: CN101606841B
Application number: CN2009101578893A
Authority: CN
Inventors: 李长英; 王健; 石林平; 蔡萍
Original assignee: First Affiliated Hospital of TMMU
Current assignee: Third Military Medical University TMMU; First Affiliated Hospital of TMMU
Priority date: 2009-07-10
Filing date: 2009-07-10
Publication date: 2012-08-15
Anticipated expiration: 2029-07-10
Also published as: CN101606841A

Abstract

The invention discloses an MRI locating measurement method for human body optic tract shape. A reconstruction technology of locating multi-layers on a cross section is adopted to obtain a clear optic tract image on the obtained MRI high resolution image data; the reconstructed layers are along the long axle directions of optic nerves and can be adjusted by small angles so as to obtain the sagittal oblique image after reconstruction and relevant morphological data parameters of the optic tract are measured according to the image. The method reduces the errors of the morphological data parameters caused by individual shape differences as well as different positions and angles, and displays the integral structure of the optic tract, thereby improving the accuracy, consistency and repetitiveness of the measurement result.

Description

A kind of MRI locating measurement method of human body optic tract shape

Technical field

The invention belongs to the medical image technical field, be specially a kind of MRI locating measurement method of human body optic tract shape.

Background technology

Complete pathways for vision by optic nerve, optic chiasma, tractus opticus, lateral geniculate body, look radiation and visual cortex constitutes, tractus opticus is a relaying anatomical structure of visual system, about sending from the optic chiasma angulus posteriolateralis two; Respectively between the tuber cinereum outside and anterior perforated substania backward, foreign side's walking, around to the outside, traveling is the side in the going up of inferior horn of lateral ventricle from the outside of belly of pedunculus cerebri; Part-structure gets into lateral geniculate body, and other has part branch to import medial geniculate body, because optic tract shape is irregular; Preceding stage casing is rounded; Traveling is more straight, and back segment gradually arrives ellipse and traveling is tortuous, so accurately show and measure human body optic tract shape and have certain difficulty.

Measuring method to human body optic tract shape mainly contains two kinds at present; The one, decomposite tractus opticus from the corpse brain and dissect the measurement of exsomatizing again, promptly under the direct-view condition of postmortem, to measure, its defective is not energy measurement live body tractus opticus; The live body form can not be represented, live body optic tract shape data can't be obtained; The 2nd, the MRI sagittal plane shows measurement method, and its method is following: the first step, and the people gets dorsal position head MRI scanning, utilizes the direct scanning of MRI equipment to obtain the other sagittal plane that is parallel to median sagittal plane; Second step, scanning to such an extent that other sagittal plane is visual, the part tractus opticus structure radial line that measurement image showed, this method exists demonstration imperfect, and tractus opticus the 5th segment structure shows shortcomings such as unclear, and error is bigger between individuality, influences the accuracy of measurement result.

In order better to study the situation of change of normal person's tractus opticus of all ages and classes, different sexes; Understand human body live body optic tract shape; Set up the standard database of normal person's optic tract shape; Studying for the size variation situation of optic tract shape provides referential data, need to be necessary a kind of new compactly can be in the measuring method of the enterprising capable human body optic tract shape of live body.

Summary of the invention

The technical problem that the present invention will solve provides under a kind of human body condition of living organism, the MRI locating measurement method of the measurement of optic tract shape, thus reach the purpose of the optic tract shape of accurate measurement human body.

In order to solve the problems of the technologies described above, the MRI locating measurement method of a kind of human body optic tract shape of the present invention may further comprise the steps:

(1) subjects is placed on the magnetic resonance examination bed; Take dorsal position; Obtain high-resolution three-dimension isotropism anatomical image data through the scanning of the three-dimensional intensity of magnetization preparation of T1 weighting gradin-echo; With all data importing 3-D view work of treatment stations, utilize work station three-dimensional reconstruction software to obtain the oblique sagittal plain positioning image of ideal head, promptly comprise the transverse section of eye socket optic nerve.

(2) utilize work station three-dimensional measurement software on positioning image, to carry out oblique sagittal plane stage construction then and rebuild, reconstructed image is along the optic nerve long axis direction, and available mouse carries out low-angle to this aspect to be regulated, to obtain tractus opticus overall structure image.

(3) rebuilding on the oblique sagittal view picture that shows, measure the tractus opticus total length with the curved measurement method, tractus opticus and lateral geniculate body connecting place are promptly directly used line measurement in the 5th section high footpath.

Adopt the MRI locating measurement method of the human body optic tract shape of present technique scheme,, adopt oblique shape position stage construction reconstruction technique on the transverse section because the basic plane that adopts is positioning image in the transverse section of head; Rebuild oblique sagittal view picture along the optic nerve long axis direction; Can carry out low-angle adjustment, can show the tractus opticus configuration, show tractus opticus and lateral geniculate body connecting place Gao Jing with optimal effectiveness along the optic nerve long axis direction; More accurately more succinct than existing measuring technique; Directly obtain and more can show complete tractus opticus configuration, the clear image that shows tractus opticus the 5th segment structure has also been avoided because of individual variation simultaneously; Form error due to the position angle difference, thus the accuracy of measurement result improved.

Further, the concrete parameter that scans is limited, limit the concrete sweep parameter of the three-dimensional intensity of magnetization preparation gradin-echo of described T1 weighting: the visual field 256 * 256mm ², the number of plies 192, bed thickness 1mm, TR/TE/TI=2000/4-4.5/1100 millisecond, flip angle 15 degree, matrix 256 * 256 * 192, voxel size 1 * 1 * 1mm ³, the parameter of standard scanning helps adopting same standard that a different person are carried out standardized data collection and contrast.

Further; Concrete parameter to rebuilding bed thickness limits, and limits described reconstruction bed thickness and interlamellar spacing of rebuilding oblique sagittal view picture along the optic nerve long axis direction and selects 2mm, 30 layers of the reconstruction numbers of plies; The parameter of standard scanning helps adopting same standard that the subjects is carried out data acquisition and contrast.

Further; The curved measurement method is limited; Limiting described curved measurement method is to adopt a plurality of somes lines again obtaining the curve total length apart from addition between points; This point sampling method can be controlled size and the spacing distance of getting a little, adopts unified standard to measure, and helps adopting same standard that the subjects is carried out data acquisition and contrast.

Adopt the MRI locating measurement method of the human body optic tract shape of present technique scheme, its measurement aspect is to be base image with the image after the scanning, and rebuilding and obtaining oblique sagittal plane is measurement image; Can carry out low-angle adjustment along the optic nerve long axis direction; Show the tractus opticus configuration with optimal effectiveness, show tractus opticus and lateral geniculate body connecting place Gao Jing, avoided because of individual variation; Form error due to the position angle difference, thus the accuracy of measurement result improved.

Description of drawings

Below in conjunction with accompanying drawing and embodiment technical scheme of the present invention is further specified:

Fig. 1 is the sagittal plain transverse section positioning image that three-dimensional reconstruction software that the inventive method utilizes work station to carry obtains head;

Fig. 2 rebuilds oblique sagittal view picture rotation sketch map along the optic nerve long axis direction among Fig. 1.

The specific embodiment

A kind of MRI locating measurement method of human body optic tract shape may further comprise the steps:

(1) human brain BIAO and BEN or human body are placed on the examinating couch; Take dorsal position; Obtain high-resolution three-dimension isotropism anatomical image data through the scanning of the three-dimensional intensity of magnetization preparation of T1 weighting gradin-echo, import work station to view data, concrete sweep parameter: the visual field 256 * 256mm ², the number of plies 192, bed thickness 1mm, TR/TE/TI=2000/4-4.5/1100 millisecond, flip angle 15 degree, matrix 256 * 256 * 192, voxel size 1 * 1 * 1mm ³。

(2) the three-dimensional isotropism anatomical data of MRI collection imports in the work station and carries out post processing in the three-dimensional measurement software; Adopting transverse section as shown in Figure 1 to locate oblique sagittal plane stage construction rebuilds; Rebuild direction along optic nerve 2 major axis A B rectilinear directions, reconstructed image can use the mouse low-angle to regulate; Be advisable to show tractus opticus overall structure and contiguous other structure, optic chiasma and opposite side portion optic structure aspect; As shown in Figure 2; Can be presented at the visible hypophysis 1 in below and back upper place stalk hypophysial 4 structures of optic chiasma 3 clearly, be optic chiasma and CON 2 looking the road with the front end that stalk hypophysial 4 intersects; In Fig. 2, looking road and stalk hypophysial cross point is tractus opticus length to the curve distance with the lateral geniculate body point-to-point transmission, is to adopt the curved measurement method to obtain; The vertical dimension of tractus opticus and lateral geniculate body remittance section is the 5th section Gao Jing.

Claims

1. the MRI locating measurement method of a human body optic tract shape is characterized in that, may further comprise the steps:

(1) subjects lies on the back on the magnetic resonance examination bed; Obtain high-resolution three-dimension isotropism anatomical image data through the scanning of the three-dimensional intensity of magnetization preparation of T1 weighting gradin-echo; With all data importing 3-D view work of treatment stations, utilize work station three-dimensional reconstruction software to obtain the ideal oblique sagittal plain positioning image of head that comprises the transverse section of eye socket optic nerve;

(2) utilize work station three-dimensional measurement software on positioning image, to carry out oblique sagittal plane stage construction then and rebuild, reconstructed image is along the optic nerve long axis direction, and available mouse carries out low-angle to this aspect to be regulated, to obtain tractus opticus overall structure image;

(3) rebuilding on the oblique sagittal view picture that shows, measure the tractus opticus total length with the curved measurement method, line measurement is directly used in the 5th section high footpath of tractus opticus and lateral geniculate body connecting place.

2. the MRI locating measurement method of a kind of human body optic tract shape according to claim 1 is characterized in that, the concrete sweep parameter of the three-dimensional intensity of magnetization preparation gradin-echo of described T1 weighting: visual field 256x 256mm ², the number of plies 192, bed thickness 1mm, TR/TE/TI=2000/4-4.5/1100 millisecond, flip angle 15 degree, matrix 256x 256x 192, voxel size 1x 1x 1mm ³

3. the MRI locating measurement method of a kind of human body optic tract shape according to claim 1 is characterized in that, described reconstruction bed thickness and interlamellar spacing of rebuilding oblique sagittal view picture along the optic nerve long axis direction selected 2 millimeters, rebuilds 30 layers of the numbers of plies.

4. the MRI locating measurement method of a kind of human body optic tract shape according to claim 1 is characterized in that, described curved measurement method is to adopt a plurality of somes lines again obtaining the curve total length apart from addition between points.