CN102525461A - Method for researching optic neuropathy by using high-resolution 3D-magnatic resonance imaging (MRI) - Google Patents
Method for researching optic neuropathy by using high-resolution 3D-magnatic resonance imaging (MRI) Download PDFInfo
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- CN102525461A CN102525461A CN201010614422XA CN201010614422A CN102525461A CN 102525461 A CN102525461 A CN 102525461A CN 201010614422X A CN201010614422X A CN 201010614422XA CN 201010614422 A CN201010614422 A CN 201010614422A CN 102525461 A CN102525461 A CN 102525461A
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Abstract
The invention provides a method for researching optic neuropathy by using high-resolution 3D-magnatic resonance imaging (MRI) and an image reconstruction technology of the high-resolution 3D-MRI. The section of any segment of an optic nerve which is fully vertical to the optic nerve can be reconstructed by using 3D-MRI scanning; by the method, the scanning time is short, and the method is easy to operate and is a good means of researching optic neuropathy, and obtained data are accurate; and the sectional area of an optic nerve of an intraorbital segment of a late primary open angle glaucoma patient is obviously smaller than that of an optic nerve of an intraorbital segment of a normal person, so the feasibility of the method is further verified.
Description
Technical field
The present invention relates to a kind of method of utilizing high resolution 3 d-MRI research optic neuropathy.
Background technology
Optic neuropathy becomes ophthalmology common disease and becomes one of position, often shows as visual deterioration or blind clinically, influences patient's life and life quality, and early discovery is correct treatment and the key that improves curative effect with correct diagnosis of optic nerve pathological changes.Tumor, inflammation, wound etc. can cause the unusual of optic nerve each item anatomic measurement value, and along with the development of neurophthalmology, glaucoma, various fundus oculi disease also are in the news to the influence of optic nerve state day by day.Therefore iconography observation optic nerve anatomic status is significant.
MRI has the soft tissue resolution height, does not have characteristics such as radiation, arbitrary cross-section imaging, asexual pseudo-shadow; The particularly development of scanning technique in recent years; Display capabilities obviously improves, can know to show optic nerve anatomical detail and little pathological changes, and be the preferable image check method of optic neuropathy.Once relatively the data and the postmortem result of MRI gained optic nerve did comparison to researcher; Reach a conclusion: MRI can be preferably under live body, embody optic nerve anatomic status (the blue or green et al.MRI of hair with dissect comparative study: the performance of section optic nerve outside optic nerve-eye plane brain. Medical Imaging magazine 18,821-824 (2008) .).
Document utilized MRI to measure optic nerve radial line (the especially diameter of each section optic nerve) (Wen Shenggui more in the past; Zhang Weiguo, Gong Shui root Chen Jinhua. the MRI measurement Research of normal adult socket of the eye inner segment optic nerve. practical radiology magazine 16,556-559 (2000). the MRI research of the outer section of the blue or green et al. normal adult brain of hair optic nerve. Chinese CT and MRI magazine 2; 4-6 (2004) .); But the optic nerve individual variation is big, is not that single standard is circular, especially in the disease that has retinal ganglial cells death and optic nerve aixs cylinder to lose; The optic nerve cross sectional shape more can the variation (Wang Hongqi; Jiang Zhike pays equal. modern neurophthalmology. and Beijing: People's Health Publisher 328,329 (2005) .), thereby detect the anatomic status and the inaccuracy of optic nerve with diameter.Thereby there is the scholar to introduce this index of optic nerve sectional area.Because the cross sectional shape of optic nerve is various, can not represent the dissection situation of optic nerve merely with the optic nerve diameter.
Because of all exist between optic nerve and each axis angle (Li Fengming. the ophthalmology pandect. middle volume. Beijing: People's Health Publisher, 1343-1 (1997)), with common MRI mode; Perhaps there is the scholar only to replace (Kitsos, G., Zikou with the approximate cross section under the crown position; A.K., Bagli, E.; Kosta, P.&Argyropoulou, M.I.Conventional MRI and magnetisation transfer imaging of the brain and optic pathway in primary open-angle glaucoma.Br J Radiol 82; 896-900 (2009) .), perhaps through twice above scanning be constructed perpendicular to optic nerve the plane (the yellow violent wind of beam length rainbow. the research of optic nerve MR imaging method. current clinical medicine biotechnology magazine 8,191-193 (2002) .); Increase operating procedure, increased less patient suffering.3D-MRI can rebuild the picture of arbitrary plane through single pass, has solved this difficult problem.In addition, 3D-MRI gained image can make up arbitrary plane, has guaranteed when obtaining the optic nerve sectional area, not influence the acquisition of the data that must obtain through other planes.
In recent years, a large amount of zoopery (Ito, Y.et al.Morphological changes in the visual pathway induced by experimental glaucoma in Japanese monkeys.Exp Eye Res89; 246-55 (2009) .), human glaucoma postmortem research (Gupta, N., Ang; L.C., Noel de Tilly, L.; Bidaisee, L.&Yucel, Y.H.Human glaucoma and neural degeneration in intracranial optic nerve; Lateral geniculate nucleus, and visual cortex.Br J Ophthalmol 90,674-8 (2006) .) and the neuroimaging of human live body research (Kitsos; G., Zikou, A.K.; Bagli, E., Kosta; P.&Argyropoulou, M.I.Conventional MRI and magnetisation transfer imaging of the brain and optic pathway in primary open-angle glaucoma.Br J Radiol 82,896-900 (2009)., Filippi; M.et al.Magnetization transfer imaging of patients with definite MS and negative conventional MRI.Neurology 52,845-8 (1999) .) prove that glaucoma is the whole comprehensive syndrome of looking the road; Begin from the retina ganglionic cell, all exist morphology and function assessment to change to the structure of looking cortex through optic nerve, optic chiasma, tractus opticus, lateral geniculate body, optic radiation.Glaucoma is classified as eye and brain neuroblastoma DD to being familiar with glaucomatous pathogenesis, the comprehensive therapeutic strategy of the system that sets up, saving patient's vision and have very significant meaning (Liu Xuyang; The sharp Chen Xiao of Wang Ning is bright. is glaucoma a kind of central nervous system disease? Ophthalmology, 4-7.).Bibliographical information glaucoma patient is because of optic atrophy; Its diameter is starkly lower than normal control (Kashiwagi, K., Okubo; T.&Tsukahara; S.Association of magnetic resonance imaging of anterior optic pathway with glaucomatous visual field damage and optic disc cupping.J Glaucoma 13,189-95 (2004) .), just crown position lower section is long-pending less than normal control.
Summary of the invention
Technical scheme of the present invention has provided a kind of method of new research optic neuropathy, and it is to utilize high resolution 3 d-MRI to study optic neuropathy.
The invention provides a kind of method of utilizing high resolution 3 d-MRI to obtain the accurate sectional area of socket of the eye inner segment optic nerve, it is to adopt T1 weighting three-dimensional imaging sequence (MPRAGE) scanning, wherein; Scan matrix is: 256x256x176; Resolution 1x1x1mm, sweep time, 7min7s utilized Siemens dedicated analysis software syngo MultiModality Workplace that the gained image is carried out three-dimensional reconstruction; Obtain the vertical cross-section of socket of the eye inner segment optic nerve, obtain sectional area; With gained statistical analysis as a result, judge the difference of patients with primary open-angle glaucoma and normal person's optic nerve sectional area.
The inventive method is applied to high resolution 3 d-MRI and image reconstruction technique thereof the measurement of optic nerve socket of the eye inner segment sectional area first; Utilize the three-dimensional reconstruction function of 3D-MRI image behind the single sweep operation; Obtain plane, measure optic nerve and go out the sectional area of eyeball, and require two gauger's repeated measure to the common tendinous ring mid point perpendicular to optic nerve; The gained result gets average after must reaching the statistics zero difference, has guaranteed result's accuracy.Utilize the method, gained patients with primary open-angle glaucoma in late period group socket of the eye inner segment optic nerve sectional area (6.67 ± 2.23mm
2) be significantly less than normal control group (10.10 ± 3.14mm
2), difference has statistical significance.
Utilize 3D-MRI scanning, can rebuild the complete cross section perpendicular to optic nerve of optic nerve any section, this method is short sweep time, and easy and simple to handle, the gained data are accurate, are the excellent means of research optic neuropathy; Late period, the socket of the eye inner segment optic nerve sectional area of patients with primary open-angle glaucoma was significantly less than the normal person, had further verified the feasibility of method.
Description of drawings
The positive sagittal plain picture of Figure 13 D-T1
Fig. 2 is constructed perpendicular to the plane graph of optic nerve
Fig. 3 ROI technique of painting
Fig. 4 eyes ROI
The specific embodiment
1.1 15 of object of study patients with primary open-angle glaucoma (9 male 6 woman), 15 of normal controls (9 male 6 woman).
Late period, patients with primary open-angle glaucoma was included standard in:
(1) is diagnosed as the eyes primary open angle glaucoma
(2) ophthalmology of system is had a medical check-up, and gets rid of the ophthalmic diseases that other possibly influence retina, optic nerve
(3) department of neurology of system is had a medical check-up, and gets rid of nervous system disease
(4) mental sickness is got rid of in the psychiatric department inspection
(5) binocular visual field is obviously damaged.
(6)C/D≥0.8
Normal control is included standard in:
(1) with matched group age, gender matched
(2) ophthalmology of system is had a medical check-up, and gets rid of the ophthalmic diseases that other possibly influence retina, optic nerve
(3) department of neurology of system is had a medical check-up, and gets rid of nervous system disease
(4) mental sickness is got rid of in the psychiatric department inspection
1.2 instrument and equipment: Siemens 3.0T superconduct magnetic resonance imager (model 3T Trio); 32 passage head coils; Siemens special image analysis software syngo MultiModality Workplace (Series Number 3064, Version VE31A).
1.3 sweep parameter
Scanning sequence: T1 weighting three-dimensional imaging sequence (MPRAGE), sweep parameter is seen Fig. 1
The echo time/TE 1900ms
The repetition time/TR 2.27ms
The visual field/FOV 240 * 240 * 170
Scan matrix 256x256x176
Sweep time 7min7s
1.4 data obtain
1.4.1 the positive sagittal plain picture of 3D-T1 is seen Fig. 1
1.4.2 be constructed perpendicular to the plane of optic nerve
Because of going up than being easier to obtain the complete section of optic nerve crown position; The reconstruction of image is basic plane with the coronalplane; Fig. 2-A red line is attached most importance to and is built the indicatrix of the oblique sagittal plane that is parallel to optic nerve, and the gained picture is Fig. 2-B, on the 2-B basis, is the vertical cross-section that benchmark can make up the optic nerve any section with the green line; This experiment is got optic nerve and is gone out the Mean section of eyeball to common tendinous ring, and rebuilding the gained image is shown in Fig. 2-C.The pulling green line can obtain the vertical cross-section of optic nerve diverse location.
Picture is got region of interest, and (Region of Interest ROI), obtains sectional area
In the MPRAGE sequence, optic nerve is a utmost point low signal black in color, and on every side around the grizzly meninges sheath of low signal, the frame inner tissue of periphery is that high signal is white in color, and our ROI gets the optic nerve part of center pole low signal black in color.Manually draw the neural cross section of getting right and left eyes utmost point low signal respectively, obtain the sectional area of optic nerve, see Fig. 3, Fig. 4.
Carry out aforesaid operations by two gaugers, two people's gained data statistic analysis zero difference sides are data available, and the two is averaged and obtains required optic nerve sectional area.
1.5 statistical procedures: (P＜0.05 is for there being significant difference for X ± S) expression, glaucoma patient group and normal control group group catch cropping t check with mean ± standard deviation for the gained measurement result.
Two. the result
Age-sex's match condition of table 1 patients with primary open-angle glaucoma group and normal control
Annotate: two groups of age-sex's couplings.
Compare between table 2 liang gauger institute value
Annotate: patients with primary open-angle glaucoma group socket of the eye inner segment optic nerve sectional area (6.67 ± 2.23mm
2) be significantly less than normal control group (10.10 ± 3.14mm
2), difference has statistical significance.
Three. conclusion
1. utilize 3D-MRI scanning, can rebuild diverse location fully perpendicular to the cross section of optic nerve, this method is short sweep time, and easy and simple to handle, the gained data are accurate, are the excellent means of research optic neuropathy.
Late period chronic open angle glaucoma patient socket of the eye inner segment optic nerve sectional area be significantly less than the normal person, further proved the feasibility and the application prospect of method.
Claims (1)
1. method of utilizing high resolution 3 d-MRI to obtain the accurate sectional area of socket of the eye inner segment optic nerve; It is characterized in that: it is to adopt T1 weighting three-dimensional imaging sequence (magnetization-prepared rapid gradient-Echo; MPRAGE) scanning, wherein, scan matrix is: 256x256x176; Resolution 1x1x1mm; Sweep time, 7min7s utilized Siemens dedicated analysis software syngo MultiModality Workplace that the gained image is carried out three-dimensional reconstruction, obtained the vertical cross-section of socket of the eye inner segment optic nerve.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008086573A1 (en) * | 2007-01-19 | 2008-07-24 | Howard Florey Institute Of Experimental Physiology And Medicine | Use of galanin in a method of treating neurodegenerative diseases or conditions |
| CN101606841A (en) * | 2009-07-10 | 2009-12-23 | 中国人民解放军第三军医大学第一附属医院 | A kind of MRI locating measurement method of human body optic tract shape |
| US20100056935A1 (en) * | 2008-07-09 | 2010-03-04 | Mckinley Laurence M | Optic function monitoring process and apparatus |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008086573A1 (en) * | 2007-01-19 | 2008-07-24 | Howard Florey Institute Of Experimental Physiology And Medicine | Use of galanin in a method of treating neurodegenerative diseases or conditions |
| US20100056935A1 (en) * | 2008-07-09 | 2010-03-04 | Mckinley Laurence M | Optic function monitoring process and apparatus |
| CN101606841A (en) * | 2009-07-10 | 2009-12-23 | 中国人民解放军第三军医大学第一附属医院 | A kind of MRI locating measurement method of human body optic tract shape |
Non-Patent Citations (3)
| Title |
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| HICKMAN S.J., ET AL: "急性视神经炎患者视神经平均面积的连续MRI研究", 《世界核心医学期刊文摘.眼科学分册》 * |
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| 梁长虹, ET AL: "视神经磁共振成像方法研究", 《现代临床医学生物工程学杂志》 * |
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Application publication date: 20120704 |