CN101601794A - The hypoglycemic and thirst-relieving Chinese medicine preparation - Google Patents
The hypoglycemic and thirst-relieving Chinese medicine preparation Download PDFInfo
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- CN101601794A CN101601794A CNA2008100118474A CN200810011847A CN101601794A CN 101601794 A CN101601794 A CN 101601794A CN A2008100118474 A CNA2008100118474 A CN A2008100118474A CN 200810011847 A CN200810011847 A CN 200810011847A CN 101601794 A CN101601794 A CN 101601794A
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Abstract
The invention discloses a kind of hypoglycemic and thirst-relieving Chinese medicine preparation for the treatment of diabetes, this Chinese medicine is formulated by 13 flavor raw material of Chinese medicine such as Radix Rehmanniae, Fructus Corni, Rhizoma Dioscoreae, Cortex Moutan; Earlier seven flavor medicines such as Radix Rehmanniae, Fructus Corni are pulverized standbyly, all the other components such as Rhizoma Alismatis, Radix Trichosanthis, Fructus Rosae Laevigatae are soaked, the decoction filtering concentration extraction makes pharmaceutically active substance again, it is 1.30～1.32 extractum that filtrate is concentrated into relative density in 80～90 ℃; Extractum is added above-mentioned fine powder mixing to get final product.Through three batches of hypoglycemic and thirst-relieving capsules of preparation of the present invention are carried out 24 months stability observing, the result shows that every index is all up to specification.Show by results of pharmacodynamic test: this product has blood sugar lowering to the hyperglycemia type animal of insulin and cell damage, improve low immunologic function, recover islet function, be fit to the non-dependence diabetics of clinical treatment II type, take safe, nontoxic, evident in efficacy.
Description
Technical field
The present invention relates to a kind of hypoglycemic Chinese medicine preparation and preparation method thereof, the hypoglycemic and thirst-relieving Chinese medicine preparation of particularly selecting for use raw material of Chinese medicine such as Radix Rehmanniae, Fructus Corni, Rhizoma Dioscoreae, Cortex Moutan, Rhizoma Alismatis, Poria, Radix Trichosanthis, Fructus Rosae Laevigatae to make.
Background technology
Diabetes are endocrine and metabolic disorders diseases that a kind of heritability and environmental factors interact and cause, pathology, physiology reduce insulin sensitivity for or relative deficiency absolute because of insulin secretion and target tissue, and then it is not normal to cause that sugar, protein, fat, power and water are separated the matter metabolism.Clinical is main common trait with hyperglycemia, then has multisystem complication, pathological changes to relate generally to internal organs such as kidney, stomach (spleen), lung for a long time.Chinese medicine thinks that primary disease is plain body innate deficiency, disorder of emotion, and eating and drinking without temperance, six climate exopathogens invasion and attack, labor desire mistakes degree is to the five internal organs weakness, Yu Huahuo for a long time, long-pending thermal burn Tianjin, fire burns and decreases cloudyly, consumes essence and is impairment of the kidney and causes.The pathogenesis key is at deficiency of YIN-essence, and dryness-heat being excessive in the interior institute extremely.The rule of treatment is based on heat clearing away YIN nourishing, supplementing QI and nourishing YIN, promoting the production of body fluid to quench thirst.Clinical again according to the sings and symptoms difference, give classification therapy.Scorching flourishing type is with the heat clearing away YIN nourishing; Type of deficiency of both QI and YIN is with supplementing QI and nourishing YIN, promoting the production of body fluid to quench thirst; The deficiency of both YIN and YANG type, with the warming YANG YIN nourishing, type of stagnation of blood stasis is with blood circulation promoting and blood stasis dispelling.
According to external epidemiological study up-to-date information, fastest-rising five countries of current diabetes are India, China and the U.S. successively, China more than 35 years old crowd's diabetes prevalence be 5.5%, Beijing more than 45 years old crowd's diabetes prevalence reached 16%, also have large quantities of impaired glucose tolerance crowds in addition, these people are edge crowds of blood glucose disease.In recent years, the Chinese medicine preparation that also occurs some treatment diabetes on the market, in the Chinese medicine preparation that has admixture chemical drugs, increase the produce effects of medicine and to the dependency of human body, belong to and cure the symptoms, not the disease, also have certain toxic and side effects simultaneously, uncertain therapeutic efficacy is cut and has been incured loss through delay the best opportunity of treatment in application process.
Summary of the invention
Given this feelings, the present invention seeks to develop a kind of pure Chinese medicinal preparation of hypoglycemic and thirst-relieving, the said preparation effect is steady, evident in efficacy definite, without any side effects, have hypoglycemic and thirst-relieving, liver and kidney tonifying, supplementing QI and nourishing YIN, cure mainly diabetes and the hepatic and renal YIN deficiency, the empty symptom such as weak of dry throat and mouth, soreness of the waist and knees, body.
The present invention finally determines prescription and dosage according to Chinese medical theory and the raw material of clinical experience screening for many years.In line with monarch, minister, the combination principle helping, make, be principal agent with Radix Rehmanniae, Fructus Corni, Fructus Schisandrae Chinensis, Cortex Moutan, Rhizoma Alismatis, Poria, Radix Ophiopogonis in the side, the usefulness of mainly play tonifying kidney and nourishing yin, slaking thirst and help produce saliva.The Radix Astragali, Radix Pseudostellariae, the collaborative principal agent tonifying kidney and nourishing yin of Rhizoma Dioscoreae promote the principal agent curative effect, to receive antiperspirant consolidating superficial resistance, invigorating the spleen and benefiting QI.More use Radix Trichosanthis, Fructus Rosae Laevigatae, Radix Adenophorae (Radix Glehniae) clearing away heat and promoting production of body fluid, controlling nocturnal emission with astringent drugs astringent therapy, nourishing YIN and clearing away lung-heat, the major-minor medicine of assistance, treat various double diseases simultaneously.
The invention provides a kind of hypoglycemic and thirst-relieving Chinese medicine preparation, it is characterized in that this Chinese medicine preparation mainly is to be made by following Chinese medicine raw materials by weight proportion:
Radix Rehmanniae 15～30g Fructus Corni 9～25g
Rhizoma Dioscoreae 25～40g Cortex Moutan 9～15g
Rhizoma Alismatis 15～30g Poria 20～30g
Radix Trichosanthis 9～15g Fructus Rosae Laevigatae 10～20g
Radix Adenophorae (Radix Glehniae) 9～15g Radix Astragali 30～50g
Fructus Schisandrae Chinensis 9～15g Radix Pseudostellariae 9～20g
Radix Ophiopogonis 10～20g.
The present invention selects for use following Chinese medicine raw materials by weight proportion to make:
Radix Rehmanniae 20～25g Fructus Corni 9～25g
Rhizoma Dioscoreae 25～30g Cortex Moutan 9～15g
Rhizoma Alismatis 20～25g Poria 20～30g
Radix Trichosanthis 9～15g Fructus Rosae Laevigatae 15～20g
Radix Adenophorae (Radix Glehniae) 9～15g Radix Astragali 30～35g
Fructus Schisandrae Chinensis 9～15g Radix Pseudostellariae 9～20g
Radix Ophiopogonis 15～20g.
Preferred version of the present invention is:
Radix Rehmanniae 20g Fructus Corni 15g
Rhizoma Dioscoreae 30g Cortex Moutan 15g
Rhizoma Alismatis 20g Poria 20g
Radix Trichosanthis 15g Fructus Rosae Laevigatae 15g
Radix Adenophorae (Radix Glehniae) 15g Radix Astragali 30g
Fructus Schisandrae Chinensis 15g Radix Pseudostellariae 20g
Radix Ophiopogonis 15g.
Screening obtains proportioning of the present invention through science, to especial patient, as serious symptom or light disease, obesity or thin and weak patient, can make corresponding adjustment, and in above-mentioned dosage interval, drug effect is comparatively desirable.Preparation of the present invention can be capsule, tablet; The application of this Chinese medicine preparation in the medicine that prevents and/or treats non-insulin-depending type patient and complication thereof.
The preparation method of Chinese medicine preparation of the present invention is to pass through following steps: it is standby that Radix Rehmanniae, Fructus Corni, Rhizoma Dioscoreae, Cortex Moutan, Radix Ophiopogonis, Poria and Fructus Schisandrae Chinensis powder are broken into 80～100 order fine powders; All the other 6 flavor components are made pharmaceutically active substance through immersion, decoction, filtration, concentration extraction, and it is 1.30～1.32 extractum that filtrate is concentrated into relative density in 80～90 ℃; Extractum is added above-mentioned fine powder mixing, according to the routine techniques preparation of pharmaceutics.
The specific embodiment
Embodiment 1: prescription: Radix Rehmanniae 20g, Fructus Corni 15g, Rhizoma Dioscoreae 30g, Cortex Moutan 15g, Rhizoma Alismatis 20g, Poria 20g, Radix Trichosanthis 15g, Fructus Rosae Laevigatae 15g, Radix Adenophorae (Radix Glehniae) 15g, Radix Astragali 30g, Fructus Schisandrae Chinensis 15g, Radix Pseudostellariae 20g, Radix Ophiopogonis 15g.
After [method for making] cleaned medical material, elder generation put Fructus Rosae Laevigatae, the Radix Astragali, Radix Adenophorae (Radix Glehniae), Radix Pseudostellariae, Rhizoma Alismatis, Radix Trichosanthis and adds 8-10 times of water gaging immersion 24 hours in the jacketed pan, and middle temperature is heated to boils, and the river in Shangdong Province fire decocts and continues 2 hours.Incline and medicinal liquid.Filter.Two fried in shallow oil same need 2 hours.Inclining medicinal liquid, filters.Merge secondary filtrate and put the extractum that is condensed into density (80 ℃-90 ℃ of temperature) 1.30～1.32 in the jacketed pan.Other gets Radix Rehmanniae, Fructus Corni, Rhizoma Dioscoreae, Cortex Moutan, Radix Ophiopogonis, Poria, clean, the oven dry of Fructus Schisandrae Chinensis, pulverizes 80～100 mesh sieves.Place in the autoclaving blender with above-mentioned extractum, be warming up to 80 ± 5 ℃, add 0.1kpa, continue 30min, active ingredient is fully activated, simultaneously kill bacteria and spore.The moist shape soft material of sterilization is put in the granulation machine and granulated, and dry back granulate makes the sugar-free granule, and packing promptly.
[character] this product is the ebonite cryptomere, and content is tan granule, little acid of distinguishing the flavor of, little hardship.
[function with cure mainly] hypoglycemic and thirst-relieving, liver and kidney tonifying, supplementing QI and nourishing YIN.Cure mainly the empty symptom such as weak of the diabetes and the hepatic and renal YIN deficiency, dry throat and mouth, soreness of the waist and knees, body.
[usage and dosage] boiled water is taken after mixing it with water, a 5-6 grain, three times on the one.
[specification] every bottled 100, every 0.5g
[storage] sealing
Through three batches of hypoglycemic and thirst-relieving capsules are carried out 24 months stability observing, the result shows that every index is all up to specification.Show by results of pharmacodynamic test: this product has blood sugar lowering to the hyperglycemia type animal of insulin and cell damage, improve low immunologic function, recover islet function, be fit to the non-dependence diabetics of clinical treatment II type, take safe, nontoxic, evident in efficacy.
The present invention's clinical operating position since 04 year is: be selected from January, 04 to 05 year December diabetics 60 examples, be all the non-insulin-depending type patient.Average minimal ages is 30 years old, and the maximum age is 65 years old.Male's 35 examples, women's 25 examples.
Instructions of taking: all patients all take routinely, and every day three times, each 5-6 grain is taken continuously, and be a therapy journey January.Pungents such as period in a medicine taboo cigarette, wine, curative effect
Standard is decided to be produce effects, effective and invalid.
Produce effects: after taking 7 days, curative effect can occur, the laboratory checks that blood glucose value is controlled.
Effectively: take a course of treatment, muscle power strengthens, and not cold perspiration or few cold perspiration, blood glucose numerical value obviously reduce or be tending towards normal value, symptoms such as xerostomia, excessive thirst be improved significantly.
Invalid: after taking a course of treatment, symptom does not have obvious improvement, blood glucose and the urine sugar value preceding state that is tending towards taking medicine.
Therapeutic outcome: among the 60 routine patients, effective 60 examples, effective percentage is 100%; Produce effects 40 examples, obvious effective rate are 67%; Invalid 0 example, untoward reaction 0 example.
This preparation is made up of the medicine of traditional treatment diabetes.In line with monarch, minister, the preparation principle helping, make, carry out dialectical executing according to the pathogeny of diabetes and control.Through clinical observation on the therapeutic effect for many years, this preparation has obvious curative effects to the non-insulin-depending type patient, a routine untoward reaction do not occur.
Following examples component further specifies the present invention, but not as limitation of the present invention.
Embodiment 2:
Radix Rehmanniae 15g, Fructus Corni 9g, Rhizoma Dioscoreae 30g, Cortex Moutan 9g, Rhizoma Alismatis 15g, Poria 20g, Radix Trichosanthis 9g, Fructus Rosae Laevigatae 10g, Radix Adenophorae (Radix Glehniae) 9g, Radix Astragali 40g, Fructus Schisandrae Chinensis 9g, Radix Pseudostellariae 9g, Radix Ophiopogonis 10g.Preparation method is with embodiment 1.
Embodiment 3:
Radix Rehmanniae 30g, Fructus Corni 25g, Rhizoma Dioscoreae 40g, Cortex Moutan 15g, Rhizoma Alismatis 30g, Poria 30g, Radix Trichosanthis 15g, Fructus Rosae Laevigatae 20g, Radix Adenophorae (Radix Glehniae) 15g, Radix Astragali 50g, Fructus Schisandrae Chinensis 15g, Radix Pseudostellariae 20g, Radix Ophiopogonis 20g.Preparation method is with embodiment 1.
Embodiment 4:
Radix Rehmanniae 25g, Fructus Corni 10g, Rhizoma Dioscoreae 30g, Cortex Moutan 10g, Rhizoma Alismatis 20g, Poria 20g, Radix Trichosanthis 15g, Fructus Rosae Laevigatae 12g, Radix Adenophorae (Radix Glehniae) 10g, Radix Astragali 40g, Fructus Schisandrae Chinensis 15g, Radix Pseudostellariae 15g, Radix Ophiopogonis 15g.Preparation method is with embodiment 1.
Claims (6)
1, a kind of hypoglycemic and thirst-relieving Chinese medicine preparation is characterized in that this Chinese medicine preparation mainly is to be made by following Chinese medicine raw materials by weight proportion:
Radix Rehmanniae 15～30g Fructus Corni 9～25g
Rhizoma Dioscoreae 25～40g Cortex Moutan 9～15g
Rhizoma Alismatis 15～30g Poria 20～30g
Radix Trichosanthis 9～15g Fructus Rosae Laevigatae 10～20g
Radix Adenophorae (Radix Glehniae) 9～15g Radix Astragali 30～50g
Fructus Schisandrae Chinensis 9～15g Radix Pseudostellariae 9～20g.
2,, it is characterized in that this medicament made by following Chinese medicine raw materials by weight proportion according to the described Chinese medicine preparation of claim 1:
Radix Rehmanniae 20～25g Fructus Corni 9～25g
Rhizoma Dioscoreae 25～30g Cortex Moutan 9～15g
Rhizoma Alismatis 20～25g Poria 20～30g
Radix Trichosanthis 9～15g Fructus Rosae Laevigatae 15～20g
Radix Adenophorae (Radix Glehniae) 9～15g Radix Astragali 30～35g
Fructus Schisandrae Chinensis 9～15g Radix Pseudostellariae 9～20g.
3,, it is characterized in that this medicament made by following Chinese medicine raw materials by weight proportion according to the described Chinese medicine preparation of claim 1:
Radix Rehmanniae 20g Fructus Corni 15g
Rhizoma Dioscoreae 30g Cortex Moutan 15g
Rhizoma Alismatis 20g Poria 20g
Radix Trichosanthis 15g Fructus Rosae Laevigatae 15g
Radix Adenophorae (Radix Glehniae) 15g Radix Astragali 30g
Fructus Schisandrae Chinensis 15g Radix Pseudostellariae 20g.
4, Chinese medicine preparation as claimed in claim 1 is characterized in that this Chinese medicine preparation is capsule, tablet.
5, Chinese medicine preparation as claimed in claim 1 is characterized in that the application of said preparation in the medicine that prevents and/or treats non-insulin-depending type patient and complication thereof.
6, the preparation method of Chinese medicine preparation according to claim 1, it is characterized in that through following steps: it is standby that Radix Rehmanniae, Fructus Corni, Rhizoma Dioscoreae, Cortex Moutan, Radix Ophiopogonis, Poria and Fructus Schisandrae Chinensis powder are broken into 80～100 order fine powders; All the other 6 flavor components are made pharmaceutically active substance through immersion, decoction, filtration, concentration extraction, and it is 1.30～1.32 extractum that filtrate is concentrated into relative density in 80～90 ℃; Extractum is added above-mentioned fine powder mixing, according to the routine techniques preparation of pharmaceutics.
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| CN2008100118474A CN101601794B (en) | 2008-06-13 | 2008-06-13 | Traditional Chinese medicine preparation for reducing glucose and removing thirst |
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| CN2008100118474A CN101601794B (en) | 2008-06-13 | 2008-06-13 | Traditional Chinese medicine preparation for reducing glucose and removing thirst |
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| CN101601794B CN101601794B (en) | 2011-01-26 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103860902A (en) * | 2014-01-17 | 2014-06-18 | 刘翠玲 | Traditional Chinese medicine for treating diabetes and preparation method of traditional Chinese medicine |
| CN104305461A (en) * | 2014-10-31 | 2015-01-28 | 庞毅 | Health royal jelly dry powder particle |
| CN105535300A (en) * | 2016-01-19 | 2016-05-04 | 王天湶 | Drug for treating hypertensive disease |
| CN105770367A (en) * | 2016-04-26 | 2016-07-20 | 郑州市中医院 | Radix codonopsis and radix salviae miltiorrhizae soup capable of quenching thirst and preparation method of radix codonopsis and radix salviae miltiorrhizae soup |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100195886B1 (en) * | 1996-11-01 | 1999-06-15 | 김상조 | Pharmaceutical composition for treating diabetes mellitus |
| CN1131053C (en) * | 2001-05-23 | 2003-12-17 | 郑国芃 | Chinese medicine for treating diabetes |
| CN1253190C (en) * | 2004-02-07 | 2006-04-26 | 李炳全 | Medicine for treating diabetes |
| CN1267144C (en) * | 2004-10-11 | 2006-08-02 | 任连智 | Compound diabetes-treating sugar-decreasing fat-reducing preparation and preparation method thereof |
-
2008
- 2008-06-13 CN CN2008100118474A patent/CN101601794B/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103860902A (en) * | 2014-01-17 | 2014-06-18 | 刘翠玲 | Traditional Chinese medicine for treating diabetes and preparation method of traditional Chinese medicine |
| CN104305461A (en) * | 2014-10-31 | 2015-01-28 | 庞毅 | Health royal jelly dry powder particle |
| CN105535300A (en) * | 2016-01-19 | 2016-05-04 | 王天湶 | Drug for treating hypertensive disease |
| CN105770367A (en) * | 2016-04-26 | 2016-07-20 | 郑州市中医院 | Radix codonopsis and radix salviae miltiorrhizae soup capable of quenching thirst and preparation method of radix codonopsis and radix salviae miltiorrhizae soup |
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