CN101601741A - Diuretic medicine and preparation method - Google Patents
Diuretic medicine and preparation method Download PDFInfo
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- CN101601741A CN101601741A CNA2008100849338A CN200810084933A CN101601741A CN 101601741 A CN101601741 A CN 101601741A CN A2008100849338 A CNA2008100849338 A CN A2008100849338A CN 200810084933 A CN200810084933 A CN 200810084933A CN 101601741 A CN101601741 A CN 101601741A
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Abstract
Diuretic medicine of the present invention is having the logical effect of closing of clearing heat and freeing strangury, blood circulation promoting and blood stasis dispelling, diuresis, being used for prostatitis, benign prostatic hyperplasia (difficulty in urination) of main medicinal ingredient with natural animal and plant medical material, belong to damp invasion of lower energizer, congestion retardance card, therapeutical effect is preferably arranged.Process for preparing medicine of the present invention is by following raw material is formed and weight proportion is made medicament: Radix Notoginseng 7-14, Hirudo 3-9, Cornu Naemorhedi powder 2-6, Fructus Psoraleae 3-9, Herba Desmodii Styracifolii 10-25, wear Caulis Akebiae 3-9, Fructus Forsythiae 3-12, Carapax Trionycis 10-30, Rhizoma Atractylodis Macrocephalae 2-8, Radix Cyathulae 3-10 makes preparation according to conventional oral agents technology.The present invention is according to the Traditional Chinese medical theory prescription, and the clinical verification in 50 years is arranged, and according to the nature and flavor characteristics of each herbal medicine, extracts its effective ingredient, develops medicament easy to use.
Description
Technical field
The present invention dredges urine, and to pass to natural animal and plant medical material be main medicinal ingredient medicine of being used for the treatment of prostatitis, benign prostatic hyperplasia (difficulty in urination) and preparation method thereof.
Background technology
Prostatitis, benign prostatic hyperplasia (BPH) the property difficulty in urination are commonly encountered diseases, are again difficult treatments.Show according to epidemiology branch of international benign prostatic hyperplasia the 4th executive session of Advisory Board (1997.7.2 Paris) statistics, BPH is the modal urological diseases of elderly men, and increase year by year along with aged tendency of population, its sickness rate is obvious rising in recent years and becomes.In the U.S., the male nearly all has the BPH symptom more than 85 years old, and the old people more than 85 years old with 1980 2,000,000 increase to 2000 4,000,000, will reach 1,800 ten thousand or more to the year two thousand fifty, growth trend is very surprising.In Britain, the male senile patient in 75-84 year has increased by 70% in 18 years, and the male more than 85 years old has increased by 1 times in the phase at the same time, and wherein 30% has BPH to block symptom.In China, postmortem in 1936 report BPH rose to 30.5% in 6.6% to 1992 year, was the former 4 times.Therefore, the morbidity of BPH will be the health problem of the maximum that faces of All Countries among the current old people.The treatment of primary disease has 3 classes at present.
Surgical result is good, and it is for removing prostatic hyperplasia morbidity condition of illness and the more effective Therapeutic Method of lower urinary tract obstruction, and the situation that the absolute indication of operation occurs is that it is unique solution.But more patient is in relative operative indication or non-operation indication.Though Shou Shu improvement greatly reduces its danger in recent years, but also non-being perfectly safe, still have certain complication and sequela, bigger prostatic hyperplasia is when carrying out urethra resection of prostate art (TURP), as not finishing excision at 60 minutes with interior, it is dangerous to be the same with the open surgery treatment.The long-term effect of TURP, 20-25% is not satisfactory, still has urinary tract symptom: more than 10 years, 15-20% needs operation once more.Therefore, be in the gerontal patient of relative operative indication and non-operation indication, majority more is ready to accept other comparatively conservative Therapeutic Method, comprises interventional therapy or Drug therapy.
Interventional therapy is the novel therapies between operation and Drug therapy, and it has opened up new approach for the treatment of BPH.
Yet the indication that these treatments have is narrow, and the long-term effect that has is undesirable, but may become one of in the future main selectable treatment the development prospect that also has.
In fact, people more are contemplated for the more conservative treatment of selection, i.e. Drug therapy.But present Drug therapy neither be very good, and quality is respectively arranged.The A-receptor blocking agent can make the prostate smooth muscle loosening, reduces functional blocking, and is effective and fast, but can not stop prostate to continue hypertrophy, and certain cardiovascular and cerebrovascular vessel side effect is arranged; 5a-reductase inhibitor prostate always continues hypertrophy, and that continues may dwindle prostate, improves and blocks symptom, and side effect is little, but curative effect is also unsatisfactory.
Along with improving constantly of living standard, people have not satisfied existing medical level, and the quality and quantity of health care is had higher requirement.Therefore, the medicine of seeking new high-efficiency low-toxicity is very necessary.And Chinese medicine has formed the theoretic knowledge of own uniqueness aspect the treatment benign prostate hyperplasia, has accumulated rich experience, and Chinese medicine has caused attracting attention of common people with its curative effect that can make and the nontoxic superiority of low toxicity.In today of whole world uphold nature therapy, actively excavate traditional medicine precious legacy, research and develop with strong points, determined curative effect, the low Chinese patent drug of side effect, solve vast benign prostate hyperplasia patient's misery, beyond doubt a significant problem.Liu Molin professor further research on the precious treatment of his father old docter of TCM Liu Yu prostatic hyperplasia (difficulty in urination) basis, " diuretic medicine " developed in the clinical verification that went through 50 years front and back, treatment prostatitis, benign prostatic hyperplasia (difficulty in urination) have been obtained gratifying curative effect, and have not been found any untoward reaction.
Summary of the invention
The objective of the invention is to propose to dredge the logical medicine that prostatitis, benign prostatic hyperplasia (difficulty in urination) is had good therapeutical effect of urine.
Medicine of the present invention is based on Chinese medicine to prostatitis, the pathogenetic understanding of benign prostatic hyperplasia (difficulty in urination) and Therapeutic Principle, with reference to the modern pharmacology achievement in research, what filter out from clinical trial for many years has a logical crude drug animal and plant Chinese crude drug of function that closes of clearing heat and freeing strangury, blood circulation promoting and blood stasis dispelling, diuresis, to prostatitis, benign prostatic hyperplasia (difficulty in urination) damp invasion of lower energizer, congestion retardance card extremely, therapeutical effect is preferably arranged.The present invention is according to the Traditional Chinese medical theory prescription, and according to the nature and flavor characteristics of each herbal medicine, extracts its effective ingredient, the preparation of the taking convenience that develops.
The present invention proposes diuretic medicine by medicament: Radix Notoginseng 7-14, Hirudo 3-9, Cornu Naemorhedi powder 2-6, Fructus Psoraleae 3-9, Herba Desmodii Styracifolii 10-25, wear Caulis Akebiae 3-9, Fructus Forsythiae 3-12, Carapax Trionycis 10-30, Rhizoma Atractylodis Macrocephalae 2-8, Radix Cyathulae 3-10 so that following raw material is formed and weight proportion is made.
The preparation technology's method that the present invention proposes diuretic medicine is made up of following steps:
1, get the Rhizoma Atractylodis Macrocephalae, Fructus Forsythiae water vapour distillation volatile oil, volatile oil solution adds the beta-schardinger dextrin-inclusion, separates, and low-temperature vacuum drying is standby;
2, Radix Notoginseng, Fructus Psoraleae are standby with 70% alcohol reflux alcohol extract;
3, incorporate Hirudo, Herba Desmodii Styracifolii, Fructus Forsythiae into after first elder generation water is carried 2 hours, wear Caulis Akebiae, Radix Cyathulae again water carry 3 times, merge the water extract, concentrate, add 70% ethanol precipitation, filter, filtrate merges with the Radix Notoginseng alcohol extract, the recovery ethanol extract, it is standby to be dried to dried cream;
4, dried cream and Cornu Naemorhedi powder, volatile oil inclusion complex mixed powder are broken into fine powder, and the abundant mixing of medicine is made required medicament.
The pharmaceutical dosage form that the present invention proposes is a said peroral dosage form on the pharmaceutics.The pill (watered pill, honeyed pill, condensed water honeyed pill, drop pill) that can be raw material of the present invention make through conventional technology with corresponding excipient substance, tablet, capsule, granule, powder, unguentum, oral liquid etc.
Its consumption is per day for adults 2-6 gram.
The present invention proposes the diuretic medicine prescription and is characterised in that the medicament of being made by following raw material components change: former prescription Radix Notoginseng, Hirudo, Cornu Naemorhedi powder, Fructus Psoraleae, Herba Desmodii Styracifolii, wear Caulis Akebiae, Fructus Forsythiae, Carapax Trionycis, the Rhizoma Atractylodis Macrocephalae, Radix Cyathulae totally 10 flavor components, increase or reduce the medicament that the 1-3 flavor is formed
Pharmacodynamics test of the present invention:
Dredge capsule for urine purgation main pharmacodynamics research catalogue
(concrete testimonial material is waited to mend)
13-1 is to the influence of urogenital sinus implantation mice prostatic hyperplasia
13-2 is to the influence of experimental rat prostatic hyperplasia
13-3 influences the rat diuretic
1, to the influence of water load rat urine amount
2, the influence of Na+, K+, CI-in the water load rat urine
13-4 influences microcirculation of mouse auricle
13-5 is to influence acute, chronic inflammatory reaction
1, the influence of xylol induced mice auricle edema
2, the influence of mice capillary permeability
13-6 is to the influence of mice pain model
1, the influence of acetic acid induced mice pain
2, to the influence of mice hot plate method pain
The specific embodiment 1:
Get 4 parts of the Rhizoma Atractylodis Macrocephalaes, 4 parts of water vapour distillation volatile oil of Fructus Forsythiae by weight ratio, volatile oil solution adds the beta-schardinger dextrin-inclusion, separates, and low-temperature vacuum drying is standby; 9 parts of Radix Notoginseng, 6 parts of Fructus Psoraleaes are standby with the alcohol reflux alcohol extract with 70%; Incorporate into after 22 parts of first water of Carapax Trionycis are carried 2 hours 9 parts of 5 parts of Hirudos, 18 parts of Herba Desmodii Styracifolii, 8 parts of Fructus Forsythiaes, 7 parts of Caulis Clematidis Armandiis, Radix Cyathulae again water carry 3 times, merge the water extract, concentrate, add 70% ethanol precipitation, filter, filtrate and Radix Notoginseng alcohol extract merge, reclaim ethanol extract, it is standby to be dried to dried cream; Dried cream and Cornu Naemorhedi powder, volatile oil inclusion complex mixed powder are broken into fine powder, the abundant mixing of medicine, and above raw material is made granule with corresponding excipient substance through conventional granule technology.
The specific embodiment 2:
Get 7 parts of the Rhizoma Atractylodis Macrocephalaes, 9 parts of water vapour distillation volatile oil of Fructus Forsythiae by weight ratio, volatile oil solution adds the beta-schardinger dextrin-inclusion, separates, and low-temperature vacuum drying is standby; 11 parts of Radix Notoginseng, 8 parts of Fructus Psoraleaes are standby with the alcohol reflux alcohol extract with 70%; Incorporate into after 25 parts of first water of Carapax Trionycis are carried 2 hours 7 parts of 5 parts of Hirudos, 20 parts of Herba Desmodii Styracifolii, 9 parts of Fructus Forsythiaes, 8 parts of Caulis Clematidis Armandiis, Radix Cyathulae again water carry 3 times, merge the water extract, concentrate, add 70% ethanol precipitation, filter, filtrate and Radix Notoginseng alcohol extract merge, reclaim ethanol extract, it is standby to be dried to dried cream; Dried cream and Cornu Naemorhedi powder, volatile oil inclusion complex mixed powder are broken into fine powder, the abundant mixing of medicine, and above raw material is made capsule system with corresponding excipient substance through conventional technology.
The specific embodiment 3:
Get 5 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of water vapour distillation volatile oil of Fructus Forsythiae by weight ratio, volatile oil solution adds the beta-schardinger dextrin-inclusion, separates, and low-temperature vacuum drying is standby; 8 parts of Radix Notoginseng, 7 parts of Fructus Psoraleaes are standby with the alcohol reflux alcohol extract with 70%; Incorporate into after 25 parts of first water of Carapax Trionycis are carried 2 hours 8 parts of 6 parts of Hirudos, 15 parts of Herba Desmodii Styracifolii, 10 parts of Fructus Forsythiaes, 7 parts of Caulis Clematidis Armandiis, Radix Cyathulae again water carry 3 times, merge the water extract, concentrate, add 70% ethanol precipitation, filter, filtrate and Radix Notoginseng alcohol extract merge, reclaim ethanol extract, it is standby to be dried to dried cream; Dried cream and Cornu Naemorhedi powder, volatile oil inclusion complex mixed powder are broken into fine powder, the abundant mixing of medicine, and above raw material is made tablet with corresponding excipient substance through conventional technology.
The specific embodiment 4:
Get 3 parts of the Rhizoma Atractylodis Macrocephalaes, 5 parts of water vapour distillation volatile oil of Fructus Forsythiae by weight ratio, volatile oil solution adds the beta-schardinger dextrin-inclusion, separates, and low-temperature vacuum drying is standby; 13 parts of Radix Notoginseng, 5 parts of Fructus Psoraleaes are standby with the alcohol reflux alcohol extract with 70%; Incorporate into after 17 parts of first water of Carapax Trionycis are carried 2 hours 6 parts of 5 parts of Hirudos, 22 parts of Herba Desmodii Styracifolii, 8 parts of Fructus Forsythiaes, 4 parts of Caulis Clematidis Armandiis, Radix Cyathulae again water carry 3 times, merge the water extract, concentrate, add 70% ethanol precipitation, filter, filtrate and Radix Notoginseng alcohol extract merge, reclaim ethanol extract, it is standby to be dried to dried cream; Dried cream and Cornu Naemorhedi powder, volatile oil inclusion complex mixed powder are broken into fine powder, the abundant mixing of medicine, and above raw material is made pill through conventional pill technology.
Claims (5)
1, the medicament of it is characterized in that is used for prostatitis, benign prostatic hyperplasia (difficulty in urination) according to the described diuretic medicine of claim: Radix Notoginseng 7-14, Hirudo 3-9, Cornu Naemorhedi powder 2-6, Fructus Psoraleae 3-9, Herba Desmodii Styracifolii 10-25, wear Caulis Akebiae 3-9, Fructus Forsythiae 3-12, Carapax Trionycis 10-30, Rhizoma Atractylodis Macrocephalae 2-8, Radix Cyathulae 3-10 by following raw material is formed and weight proportion is made.
2, preparation technology's method of diuretic medicine in accordance with claim is characterized in that being made up of following steps:
(1), get the Rhizoma Atractylodis Macrocephalae, Fructus Forsythiae water vapour distillation volatile oil, volatile oil solution adds the beta-schardinger dextrin-inclusion, separates, low-temperature vacuum drying is standby;
(2), get Radix Notoginseng, Fructus Psoraleae is standby with 70% alcohol reflux alcohol extract;
(3), Carapax Trionycis elder generation water incorporates Hirudo, Herba Desmodii Styracifolii, Fructus Forsythiae into after carrying 2 hours, wear Caulis Akebiae, Radix Cyathulae again water carry 3 times, merge the water extract, concentrate, add 70% ethanol precipitation, filter, filtrate merges with the Radix Notoginseng alcohol extract, the recovery ethanol extract, it is standby to be dried to dried cream;
(4), dried cream and Cornu Naemorhedi powder, volatile oil inclusion complex mixed powder be broken into fine powder, the abundant mixing of medicine is made required medicament.
3, diuretic medicine dosage form in accordance with claim is that said peroral dosage form can be that raw material of the present invention is made through conventional technology with corresponding excipient substance: pill (watered pill, honeyed pill, condensed water honeyed pill, drop pill), tablet, capsule, granule, powder, unguentum, oral liquid etc. on the pharmaceutics.Its consumption is per day for adults 2-6 gram.
4, extraction solvent, the inclusion complex that adopts in the preparation method of diuretic medicine in accordance with claim:
(1), the Rhizoma Atractylodis Macrocephalae, Fructus Forsythiae steam distillation be as solvent extraction volatile oil, adds beta-schardinger dextrin-as the thing inclusion complex;
(2), Radix Notoginseng, Fructus Psoraleae add 70% ethanol and extract as solvent refluxing;
5, diuretic medicine prescription in accordance with claim is characterised in that the medicament of being made by following raw material components change: former prescription Radix Notoginseng, Hirudo, Cornu Naemorhedi powder, Fructus Psoraleae, Herba Desmodii Styracifolii, wear Caulis Akebiae, Fructus Forsythiae, Carapax Trionycis, the Rhizoma Atractylodis Macrocephalae, Radix Cyathulae and increase or reduce 13 medicaments of forming.
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| CN2008100849338A CN101601741B (en) | 2008-03-07 | 2008-03-07 | Diuretic medicine |
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| CN2008100849338A CN101601741B (en) | 2008-03-07 | 2008-03-07 | Diuretic medicine |
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| CN101601741B CN101601741B (en) | 2012-05-30 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102641379A (en) * | 2012-05-09 | 2012-08-22 | 甘肃陇神戎发药业股份有限公司 | Seven-ingredient yang-warming soft capsule preparation and preparing technology thereof |
| CN104027634A (en) * | 2014-05-26 | 2014-09-10 | 烟台瑞智生物医药科技有限公司 | Traditional Chinese medicine for treating bladder damp-heat type retention of urine |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6790464B2 (en) * | 2003-01-16 | 2004-09-14 | Healthaid Enterprise Pte. Ltd. | Herbal compositions for prostate conditions |
| CN100342888C (en) * | 2005-03-14 | 2007-10-17 | 庹元斌 | Chinese medicine preparation for treating prostatic hyperplasia |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102641379A (en) * | 2012-05-09 | 2012-08-22 | 甘肃陇神戎发药业股份有限公司 | Seven-ingredient yang-warming soft capsule preparation and preparing technology thereof |
| CN102641379B (en) * | 2012-05-09 | 2013-11-06 | 甘肃陇神戎发药业股份有限公司 | Seven-ingredient yang-warming soft capsule preparation and preparing technology thereof |
| CN104027634A (en) * | 2014-05-26 | 2014-09-10 | 烟台瑞智生物医药科技有限公司 | Traditional Chinese medicine for treating bladder damp-heat type retention of urine |
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| CN101601741B (en) | 2012-05-30 |
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Inventor after: Liu Yuzhen Inventor after: Liu Molin Inventor after: Liu Senlin Inventor after: Liu Changlin Inventor after: Liu Wenlin Inventor after: Liu Jianguo Inventor after: Liu Guanglin Inventor after: Liu Wulin Inventor after: Liu Wenping Inventor before: Liu Yuzhen Inventor before: Liu Molin Inventor before: Liu Senlin Inventor before: Liu Changlin Inventor before: Liu Wenlin Inventor before: Liu Jianguo Inventor before: Liu Guanglin |
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Free format text: CORRECT: INVENTOR; FROM: LIU YUZHEN LIU MOLIN LIU SENLIN LIU CHANGLIN LIU WENLIN LIU JIANGUO LIU GUANGLIN TO: LIU YUZHEN LIU MOLIN LIU SENLIN LIU CHANGLIN LIU WENLIN LIU JIANGUO LIU GUANGLIN LIU WULIN LIU WENPING |
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Assignee: Sunlon Pharmaceutical Co., Ltd. Assignor: Liu Molin|Liu Yuzhen|Liu Senlin Contract record no.: 2012990000487 Denomination of invention: Diuretic medicine and preparation method thereof Granted publication date: 20120530 License type: Exclusive License Open date: 20091216 Record date: 20120710 |