CN100358548C - Chinese medicine rinsing liquid after nasal endoscope operation - Google Patents

Abstract

The present invention is Chinese medicine rinsing liquid for use after nasal endoscope operation and belongs to the field of Chinese medicine preparation. The Chinese medicine rinsing liquid is prepared with 12 kinds of Chinese medicinal materials, including magnolia flower, cocklebur fruit, dahurian angelica root, asarum herb, Chuanxiong rhizome, etc in certain weight proportion. It has the functions of dispelling wind and heat, promoting blood circulation, relieving swelling, promoting the dispersing function of lung and relieving stasis, and has obvious curative effect, no irritation and no toxic side effect.

Description

Cflush liquid behind the nasal endoscope operation

Technical field:

The present invention relates to a kind of cflush liquid and preparation method thereof that is used for behind the nasal endoscope operation, belong to Chinese medicine preparation and preparation method thereof field.

Background technology:

Nasal endoscope operation is to treat chronic sinusitis, polypous effective method at present.But nasal endoscope operation post processing and treatment are also very important, and appropriate Comprehensive Treatment is the important assurance that obtains satisfactory effect.Select suitable art chamber flushing medicine for use, will help to improve the efficient of cleaning of art chamber and flushing, promote mucosal epitheliumization and functional rehabilitation, the time of desmopyknosis chamber healing.The compound method and the kind of flushing liquor are a lot of at present, but still do not have specific drug.In the past normal saline, injection liquid of gentamicin and dexamethasone injection flush operation chambeies of adopting more, have that the nasal cavity retention time is short, medicinal liquid easily evaporates, nasal cavity is dry and antibiotic application such as long-term hormone, gentamycin easily to shortcomings such as human body have side effects, and still have pathological changes such as more patient's postoperative generation mucosa edema, vesicle, granulation, polyp regeneration and adhesion of nasal cavity after using, cause operative failure.Thereby select suitable medicinal liquid to carry out art chamber flushing, Rhizoma Atractylodis Macrocephalae chamber mucosa is lapsed to process with epithelization shorten and have great importance.

Summary of the invention:

The objective of the invention is at the existing defective of state of the art, by excavating the abundant Chinese medicine resource of motherland, provide a kind of prescription science, curative effect is high and the pure Chinese medicinal preparation that is exclusively used in art chamber flushing behind the nasal endoscope operation that human body is had no side effect and preparation method thereof.

Technical solution of the present invention is: based on China's Chinese medicine to sinusitis, polypous general cognition and modern rhinology to this disease pathogeny and Therapeutic Principle, stop up knot according to the easy pyretic toxicity in art chamber behind the nasal endoscope operation, qi depression to blood stasis, with wind and heat dispersing, removing toxic substances and promoting pus discharge, promoting blood circulation and detumescence, lung qi dispersing is sensible and make laws, select the pure natural Chinese herbal medicine for use, by the theory of Chinese medical science prescription, combine in conjunction with modern advanced technologies method for making.The raw material of Chinese medicine of effective component extracting is made up of following medicine and weight proportion:

Flos Magnoliae 500～2000g, Fructus Xanthii 500～2000g, the Radix Angelicae Dahuricae 500～1500g, Herba Asari 300～750g, Rhizoma Ligustici 500～1500g, Rhizoma Chuanxiong 500～2000g, the Radix Astragali 500～2000g, Flos Lonicerae 500～2000g, Radix Scutellariae 500～2000g, Radix Bupleuri 500～2000g, Radix Saposhnikoviae 500～2000g, Radix Glycyrrhizae 500～1000g.

Raw material of Chinese medicine preferred weight proportioning of the present invention is as follows: Flos Magnoliae 1500g, Fructus Xanthii 1500g, Radix Angelicae Dahuricae 1000g, Herba Asari 750g, Rhizoma Ligustici 1000g, Rhizoma Chuanxiong 1500g, Radix Astragali 1500g, Flos Lonicerae 1500g, Radix Scutellariae 1500g, Radix Bupleuri 1500g, Radix Saposhnikoviae 1500g, Radix Glycyrrhizae 1000g.

Preparation method of the present invention is: said medicine is taken by weighing by the prescription specified weight ratio, remove impurity, add clear water and soaked 1～2 hour.Get Flos Magnoliae, the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Flos Lonicerae, Herba Asari, Radix Scutellariae, Radix Saposhnikoviae and use steam distillation, extract volatile oil, collect distillate.Get that medicinal residues and Fructus Xanthii, Rhizoma Ligustici, the Radix Astragali, Radix Bupleuri and Radix Glycyrrhizae merge after the above-mentioned distillation, decoct with water, decocting liquid is filtered standby for twice.Gained decocting liquid and the distillate that obtains are merged, filter, concentrate, add 95% ethanol precipitation, put 4 ℃ of refrigerator cold-storages and get supernatant liquid filtering after 24 hours, ethanol in the filtrate is removed with distillation under vacuum, get medicinal liquid.The gained medicinal liquid is added the resulting volatile oil of distillation and water for injection to 100000 milliliter, stir evenly, packing 500ml/ bottle, sealing, standby after sterilizing.

Usage and consumption: gave drug irrigation art of the present invention chamber on the 3rd day behind the nasal endoscope operation, with nasal irrigator (Beijing Tongren Hospital's ear,nose ﹠ throat research institute produces) flushing nasal cavity, every side 250ml changed into after continuous 2 weeks 1 time on the 3rd every day 1 time, until full 3 months.

The Fang Xieyu pharmacology analysis: Flos Magnoliae contains volatile oil, and energy dispersing wind and cold, clearing the nasal passage promote the absorption of secretions, and the nasal mucosa blood vessel of contraction and antihistamine effect are arranged, and are particularly useful for diseases such as nasal sinusitis, nasal obstruction, turbid nasal discharge; Fructus Xanthii energy heat clearing and damp drying, eliminating fire and detoxication have inhibitory action to staphylococcus aureus, streptococcus, streptococcus pneumoniae and fungus, energy antiinflammatory, antiallergic, reduction capillary permeability; Herba Asari property and flavor of peppery and warm, aroma are dense, property is apt to away scurry, and the phoenix of dispelling preferably, cold expelling, analgesic effect are arranged; Flos Lonicerae and Radix Angelicae Dahuricae energy dispelling wind dampness, heat-clearing and toxic substances removing, detumescence and apocenosis; Rhizoma Chuanxiong, Rhizoma Ligustici blood-activating and qi-promoting, dispel phoenix dampness removing, reducing swelling and alleviating pain; Radix Saposhnikoviae is hot diffusing up, top wind kind; The effect of Radix Scutellariae is heat clearing and damp drying, lets out lung-fire clearly, and heat clearing away and convergence dual function are arranged; The Radix Astragali has diuresis damp eliminating, consolidating superficial resistance evacuation of pus, promoting pus discharge and tissue regeneration strengthening, human body immunity improving effect and lowers the toxic and side effects of other drug; Radix Glycyrrhizae has QI invigorating and improves the body disease-resistant effect, can strengthen the effect of the Radix Astragali, have the effect of heat-clearing and toxic substances removing, the mitigation property of medicine, coordinating the actions of various ingredients in a prescription concurrently, in recent years some of certificate studies show that in addition, Radix Glycyrrhizae also has the effect of antiinflammatory and antiallergic action, and the mucosa edema in nasal cavity, hole chamber, inflammation, ulcer etc. are all had obvious suppression and impels the effect of its recovery.Radix Bupleuri has airway dysfunction in heat-clearing and toxic substances removing, dispersing the stagnated live-QI to relieve the stagnation of QI, the lifting.Above-mentioned all medicine compatibilities have wind and heat dispersing, removing toxic substances and promoting pus discharge, promoting blood circulation and detumescence, the sensible effect of lung qi dispersing, have antibacterial and the enhance immunity effect.

Indication of the present invention comprises various postoperative nasal endoscopic patients.

Prescription of the present invention also can decoct into decoction, is used for oral medication behind the nasal endoscope operation.

Good effect of the present invention is: can alleviate and even eliminate the swelling of sinunasal mucosa, the obstruction of crust piece after the application, secretions increases and retention, hypertrophy such as vesicle and granulation, former or secondary infection, allergy etc.Recover fibre swing and promote the serous gland secretion, promote epithelization in sinuous cavity.Can improve nose, nasal sinuses ventilation drain, diminish inflammation, impel the pathological state mucosa to recover its normal 26S Proteasome Structure and Function.Because be pure Chinese medicinal preparation, its anti-inflammation detumescence antiallergic, prevent that effects such as dry nasal cavity from can promote mucosa form and fibre function to recover as early as possible, evident in efficacy, life-time service is non-stimulated, have no side effect.

Observation of curative effect: the inventor uses medicine of the present invention to 210 routine sinusitis, nasal polyp patient row postoperative nasal endoscopic flush operation chamber, and the patient adopts normal saline, dexamethasone and gentamycin liquid flush operation chamber behind the matched group 80 routine nasal endoscope operations.Postoperative 3 months is evaluated by the scope nasal sinuses operative effect evaluation criteria that otolaryngology branch of Chinese Medical Association, Chinese hals,Nasen und Ohrenheilkunde magazine editorial board formulate: cure (transference cure, nasal endoscopy Dou Kou is open good, hole chamber mucosal epitheliumization, no purulent secretion); (symptom is obviously improved, and nasal endoscopy sees that mucosa subregion, hole chamber edema, plumpness or granulation tissue form, and have a small amount of purulent secretion) takes a turn for the better; Invalid (doing well,improving, nasal endoscopy see that the adhesion of art chamber, hole stenostomy or locking, polyp form, and have purulent secretion).Medicine group cure rate 71.32% of the present invention as a result, effective percentage 94.17%; Matched group cure rate 52.19%, effective percentage 76.12%, the cure rate of medicine group of the present invention, effective percentage obviously are better than matched group (P＜0.05).

The specific embodiment:

Embodiment 1

Take by weighing Flos Magnoliae 1500g, Fructus Xanthii 1500g, Radix Angelicae Dahuricae 1000g, Herba Asari 750g, Rhizoma Ligustici 1000g, Rhizoma Chuanxiong 1500g, Radix Astragali 1500g, Flos Lonicerae 1500g, Radix Scutellariae 1500g, Radix Bupleuri 1500g, Radix Saposhnikoviae 1500g, Radix Glycyrrhizae 1000g, remove impurity, adding clear water soaked 1～2 hour, get Flos Magnoliae, the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Flos Lonicerae, Herba Asari, Radix Scutellariae and Radix Saposhnikoviae and use steam distillation, extract volatile oil, collect distillate.Get above-mentioned medicinal residues and Fructus Xanthii, Rhizoma Ligustici, the Radix Astragali, Radix Bupleuri and Radix Glycyrrhizae and merge, add 4 times of water gagings and decocted 30 minutes, get supernatant, add 4 times of decoctings again and boiled 30 minutes, get supernatant, collecting decoction filters decocting liquid standby.Gained decocting liquid and the distillate that obtains are merged, filter, concentrate, add 95% ethanol precipitation, put 4 ℃ of refrigerator cold-storages and get supernatant liquid filtering after 24 hours, ethanol in the filtrate is removed with distillation under vacuum, get medicinal liquid.The gained medicinal liquid is added the volatile oil that obtains after the distillation and water for injection to 100000 milliliter, stir evenly, packing 500ml/ bottle, sealing, standby after sterilizing.

Embodiment 2

Take by weighing Flos Magnoliae 2000g, Fructus Xanthii 2000g, Radix Angelicae Dahuricae 1000g, Herba Asari 750g, Rhizoma Ligustici 1000g, Rhizoma Chuanxiong 1500g, Radix Astragali 1500g, Flos Lonicerae 2000g, Radix Scutellariae 1000g, Radix Bupleuri 1000g, Radix Saposhnikoviae 1000g Radix Glycyrrhizae 750g, remove impurity, adding clear water soaked 1～2 hour, get Flos Magnoliae, the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Flos Lonicerae, Herba Asari, Radix Scutellariae and Radix Saposhnikoviae and use steam distillation, extract volatile oil, collect distillate.Get above-mentioned medicinal residues and Fructus Xanthii, Rhizoma Ligustici, the Radix Astragali, Radix Bupleuri and Radix Glycyrrhizae and merge, add 4 times of water gagings and decocted 1.5 hours, get supernatant, add 4 times of decoctings again and boiled 1.5 hours, get supernatant, collecting decoction filters decocting liquid standby.Gained decocting liquid and the distillate that obtains are merged, filter, concentrate, add 95% ethanol precipitation, put 4 ℃ of refrigerator cold-storages and get supernatant liquid filtering after 24 hours, ethanol in the filtrate is removed with distillation under vacuum, get medicinal liquid.The gained medicinal liquid is added the volatile oil that obtains after the distillation and water for injection to 100000 milliliter, stir evenly, packing 500ml/ bottle, sealing, standby behind high temperature sterilize.

Claims (4)

1, cflush liquid behind the nasal endoscope operation is characterized in that the raw material of Chinese medicine composition of effective component extracting is by weight ratio:

Flos Magnoliae 500～2000g, Fructus Xanthii 500～2000g, the Radix Angelicae Dahuricae 500～1500g, Herba Asari 300～750g, Rhizoma Ligustici 500～1500g, Rhizoma Chuanxiong 500～2000g, the Radix Astragali 500～2000g, Flos Lonicerae 500～2000g, Radix Scutellariae 500～2000g, Radix Bupleuri 500～2000g, Radix Saposhnikoviae 500～2000g, Radix Glycyrrhizae 500～1000g.

2, cflush liquid behind the nasal endoscope operation according to claim 1 is characterized in that the weight proportion that above-mentioned raw material of Chinese medicine is formed is: Flos Magnoliae 1500g, Fructus Xanthii 1500g, Radix Angelicae Dahuricae 1000g, Herba Asari 750g, Rhizoma Ligustici 1000g, Rhizoma Chuanxiong 1500g, Radix Astragali 1500g, Flos Lonicerae 1500g, Radix Scutellariae 1500g, Radix Bupleuri 1500g, Radix Saposhnikoviae 1500g, Radix Glycyrrhizae 1000g.

3, the preparation method of cflush liquid behind the nasal endoscope operation according to claim 1 is characterized in that: said medicine is taken by weighing by the prescription predetermined weight, remove impurity, add clear water and soaked 1～2 hour; Get Flos Magnoliae, the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Flos Lonicerae, Herba Asari, Radix Scutellariae, Radix Saposhnikoviae and use steam distillation, extract volatile oil, collect distillate; Get that medicinal residues and Fructus Xanthii, Rhizoma Ligustici, the Radix Astragali, Radix Bupleuri and Radix Glycyrrhizae merge after the above-mentioned distillation, decoct with water, decocting liquid is filtered standby for twice; Gained decocting liquid and the distillate that obtains are merged, filter, concentrate, add 95% ethanol precipitation, put 4 ℃ of refrigerator cold-storages and get supernatant liquid filtering after 24 hours, ethanol in the filtrate is removed with distillation under vacuum, get medicinal liquid; The gained medicinal liquid is added the resulting volatile oil of distillation and water for injection to 100000 milliliter, stir evenly, packing 500ml/ bottle, sealing, standby after sterilizing.

4, cflush liquid behind the nasal endoscope operation according to claim 1 is characterized in that also can being made into oral decoction.