CN101590176B - Chinese medicinal preparation for treating esophagus cancer - Google Patents

Abstract

The invention discloses a Chinese medicinal preparation for treating esophagus cancer. The Chinese medicinal preparation adopts a method of treating both primary and secondary symptoms to strengthen body resistance and eliminate pathogenic factors so as to achieve the aim of treating esophageal cancer by inhibiting the proliferation of cancer cells and the killing cancer cells. The inventor takesancestral secret prescriptions and Chinese traditional medical theories as foundation, and prepares the Chinese medicinal preparation according to the monarch-minister-assistant-guide composition principle and compatibility of Chinese prescriptions. By taking red sage roots, scorpion, toad skin, airpotato yam and nidus vespae as monarch medicines, taking arrowhead leaves, white stiff silkworms, sun euphorbia herbs, house lizards, kiwi roots, walnuts and peperomia dindygulensis as minister medicines, assisting the monarch medicines and the minister medicines with Chinese olive, seaweed, disporum leschenaultianum, gynura bicolor grass and rhizoma bolbostemmae, and taking dried persimmon frost, magnolia officinalis, rhizoma anemarrhenae, hippocampus, cordyceps sinensis and musk as guide medicines, the Chinese medicinal preparation is prepared through scientific compatibility and a preparation process.

Description

A kind of Chinese medicine preparation for the treatment of esophageal carcinoma

Technical field

The present invention relates to the field of Chinese medicines, a kind of specifically Chinese medicine preparation for the treatment of esophageal carcinoma.

Background technology

The epithelium of esophagus dysplasia is precancerous condition.Early symptom: uncomfortable behind the breastbone, burn feeling or pain, food by the time part foreign body sensation or friction sense are arranged, swallowing food sometimes has at a certain position and stagnates or slight sense of obstruction, the hypomere esophageal carcinoma can also cause under the xiphoid-process or epigastric discomfort, singultus, belch.Middle and advanced stage symptom: dysphagia, block, pain, hemorrhage, hoarseness, lose weight and anorexia.Whole latter stage symptom and complication: dyscrasia, dehydration, depletion, mediastinitis, abscess, pneumonia, lethal massive hemorrhage, jaundice, dyspnea, stupor.

The esophageal carcinoma is the malignant tumor that occurs in the epithelium of esophagus tissue, accounts for 2% of all malignant tumor.The whole world has 200,000 people to die from the esophageal carcinoma every year approximately, and China is esophageal carcinoma district occurred frequently, occupies second because of esophageal carcinoma death person is only second to gastric cancer, and age of onset is many more than 40 years old, and the male is more than the women.But send out the patient in recent years below 40 years old growth trend is arranged.The generation of the esophageal carcinoma is relevant with the micronutrient levels in nitrosamine chronic stimulation, inflammation and wound, inherited genetic factors and drinking-water, grain and the vegetable, but definite reason is fuzzy.

The traditional Chinese medical science thinks that the basic of esophageal carcinoma pathogenesis is a little less than the deficiency of YANG QI, and body function descends, the suitable warming YANG and invigorating QI of main strong treatment, and reinforcing body resistance improves body function, so the treatment main formula will embody this Chinese traditional treatment principle.Branch card about the esophageal carcinoma is had nothing in common with each other, and the legislation medication is also different thereupon.But method of treatment always not from depressed liver-energy dispersing and QI regulating, sending down the abnormal ascending QI blood stasis dispelling, blood circulation promoting and blood stasis dispelling, hard masses softening and resolving, the body resistance strengthening and constitution consolidating, promote the production of body fluid moisturize, heat-clearing and toxic substances removing, anticancer analgetic, warming YANG and invigorating QI etc.

Summary of the invention

Technical assignment of the present invention is at the deficiencies in the prior art, and a kind of Chinese medicine preparation for the treatment of esophageal carcinoma is provided, and it adopts the method for the treatment of both the principal and secondary aspects of a disease, and strengthening vital QI to eliminate pathogenic factors reaches the propagation that can suppress cancer cell, and the purpose of the treatment esophageal carcinoma of kill cancer cell.

The technical solution adopted for the present invention to solve the technical problems is:

The present invention is based on secret prescription handed down in the family from generation to generation and traditional Chinese medical science traditional medical theory, forms according to Chinese medicinal formulae monarch, minister, the composing principle compatibility helping, make.With Radix Salviae Miltiorrhizae, Scorpio, Cutis Bufonis, Rhizoma Dioscoreae Bulbiferae, Nidus Vespae is monarch drug, with Folium sagittariae sagittifoliae, Bombyx Batryticatus, Herba Euphorbiae Helioscopiae, Gekko Swinhonis, Radix Actinidiae Chinensis, Semen Juglandis, Herba Peperomiae Dindygulensis is ministerial drug, assistant is with Fructus Canarii, Sargassum, Radix et Rhizoma Dysosmatis, Herba Senecionis nudicaulis, Rhizoma Bolbostematis, messenger drug makes Chinese medicine preparation of the present invention with Mannosum Kaki, Cortex Magnoliae Officinalis, the Rhizoma Anemarrhenae, Hippocampus, Cordyceps and Moschus by science compatibility and preparation technology.

A kind of Chinese medicine preparation for the treatment of esophageal carcinoma of the present invention is to be formed by following raw material of Chinese medicine compatibility:

Radix Salviae Miltiorrhizae 6-12 part, Scorpio 6-12 part, Cutis Bufonis 6-12 part, Rhizoma Dioscoreae Bulbiferae 6-12 part, Nidus Vespae 6-12 part, Folium sagittariae sagittifoliae 4-9 part, Bombyx Batryticatus 4-9 part, Herba Euphorbiae Helioscopiae 4-9 part, Gekko Swinhonis 4-9 part, Radix Actinidiae Chinensis 4-9 part, Semen Juglandis 4-9 part, Herba Peperomiae Dindygulensis 4-9 part, Fructus Canarii 3-8 part, Sargassum 3-8 part, Radix et Rhizoma Dysosmatis 3-8 part, Herba Senecionis nudicaulis 3-8 part, Rhizoma Bolbostematis 3-8 part, Mannosum Kaki 1-5 part, Cortex Magnoliae Officinalis 1-5 part, Rhizoma Anemarrhenae 1-5 part, Hippocampus 1-5 part, Cordyceps 1-5 part, Moschus 1-5 part.

Preparation method:

1, according to formula proportion with described each crude drug decontamination, Scorpio, Cutis Bufonis, Bombyx Batryticatus, Gekko Swinhonis, Hippocampus mixed to dry pulverize to such an extent that the fine powder of 100-120 mesh sieve is standby;

2, according to formula proportion Radix Salviae Miltiorrhizae, Rhizoma Dioscoreae Bulbiferae, Nidus Vespae, Folium sagittariae sagittifoliae, Herba Euphorbiae Helioscopiae, Radix Actinidiae Chinensis, Semen Juglandis, Herba Peperomiae Dindygulensis, Fructus Canarii, Sargassum, Radix et Rhizoma Dysosmatis, Herba Senecionis nudicaulis, Rhizoma Bolbostematis, Mannosum Kaki, Cortex Magnoliae Officinalis, the Rhizoma Anemarrhenae, Cordyceps were immersed in the 450-600 ml water 40-60 minute, decocted 1-2 hour, after the filtrate, medicinal residues add 150-200 milliliter decocting 15 minutes, the filtrate waste, with twice filtrate collecting decoction, be evaporated to thick paste;

3, by formula proportion Moschus is added 1-2 times of water distillation, it is standby to extract Moschus volatile oil;

4, standby fine powder is mixed oven dry with concentrated thick paste and pulverize the back and add standby Moschus volatile oil, mixing, it is encapsulated seal after 72 hours branch.

Usage and dosage: oral, 3 times on the one, one time 4 (1.5g/ grain), and one after each meal, period in a medicine is avoided maror.

A kind of Chinese medicine preparation for the treatment of esophageal carcinoma of the present invention is to be formed by following raw material of Chinese medicine compatibility:

Radix Salviae Miltiorrhizae 8-10 part, Scorpio 8-10 part, Cutis Bufonis 8-10 part, Rhizoma Dioscoreae Bulbiferae 8-10 part, Nidus Vespae 8-10 part, Folium sagittariae sagittifoliae 6-8 part, Bombyx Batryticatus 6-8 part, Herba Euphorbiae Helioscopiae 6-8 part, Gekko Swinhonis 6-8 part, Radix Actinidiae Chinensis 6-8 part, Semen Juglandis 6-8 part, Herba Peperomiae Dindygulensis 6-8 part, Fructus Canarii 4-7 part, Sargassum 4-7 part, Radix et Rhizoma Dysosmatis 4-7 part, Herba Senecionis nudicaulis 4-7 part, Rhizoma Bolbostematis 4-7 part, Mannosum Kaki 2-4 part, Cortex Magnoliae Officinalis 2-4 part, Rhizoma Anemarrhenae 2-4 part, Hippocampus 2-4 part, Cordyceps 2-4 part, Moschus 2-4 part.

A kind of Chinese medicine preparation for the treatment of esophageal carcinoma of the present invention is to be formed by following raw material of Chinese medicine compatibility:

9 parts of Radix Salviae Miltiorrhizaes, 9 parts of Scorpios, 9 parts of Cutis Bufoniss, 9 parts of Rhizoma Dioscoreae Bulbiferaes, 9 parts of Nidus Vespaes, 7 parts of Folium sagittariae sagittifoliaes, 7 parts of Bombyx Batryticatus, 7 parts of Herba Euphorbiae Helioscopiae, 7 parts of Gekko Swinhonis, 7 parts of Radix Actinidiae Chinensiss, 7 parts of Semen Juglandiss, 7 parts of Herba Peperomiae Dindygulensiss, 5 parts of Fructus Canariis, 5 parts of Sargassums, 5 parts of Radix et Rhizoma Dysosmatiss, 5 parts of Herba Senecionis nudicauliss, 5 parts of Rhizoma Bolbostematiss, 3 parts of Mannosum Kakis, 3 parts of Cortex Magnoliae Officinalis, 3 parts of the Rhizoma Anemarrhenaes, hippocampus 3 part, 3 parts of Cordyceps, 3 parts in Moschus.

The medicine pharmacology of the present invention and the property of medicine:

Radix Salviae Miltiorrhizae:

[meridian distribution of property and flavor] hardship is slightly cold; Return, Liver Channel.

[function cures mainly] stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, relieving restlessness clears away heart-fire.Be used for menoxenia, the amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris." book on Chinese herbal medicine justice ": Radix Salviae Miltiorrhizae, what " herbal classic " called is slightly cold, and TAO Hong-Jing has been doubted its mistake, and Miao's secondary alcohol is also doubted it, and stupid to a stone is to transform tepor into." herbal classic ": main trusted subordinate's pathogen, borborygmus are faint as leaking water, and cold and heat gather; Broken disease is removed abdominal mass, ends stuffy sensation with restlessness, QI invigorating." WU Pu Bencao ": control cardiac and abdominal pain." not Lu ": nourish blood, remove trusted subordinate's obstinate disease stagnation of QI, stiffness along the spinal column, foot numbness; Remove wind Xing and stay heat, obey sharp people for a long time.TAO Hong-Jing: the stain beverage it, treat migratory arthralgia." property of medicine opinion ": control flaccidity of the lower limbs, painful numbness, main attacked by pestiferous factors; Control stomachache, gas is done the sound ring and is shouted." Japan hanako materia medica ": the sedate of reposing, tonneau GUAN-pulse.Control cold and hot labor, arthralgia, extremity are unsuccessful; The evacuation of pus pain relieving, granulation promoting is put on flesh; Broken stagnated blood is mended new hemopoietic; Peaceful tire, stillborn fetus falls; Under the hemostasis metrorrhagia and leukorrhagia, transfer married woman's passages through which vital energy circulates irregular, the blood evil thought is tired; Malignant boil scabies, the wart toxic swelling of going to live in the household of one's in-laws on getting married, erysipelas; Headache, acute conjunctivitis, the heat temperature is mad vexed." the southern regions of the Yunnan Province book on Chinese herbal medicine ": reinforcing the heart sedate, calming heart and tranquilizing mind.Control forgetful palpitation with a distress feeling, palpitation with fear is insomnia." detailed outline ": invigorate blood circulation logical percardium.Control colic." choosing of Yunnan Chinese herbal medicine ": promoting blood circulation to remove blood stasis, sedation-analgesia.Control menoxenia, dysmenorrhea, rheumatic arthralgia, metrorrhagia is spitted blood mastitis, carbuncle.

Scorpio:

[meridian distribution of property and flavor] suffering, flat; Poisonous; Return Liver Channel.

[function cures mainly] endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.Be used for infantile convulsion, the tic spasm, middle air port is askew, hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, skin infection, scrofula.

Cutis Bufonis:

[meridian distribution of property and flavor] acrid in the mouth; Cool in nature; Poisonous; GUIXIN; Liver; Spleen; Lung meridian.

[function cures mainly] detoxicating and resolving stagnation of pathogens; The removing food stagnancy diuretic; Destroying parasites for curing malnutrition.Main dysentery cellulitis; Furuncle; Carbuncle on the back; Scrofula; Malignant boil; The lump in the abdomen hypochondriac lump; Expand; Edema; Infantile malnutrition; Tetanus; Chronic cough and asthma.

Rhizoma Dioscoreae Bulbiferae:

[meridian distribution of property and flavor] is bitter, hot, cold; Slightly poisonous.

[function cures mainly] removing toxic substances and promoting subsidence of swelling, dissipating phlegm and resolving masses, cooling blood for hemostasis.Be used for thyromegaly, tuberculous lymphadenitis, laryngopharynx swelling and pain is spitted blood, spitting of blood, pertussis, cancerous protuberance; Furuncle is controlled in external.

Nidus Vespae:

Flat, the mild toxicity of little sweet, the property of [meridian distribution of property and flavor] flavor; Return liver, stomach, kidney channel.

[function cures mainly] wind-expelling pain-stopping; The detumescence of rose poison; Killing parasites for relieving itching.Main air temperature arthralgia pain; The wind carious pain; The carbuncle malignant boil; Scrofula; Mouthpiece swells and ache; Anal fistula; The rubella pruritus; Skin stubborn dermatitis.

Folium sagittariae sagittifoliae:

[meridian distribution of property and flavor] be " Bencao Tujing " 1.: sweet and slightly bitter taste, and cold, nontoxic.2. " Chongqing medical herbs ": (Herb) is pungent, and be slightly poisonous.

[function cures mainly] detumescence, detoxifcation.It is swollen to control skin ulcer, erysipelas, malignant boil.1. " Japan hanako materia medica ": grind deposited snakeworm and sting.2. " Bencao Tujing ": be coated with the swollen children's of reaching of all malignant boil of effect and swim the tumor erysipelas.3. " detailed outline ": transfer Pulvis concha Anodonta seu Cristaria Tu Sao Rush.4. " Chongqing medical herbs ": (Herb) removing toxic substances and promoting subsidence of swelling, control lymphogranuloma inguinale, doublely can control the excrement poison.

Bombyx Batryticatus:

[meridian distribution of property and flavor] is hot salty, and be flat.1. " herbal classic ": salty in the mouth is flat.2. " not Lu ": suffering, flat, nontoxic.3. " property of medicine opinion ": tepor, slightly poisonous.Go into liver, lung, the stomach warp.1. " detailed outline ": the yin, yang of fainting is bright.2. " Thunder God is concocted the property of medicine and is separated ": go into the heart, liver, spleen, lung four warps.Expelling wind to relieve convulsion, dissipating phlegm and resolving masses.

[function cures mainly] controls apoplectic aphasia, infantile convulsion, wind syndrome of head, acute throat trouble.Sore throat, scrofula tuberculosis.Wind skin ulcer urticaria, erysipelas, mastitis.1. " herbal classic ": main pediatric epilepsy scared night cry, go three worms, Mie Hei über, the cloudy infections disease of man.2. " not Lu ": woman's metrorrhagia be red white, puerperal surplus pain, all skin ulcer cicatrixs of going out.It does not seal furuncle and swells, and root ought go out certainly.3. " property of medicine opinion ": control locked mouth, diaphoresis, housewife people's metrorrhagia hematochezia is more than.4. " Japan hanako materia medica ": control apoplectic aphasia, and a wind cutting disease, convulsive seizure induced by terror in children, man's pudendal pruritus pain, woman's leukorrhagia.5. " Bencao Tujing ": control apoplexy, acute inflammation of the throat is smash the sieve smalls, the filling of Rhizoma Zingiberis Recens nature juice accent.6. " medicine origin ": all wind between the peeling skin.7. " detailed outline ": the wind-phlegm tuberculosis of loosing, scrofula, wind syndrome of head, wind worm toothache, skin wind skin ulcer, erysipelas is had an itch, intermittent fever due to phlegm crux, married woman's galactostasis, metrorrhagia hematochezia, children's's infantile malnutrition erosion squama body, all incised wounds, the furuncle wind hemorrhoid that swell.8. " book on Chinese herbal medicine just ": control the erosion of children's's infantile malnutrition, ulcer of gums, congenital deformity of the tongue, swollen and rigid tongue.9. " beautiful Chinese catalpa medicine is separated ": active stimulating the menstrual flow, wind dispelling is opened numbness.Control the headache thoracic obstruction, locked mouth is had a toothache, urticaria wind scabies; Burning is ground the wine clothes, and the stranguria with blood metrorrhagia is controlled on the broken top of the carbuncle of bursting again.

Herba Euphorbiae Helioscopiae:

[meridian distribution of property and flavor] is hot, bitter, is slightly cold; Poisonous.Return lung, small intestinal, large intestine channel.

[function cures mainly] inducing diuresis to remove edema, dissipating phlegm and resolving masses, parasite killing.Be used for edema, cirrhotic ascites, bacillary dysentery; Tuberculous lymphadenitis is controlled in external, tuberculosis fistula, neurodermatitis.And can go out maggot, wriggler.These species are the poisonous plants that include in Chinese Plants spectrum data storehouse, and its toxicity is that Herb is poisonous, and milk swashs effect to the oral mucosa spinosity, as goes into ophthalmic and lose bright danger.Excessive cause stomachache, diarrhoea, vomiting, severe patient dehydration for oral administration.

Gekko Swinhonis:

[meridian distribution of property and flavor] is salty, and be cold.Slightly poisonous.

[function cures mainly] dispels the wind, and be active, eliminating stagnation.Be used for paralysis due to windstroke, rheumatic arthritis, osteomyelitis, tuberculous lymphadenitis, tumor.

Radix Actinidiae Chinensis:

[nature and flavor] " Shaanxi Chinese herbal medicine ": " acid is little sweet, and cold is slightly poisonous.″

[function cures mainly] heat clearing away, diuresis is invigorated blood circulation, detumescence.The treating the liver inflammation, edema, traumatic injury, rheumatic arthritis, stranguria with turbid discharge, leukorrhagia, furuncle, scrofula.1. " Guizhou side's medicine among the people collection ": " diuresis, cathartic.Control ascites; The external synthetism, wound disappears." 2. " Zhejiang medical herbs commonly used among the people ": " is good for the stomach, and invigorates blood circulation lactogenic, antiinflammatory." 3. " Shaanxi Chinese herbal medicine ": " heat-clearing and toxic substances removing, promoting blood circulation and detumescence, anticancer.Control furuncle, scrofula.

Semen Juglandis:

[nature and flavor] sweet, flat temperature, nontoxic.

[return through] goes into lung, kidney, liver.

[effect] kidney-replenishing blood-nourishing, the lung moistening improving inspiration by invigorating kidney-QI, the intestine moistening leukorrhagia stopping, strengthening the tendons and bones, logical profit blood vessels, profit flesh black hair, Gu tooth, tonify deficiency labor.

[curing mainly] Semen Juglandis is controled the inferior burnt deficiency and coldness, a little less than the deficiency of kidney-QI, and frequent micturition, myasthenia of limbs, lumbago and skelalgia, bones and muscles pain, asthenia are breathed heavily and are coughed, woman's metrorrhagia and leukorrhagia, nutcracker can be controlled the cancer of the esophagus, seminal emission, the enuresis.

Herba Peperomiae Dindygulensis:

[effect]: clearing heat and moistening lung, invigorating the spleen and replenishing QI.

[curing mainly]: control carbuncle furuncle, edema, traumatic injury, asthma, tuberculosis.

[meridian distribution of property and flavor]: sweet, suffering, cold.1. " choosing of Yunnan Chinese herbal medicine ": " hot light, flat." 2. " choosing of Simao, Yunnan Chinese herbal medicine ": " cool in nature, lightly seasoned." go into lung, spleen, liver, kidney channel

Fructus Canarii:

[nature and flavor] nature and flavor are flat, sweet in the mouth, acid.

[function cures mainly] heat clearing away, sore-throat relieving promotes the production of body fluid, detoxifcation.Be used for laryngopharynx swelling and pain, cough, excessive thirst, the poisoning of fish Eriocheir sinensis.

Sargassum:

[meridian distribution of property and flavor] is bitter, salty, and be cold.Return liver, stomach, kidney channel.

[function cures mainly] hard masses softening and resolving, expectorant, diuretic.Be used for goiter, scrofula, painful and swollen testis, phlegm retention edema.Shennong's Herbal: " main thin tumor gas, neck is nuclear down, broken eliminating stagnation gas, carbuncle, the hard gas of carcinoma, abdomen is ended ring down, down 12 edema." " Mingyi Bielu ": " treat between skin and gather, sudden and violent bursting stayed gas, accumulation of heat, diuresis " " property of medicine opinion ": " treat the hernia tenesmus, pain, nuclear is swollen." " Treatise on Dietetic Therapy ": " led the cloudy gas of man, often eaten it, the man that the disappears disease of bursting.”

Radix et Rhizoma Dysosmatis:

[meridian distribution of property and flavor] is warm in nature, bitter in the mouth, suffering; Poisonous.

[function cures mainly] heat-clearing and toxic substances removing, dissipating phlegm and resolving masses, eliminating phlegm for diminishing swelling.Be used for carbuncle furuncle, scrofula, laryngopharynx swelling and pain, traumatic injury, venom.

Herba Senecionis nudicaulis:

[nature and flavor]: sweet light cold.

[function cures mainly] 1, exogenous high fever, the heatstroke fever; 2, cough due to lung-heat; 3, treating swelling and pain by traumatic injury.Heat-clearing and toxic substances removing moistens dryness and relieve cough, dissipating blood stasis for subsidence of swelling

Rhizoma Bolbostematis:

[meridian distribution of property and flavor] hardship is slightly cold; Return lung, spleen channel.

[function cures mainly] eliminating stagnation, detumescence, detoxifcation.Be used for acute mastitis, scrofula, mastitis, lymphoid tuberculosis, chronic lymphadenitis, hypertrophic rhinitis.

Mannosum Kaki:

[meridian distribution of property and flavor] is sweet, cold.

[function cures mainly] secretion replenishing and throat moistening, nourishing the lung to arrest cough.Be used for aphtha, throat pain, dry pharynx cough.The energy removing heat-phlegm is moisturized and is promoted the production of body fluid.Be used for lung-heat type cough, expectorant is thick, the dry pharynx laryngalgia, and the xerostomia of quenching one's thirst, and spit blood spitting of blood.

Cortex Magnoliae Officinalis:

[meridian distribution of property and flavor] is bitter, hot, temperature.Return spleen, stomach, lung, large intestine channel.

The expectorant of [function cures mainly] dampness, the therapeutic method to keep the adverse QI flowing downwards is removed full.Be used for the humidity hysteresis damaging the spleen and stomach, the gastral cavity painful abdominal mass is vomited and diarrhoea, stagnation of QI due to dyspepsia, and abdominal distention constipation, phlegm retention is breathed with cough." pharmacological research of Chinese pharmacopoeia Cortex Magnoliae Officinalis: 1. to 2. antiulcer of the influence of gastrointestinal motility: Cortex Magnoliae Officinalis is given birth to product, Rhizoma Zingiberis Recens and is processed product anti-experimental character gastric ulcer (pyloric ligation ulcers, stress type).Antibiotic, antiviral.

The Rhizoma Anemarrhenae:

[meridian distribution of property and flavor] is bitter, sweet, and be cold; Return lung, stomach, kidney channel.

[function cures mainly] clearing away heat-fire promotes the production of body fluid and moisturizes.Be used for fever caused by exogenous pathogenic factors, the hyperpyrexia excessive thirst, lung-heat type cough, osteopyrexia and fever, interior-heat is quenched one's thirst, the dryness of the intestine constipation.1. Shennong's Herbal: main quenching one's thirst pined for, and removes pathogen limbs edema, following water, tonifying for the deficiency, QI invigorating.2. " Mingyi Bielu ": the cold chronic malaria dysphoria with smothery sensation of curing the wound, the side of body is pathogen down, and the disease due to obstruction of QI of middle-JIAO is disliked and the interior subcutaneous ulcer of wind antiperspirant.3. TAO Hong-Jing: very treat accumulation of heat, also main malaria heat is tired.4. " property of medicine opinion ": cure mainly vexed hot-tempered vexedly, the back postpartum debility is produced in the contact of the hot labor of bone, kidney qi labor, and the loathing of cold is deficient, suffers from people's void and xerostomia, adds and uses it.5. " Japan hanako materia medica ": logical small intestinal, the expectorant antitussive, the profit cardiopulmonary, tonify deficiency is weary, and the spasmolytic of feeling at ease is throbbed with fear.6. Zhang Yuansu: the cool heart reduces phlegm and internal heat, and controls positive naked light heat, rushes down bladder kidney channel fire, pyretic headache, the dysentery lumbago is stench in the larynx.7. Wang Haogu: purte the white, kidney nourishing water, control the gate of vitality mutually fire have a surplus.8. Compendium of Material Medica: antiabortive, end restlessness during pregnancy, ward off and penetrate worker's small stream poison.9. " it is former that book on Chinese herbal medicine is asked ": control hemoptysis, breathe heavily, drench, stomatosis, hematuria, contrary, night sweat, seminal emission, numbness flaccidity, clonic convulsion desert.10. " medicine origin ": the Rhizoma Anemarrhenae, the assistant that " curing mainly secret wanting " cloud is made diuresis makes this medicine in the kidney.The higher authorities, tying-in all wine are fried.Scrape unhairing, the Diplopterygium glaucum (Thunb ex Houtt) Nakai person

Hippocampus:

[nature and flavor] Gan Wen.

[function] kidney invigorating and YANG supporting, the eliminating mass abdominal mass.

Diseases such as [curing mainly] impotence due to deficiency of the kidney, difficult labour, lump in the abdomen, furuncle swelling toxin.

Moschus:

[meridian distribution of property and flavor] acrid in the mouth, temperature.GUIXIN, spleen channel.

[function cures mainly] refreshment of having one's ideas straightened out, promoting blood circulation to restore menstrual flow, reducing swelling and alleviating pain.Be used for the calentura coma, the apoplexy syncope due to accumulation of phlegm, stagnation of QI sudden syncope, the attacked by pestiferous factors stupor, amenorrhea ， WEIJIA, the difficult labour stillborn fetus, trusted subordinate's sudden pain, the carbuncle scrofula, laryngopharynx swelling and pain falls and pounces on the pain of injury, the arthralgia pain numbness.

Cordyceps:

[meridian distribution of property and flavor] is sweet, temperature; Go into lung, kidney two warps.

[function cures mainly] tonifying deficiency, beneficial vital essence, relieving cough and resolving phlegm, phlegm retention is breathed heavily and is coughed, and the dyspnea due to deficiency consumptive disease is coughed, spitting of blood, spontaneous sweating, impotence and seminal emission, soreness of waist and knee joint, prolonged deficiency is not multiple after being ill.

The Chinese medicine preparation of treatment esophageal carcinoma of the present invention is compared with prior art, and the beneficial effect that is produced is: the propagation of this Chinese medicine preparation energy anticancer, and broken knot parasite killing, convergence, the energy kill cancer cell disappears the esophagus epithelial cancer cells.

The specific embodiment:

Embodiment 1:

Prescription: Radix Salviae Miltiorrhizae 6g, Scorpio 6g, Cutis Bufonis 6g, Rhizoma Dioscoreae Bulbiferae 6g, Nidus Vespae 6g, Folium sagittariae sagittifoliae 4g, Bombyx Batryticatus 4g, Herba Euphorbiae Helioscopiae 4g, Gekko Swinhonis 4g, Radix Actinidiae Chinensis 4g, Semen Juglandis 4g, Herba Peperomiae Dindygulensis 4g, Fructus Canarii 3g, Sargassum 3g, Radix et Rhizoma Dysosmatis 3g, Herba Senecionis nudicaulis 3g, Rhizoma Bolbostematis 3g, Mannosum Kaki 1g, Cortex Magnoliae Officinalis 1g, Rhizoma Anemarrhenae 1g, Hippocampus 1g, Cordyceps 1g, Moschus 1g.

Preparation method:

1, according to formula proportion with described each crude drug decontamination, Scorpio, Cutis Bufonis, Bombyx Batryticatus, Gekko Swinhonis, Hippocampus mixed to dry pulverize to such an extent that the fine powder of 100-120 mesh sieve is standby;

2, according to formula proportion Radix Salviae Miltiorrhizae, Rhizoma Dioscoreae Bulbiferae, Nidus Vespae, Folium sagittariae sagittifoliae, Herba Euphorbiae Helioscopiae, Radix Actinidiae Chinensis, Semen Juglandis, Herba Peperomiae Dindygulensis, Fructus Canarii, Sargassum, Radix et Rhizoma Dysosmatis, Herba Senecionis nudicaulis, Rhizoma Bolbostematis, Mannosum Kaki, Cortex Magnoliae Officinalis, the Rhizoma Anemarrhenae, Cordyceps were immersed in the 450-600 ml water 40-60 minute, decocted 1-2 hour, after the filtrate, medicinal residues add 150-200 milliliter decocting 15 minutes, the filtrate waste, with twice filtrate collecting decoction, be evaporated to thick paste;

3, by formula proportion Moschus is added 1-2 times of water distillation, it is standby to extract Moschus volatile oil;

4, standby fine powder is mixed oven dry with concentrated thick paste and pulverize the back and add standby Moschus volatile oil, mixing, it is encapsulated seal after 72 hours branch.

Usage and dosage: oral, 3 times on the one, one time 4 (1.5g/ grain), and one after each meal, period in a medicine is avoided maror.

Embodiment 2:

Prescription: Radix Salviae Miltiorrhizae 8g, Scorpio 8g, Cutis Bufonis 8g, Rhizoma Dioscoreae Bulbiferae 8g, Nidus Vespae 8g, Folium sagittariae sagittifoliae 6g, Bombyx Batryticatus 6g, Herba Euphorbiae Helioscopiae 6g, Gekko Swinhonis 6g, Radix Actinidiae Chinensis 6g, Semen Juglandis 6g, Herba Peperomiae Dindygulensis 6g, Fructus Canarii 4g, Sargassum 4g, Radix et Rhizoma Dysosmatis 4g, Herba Senecionis nudicaulis 4g, Rhizoma Bolbostematis 4g, Mannosum Kaki 2g, Cortex Magnoliae Officinalis 2g, Rhizoma Anemarrhenae 2g, Hippocampus 2g, Cordyceps 2g, Moschus 2g.

Preparation method is identical with embodiment 1 with usage and dosage.

Embodiment 3:

Prescription: Radix Salviae Miltiorrhizae 9g, Scorpio 9g, Cutis Bufonis 9g, Rhizoma Dioscoreae Bulbiferae 9g, Nidus Vespae 9g, Folium sagittariae sagittifoliae 7g, Bombyx Batryticatus 7g, Herba Euphorbiae Helioscopiae 7g, Gekko Swinhonis 7g, Radix Actinidiae Chinensis 7g, Semen Juglandis 7g, Herba Peperomiae Dindygulensis 7g, Fructus Canarii 5g, Sargassum 5g, Radix et Rhizoma Dysosmatis 5g, Herba Senecionis nudicaulis 5g, Rhizoma Bolbostematis 5g, Mannosum Kaki 3g, Cortex Magnoliae Officinalis 3g, Rhizoma Anemarrhenae 3g, hippocampus 3 g, 3 parts of Cordyceps, Moschus 3g.

Preparation method is identical with embodiment 1 with usage and dosage.

Embodiment 4:

Prescription: Radix Salviae Miltiorrhizae 10g, Scorpio 10g, Cutis Bufonis 10g, Rhizoma Dioscoreae Bulbiferae 10g, Nidus Vespae 10g, Folium sagittariae sagittifoliae 8g, Bombyx Batryticatus 8g, Herba Euphorbiae Helioscopiae 8g, Gekko Swinhonis 8g, Radix Actinidiae Chinensis 8g, Semen Juglandis 8g, Herba Peperomiae Dindygulensis 8g, Fructus Canarii 7g, Sargassum 7g, Radix et Rhizoma Dysosmatis 7g, Herba Senecionis nudicaulis 7g, Rhizoma Bolbostematis 7g, Mannosum Kaki 4g, Cortex Magnoliae Officinalis 4g, Rhizoma Anemarrhenae 4g, Hippocampus 4g, Cordyceps 4g, Moschus 4g.

Preparation method is identical with embodiment 1 with usage and dosage.

Embodiment 5:

Prescription: Radix Salviae Miltiorrhizae 12g, Scorpio 12g, Cutis Bufonis 12g, Rhizoma Dioscoreae Bulbiferae 12g, Nidus Vespae 12g, Folium sagittariae sagittifoliae 9g, Bombyx Batryticatus 9g, Herba Euphorbiae Helioscopiae 9g, Gekko Swinhonis 9g, Radix Actinidiae Chinensis 9g, Semen Juglandis 9g, Herba Peperomiae Dindygulensis 9g, Fructus Canarii 8g, Sargassum 8g, Radix et Rhizoma Dysosmatis 8g, Herba Senecionis nudicaulis 8g, Rhizoma Bolbostematis 8g, Mannosum Kaki 5g, Cortex Magnoliae Officinalis 5g, Rhizoma Anemarrhenae 5g, Hippocampus 5g, Cordyceps 5g, Moschus 5g.

Preparation method is identical with embodiment 1 with usage and dosage.

The clinical experiment that Chinese medicine preparation of the present invention is waken up with a start below:

The Chinese medicine preparation of treatment esophageal carcinoma of the present invention, its therapeutic effect 1-2 week produce effects can be taken food, and esophagus is had a meal and is easily led to effective percentage 90%, life-saving rate 80% after 30-50 days.

Clinical experiment amounted to for five phases, and the test first phase is finished needs four months the full course of treatment.

It all is the case of making a definite diagnosis through checking that case is selected, and also is the middle and terminal cancer patient simultaneously.

Clinical trial number 1050 people, male 750 people, women 300 people, the oldest 81 years old, minimum 38 years old, 60 years old mean age, total effective rate 90%.

Efficient Time Calculation, effectively, generating 1-2 is that effectively generation 2-5 is a produce effects, recovery from illness, cancerous cell disappears entirely on inspection, and it is normal that every index is recovered, and is recovery from illness.

Model case:

Case 1:

Wei xx, woman, 71 years old, housewife.In April, 2002, because of dysphagia half a year, with tussiculaing, chest and back pain three months and going to a doctor.Once by Beijing Friendship Hospital's diagnosis, obeyed several anti-tumor Chinese medicines, the diet difficulty appearred in the patient in nearly one month, and pain often appears in the left side chest and back.Clinical diagnosis: hypomere cancer in the esophagus, left ligule central type lung tumor, left hilus pulumonis shifts.Take medicine four courses of treatment of medicament of the present invention, consolidate and have a meal now after a course of treatment, can eat and can sleep as ordinary person, and more competent housework in power, continue to strengthen treatment.(in January, 2003 is once at local examination in hospital: esophagus and pulmonary lesion all are effectively controlled)

Case 2:

Korea Spro XX man, 55 years old, to suffer from esophagus and interrupt cancer, symptom be no appetite, has a meal and chokes, lassitude, JIUYUE in 2003 beginning on the 19th takes medicine, and has a meal normally after after two courses of treatment, and the carcinoma disappearance can be gone to work in the fields after 30 days.

Case 3:

Man 65 years old.Begin to occur pharyngeal swelling and ache mid-August calendar year 2001, local hospital does not feel any better by " acute pharyngitis " treatment, and hospital makes pharynx rear wall biopsy and is reported as " T cell lymphoma ".JIUYUE nasopharynx part CT report on the 11st: " pharynx rear wall soft tissue is swollen thick for nasopharynx top rear wall, lateral wall of oropharynx.Meet the malignant lymphoma performance ".October 16 began to take this institute Chinese medicine, and slight illness obviously alleviates, check check after two courses of treatment, and the CT report is shown: the nasopharynx part malignant lymphoma is cured.

Case 4:

Mr. Tian, man, 68 years old.Calendar year 2001, December was made a definite diagnosis the upper esophagus cancer in local hospital, and pathological changes is grown 8 centimetres.Bake electricity and obeyed anticarcinogen, nearly 50 diet difficulties, it is a lot of to tell sticking expectorant, earns a bare living by transfusion entirely.Clothes on January 11st, 2005 medicament of the present invention relatives' incoming call after 30 days: " medication took effect in 10 days, can drink a small amount of gruel, and medication can be eaten noodles, rice in 30 days, and what meal can both have been eaten now, got the medicine after treatment of a course of treatment again." after taking 30 days Chinese medicine again, get well.

Case 5:

Mr. Lu, 65 years old, the patient was because of carrying out property dysphagia, the companion have when swallowing block and pain surplus January, the conscious dysphagia of patient can only influent stream matter and semi-fluid food, the front is burnt and dull pain.After in February, 2006 diagnosis, prepared the special effect Chinese treatment to the ill, taken Chinese medicine after 2 courses of treatment, patient symptom all disappears, and diet is normal.On inspection, the tumor body dwindles more than 90%, does not find tumor development or transfer so far.

Case 6:

Chen, man, 70 years old.Make a definite diagnosis carcinoma of gastric cardia by hospital in January, 2004, made resection operation.Less than having recurred half a year, can only eat a small amount of liquid food, acataposis, the shirtfront back pain is had the hiccups.Medication was fully recovered after 1 course of treatment, and is healthy so far.

Case 7:

Mrs Yuan, 58 years old.The patient is in conscious diet dysphagia of in January, 2005, not treatment in time, and original symptom increases the weight of gradually, and diet all can't be swallowed, and can only drink low amounts of water and earn a bare living, but occur retrosternal pain again subsequently, burn symptom such as sample sensation.Go to a doctor to local tumour hospital, be diagnosed as esophagus stage casing scale cancer, focus is about 7.5cm, can't perform the operation, and symptom increases the weight of gradually, and focus increases to 12cm, and hospital notifies its family members to have no idea to treat.Seek medical advice to Jinan in February, 2007, and the Chinese medicine of taking preparation continuously is after course of treatment, and appetite increases, and is conscious full of physical strength, can be free movable.

Case 8:

Mr. Wang, 50 years old, hospital's fibergastroscopy was made a definite diagnosis the esophageal carcinoma.Be in the visible neoplasm of the right back wall of esophagus apart from 27 centimetres on front tooth, the surface is congested, soak downwards and esophagus around, tube chamber is stiff, the swollen following 4 centimetres of gastroscopes of thing can not pass through.Can drink a small amount of rice water, acataposis.Leave hospital a course of treatment of radiotherapy (40 days), and still acataposis arrives other hospitalize one wheat harvesting period again, and the state of an illness is more and more heavier, does not take even a drop of water in 8 days, drinks some and tells several mouthfuls, earns a bare living by transfusion entirely.The Chinese medicine preparation of the present invention of taking medicine can be drunk the influent stream food in more than 10 day, and complexion takes a turn for the better, after the course of treatment, and rehabilitation.So far healthy.

Case 9:

Mrs Feng, 69 years old people.Made a definite diagnosis hypomere cancer in the esophagus in local tumour hospital in 2007, and left hospital in 45 days in hospitalize, the left clavicle lymph metastasis, the diet difficulty is told sticking expectorant, sticking foam, precedingly uncomfortable in chestly expands, weak.Take medicine two courses of treatment of Chinese herbal medicine, medication took effect in 7 days, told sticking expectorant and reduced, and diet is more smooth than in the past, and spirit takes a turn for the better, take medicine after the Rechecking List result of hospital be: esophageal carcinoma treatment back recovers normal substantially.This year, JIUYUE was followed up a case by regular visits on the 21st, patient body health, and all are normal.

Case 10:

Mr. Li, 45 years old.Esophagus stage casing squamous cell carcinoma is made a definite diagnosis by local tumour hospital, and is uneven apart from front tooth 22-26 centimeters, and mucosa destroys, and luminal stenosis is about 4 centimetres.Shirtfront back pain severity, hospital does not give and makes resection operation.Can only drink milk powder and a small amount of gruel, acataposis.Taken 10 days Chinese medicine in March, 2007, medication took effect in 3 days, and diet increases, pain relief.After taking effect, taken 30 days Chinese medicine again, taken back pain and disappear, diet is normal, leads a happy life.

Claims (3)

1. Chinese medicine preparation for the treatment of esophageal carcinoma, it is characterized in that, be to be formed by following raw material of Chinese medicine compatibility: Radix Salviae Miltiorrhizae 6-12 part, Scorpio 6-12 part, Cutis Bufonis 6-12 part, Rhizoma Dioscoreae Bulbiferae 6-12 part, Nidus Vespae 6-12 part, Folium sagittariae sagittifoliae 4-9 part, Bombyx Batryticatus 4-9 part, Herba Euphorbiae Helioscopiae 4-9 part, Gekko Swinhonis 4-9 part, Radix Actinidiae Chinensis 4-9 part, Semen Juglandis 4-9 part, Herba Peperomiae Dindygulensis 4-9 part, Fructus Canarii 3-8 part, Sargassum 3-8 part, Radix et Rhizoma Dysosmatis 3-8 part, Herba Senecionis nudicaulis 3-8 part, Rhizoma Bolbostematis 3-8 part, Mannosum Kaki 1-5 part, Cortex Magnoliae Officinalis 1-5 part, Rhizoma Anemarrhenae 1-5 part, Hippocampus 1-5 part, Cordyceps 1-5 part, Moschus 1-5 part;

Preparation method:

(1) according to formula proportion with described each crude drug decontamination, Scorpio, Cutis Bufonis, Bombyx Batryticatus, Gekko Swinhonis, Hippocampus mixed to dry pulverize to such an extent that the fine powder of 100-120 mesh sieve is standby;

(2) according to formula proportion Radix Salviae Miltiorrhizae, Rhizoma Dioscoreae Bulbiferae, Nidus Vespae, Folium sagittariae sagittifoliae, Herba Euphorbiae Helioscopiae, Radix Actinidiae Chinensis, Semen Juglandis, Herba Peperomiae Dindygulensis, Fructus Canarii, Sargassum, Radix et Rhizoma Dysosmatis, Herba Senecionis nudicaulis, Rhizoma Bolbostematis, Mannosum Kaki, Cortex Magnoliae Officinalis, the Rhizoma Anemarrhenae, Cordyceps were immersed in the 450-600 ml water 40-60 minute, decocted 1-2 hour, after the filtrate, medicinal residues add 150-200 milliliter decocting 15 minutes, the filtrate waste, with twice filtrate collecting decoction, be evaporated to thick paste;

(3) by formula proportion Moschus is added 1-2 times of water distillation, it is standby to extract Moschus volatile oil;

(4) standby fine powder is mixed oven dry with concentrated thick paste and pulverize the back and add standby Moschus volatile oil, mixing, it is encapsulated seal after 72 hours branch.

2. a kind of Chinese medicine preparation for the treatment of esophageal carcinoma according to claim 1, it is characterized in that, be to be formed by following raw material of Chinese medicine compatibility: Radix Salviae Miltiorrhizae 8-10 part, Scorpio 8-10 part, Cutis Bufonis 8-10 part, Rhizoma Dioscoreae Bulbiferae 8-10 part, Nidus Vespae 8-10 part, Folium sagittariae sagittifoliae 6-8 part, Bombyx Batryticatus 6-8 part, Herba Euphorbiae Helioscopiae 6-8 part, Gekko Swinhonis 6-8 part, Radix Actinidiae Chinensis 6-8 part, Semen Juglandis 6-8 part, Herba Peperomiae Dindygulensis 6-8 part, Fructus Canarii 4-7 part, Sargassum 4-7 part, Radix et Rhizoma Dysosmatis 4-7 part, Herba Senecionis nudicaulis 4-7 part, Rhizoma Bolbostematis 4-7 part, Mannosum Kaki 2-part, Cortex Magnoliae Officinalis 2-4 part, Rhizoma Anemarrhenae 2-4 part, Hippocampus 2-4 part, Cordyceps 2-4 part, Moschus 2-4 part.

3. a kind of Chinese medicine preparation for the treatment of esophageal carcinoma according to claim 1 is so its feature is also being formed by following raw material of Chinese medicine compatibility: 9 parts of Radix Salviae Miltiorrhizaes, 9 parts of Scorpios, 9 parts of Cutis Bufoniss, 9 parts of Rhizoma Dioscoreae Bulbiferaes, 9 parts of Nidus Vespaes, 7 parts of Folium sagittariae sagittifoliaes, 7 parts of Bombyx Batryticatus, 7 parts of Herba Euphorbiae Helioscopiae, 7 parts of Gekko Swinhonis, 7 parts of Radix Actinidiae Chinensiss, 7 parts of Semen Juglandiss, 7 parts of Herba Peperomiae Dindygulensiss, 5 parts of Fructus Canariis, 5 parts of Sargassums, 5 parts of Radix et Rhizoma Dysosmatiss, 5 parts of Herba Senecionis nudicauliss, 5 parts of Rhizoma Bolbostematiss, 3 parts of Mannosum Kakis, 3 parts of Cortex Magnoliae Officinalis, 3 parts of the Rhizoma Anemarrhenaes, hippocampus 3 part, 3 parts of Cordyceps, 3 parts in Moschus.