CN101579381B - Medicinal composition for treating diabetes mellitus - Google Patents
Medicinal composition for treating diabetes mellitus Download PDFInfo
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- CN101579381B CN101579381B CN 200810106788 CN200810106788A CN101579381B CN 101579381 B CN101579381 B CN 101579381B CN 200810106788 CN200810106788 CN 200810106788 CN 200810106788 A CN200810106788 A CN 200810106788A CN 101579381 B CN101579381 B CN 101579381B
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- extract
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- angelicae sinensis
- panacis quinquefolii
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Abstract
The invention discloses a medicinal composition for treating diabetes mellitus, which consists of extracts of red infested rice, Chinese angelica and American ginseng. The extracts are prepared by theprior method, comprise but are not limited to aqueous extract, alcohol extract, macroporous resin column extract by water extraction and alcohol sedimentation or a supercritical extraction method. Th e medicinal composition is added with conventional accessories and made into clinically acceptable medicament formulations according to the prior process. The medicinal composition has remarkable effect of treating the diabetes mellitus and no side effects.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, particularly relate to a kind of pharmaceutical composition of treating diabetes.
Background technology
Diabetes are that a kind of more common endocrine metabolism is sick.Under the fasting situation, normal person's fasting blood glucose level is 3.9～6.4mmol/l.Even after being at table, the highlyest can not surpass 10mmol/l yet.The hormone of blood sugar increasing is had: pancreas hyperglycemia honey, epinephrine, glucocorticoid and growth hormone, insulin then make blood glucose reduce.Both confronted with each other between them, regulated each other again.When blood sugar increasing, will stimulate insulin to discharge; And when blood glucose reduces, can cause that then this parahormone that makes blood sugar increasing discharges, wherein it is especially important epinephrine, glucagon and glucocorticoid.Nerve also plays an important role aspect blood sugar regulation.Will make blood sugar increasing behind the sympathetic activation, the parasympathetic nervous excitement then makes blood glucose reduce.Blood glucose is too high or too low, all can cause disease.Diabetes cause that because of insulin deficit blood glucose is too high exactly.Up to the present treating diabetes does not still have the radical cure method, and the method for treating diabetes at present mainly contains Diet Therapy, OHA and insulin.The quality of diabetes control is related to the health of health, labour force's maintenance, the generation of complication and development and life-span.
Summary of the invention
The object of the invention is to provide a kind of pharmaceutical composition of treating diabetes and preparation method thereof.
Another purpose of the present invention is to provide the new purposes of this pharmaceutical composition extract.
The present invention realizes through following technical scheme:
The crude drug of pharmaceutical composition of the present invention consists of:
Monas cuspurpureus Went extract 1-5 weight portion Radix Angelicae Sinensis extract 3-8 weight portion
Radix Panacis Quinquefolii extract 1-5 weight portion
The crude drug composition of pharmaceutical composition of the present invention is preferably:
Monas cuspurpureus Went extract 3 weight portion Radix Angelicae Sinensis extracts 5 weight portion Radix Panacis Quinquefolii extracts 3 weight portions
The crude drug composition of pharmaceutical composition of the present invention is preferably:
Monas cuspurpureus Went extract 2 weight portion Radix Angelicae Sinensis extracts 7 weight portion Radix Panacis Quinquefolii extracts 4 weight portions
The crude drug composition of pharmaceutical composition of the present invention is preferably:
Monas cuspurpureus Went extract 4 weight portion Radix Angelicae Sinensis extracts 4 weight portion Radix Panacis Quinquefolii extracts 2 weight portions
Extract according to the invention is processed by conventional method, includes but not limited to that water extract, ethanol extract, water extract-alcohol precipitation cross macroporous resin column extract or supercritical extraction.
Said water extraction method includes but not limited to following method:
Get arbitrary medical material in the crude drug of the present invention, decocting boils 1-2 time, adds 4-8 times of water gaging respectively, decocts 1-2 hour at every turn, merges decocting liquid, and concentrate drying must this medical material water extract.Perhaps get arbitrary medical material in the crude drug of the present invention, decocting boils 1-2 time, adds 4-8 times of water gaging respectively, decocts 1-2 hour; Merge decocting liquid, be concentrated into relative density and be 1-1.1, centrifugal, supernatant is crossed macroporous resin column; Washing is abandoned water lotion, the 30-80% ethanol elution; Reclaim ethanol, concentrate drying must this medical material water extract.
Said decoction and alcohol sedimentation technique includes but not limited to following method:
Get arbitrary medical material in the crude drug of the present invention, decocting boils 2-3 time, adds 4-8 times of water gaging respectively; Decocted 1-2 hour, and merged decocting liquid, being concentrated into relative density is 1-1.1; Centrifugal, supernatant added 4-8 times of weight 30-80% ethanol precipitation 24 hours, reclaimed ethanol; Concentrate drying must this medical material water extract-alcohol precipitation extract.
Said water extract-alcohol precipitation is crossed macropore adsorption column method and is included but not limited to following method:
Get arbitrary medical material in the crude drug of the present invention, decocting boils 2-3 time, adds 4-8 times of water gaging respectively, decocts 1-2 hour; Merge decocting liquid, be concentrated into relative density and be 1-1.1, centrifugal, supernatant added 4-8 times of weight 30-80% ethanol precipitation 24 hours; Reclaim ethanol, be concentrated into relative density and be 1-1.1, centrifugal, supernatant is crossed macroporous resin column; The 30-80% ethanol elution reclaims ethanol, and concentrate drying must be crossed macropore adsorption column extract by this medical material water extract-alcohol precipitation.
Said ultra zero boundary extraction includes but not limited to following method:
Get arbitrary medical material in the crude drug of the present invention, supercritical CO
2Extraction adds in the 10-40% crude drug of the present invention arbitrary medical material amount 75-95% ethanol and makes entrainer, and extracting pressure 20-40Mpa, temperature 30-60 ℃, must this medical material supercritical extract.Perhaps get arbitrary medical material in the crude drug of the present invention, behind the supercritical extraction, medicated powder is taken out, decocting boils 1-2 time; Add 6-8 times of water gaging respectively, decocted 0.5-1 hour, merge decocting liquid; Concentrate, add 75-95% ethanol and make and contain the alcohol amount and reach 60-80%, left standstill 12-24 hour; Filter, the filtrating concentrate drying must this medical material supercritical CO
2Extraction water extract-alcohol precipitation extract.
Pharmaceutical composition of the present invention is according to common process; Add conventional adjuvant; Process the dosage form of clinical acceptance, like tablet, capsule, powder, soft capsule, drop pill, honeyed pill, pill, granule, soft extract with bee honey agent, slow releasing preparation, quick releasing formulation, controlled release preparation, oral liquid, lyophilized injectable powder or ejection preparation.
Medicine composite for curing diabetes effect of the present invention significantly and have no side effect.
Following experimental example and embodiment are used to further specify but are not limited to the present invention.
Pharmaceutical composition of the present invention (forming by water extract) reaches more than 96% through clinical treatment diabetes 100 routine patient's total effective rates, and diabetes cases diagnostic criteria and criterion of therapeutical effect press the Ministry of Public Health standard and confirmed, 80 routine produce effects wherein, 16 examples effectively, 4 is routine invalid.(seeing the following form)
| Criterion of therapeutical effect | Produce effects (routine number) | Effectively (routine number) | Invalid (routine number) |
| 100 examples | 80 examples | 16 examples | 4 examples |
| Effective percentage | 80％ | 16％ | 4％ |
Following embodiment all can realize the effect of above-mentioned experimental example.
The specific embodiment
Embodiment 1:
Monas cuspurpureus Went water extract 3kg Radix Angelicae Sinensis water extract 5kg Radix Panacis Quinquefolii water extract 3kg
Said medicine adds conventional adjuvant according to common process and processes capsule.
Embodiment 2:
Monas cuspurpureus Went alcohol extract 2kg Radix Angelicae Sinensis water extract 7kg Radix Panacis Quinquefolii alcohol extract 4kg
Said medicine adds conventional adjuvant according to common process and processes oral liquid.
Embodiment 3:
Monas cuspurpureus Went alcohol extract 4kg angelol extract 4g Radix Panacis Quinquefolii water extract 2kg
Said medicine adds conventional adjuvant according to common process and processes slow releasing tablet.
Embodiment 4:
Monas cuspurpureus Went water extract 2kg angelol extract 3kg Radix Panacis Quinquefolii alcohol extract 2kg
Said medicine adds conventional adjuvant according to common process and processes lyophilized injectable powder.
Embodiment 5:
The Monas cuspurpureus Went water extract-alcohol precipitation is crossed macroporous resin column extract 4kg
The Radix Angelicae Sinensis water extract-alcohol precipitation is crossed macroporous resin column extract 8kg
The Radix Panacis Quinquefolii water extract-alcohol precipitation is crossed macroporous resin column extract 4kg
Said medicine adds conventional adjuvant according to common process and processes injection.
Claims (9)
1. a pharmaceutical composition of treating diabetes is characterized in that the crude drug of said composition consists of: Monas cuspurpureus Went extract 1-5 weight portion, Radix Angelicae Sinensis extract 3-8 weight portion, Radix Panacis Quinquefolii extract 1-5 weight portion; Said extract is processed by water extraction: get arbitrary medical material in Monas cuspurpureus Went, Radix Angelicae Sinensis and the Radix Panacis Quinquefolii, decocting boils 1-2 time, adds 4-8 times of water gaging respectively, decocts 1-2 hour at every turn, merges decocting liquid, and concentrate drying must this medical material water extract.
2. pharmaceutical composition as claimed in claim 1 is characterized in that this pharmaceutical composition crude drug consists of: Monas cuspurpureus Went extract 3 weight portions, Radix Angelicae Sinensis extract 5 weight portions, Radix Panacis Quinquefolii extract 3 weight portions.
3. pharmaceutical composition as claimed in claim 1 is characterized in that this pharmaceutical composition crude drug consists of: Monas cuspurpureus Went extract 2 weight portions, Radix Angelicae Sinensis extract 7 weight portions, Radix Panacis Quinquefolii extract 4 weight portions.
4. pharmaceutical composition as claimed in claim 1 is characterized in that this pharmaceutical composition crude drug consists of: Monas cuspurpureus Went extract 4 weight portions, Radix Angelicae Sinensis extract 4 weight portions, Radix Panacis Quinquefolii extract 2 weight portions.
5. like the described pharmaceutical composition of one of claim 1-4, it is characterized in that said composition, add conventional adjuvant, process the dosage form of clinical acceptance according to common process.
6. pharmaceutical composition as claimed in claim 5 is characterized in that said dosage form is tablet, capsule, powder, pill, granule, soft extract with bee honey agent, oral liquid or ejection preparation.
7. pharmaceutical composition as claimed in claim 5 is characterized in that said dosage form is soft capsule, drop pill, honeyed pill or lyophilized injectable powder.
8. preparation of drug combination method as claimed in claim 6; It is characterized in that this method is: this pharmaceutical composition is according to common process; Add conventional adjuvant, process tablet, capsule, powder, pill, granule, soft extract with bee honey agent, oral liquid or ejection preparation.
9. like the application of the described pharmaceutical composition of one of claim 1-4 in the medicine of preparation treatment diabetes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200810106788 CN101579381B (en) | 2008-05-15 | 2008-05-15 | Medicinal composition for treating diabetes mellitus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200810106788 CN101579381B (en) | 2008-05-15 | 2008-05-15 | Medicinal composition for treating diabetes mellitus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101579381A CN101579381A (en) | 2009-11-18 |
| CN101579381B true CN101579381B (en) | 2012-07-04 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200810106788 Active CN101579381B (en) | 2008-05-15 | 2008-05-15 | Medicinal composition for treating diabetes mellitus |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101579381B (en) |
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2008
- 2008-05-15 CN CN 200810106788 patent/CN101579381B/en active Active
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| Publication number | Publication date |
|---|---|
| CN101579381A (en) | 2009-11-18 |
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