CN101578038B - Water soluble granule of spinosad and its preparation - Google Patents
Water soluble granule of spinosad and its preparation Download PDFInfo
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- CN101578038B CN101578038B CN200880000075.2A CN200880000075A CN101578038B CN 101578038 B CN101578038 B CN 101578038B CN 200880000075 A CN200880000075 A CN 200880000075A CN 101578038 B CN101578038 B CN 101578038B
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- spinosad
- water soluble
- soluble granule
- pleocidin
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/22—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom rings with more than six members
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
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- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
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Abstract
The invention provides a water soluble granule of spinosad. It is made from (by wt%) spinosad 0.5-40%, emulsifier 1-30%, dispersing agent 1-10%, wetting agent 1-5%, binder 2-4%, stabilizer 1-3% and the rest is filling material. The invention comprises no or small toxic and inflammable aromatic hydrocarbon solvent, therefore the risk of burning and exploding during manufacture, storage and transportation can be reduced. Its advantages include no poison and pollution, no unpleasant odor, low eye irritation, higher safety for producers, transporters and users.
Description
Technical field
The present invention relates to a kind of insecticide of novel form, relate in particular to a kind of water dissolvable granula that contains pleocidin and preparation method thereof.
Background technology
Along with the raising of people to environmental protection consciousness; and national governments are to the attention of ecotope, people are increasing to the demand of efficient, the low toxicity, low-residual, free of contamination environment protection biological agricultural chemicals and the chemical pesticide that are applicable to controlling crop diseases and insect pests and nuisanceless need of production.
It is a kind of macrolides Nuisanceless high-efficient biological insecticides that extract in thorn sugared many born of the same parents bacterium (Saccharopolyspora spinosa) zymotic fluid that pleocidin has another name called multiple killing teichomycin (Spinosad).The mode of action novelty of pleocidin, can sustained activation target insect acetylcholine nicotine receptor, but its binding site is different from nicotine and Imidacloprid.Pleocidin also can affect the GABA acceptor, but mechanism of action is unclear.At present also do not know whether with the insecticide of other types, cross tolerance is arranged.These compounds can cause that the target plant-feed insect is as dead rapidly as caterpillar, leaf miner, thrips and leaf-feeding beetle.
The kind of the insecticide that plant protection is used is a lot, and it is that missible oil, suspending agent, wetting powder, pulvis, granula, aqua, poison bait, mother liquor, female powder etc. more than ten are planted formulation that various countries are used maximum formulations at present.As everyone knows, contain a large amount of organic solvents in missible oil, be easy to volatilization catch fire, toxic to human body and plant, contaminated environment, transportation is also inconvenient; Wetting powder has a large amount of dust in producing, using, and contaminated environment affects operating personnel's health.Present stage, the developments of the formulations of pesticide was mainly to advocate exploitation environment-friendly type novel form, as: 1. liquid formulation trend Water-borne modification.Aqueous emulsion (EW), microemulsion (ME), aqueous suspension (SC), water dissolvable liquor (SL) etc. are representative Water-borne modification novel forms, its common feature is to replace a large amount of organic solvents with water, reduce waste and the pollution of solvent, reduce preparation toxicity, improving safety, is the novel form that replaces missible oil.2. solid formulation spheroidizing.By the powderous preparations spheroidizing, avoid dust pollution, being convenient to packing is also the direction of dosage form research.Water-dispersible granules (WDG) is representative granular dose.This formulation, outward appearance is graininess, drops into disintegration dispersion rapidly in water during use, forms the dispersion of higher suspension, in order to spraying, uses.Formulation content and suspensibility all substantially exceed wetting powder, good fluidity, and no dust pollution, packing, storing conveniently, are the novel forms that integrates the advantage of wetting powder, suspension emulsion, granule.But these formulations all do not have both advantages are combined, embody simultaneously.
Summary of the invention
Purpose of the present invention is exactly the shortcoming existed in order to overcome above-mentioned prior art, provide a kind of and replace a large amount of organic solvents with water, reduce waste and the pollution of solvent, reduce preparation toxicity, improve safety, outward appearance is graininess, drops into water dissolvable granula (WSG) that contains pleocidin that in water, disintegration disperses rapidly and preparation method thereof during use.
For solving the problems of the technologies described above, the present invention is achieved through the following technical solutions:
A kind of water soluble granule of spinosad, mainly by the material of following percentage by weight, made:
Pleocidin: 0.5～40%;
Emulsifier: 1～30%;
Dispersant: 1～10%;
Wetting agent: 1～5%;
Binding agent: 2～4%;
Stabilizing agent: 1～3%;
Surplus is filler.
Water soluble granule of spinosad of the present invention, wherein said emulsifier is selected from one or both mixtures in castor oil ethylene oxide adduct, alkylphenol polyoxyethylene, Ben-zylphenol Polyoxyethyl Ether and analog, phenethyl phenol polyethenoxy ether or fatty alcohol-polyoxyethylene ether and analog.
Described alkylphenol polyoxyethylene can be polyoxyethylene nonylphenol ether, OPEO etc.; Described Ben-zylphenol Polyoxyethyl Ether and analog can be Ben-zylphenol Polyoxyethyl Ether, benzyl alkylphenol polyoxyethylene etc.; Described fatty alcohol-polyoxyethylene ether and analog can be for take the products C that laruyl alcohol is principal component
nh
2n+1o (EO)
mh, n=12～16 wherein, m=15～30.
Water soluble granule of spinosad of the present invention, wherein said dispersant is selected from alkylnaphthalene sulfonate, two naphthalenesulfonate formaldehyde condensation compound or sodium lignin sulfonate.
Described alkylnaphthalene sulfonate can be for Nekal BX, pull open powder AC etc.; Described pair of naphthalenesulfonate formaldehyde condensation compound can be dispersant N, dispersant NNO etc.
Water soluble granule of spinosad of the present invention, wherein said wetting agent is selected from one or both mixtures in alkylbenzenesulfonate, fatty acid amide N-metilsulfate, alkylaryl polyoxyethylene ether sulfate.
Water soluble granule of spinosad of the present invention, wherein said binding agent is selected from one or both mixtures in beta-schardinger dextrin-, polyvinyl alcohol, methylcellulose.
Water soluble granule of spinosad of the present invention, wherein said stabilizing agent is selected from a kind of in borax, Sodium Benzoate.
Water soluble granule of spinosad of the present invention, wherein said filler is selected from one or both mixtures in bicarbonate, anhydrous citric acid, maltose, anhydrous sodium sulfate.
The preparation method of water soluble granule of spinosad of the present invention is: described material is proportionally carried out to homogeneous, kneading and extruder grain, and 65～75 ℃ of lower vacuum dryings were sieved after 1～2 hour, and the product sieved is packed after testing afterwards; The product that the product of not crossing sieve is not crossed sieve repeats above step.
Its concrete preparation method comprises the following steps:
1. homogeneous: the former medicine of pleocidin and binding agent, wetting agent are mixed in 50～60 ℃ of water, in 420～450 kilograms per centimeter
2stir homogeneous under high pressure;
2. the aforesaid liquid mixture after homogeneous is carried out to atomized drying, make compound female medicine;
3. mediate: by after the emulsifier heat of solution, with dispersant, stabilizing agent, filler and compound female medicine heat at 45～50 ℃ of temperature, mix, then in 4～6 kilograms per centimeter
2stir under pressure, mediate evenly, the group's of obtaining agent;
4. extruder grain: will roll into a ball agent in 6～12 kilograms per centimeter
2extrude into cylindrical particle under pressure;
5. cylindrical particle is sieved to shaping 70 ℃ of lower vacuum dryings after 1 hour.
Water dissolvable granula of the present invention meets and replaces organic solvent, medicine shape solid particle or tableted, agricultural chemicals high-load and four requirements of functionalization such as dimethylbenzene, methyl alcohol, toluene with aqueous solvent in current Agrochemicals trend, wherein the former medicine effect of the embedding of binding agent and stabilizing agent stablizes and antioxidation, the anti-width of former medicine is penetrated with the illumination ability and improved, extended the quality guarantee period of medicament phase; Bicarbonate in filler and citric acid, can play the effect of effervescent agent, promotes granula to dissolve.Water dissolvable granula of the present invention can be dissolved fast in water, dispersion rate is high, without floating and sinkage, have with water and replace a large amount of organic solvents, reduce waste and the pollution of solvent, reduce preparation toxicity, improve safety, outward appearance is graininess, drops into disintegration dispersion rapidly in water during use, transportation and keeping are convenient, the characteristics of long shelf-life, and its preparation method is simple, be easy to operate and control.
The present invention compares with existing main flow insecticide formulation, does not contain or only contains poisonous, inflammable on a small quantity aromatic hydrocarbon solvent, thereby can avoid the inflammable and explosive phenomenon in the producing and casting process.This formulation does not have unpleasant poisonous smell, little to eye irritation, has reduced the pollution to environment, has greatly improved the safety to production, storing and user.Therefore after forming industrialization, not only economic benefit is obvious, and is conducive to promote the development of high-new environment friendly agricultural technology, to promoting environmental protection, has obvious social benefit, is the research direction of sustainable development.
Embodiment
Below in conjunction with embodiment, the invention will be further described:
Embodiment 1
The preparation process of water soluble granule of spinosad:
1. get the raw materials ready: by following formula, be ready to raw material:
Pleocidin: 0.5%;
Castor oil ethylene oxide adduct: 5%;
Neopelex: 4%;
Beta-schardinger dextrin-: 1.5%;
Dispersant NNO:4%;
Sodium Benzoate: 1%;
Sodium bicarbonate: 44%;
Anhydrous citric acid: 40%;
2. the former medicine of pleocidin and beta-schardinger dextrin-, neopelex are mixed in 55 ℃ of water, in 420 kilograms per centimeter
2stir homogeneous under high pressure, the aforesaid liquid mixture after homogeneous is carried out to atomized drying, make compound female medicine;
3. by after the heat of solution of castor oil ethylene oxide adduct, with dispersant NNO, Sodium Benzoate, sodium bicarbonate, anhydrous citric acid and compound female medicine heat at 45 ℃ of temperature, mix, then in 6 kilograms per centimeter
2stir under pressure, mediate evenly, the group's of obtaining agent;
4. will roll into a ball agent in 8 kilograms per centimeter
2extrude into cylindrical particle under pressure;
5. cylindrical particle is sieved after 1 hour 70 ℃ of lower vacuum dryings, the product sieved is packed after testing afterwards; The product of not crossing sieve repeats above process again by detecting qualified packing.
By above preparation, every mu is used 400g, to cotton bollworm, every mu of use 250g, Cruciferous Vegetable Pests diamond-back moth, every mu of use 390g are prevented and treated to test to joint melon thrips, and preventive effect is good, and control efficiency is in Table 1:
Table 1
Embodiment 2
Preparation process is with embodiment 1, and raw materials used formula is:
Pleocidin: 10%;
Polyoxyethylene nonylphenol ether: 11%;
Ben-zylphenol Polyoxyethyl Ether: 1%;
Sodium lignin sulfonate: 3%;
Fatty acid amide N-metilsulfate: 4%;
Methylcellulose: 2%;
Sodium Benzoate: 1%;
Maltose: 30%;
Anhydrous citric acid: 38%.
Use 21g, to cotton bollworm, every mu of use 11g, Cruciferous Vegetable Pests diamond-back moth, every mu of use 20g are prevented and treated to test to joint melon thrips in every mu, this preparation, preventive effect is good, and control efficiency is in Table 2:
Table 2
Embodiment 3
Preparation process is with embodiment 1, and raw materials used formula is:
Pleocidin: 25%;
Phenethyl phenol polyethenoxy ether: 9%;
Fatty alcohol-polyoxyethylene ether: 2%;
Nekal BX: 1%;
Pull open powder AC:2%;
Dodecyl sodium naphthalene sulfonate: 4%;
Beta-schardinger dextrin-: 2%;
Borax: 1%;
Anhydrous sodium sulfate: 28%;
Anhydrous citric acid: 26%.
By this preparation, every mu is used 8.5g, to cotton bollworm, every mu of use 4.6g, Cruciferous Vegetable Pests diamond-back moth, every mu of use 8g are prevented and treated to test to joint melon thrips, and preventive effect is good, and control efficiency is in Table 3:
Table 3
Embodiment 4
Preparation process is with embodiment 1, and formula used is:
Pleocidin: 40%;
Phenethyl phenol polyethenoxy ether: 9%;
Fatty alcohol-polyoxyethylene ether: 2%;
Dispersant N:3%;
Alkylaryl polyoxyethylene ether sulfate: 4%;
Polyvinyl alcohol: 2%;
Borax: 1%;
Anhydrous sodium sulfate: 20%;
Anhydrous citric acid: 19%.
Use 5g, to cotton bollworm, every mu of use 3g, Cruciferous Vegetable Pests diamond-back moth, every mu of use 4.8g are prevented and treated to test to joint melon thrips in every mu, this preparation, preventive effect is good, and control efficiency is in Table 4:
Table 4
Industrial applicibility
The present invention compares with existing main flow insecticide formulation, does not contain or only contains poisonous, inflammable on a small quantity aromatic hydrocarbon solvent, thereby can avoid the inflammable and explosive phenomenon in the producing and casting process.This formulation does not have unpleasant poisonous smell, little to eye irritation, has reduced the pollution to environment, has greatly improved the safety to production, storing and user.Therefore after forming industrialization, not only economic benefit is obvious, and is conducive to promote the development of high-new environment friendly agricultural technology, to promoting environmental protection, has obvious social benefit, is the research direction of sustainable development.
Explanation to application documents: unless otherwise indicated, the percentage related in present specification all is weight percentage.
Claims (4)
1. a water soluble granule of spinosad, it is characterized in that: the material by following percentage by weight is made:
Pleocidin: 0.5%;
Castor oil ethylene oxide adduct: 5%;
Neopelex: 4%;
Beta-schardinger dextrin-: 1.5%;
Dispersant NNO:4%;
Sodium Benzoate: 1%;
Sodium bicarbonate: 44%;
Anhydrous citric acid: 40%.
2. a water soluble granule of spinosad, it is characterized in that: the material by following percentage by weight is made:
Pleocidin: 10%;
Polyoxyethylene nonylphenol ether: 11%;
Ben-zylphenol Polyoxyethyl Ether: 1%;
Sodium lignin sulfonate: 3%;
Fatty acid amide N-metilsulfate: 4%;
Methylcellulose: 2%;
Sodium Benzoate: 1%;
Maltose: 30%;
Anhydrous citric acid: 38%.
3. a water soluble granule of spinosad, it is characterized in that: the material by following percentage by weight is made:
Pleocidin: 40%;
Phenethyl phenol polyethenoxy ether: 9%;
Fatty alcohol-polyoxyethylene ether: 2%;
Dispersant N:3%;
Alkylaryl polyoxyethylene ether sulfate: 4%;
Polyvinyl alcohol: 2%;
Borax: 1%;
Anhydrous sodium sulfate: 20%;
Anhydrous citric acid: 19%.
4. the preparation method of the described water soluble granule of spinosad of claim 1-3 any one, it is characterized in that: described material is proportionally carried out to homogeneous, kneading and extruder grain, 65～75 ℃ of lower vacuum dryings were sieved after 1～2 hour, and the product sieved is packed after testing afterwards; The product of not crossing sieve repeats above step.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2008/070065 WO2009086741A1 (en) | 2008-01-09 | 2008-01-09 | Water soluble granule of spinosad and its preparation |
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| Publication Number | Publication Date |
|---|---|
| CN101578038A CN101578038A (en) | 2009-11-11 |
| CN101578038B true CN101578038B (en) | 2013-12-18 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN200880000075.2A Active CN101578038B (en) | 2008-01-09 | 2008-01-09 | Water soluble granule of spinosad and its preparation |
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| WO (1) | WO2009086741A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106614756A (en) * | 2016-12-20 | 2017-05-10 | 陕西麦可罗生物科技有限公司 | Preparation method of nikkomycin soluble granules |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101803605B (en) * | 2010-04-20 | 2013-03-27 | 北京燕化永乐农药有限公司 | Insecticidal composition of butene-fipronil and spinosad |
| CN101889571B (en) * | 2010-07-08 | 2013-02-13 | 河北益海安格诺农化有限公司 | Spinosad soluble agent and preparation method thereof |
| CN102027926A (en) * | 2011-01-06 | 2011-04-27 | 北京燕化永乐农药有限公司 | Pesticidal composition of ethiprole and spinosad |
| CN103975918B (en) * | 2014-06-11 | 2016-08-24 | 联保作物科技有限公司 | A kind of Nitenpyram soluble granula and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1775027A (en) * | 2005-11-21 | 2006-05-24 | 河北威远生物化工股份有限公司 | Disinsection soluble granules containing methylamino avermection benzoate |
| CN101073324A (en) * | 2006-05-15 | 2007-11-21 | 中国科学院生态环境研究中心 | Synergistic insect-killing composition |
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- 2008-01-09 WO PCT/CN2008/070065 patent/WO2009086741A1/en active Application Filing
- 2008-01-09 CN CN200880000075.2A patent/CN101578038B/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106614756A (en) * | 2016-12-20 | 2017-05-10 | 陕西麦可罗生物科技有限公司 | Preparation method of nikkomycin soluble granules |
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| Publication number | Publication date |
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| WO2009086741A1 (en) | 2009-07-16 |
| CN101578038A (en) | 2009-11-11 |
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