CN101574413B - Traditional Chinese medicine preparation for curing rheumatoid arthritis and preparation method thereof - Google Patents
Traditional Chinese medicine preparation for curing rheumatoid arthritis and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to a traditional Chinese medicine (TCM) preparation and a preparation method thereof, in particular to a TCM preparation for curing rheumatoid arthritis and a preparation method thereof. The technical scheme of the invention is as follows: the TCM preparation comprises the following components by weight percentage: 0.60% to 1.20% of artificial musk, 45.3% to 49.6% of processed monkshood, 16.7% to 21.3% of raw earthworm, 12.4% to 18.6% of raw scorpion, 5.8% to 9.4% of raw black bean and 8.9% to 13.2% of starch. The invention has the following characteristics: (1) the whole formula is appropriately compatible with the disease mechanism of rheumatoid arthritis, the formula is reasonable and well-ordered, the effect of the TCM preparation is deep-going and long-lasting, and the effect is concentrated and the formula is simple; (2) the TCM preparation has obvious effects of resisting inflammation, killing pain and diminishing swelling; (3) the TCM preparation has the multi-link and multi-target therapeutic effects of regulating hormone and sex hormone levels; (4) the TCM has the effects of immune regulation and repairing; and (5) By combining the plastic preparation method with the dense preparation method, the unique preparation method ensures that the musk cannot volatilize, thereby maintaining the effect of the TCM preparation.
Description
Technical field:
The present invention relates to a kind of Chinese medicine preparation and preparation method thereof, particularly treat rheumatoid arthritis Chinese medicine preparation and preparation method.
Background technology:
Motherland's medical science control rheumatism is with a long history, and the successive dynasties have accumulated rich experiences.At present, having developed some is the main compound preparation of forming by single medicinal material such as Radix Tripterygii Wilfordii, Tripterygium hypoglaucum with by medicines such as Radix Angelicae Sinensis, Herba Epimedii, Scorpio, Scolopendra, Nidus Vespae, Eupolyphaga Seu Steleophaga and Caulis Sinomenii, Radix Aconiti Lateralis Preparata, Cornu Cervi Pantotrichum, the Radix Astragali and Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Olibanum (processed), Myrrha (processed), Semen Strychni (processed), Huai Radix Rehmanniae, and control has obtained better effect to rheumatism.But the side effect of said medicine is more, as infringement reproductive system function, causes that endocrine dysfunction and stimulating gastrointestinal mucosa cause nausea, vomiting, stomachache, gastrointestinal side effects such as diarrhoea can cause hepatic injury, make Glutamate pyruvate transaminase rises in the blood, suppress bone marrow hematogenesis, make leukocyte, thrombocytopenia, body is easily infected, aplastic anemia be can bring out when serious, heart damage, skin pruritus anaphylaxis and xerostomia, constipation etc. such as arrhythmia also can be occurred.
Summary of the invention:
The object of the invention provides a kind of treatment rheumatoid arthritis Chinese medicine preparation and preparation method, reduces untoward reaction, the curative effect height, and non-evident effect solves the problems referred to above that background technology exists.
The present invention seeks to realize by following technical scheme:
Treatment rheumatoid arthritis Chinese medicine preparation comprises artificial Moschus, Radix Aconiti Preparata, Pheretima, Scorpio, gives birth to Semen sojae atricolor, starch, and the percentage by weight of each component is: artificial Moschus 0.60%--1.20%, Radix Aconiti Preparata 45.3%--49.6%, Pheretima 16.7%--21.3%, Scorpio 12.4%--18.6%, living Semen sojae atricolor 5.8%--9.4%, starch 8.9%--13.2%.
The preparation method of treatment rheumatoid arthritis Chinese medicine preparation comprises following steps:
1. it is standby to choose a component by weight percentage, artificial Moschus 0.60%--1.20%, Radix Aconiti Preparata 45.3%--49.6%, Pheretima 16.7%--21.3%, Scorpio 12.4%--18.6%, living Semen sojae atricolor 5.8%--9.4%, starch 8.9%--13.2%;
2. Radix Aconiti Preparata, Pheretima, Scorpio, living Semen sojae atricolor are removed impurity, and cleaning, drying are pulverized, and cross the 80--120 mesh sieve;
3. with Radix Aconiti Preparata powder, Pheretima powder, Scorpio powder, living Semen sojae atricolor powder and starch, put abundant stirring, mix homogeneously in the blender, be called medicated powder;
4. the artificial Moschus is added in the yellow wine, stir, it is fully dissolved, make and contain artificial Moschus 1.48%--2.9% solution, be called the yellow wine that contains Moschus, standby;
5. get the 60%--80% of the sufficient medicated powder total amount of aforementioned mixing, add the yellow wine that contains Moschus, medicated powder is 2: 1 with the weight ratio that contains the yellow wine of Moschus, puts abundant stirring, mix homogeneously in the blender;
Pill
Make wet ball with moulding method for making; To mould the wet ball that method for making is made, adopt general method for making to make wetter ball, put 60--65 ℃ of oven dry promptly with remaining 20%--40% medicated powder.
Moulding method for making and general method for making all is known, the public preparation method of important preparing technical field.
The characteristics of each component and effect are as follows among the present invention:
1, Moschus: hot, warm, the refreshment of having one's ideas straightened out, promoting blood circulation to restore menstrual flow, reducing swelling and alleviating pain is used for injury from falling down, arthralgia pain numbness etc.
2, Radix Aconiti Preparata: suffering, hardship, heat; Very toxic.Expelling wind and removing dampness, antalgic.Be used for anemofrigid-damp arthralgia, arthralgia, trusted subordinate's cold type of pain, colic of cold type is had a pain, narcotic analgesic.
3, Pheretima: salty, cold.The heat clearing away arresting convulsion, collateral dredging is relievingd asthma, and diuresis is used for arthralgia, numb limbs and tense tendons, hemiplegia etc.
4, Scorpio: suffering, flat; Poisonous.Endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.Be used to the spasm of twitching, hemiplegia, rheumatoid arthritis stubborn etc.
5, give birth to Semen sojae atricolor: sweet, flat.Strengthening spleen, tonifying kidney, detumescencing diuresis, the detoxifcation of dispeling the wind.Be used for spleen-kidney vacuity cold, edema distension, migratory arthralgia clonic spasm of the muscle, cushion poisoning etc.
6, starch: adjuvant.
Adopt the pill of preparation method preparation of the present invention can be called Moschus oolong ball.Its side separates with function and cures mainly:
The hot temperature of Moschus has the promoting the circulation of blood collateral dredging, reducing swelling and alleviating pain, and about 12 warps that can pass through, interior deep marrow, outer thorough fur, the logical merit that opens and closes the resistance channel tunnel is as monarch drug; Be aided with the Radix Aconiti warming YANG to expel cold, dispeling the wind by wetting is minister; Pheretima is apt to the meridian dredging, can draw the through part that wind-cold damp pathogen is tied of Radix Aconiti; The pain relieving of Scorpio relieving spasm by calming endogenous wind, and 5 search to pick and scurry mutually with Pheretima, the wind-cold damp pathogen that penetrates with meridians, muscles and bones, muscle is searched picked, be adjuvant drug altogether: the Semen sojae atricolor tonifying speen and tonifying kidney, the effect of dispelling the wind and dampness pathogens arthralgia pain is arranged, and separate the poison of all medicines, think messenger drug; Full side cooperates appropriate severe and migratory arthralgia pathogenesis, forms reasonable orderly, medicine letter and power is special.
Function cures mainly: dispelling cold by warming the meridian, relaxing muscles and tendons and activating QI and blood in the collateral, promoting the circulation of blood blood stasis dispelling, reducing swelling and alleviating pain.Be used for the severe and migratory arthralgia of wind and cold due to wet, the muscle bones and muscles pain, the contracture of muscle arteries and veins, the arthroncus deformity, song is stretched unfavorable; Fracture soft tissue contusion, swelling and pain due to blood stasis, hemiplegia etc.
Chinese medicine preparation of the present invention meets the etiology and pathogenesis theory of the traditional Chinese medical science to rheumatoid arthritis, also meet the understanding of modern medicine to this disease, this medical instrument has good modern pharmacology basis, test in clinical, compare with existing Chinese patent medicine, effective in cure height, advantages such as non-evident effect have powerful pain-stopping, fast detumescence, prevent joint deformity, recover the effect of function of joint.Improve early stage cure rate, control develops mid-term, improves the good action of symptom in late period.
The present invention has following characteristics: 1. full side cooperates appropriate rheumatoid arthritis pathogenesis, and prescription is reasonable, and drug effect is deeply lasting in order, medicine letter and power is special.2. tangible antiinflammatory, analgesia, detumescence effect are arranged.3. have the hormone of adjusting, sex hormone level, too many levels, many target spots play therapeutical effect.4. has the immunomodulating repair.5., mould method for making and general method for making combines, distinctive preparation method guarantees that Moschus is non-volatile, keeps drug effect.6. the present invention has obtained ideal therapeutic effect by the choose reasonable to medicine components, proportioning, has both met the requirement of state-promulgated pharmacopoeia to relevant drug dose, can guarantee excellent curative, non-evident effect again.
The specific embodiment:
Below in conjunction with embodiment, further specify the present invention.
In an embodiment, treatment rheumatoid arthritis Chinese medicine preparation comprises artificial Moschus, Radix Aconiti Preparata, Pheretima, Scorpio, gives birth to Semen sojae atricolor, starch, and the percentage by weight of each component is: artificial Moschus 0.60%--1.20%, Radix Aconiti Preparata 45.3%--49.6%, Pheretima 16.7%--21.3%, Scorpio 12.4%--18.6%, living Semen sojae atricolor 5.8%--9.4%, starch 8.9%--13.2%.
The preparation method of treatment rheumatoid arthritis Chinese medicine preparation:
1. it is standby to choose a component by weight percentage, artificial Moschus 0.60%--1.20%, Radix Aconiti Preparata 45.3%--49.6%, Pheretima 16.7%--21.3%, Scorpio 12.4%--18.6%, living Semen sojae atricolor 5.8%--9.4%, starch 8.9%--13.2%;
2. Radix Aconiti Preparata, Pheretima, Scorpio, living Semen sojae atricolor are removed impurity, and cleaning, drying are pulverized, and cross the 80--120 mesh sieve;
3. with Radix Aconiti Preparata powder, Pheretima powder, Scorpio powder, living Semen sojae atricolor powder and starch, put abundant stirring, mix homogeneously in the blender, be called medicated powder;
4. the artificial Moschus is added in the yellow wine, stir, it is fully dissolved, make and contain artificial Moschus 1.48%--2.9% solution, be called the yellow wine that contains Moschus, standby;
5. get the 60%--80% of the sufficient medicated powder total amount of aforementioned mixing, add the yellow wine that contains Moschus, medicated powder is 2: 1 with the weight ratio that contains the yellow wine of Moschus, puts abundant stirring, mix homogeneously in the blender;
Pill
Make the heavy 11.6--12.5g/100 grain of wet ball with moulding method for making; To mould the wet ball that method for making is made, adopt general method for making to make the wet ball of 15.6--16.5g/100 grain, put 60--65 ℃ of oven dry promptly with remaining 20%--40% medicated powder.
Adopt the pill of preparation method preparation of the present invention can be called " Moschus oolong ball ".
Among each embodiment of the present invention, the each component percentage by weight sees the following form:
| Flavour of a drug percentage ratio | The artificial Moschus | Radix Aconiti Preparata | Pheretima | Scorpio | Give birth to Semen sojae atricolor | Starch |
| 1 | 1.2 | 45.3 | 16.7 | 18.6 | 5.8 | 12.4 |
| 2 | 0.6 | 47.3 | 21.3 | 12.5 | 9.4 | 8.9 |
| 3 | 0.8 | 49.6 | 18.2 | 13.5 | 8.4 | 9.5 |
| 4 | 1.1 | 48.4 | 17.8 | 16.3 | 6.8 | 9.6 |
| 5 | 0.9 | 46.8 | 19.2 | 14.6 | 7.4 | 11.1 |
| 6 | 1.0 | 46.5 | 19.6 | 12.4 | 7.3 | 13.2 |
Clinical efficacy report of the present invention
Estimate the clinical efficacy and the safety of Moschus oolong ball, perspective study 150 routine rheumatoid arthritis patients treat index such as deadlock in forward and backward morning, arthralgia, tenderness, swelling, joint function disturbance, allomeric function and projects such as laboratory blood RF, CRP, ESR, ASO, immunoglobulin inspection and swollen joint X-ray film are observed.
Diagnostic criteria:
The standard of ARA the 51st ARA meeting revision June in 1987.
1. at least 1 hour (〉=6 week) of getting up early ankylosis.
2.3 individual above arthroncus (≤6 week).
3. joints of hand or metacarpophalangeal joints or proximal interphalangeal joint swelling (≤6 week).
4. symmetrical swelling.
6. the X line of hands changes.
6. subcutaneous nodule.
7. rheumatoid factor.
As possess 4 above indexs and can make a definite diagnosis.
Curative effect determinate standard:
Control in the recent period: the arthralgia of getting involved after treatment disappears, and function of joint is improved or recovered normal, and it is normal that RF, ESR recover, and can keep more than 3 months after the drug withdrawal.
Produce effects: the arthralgia of getting involved is clearly better or disappears, and ESR, RF titre reduce, or ESR, RF recovered normally, but arthralgia disappearance as yet.
Effectively: the arthralgia or swell and ache and take a favorable turn of after treatment, getting involved.Invalid: through treating 1-3 the course of treatment (each course of treatment is more than 30 days), the arthralgia of getting involved does not have improvement.
Result: see Table 1, table 2
Control 43 examples (28.67%), produce effects 56 examples (37.33%), effective 45 examples (30%), invalid 6 examples (4%), total effective rate 96% in the recent period.Compare before and after the treatment of table 1 clinical index (x ± s)
| Project | The example number | Before the treatment | After the treatment |
| Morning stiff index arthralgia index articular pain index | 150 150 123 | 6.58±2.57 13.86±5.26 9.22±5.11 | 1.96±0.64** 5.26±1.88** 3.34±1.11** |
| The swelling index | 84 | 27.46±13.32 | 8.57±4.32** |
| Joint function disturbance index allomeric function index | 105 46 | 16.33±8.45 2.13±0.75 | 11.89±3.16* 1.47±0.86* |
Annotate: treat forward and backward relatively * P＜0.05 * * P＜0.01
Attached: every index is divided into 4 grades, counts I level meter 1 minute, II level meter 2 minutes, III level meter 3 minutes 0 fen for 0 grade.Computational methods: all suffer from joint score sum to obtain the each patient earlier, and the average of obtaining every whole cases is again carried out statistical disposition as index
Lab testing data comparison before and after table 2 treatment (x ± s)
| Project | The example number | Before the treatment | After the treatment |
| Hb(g/dl) WBC(×10 9/L) ESR(mm/h) | 150 150 102 | 9.80±1.24 11.48±1.03 54.60±16.38 | 11.36±1.54* 9.67±1.21* 32.61±12.52** |
| CRP(mg/dl) | 96 | 48.76±21.3 | 29.82±10.63** |
| IgG(mg/dl) IgM(mg/dl) | 73 73 | 3418±896 384±78.23 | 2836±1025* 210±57.76* |
Annotate: treat forward and backward relatively * P＜0.05 * * P＜0.01.
Model case
Dong, woman, 39 years old, workman.Because of extremities joint migration pain 4 years, the aggravation companion limitation of activity that swells and ache came hospital admission.Once used prednisone, indometacin, ibuprofen and treatment by Chinese herbs, heavy when light during symptom, control repeatly and do not heal.Have a medical check-up: the both hands proximal interphalangeal joint of finger is the enlargement of shuttle shape, metacarpophalangeal joints, the obvious pain of sole of the foot toe, and functional activity is limited.Chemical examination ESR56mm/h, the RF strong positive.X-ray film shows that two palms refer to and proximal interphalangeal joint has osteoporosis to change, and articular surface is coarse, gap turn narrow.Diagnosis: rheumatoid arthritis.After 30 days, Chu's arthralgia obviously alleviates through clothes Moschus oolong ball, and arthroncus is obviously disappeared, and dysfunction is also significantly improved, and chemical examination ESR36mm/h, RF are weak positive.Advising continues obeyed Moschus oolong ball 30 days.Arthralgia disappears when examining again, and ESR, RF turn out cloudy, and the X line shows that osteoporosis also improves.Follow up a case by regular visits to so far efficacy consolidation.
End certain, man, 54 years old, the workman of ceramics factory.The little arthralgia of main cause extremity 2 years is surplus, increases the weight of in nearly 1 month, and activity is seriously limited, plays both hands morning and can not clench fist, and wears the clothes, taking food needs other people to help.Once took medicine treatments such as meloxicam, methotrexate, Biqi capsules.Because of gastrointestinal reaction is withdrawn medicine-feeding.Have a medical check-up: the both hands proximal interphalangeal joint is the enlargement of shuttle shape, right carpal joint is stiff, right elbow joint is stretched the subcutaneous big tag of almond that touches of side, Pi Wenlvegao, the enlargement of bilateral sole of the foot toe, chemical examination ESR48mm/h, rheumatoid factor 126IU/ml, X-ray film shows: two carpal joint osteoporosises, the both hands proximal interphalangeal joint is coarse, gap turn narrow.Diagnosis: rheumatoid arthritis.It is oral to give Moschus oolong ball, and early, respectively obey 1 time evening, each 30, after obeying 20 days, arthroncus, pain, functional activity obviously improve, and chemical examination ESR34mm/h advising the clothes 60 days of continuing.When examining, Chu's arthroncus is disappeared again, and pain disappears.The little joint motion of distal limbs freely, right elbow joint is stretched the side subcutaneous nodule and is disappeared.Chemical examination ESR13mm/h, the check of X line is the same, with examining so far efficacy consolidation.
Claims (3)
1. treatment rheumatoid arthritis Chinese medicine preparation is characterized in that by percentage by weight being that the artificial Moschus of 0.60%--1.20%, the Radix Aconiti Preparata of 45.3%--49.6%, the Pheretima of 16.7%--21.3%, the Scorpio of 12.4%--18.6%, the living Semen sojae atricolor of 5.8%--9.4%, the starch of 8.9%--13.2% make.
2. preparation method for the treatment of the rheumatoid arthritis Chinese medicine preparation is characterized in that comprising following steps:
1. it is standby to choose each component by weight percentage, artificial Moschus 0.60%--1.20%, Radix Aconiti Preparata 45.3%--49.6%, Pheretima 16.7%--21.3%, Scorpio 12.4%--18.6%, living Semen sojae atricolor 5.8%--9.4%, starch 8.9%--13.2%;
2. Radix Aconiti Preparata, Pheretima, Scorpio, living Semen sojae atricolor are removed impurity, and cleaning, drying are pulverized, and cross the 80--120 mesh sieve;
3. with Radix Aconiti Preparata powder, Pheretima powder, Scorpio powder, living Semen sojae atricolor powder and starch, put abundant stirring, mix homogeneously in the blender, be called medicated powder;
4. the artificial Moschus is added in the yellow wine, stir, it is fully dissolved, make and contain artificial Moschus 1.48%--2.9% solution, be called the yellow wine that contains Moschus, standby;
5. get the 60%--80% of the sufficient medicated powder total amount of aforementioned mixing, add the yellow wine that contains Moschus, medicated powder is 2:1 with the weight ratio that contains the yellow wine of Moschus, puts abundant stirring, mix homogeneously in the blender;
6. pill
Make wet ball with moulding method for making; To mould the wet ball that method for making is made, adopt general method for making to make wetter ball, put 60--65 ℃ of oven dry promptly with remaining 20%--40% medicated powder.
3. according to the preparation method of the described treatment rheumatoid arthritis Chinese medicine preparation of claim 2, it is characterized in that in the said pill operation, make the heavy 11.6--12.5g/100 grain of wet ball with moulding method for making; To mould the wet ball that method for making is made, adopt general method for making to make the wet ball of 15.6--16.5g/100 grain with remaining 20%--40% medicated powder.
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| CN101574413B true CN101574413B (en) | 2011-10-19 |
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