CN102284028A - Medicine for treating rheumatoid arthritis - Google Patents

Abstract

The invention relates to a medicine for treating rheumatoid arthritis, which is prepared by the following steps: taking selected and cleaned antler, radix salviae miltiorrhizae, angelica, stir-fried radix paeoniae alba, radix rehmanniae preparata, hemlock parsley, peach kernel, safflower, prepared monkshood, cassia twig, stir-fried rhizoma atractylodis, stir-fried coix seed, eucommia carbon, pawpaw, radix achyranthis bidentatae, himalayan teasel root, mistletoe, black-tail snake, centipede, futokadsura stem, schizophragma integrifolium, homalomena rhizoma, club moss, american lopseed, radix gentianae macrophyllae, radix clematidis, asarum, radix sileris, scorpion and gastrodia tuber; and evenly mixing, pulverizing into 100-120 mesh medicinal powder, adding honey, drawing the pattern, and making pills. The medicine provided by the invention has the effects of warming and invigorating the kidney yang, managing blood, dispersing pathogenic wind and cold dampness and exciting the junior fire, and can perform the functions of alleviating pain, promoting the subsidence of swelling, softening the tendon and strengthening the bone, thereby achieving the goal of treating rheumatoid arthritis.

Description

A kind of medicine for the treatment of rheumatoid arthritis

Technical field

The present invention relates to a kind of medicine for the treatment of rheumatoid arthritis, particularly relating to a kind of is the medicine of the treatment rheumatoid arthritis of crude drug preparation with Chinese medicine.

Background technology

Rheumatoid arthritis (rheumatoid arthritis) be a kind of be the chronic systemic autoimmune disease of feature with the articular synovitis.Synovitis is outbreak repeatedly lastingly, the destruction that can cause intraarticular cartilage and bone, and joint function disturbance, in addition maimed.The vasculitis pathological changes is involved each organ of whole body, so primary disease is called rheumatoid disease again.

The treatment primary disease is protected function of joint to prevent destruction of joint at present, and the quality of life of improving the patient to greatest extent is a target.Use early in the medication and act on antirheumatic slowly.Symptom such as Western medicine pain management commonly used during arthralgia swelling, but Western medicine can only one-side pain management, does not have the effect of treatment.

Summary of the invention

The purpose of this invention is to provide a kind of medicine for the treatment of rheumatoid arthritis, this medicine is made up of Chinese medicine, have the temperature compensation kidney-Yang, control blood, the cold-damp of dispeling the wind and excite the effect of few fire, thereby the effect that treatment of rheumatoid arthritis can play pain relieving, detumescence, gentle muscle, bone strengthening is reached the purpose of treatment.

Medicine of the present invention is that crude drug prepares by following parts by weight of traditional Chinese medicines:

Cornu Cervi Pantotrichum 4～6 Radix Salviae Miltiorrhizaes 8～12 Radix Angelicae Sinensis 8～12 Radix Paeoniae Alba (parched)s 8～12

Radix Rehmanniae Preparata 8～12 Rhizoma Chuanxiongs 8～12 Semen Persicaes 8～12 Flos Carthamis 8～12

Radix Aconiti Lateralis Preparata 8～12 Ramulus Cinnamomi 8～12 Rhizoma Atractylodis (parched) 8～12 Semen Coicis (parched) 16～24

Charred Cortex Eucommiae 16～24 Fructus Chaenomeliss 16～24 Radix Achyranthis Bidentataes 16～24 Radix Dipsacis 8～12

Herba Taxilli 8～12 Zaocyss 1～3 Scolopendra 1～3 Caulis Piperis Kadsurae 8～12

Cortex schizophragmatis integrifolii radicis 8～12 Rhizoma Homalomenaes 8～12 Herba Lycopodiis 8～12 Herba speranskiae tuberculataes 8～12

Radix Gentianae Macrophyllae 8～12 Radix Clematidis 8～12 Herba Asaris 2～4 Radix Saposhnikoviaes 8～12

Scorpio 8～12 Rhizoma Gastrodiaes 8～12.

Said medicine can be made any dosage form on the pharmaceutics, as tablet, pill, powder, capsule etc., the preferred dosage form of the present invention is a pill.

The concrete preparation method of medicine of the present invention being made pill is:

Said medicine is cleaned mix homogeneously by described parts by weight, be ground into 100～120 medicated powder, add sweet molding, make pill.

The traditional Chinese medical science thinks, rheumatoid arthritis is because wind, cold, wet invasion and attack cause that hyperactivity of the ministerial fire forms this disease.Hyperactivity of the ministerial fire walks to go here and there the joint, so the joint is red, swollen, hot, bitterly.Disease then forms blood stasis, damp-edema for a long time, sick asthenia of qi and blood then occurs to liver spleen, kidney, and muscles and bones muscle loses supports, and forms atrophy, pneumatic, bad bone so that joint deformity.Unit's YANG deficiency is the main cause of primary disease middle and late stage, and the liver,spleen,kidney YANG QI deficiency is main sick dirty, liver governing tendons, deficiency of the liver then essence and blood thanks to, irritability declines, for a long time flaccidity due to malnutrition of tendons then; Deficiency of spleen-QI then essence and blood loses, for a long time muscular atrophy then; The not nourishing bone of suffering from a deficiency of the kidney, the atrophic debility of bones then for a long time, sick after phase five body constituents flaccidity syndrome and arthralgia syndrome then, very then disable.The Therapeutic Principle should be the temperature compensation kidney-Yang, controls blood, the cold-damp of dispeling the wind and excite few fiery enhancing immunity with the toxicity medicine.Cornu Cervi Pantotrichum invigorating kidney-YANG, benefit marrow, bone and muscle strengthening; Radix Salviae Miltiorrhizae promoting blood flow to regulate menstruation, removing heat from blood eliminating carbuncle; Chinese angelica blood supplementing, invigorate blood circulation, pain relieving; The pain relieving of Radix Paeoniae Alba (parched) suppressing the hyperactive liver, astringing YIN to stop sweating; Enrich blood YIN nourishing, beneficial essence of Radix Rehmanniae Preparata filled out marrow; Rhizoma Chuanxiong blood-activating and qi-promoting, wind-expelling pain-stopping; The Semen Persicae blood circulation promoting and blood stasis dispelling; Flos Carthami promoting blood circulation to restore menstrual flow, stasis-dispelling and pain-killing; Ramulus Cinnamomi diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI; Radix Aconiti Lateralis Preparata recuperating depleted YANG and rescuing the patient from collapse, supporing yang benefit fire, dispersing cold for relieving pain; Rhizoma Atractylodis (parched) is drying damp and strengthening spleen, wind-damp dispelling; Semen Coicis (parched) promoting diuresis to eliminate damp pathogen, eliminating impediment, clearing away heat and discharging pus; Charred Cortex Eucommiae invigorating the liver and kidney, bone and muscle strengthening; Fructus Chaenomelis relaxing muscles and tendons and activating QI and blood in the collateral, dehumidifying stomach function regulating; Radix Achyranthis Bidentatae promoting blood circulation to restore menstrual flow, invigorating the liver and kidney, bone and muscle strengthening; Radix Dipsaci invigorating the liver and kidney, bone and muscle strengthening, the continuous folding of curing the wound; Herba Taxilli wind-damp dispelling, liver and kidney tonifying, bone and muscle strengthening; Zaocys dispelling wind and removing obstruction in the collateral, arresting convulsion relieving convulsion; Scorpio endogenous wind stopping relieving convulsion, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain; Scolopendra endogenous wind stopping relieving convulsion, dispersing pathogen accumulation; Caulis Piperis Kadsurae expelling wind and removing dampness, dredge the meridian passage; Rhizoma Homalomenae wind-damp dispelling, bone and muscle strengthening, stopping numbness pain; Radix Gentianae Macrophyllae wind-damp dispelling, stopping numbness pain, reducing the asthenic fever, clearing away damp-heat; Radix Clematidis wind-damp dispelling, the meridian dredging; Herba Asari expelling wind and cold, sensible, pain relieving; Radix Saposhnikoviae is delivered diffusing wind, removing dampness to relieve pain; Herba Lycopodii wind-damp dispelling, activating collaterals; Herba speranskiae tuberculatae wind-damp dispelling, inducing menstruation to relieve menalgia; Cortex schizophragmatis integrifolii radicis wind-damp dispelling, pain relieving; Rhizoma Gastrodiae endogenous wind stopping relieving convulsion, suppressing liver-YANG, dispelling wind and removing obstruction in the collateral.All medicines share, and can play the temperature compensation kidney-Yang, control blood, the cold-damp of dispeling the wind and excite the effect of few fire.Be used for the effect that treatment of rheumatoid arthritis can play pain relieving, detumescence, gentle muscle, bone strengthening.

For further investigating the clinical efficacy and the safety of medicine of the present invention, select 51 routine rheumatoid arthritis patients that the curative effect of medicine of the present invention has been carried out clinical observation.

51 routine cases are divided into two groups at random, and 26 examples are organized in treatment, matched group 25 examples.All case is diagnosed as rheumatoid arthritis all according to the diagnostic criteria in 1985 of U.S. rheumatology association.

Diagnostic criteria

1) at least 1 hour (〉=6 week) of deadlock morning;

2) individual or 3 above swollen joints (〉=6 week);

3) wrist, metacarpophalangeal joints or proximal interphalangeal joint swollen (〉=6 week);

4) symmetry swollen joint (〉=6 week);

5) subcutaneous nodule;

6) hands X-ray sheet changes;

7) the rheumatoid factor positive (titre＞1: 32);

Be diagnosed as rheumatoid arthritis and need possess 4 or 4 above standards.

Therapeutic Method

Matched group adopts indometacin enteric-coated tablet, and is oral, one time 1,2 times on the one.The treatment group adopts pill medicine of the present invention to treat every day 3 times, each 1 ball.30 days is a course of treatment, uses 2 courses of treatment altogether.

Criterion of therapeutical effect

According to the recent clinical remission standard that U.S. rheumatology association formulated in 1985, produce effects: the arthralgia of getting involved is clearly better or disappears, erythrocyte sedimentation rate, and the rheumatoid factor titre reduces; Or erythrocyte sedimentation rate, rheumatoid factor be with multiple normal, but arthralgia is still for disappearing; Effectively: the arthralgia or swell and ache of getting involved after treatment weakens or disappears; Invalid: more than treatment 1-3 the course of treatment (30 days each courses of treatment), the arthralgia of getting involved does not have improvement.

Two groups of case treatment back curative effect comparative results see Table 1.

Table 1 liang group case treatment back curative effect relatively

Group	The example number	Produce effects n(%)	Effective n(%)	Invalid n(%)	Total effective rate n(%)
						Matched group	25	5（20）	10（40）	10（40）	15（60）
The treatment group	26	10（38.5）	12（46.1）	4（15.4）	22（84.6）

Statistical result showed, treatment group curative effect obviously is better than matched group, and two group differences are remarkable, P＜0.05.

The specific embodiment

Embodiment 1

Get selected, the Cornu Cervi Pantotrichum 40g that clear water is cleaned, Radix Salviae Miltiorrhizae 80g, Radix Angelicae Sinensis 80g, Radix Paeoniae Alba (parched) 80g, Radix Rehmanniae Preparata 80g, Rhizoma Chuanxiong 80g, Semen Persicae 80g, Flos Carthami 80g, Radix Aconiti Lateralis Preparata 80g, Ramulus Cinnamomi 80g, Rhizoma Atractylodis (parched) 80g, Semen Coicis (parched) 160g, charred Cortex Eucommiae 160g, Fructus Chaenomelis 160g, Radix Achyranthis Bidentatae 160g, interrupted 80g, Herba Taxilli 80g, Zaocys 10g, Scolopendra 10g, Caulis Piperis Kadsurae 80g, Cortex schizophragmatis integrifolii radicis 80g, Rhizoma Homalomenae 80g, Herba Lycopodii 80g, Herba speranskiae tuberculatae 80g, Radix Gentianae Macrophyllae 80g, Radix Clematidis 80g, Herba Asari 20g, Radix Saposhnikoviae 80g, Scorpio 80g, Rhizoma Gastrodiae 80g mix homogeneously, be ground into 100～120 medicated powder, add sweet molding, make pill.

Embodiment 1

Get selected, the Cornu Cervi Pantotrichum 60g that clear water is cleaned, Radix Salviae Miltiorrhizae 120g, Radix Angelicae Sinensis 120g, Radix Paeoniae Alba (parched) 120g, Radix Rehmanniae Preparata 120g, Rhizoma Chuanxiong 120g, Semen Persicae 120g, Flos Carthami 120g, Radix Aconiti Lateralis Preparata 120 g, Ramulus Cinnamomi 120 g, Rhizoma Atractylodis (parched) 120 g, Semen Coicis (parched) 240 g, charred Cortex Eucommiae 240 g, Fructus Chaenomelis 240 g, Radix Achyranthis Bidentatae 240 g, interrupted 120 g, Herba Taxilli 120 g, Zaocys 30 g, Scolopendra 30 g, Caulis Piperis Kadsurae 120 g, Cortex schizophragmatis integrifolii radicis 120 g, Rhizoma Homalomenae 120 g, Herba Lycopodii 120 g, Herba speranskiae tuberculatae 120 g, Radix Gentianae Macrophyllae 120 g, Radix Clematidis 120 g, Herba Asari 40 g, Radix Saposhnikoviae 120 g, Scorpio 120 g, Rhizoma Gastrodiae 120 g mix homogeneously, be ground into 100～120 medicated powder, add sweet molding, make pill.

Claims (2)

1. medicine for the treatment of rheumatoid arthritis is that crude drug prepares by the Chinese medicine of following portions by weight:

Cornu Cervi Pantotrichum 4～6 Radix Salviae Miltiorrhizaes 8～12 Radix Angelicae Sinensis 8～12 Radix Paeoniae Alba (parched)s 8～12

Radix Rehmanniae Preparata 8～12 Rhizoma Chuanxiongs 8～12 Semen Persicaes 8～12 Flos Carthamis 8～12

Radix Aconiti Lateralis Preparata 8～12 Ramulus Cinnamomi 8～12 Rhizoma Atractylodis (parched) 8～12 Semen Coicis (parched) 16～24

Charred Cortex Eucommiae 16～24 Fructus Chaenomeliss 16～24 Radix Achyranthis Bidentataes 16～24 Radix Dipsacis 8～12

Herba Taxilli 8～12 Zaocyss 1～3 Scolopendra 1～3 Caulis Piperis Kadsurae 8～12

Cortex schizophragmatis integrifolii radicis 8～12 Rhizoma Homalomenaes 8～12 Herba Lycopodiis 8～12 Herba speranskiae tuberculataes 8～12

Radix Gentianae Macrophyllae 8～12 Radix Clematidis 8～12 Herba Asaris 2～4 Radix Saposhnikoviaes 8～12

Scorpio 8～12 Rhizoma Gastrodiaes 8～12.

2. the medicine of treatment rheumatoid arthritis according to claim 1 is characterized in that described medicine is made pill.