CN101574311B - Cosmetic additive with permanent anti-acne function and preparation method thereof - Google Patents
Cosmetic additive with permanent anti-acne function and preparation method thereof Download PDFInfo
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- CN101574311B CN101574311B CN2009100401453A CN200910040145A CN101574311B CN 101574311 B CN101574311 B CN 101574311B CN 2009100401453 A CN2009100401453 A CN 2009100401453A CN 200910040145 A CN200910040145 A CN 200910040145A CN 101574311 B CN101574311 B CN 101574311B
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Abstract
The invention discloses a cosmetic additive with the permanent anti-acne function and a preparation method thereof. The method comprises: dissolving 40 to 60 mass portions of active substances into 20to 30 mass portions of deionized water, adding 30 to 50 mass portions of film-forming substances into the mixture, uniformly stirring the mixture, adding the mixture into a uniform base fluid contain ing 8 to 20 mass portions of auxiliary substances and 40 to 60 mass portions of deionized water, uniformly dispersing the obtained product in a viscolizer, hermetically standing the obtained product for 24 to 36 hours at the temperature of between 20 and 30 DEG C, and filtering the obtained product to obtain clear filtrate; and drying and crushing the clear filtrate to obtain powder with the granularity of between 60 and 1,000 meshes. The prepared powdery cosmetic additive has good water solubility and large solubility, is convenient to use, has good anti-acne efficacy in anti-acne water, anti-acne gel and anti-acne cream, and has good combination effect, large use range and long service life, wherein the service life of the powdery cosmetic additive is 1 to 2 times longer than that of theconventional additive with the anti-acne function.
Description
Technical field
The present invention relates to a kind of cosmetics additive, belong to cosmetics intermediate field with permanent anti-acne function.
Background technology
Cosmetics are meant to smear, to spray or other similar methods are granted any position of human body surface (skin, hair, fingernail, lip, oral cavity etc.), are the general name that cleans, protects, beautifies or eliminate bad smell and health is played protection and alleviative class daily chemical industry articles for use.Along with improving constantly of living standard, people have proposed more and more higher requirement to cosmetics, to the functional also pay attention to day by day of cosmetics.
Acne claim " acne " again, are a kind of hair follicle, sebaceous gland chronic inflammation of tissue dermatoses, because be mainly in adolescence, so be called comedo again.Acne are common on the face, bring very big physiology and psychology harm to people.The formation reason of acne mainly contains following 3 kinds: (1) hair follicle angle of spot hole materialization is hyperfunction, stops up pore; (2) sebum secretion is vigorous; (3) influence of antibacterial.
Acne-eliminating cosmetic acts on skin surface with one or more active substances, by the formation reason of eliminating acne and the forming process of controlling acne, reaches the effect of anti-acne.The effect of active substance mainly is reflected in three aspects: (1) suppresses the surplus secretion of sebum; (2) cutin dissolving remover, the hair follicle that control causes because of keratinization is hyperfunction stops up, and cutin is peeled off in dissolving; (3) breeding of the facial antibacterial of inhibition.Active substance mainly contains following three classes: the first kind is mainly the material that sulfur, salicylic acid and benzoyl peroxide etc. have acne-removal function.Sulfur has good sterilization power, can kill the antibacterial of face, control of bacterial infection and inflammation; Salicylic acid has effects such as certain destratum corneum, dredging pore; Benzoyl peroxide then can peel off cutin, reduces hair follicle and stops up.But, because this class active matter exists side effect big, shortcomings such as allergy is many, such as salicylic acid skin there is stronger stimulation, some skin sensitivity patients are inapplicable, and now a lot of cosmetics workers replace salicylic acid with fruit acid, because fruit acid not only has good exfoliation effect, and, be suitable for the skin sensitivity patient and use because its zest to skin is little.Second class is mainly antibiotic or antibiotics material, as metronidazole, chloromycetin etc., adds the dexamethasone antiallergic again, and these materials have obvious effect really for anti-acne.But these materials of life-time service can make generated human antibody, and skin is had the irritated effect of stronger stimulation.The anti-pox active substance of the 3rd class mainly is some natural extracts, as the extract of Chinese herbal medicine Radix Salviae Miltiorrhizae, Radix Sophorae Flavescentis, Radix Glycyrrhizae, Radix Scutellariae and Flos Lonicerae etc., contains very high-load plant sterol, VE and natural allantoin etc.These materials are owing to be the extract of natural plants and medicine, thus safe, acne also there is very strong inhibitory action, they are all from improving keratodermatitis, efficient bacteriostasis and sterilization, and energy Sage Extract.Particularly allantoin can promote the growth of cell tissue, accelerates the renewal process of skin; Still be a kind of good wetting agent, anti-sensitizer and cutin inorganic agent simultaneously.
Existing acne-eliminating cosmetic, be fruit acid, salicylic acid, plant sterol or allantoin isoreactivity material not to be added to handle directly add, active substance just directly acts on skin like this, it is big to the stimulation of skin because concentration is high to cause active substance, even can cause allergic reaction, on the other hand, micromolecular active substance rapid release, the activity of can not remaining valid on skin for a long time influences the anti-acne effect.
Summary of the invention
The objective of the invention is to overcome the shortcoming of prior art, provide a kind of on skin spreading property, prolong active substance in time of staying of skin surface, little and anti-acne outstanding effect has the cosmetics additive of permanent anti-acne function to the stimulation of skin.
Another object of the present invention is to provide the preparation method of above-mentioned cosmetics additive.
Utilization of the present invention has the film forming matter of polysaccharide structures the anti-acne active substance is handled, make a kind of cosmetics additive with permanent anti-acne function, when making the acne-removal function cosmetics, can not only give play to the spreading property of film forming matter on skin, and make active substance have the process of slow release, fully prolong the time of staying of active substance at skin surface, the acne-removing of performance active substance, reduce stimulation simultaneously, for user brings great convenience and satisfies to skin.
Purpose of the present invention is achieved through the following technical solutions:
The preparation method of the persistent cosmetics additive of a kind of acne-removal function comprises the steps and process conditions:
The first step is got 40～60 parts of active substances in mass fraction, is dissolved in 20～30 parts of deionized waters, adds 30～50 parts of film forming matters, stirs, and obtains the entity substance solution; Described active substance is fruit acid, threonine, serine, salicylic acid, plant sterol or allantoin; Described film forming matter is starch, pectin, Resina persicae, arabic gum or trehalose;
Join in the even base fluid that contains 8～20 parts of auxiliary substances and 40～60 parts of deionized waters in the entity substance solution that second step obtained the first step, homodisperse 3h～4h in homogenizer, then under 20 ℃～30 ℃ condition, sealing and standing 24h～36h, filter, obtain clear filtrate; Described auxiliary substance is potassium hydroxide, triethanolamine or sodium hydroxide;
The 3rd step was carried out drying and pulverizing with the clear filtrate that second step obtained, and obtained granularity at 60 orders～1000 purpose powder body.
Described drying is spray drying, vacuum drying or vacuum lyophilization.
The persistent cosmetics additive of a kind of acne-removal function is by method for preparing.
The present invention compared with prior art has following advantage and beneficial effect:
Since the anti-pox active substance in this acne-removal function property additive have safe, anti-acne effect excellent characteristic, so the prepared anti-acne additive of the present invention has good anti-acne effect, and safety is good, little to skin irritation.The present invention adopts the film forming matter with macromolecular polysaccharide structure, as starch, pectin, Resina persicae, arabic gum or trehalose etc., active substance is carried out keyed jointing or microcapsule coating processing, can reduce the concentration that active substance directly acts on skin, minimizing is to the stimulation of skin, keep active substance slowly to discharge in a long time simultaneously, prolong the effective anti-acne time of active substance skin.The film forming matter of polysaccharide structures can pass through molecular separating force, hydrogen bond or chemical bond and link with active substance, also can carry out microcapsule to active substance and coat; Have link or through the active substance intermediate behind the micro encapsulation when film forming is sprawled on skin, active substance can slowly be opened with linking of film forming matter when this, perhaps microcapsules reaches active substance slow purpose of release on skin.In addition, active substance can also fully be sprawled at skin surface by the good film property of film forming matter, and delays to see through the time of skin surface, brings into play its anti-acne skin-care effect to greatest extent.
2. owing to adopted the macromole with polysaccharide structures as film forming matter, active substance can fully be sprawled on skin, fully prolongs the time of staying of active substance at skin surface; The anti-acne effect stability of prepared anti-acne additive, lasting under the prerequisite that reduces the user access times, still can be given full play to its acne-removing.
3. owing to adopt film forming matter that active substance is linked or microcapsule coating processing, resulting anti-acne additive has tangible slow releasing function.
4. the anti-acne additive good water solubility of the present invention preparation, dissolubility is big, and is easy to use, and compatibility is good in various product for resolving poxes, stable storing, effect is remarkable.
5. raw material of the present invention obtains easily, and the preparation method simple possible helps the marketization and produces.
The specific embodiment
For the present invention can better be described, below in conjunction with embodiment the present invention is carried out explaining in detail further and introducing, but the present invention's scope required for protection is not limited to the scope that embodiment represents.
Embodiment 1
The first step is got the 45.0g salicylic acid and is dissolved in fully in the 22g deionized water, adds the 45.0g Resina persicae then, stirs, and obtains the entity substance solution.
Second step joined the entity substance solution that the first step obtains in the even base fluid that contains 10.0g triethanolamine and 44g deionized water, and homodisperse 3h in dispersion machine leaves standstill 24h at 25 ℃ of lower seals then, and filter 23 obtains clear filtrate.
The filtrate that the 3rd step obtained for second step is carried out vacuum lyophilization, and baking temperature is-50 ℃, and vacuum is 0.1mbar, and be 18h drying time; Take out dried object then and pulverize, powder granularity promptly gets product about 900 orders.
Embodiment 2
The first step is got the 50.0g allantoin and is dissolved in fully in the 28g deionized water, adds 50.0g starch then, stirs, and obtains the entity substance solution.
The entity substance solution that second step obtained the first step, join in the base fluid that contains 8.0g triethanolamine and 6.5g potassium hydroxide and 40g deionized water, homodisperse 3h in dispersion machine leaves standstill 36h at 28 ℃ of lower seals then, filter 23 obtains clear filtrate.
The 3rd step was carried out vacuum lyophilization with the filtrate that second step obtained, and baking temperature is-50 ℃, and vacuum is 0.05mbar, and be 18h drying time; Take out dried object then and pulverize, powder granularity promptly gets product about 500 orders.
Embodiment 3
The first step gets the 35.0g allantoin and the 25.0g plant sterol is dissolved in the 25g deionized water fully, adds 46.0g pectin then, stirs, and obtains the entity substance solution.
Second step joined the entity substance solution that the first step obtains in the base fluid that contains 12.0g sodium hydroxide and 50g deionized water, and homodisperse 4h in dispersion machine leaves standstill 34h at 30 ℃ of lower seals then, filters 2 times, obtains clear filtrate.
The filtrate that the 3rd step obtained for second step is carried out vacuum lyophilization, and baking temperature is-45 ℃, and vacuum is 0.08mbar, and be 19h drying time; Take out dried object then and pulverize, powder granularity promptly gets product about 100 orders.
Embodiment 4
The first step gets the 30.0g allantoin and the 28.0g fruit acid is dissolved in the 25g deionized water fully, adds 38.0g arabic gum and 12.0g starch then, stirs, and obtains the entity substance solution.
Second step joined the entity substance solution that the first step obtains in the base fluid that contains 14.0g triethanolamine and 60g deionized water, and homodisperse 4h in dispersion machine leaves standstill 30h at 22 ℃ of lower seals then, and filter 23 obtains clear filtrate.
The filtrate that the 3rd step obtained for second step is carried out vacuum lyophilization, and baking temperature is-50 ℃, and vacuum is 0.01mbar, and be 20h drying time; Take out dried object then and pulverize, powder granularity promptly gets product about 700 orders.
Embodiment 5
The first step is got the 48.0g serine and is dissolved in fully in the 25g deionized water, adds 18.0g starch and 14.0g trehalose then, stirs, and obtains the entity substance solution.
Second step joined the entity substance solution that the first step obtains to contain 9.0g sodium hydroxide and 45g, and in the base fluid of 40 ℃ of deionized waters, homodisperse 4h in dispersion machine leaves standstill 28h at 27 ℃ of lower seals then, and filter 23 obtains clear filtrate.
The 3rd step was carried out spray drying with the filtrate that second step obtained, and inlet temperature is 110 ℃; Outlet temperature is 160 ℃; After the drying, promptly get product.
Embodiment 6
The first step is got the 54.0g fruit acid and is dissolved in fully in the 26g deionized water, adds 16.0g pectin and 17.0g arabic gum then, stirs, and obtains the entity substance solution.
The entity substance solution that second step obtained the first step, join in the base fluid that contains 4.0g potassium hydroxide, 7.0g sodium hydroxide and 43g deionized water, homodisperse 3.5h in dispersion machine leaves standstill 25h at 24 ℃ of lower seals then, filter 23 obtains clear filtrate.
The filtrate that the 3rd step obtained for second step is carried out vacuum drying, and baking temperature is 100 ℃, and vacuum is 0.015Mpa, and be 22h drying time; Take out dried object then and pulverize, powder granularity promptly gets product about 300 orders.
Embodiment 7
The first step is got 15.0g Su An acid and the 28.0g allantoin is dissolved in the 30g deionized water fully, adds the 48.0g Resina persicae then, stirs, and obtains the entity substance solution.
The entity substance solution that second step obtained the first step joins in the base fluid that contains 2.0g triethanolamine, 13.0g sodium hydroxide and 60g deionized water, homodisperse 4h in dispersion machine, leave standstill 32h at 23 ℃ of lower seals then, filter 23 obtains clear filtrate.
The filtrate that the 3rd step obtained for second step is carried out vacuum lyophilization, and baking temperature is-50 ℃, and vacuum is 0.06mbar, and be 20h drying time; Take out dried object then and pulverize, powder granularity promptly gets product about 800 orders.
Embodiment 8
The first step gets the 40.0g serine and the 18.0g allantoin is dissolved in the 30g deionized water fully, adds 28.0g starch and 19.0g pectin then, stirs, and obtains the entity substance solution.
The entity substance solution that second step obtained the first step, join in the base fluid that contains 10.0g sodium hydroxide, 10.0g potassium hydroxide and 60g deionized water, homodisperse 4h in dispersion machine leaves standstill 36h at 21 ℃ of lower seals then, filter 23 obtains clear filtrate.
The 3rd step was carried out vacuum drying with the filtrate that second step obtained, and baking temperature is 110 ℃, and vacuum is 0.01Mpa, and be 24h drying time; Take out dried object then and pulverize, powder granularity promptly gets product about 600 orders.
Embodiment 9
Embodiment 1 anti-acne additive is applied to carry out in the anti-acne water compatibility experiment.
Anti-acne water prescription is as follows:
Title mass content %
Anti-acne additive 3.0
Glycerol 3.0
Germall?IS-45 0.5
Deionized water 93.5
Keeping changing the anti-acne additive into the active substance salicylic acid in the composition of raw materials ratio under the constant situation of anti-acne water prescription.Find that through on probation the anti-acne water that directly adds the salicylic acid active substance obviously is better than the anti-acne water that has added the anti-acne additive to the excitement of skin.
Embodiment 10
Embodiment 2 anti-acne additives are applied to carry out in anti-acne Gel mile the compatibility experiment.
Anti-acne Gel mile prescription is as follows:
Title mass content %
U20 1.0
10％KOH 3.0
Anti-acne additive 2.0
Glycerol 3.0
6ermall?IS-45 0.5
Deionized water 90.5
Guaranteeing to change the anti-acne additive into the active substance allantoin in the composition of raw materials ratio under the constant situation of Gel mile prescription of anti-acne.Through discovery on probation, anti-acne Gel mile of having added the anti-acne additive for the product of direct interpolation active substance allantoin, when spreading upon on the skin, has the soft and smooth sense of good film forming.
Embodiment 11
Embodiment 6 anti-acne additives are applied to carry out in the acne eliminating cream compatibility experiment.
The acne eliminating cream prescription is as follows:
Title mass content %
16 octadecanol 2.5
GMS 2.5
M-5 4.0
IPM 3.0
Silsoft?034 2.5
Propyl ester 0.1
Methyl ester 0.2
HANSHENGJIAO 0.1
Glycerol 4.0
EDTA-2NA 0.05
Emulsiph?os 2.0
NJGELA-EG 1.5
Anti-acne additive 5.0
NEOLONE950 0.1
Essence 0.2
Deionized water 68.25
Guaranteeing to change the anti-acne additive into the active substance fruit acid in the composition of raw materials ratio under the constant situation of acne eliminating cream prescription.Find that through experiment when the acne eliminating cream that directly adds the fruit acid active substance spread upon on the skin, fruit acid was 1h～3h in the time of staying of skin surface; And added the acne eliminating cream of anti-acne additive, the time of staying of its fruit acid active substance can extend to 8h～10h.Added the acne eliminating cream of anti-acne additive, the anti-acne time is long, and anti-acne is effective.
Claims (3)
1. the preparation method of the persistent cosmetics additive of acne-removal function is characterized in that comprising the steps and process conditions:
The first step is got 40～60 parts of active substances in mass fraction, is dissolved in 20～30 parts of deionized waters, adds 30～50 parts of film forming matters, stirs, and obtains the entity substance solution; Described active substance is fruit acid, threonine, serine, salicylic acid, plant sterol or allantoin; Described film forming matter is starch, pectin, Resina persicae, arabic gum or trehalose;
Join in the even base fluid that contains 8～20 parts of auxiliary substances and 40～60 parts of deionized waters in the entity substance solution that second step obtained the first step, homodisperse 3h～4h in homogenizer, then under 20 ℃～30 ℃ condition, sealing and standing 24h～36h, filter, obtain clear filtrate; Described auxiliary substance is potassium hydroxide, triethanolamine or sodium hydroxide;
The 3rd step was carried out drying and pulverizing with the clear filtrate that second step obtained, and obtained granularity at 60 orders～1000 purpose powder body.
2. according to the preparation method of the persistent cosmetics additive of claims 1 described acne-removal function, it is characterized in that: described drying is spray drying or vacuum drying.
3. the persistent cosmetics additive of acne-removal function is prepared by claims 1 described method.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2009100401453A CN101574311B (en) | 2009-06-10 | 2009-06-10 | Cosmetic additive with permanent anti-acne function and preparation method thereof |
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| CN2009100401453A CN101574311B (en) | 2009-06-10 | 2009-06-10 | Cosmetic additive with permanent anti-acne function and preparation method thereof |
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| Publication Number | Publication Date |
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| CN101574311A CN101574311A (en) | 2009-11-11 |
| CN101574311B true CN101574311B (en) | 2011-04-27 |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102283792B (en) * | 2011-08-24 | 2013-01-16 | 迪特克(济源)绿色生物科技有限公司 | Natural anti-acne cream |
| CN102949322B (en) * | 2012-12-17 | 2013-11-27 | 扬州大学 | Functional cosmetic and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1148334A (en) * | 1995-03-03 | 1997-04-23 | 雅芳产品股份有限公司 | Gentle anti-acne composition |
| CN1148808A (en) * | 1994-05-19 | 1997-04-30 | 普罗克特和甘保尔公司 | Anti-acne composition |
| CN1813664A (en) * | 2005-11-24 | 2006-08-09 | 曾能 | Hydrogel beauty skin care paster and essence skin care liquid manufacturing process and product |
-
2009
- 2009-06-10 CN CN2009100401453A patent/CN101574311B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1148808A (en) * | 1994-05-19 | 1997-04-30 | 普罗克特和甘保尔公司 | Anti-acne composition |
| CN1148334A (en) * | 1995-03-03 | 1997-04-23 | 雅芳产品股份有限公司 | Gentle anti-acne composition |
| CN1813664A (en) * | 2005-11-24 | 2006-08-09 | 曾能 | Hydrogel beauty skin care paster and essence skin care liquid manufacturing process and product |
Non-Patent Citations (1)
| Title |
|---|
| 宋彦，等.祛痘功效添加剂的研究进展.《北京工商大学学报（自然科学版）》.2008,第26卷(第6期),13-17. * |
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