CN101573338B - 环烷基胺取代的异喹诺酮和异喹啉酮衍生物 - Google Patents

环烷基胺取代的异喹诺酮和异喹啉酮衍生物 Download PDF

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CN101573338B
CN101573338B CN2007800485212A CN200780048521A CN101573338B CN 101573338 B CN101573338 B CN 101573338B CN 2007800485212 A CN2007800485212 A CN 2007800485212A CN 200780048521 A CN200780048521 A CN 200780048521A CN 101573338 B CN101573338 B CN 101573338B
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alkyl
alkylene
aryl
formula
cycloalkyl
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CN101573338A (zh
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O·普来登伯格
A·霍夫迈斯特
J·格利策
M·勒恩
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Sanofi SRL
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    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
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CN2007800485212A 2006-12-27 2007-12-19 环烷基胺取代的异喹诺酮和异喹啉酮衍生物 Expired - Fee Related CN101573338B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06026895.0 2006-12-27
EP06026895 2006-12-27
PCT/EP2007/011166 WO2008077553A1 (en) 2006-12-27 2007-12-19 Cycloalkylamine substituted isoquinolone and isoquinolinone derivatives

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CN101573338A CN101573338A (zh) 2009-11-04
CN101573338B true CN101573338B (zh) 2013-03-20

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US (1) US20100056568A1 (https=)
EP (1) EP2125744B1 (https=)
JP (1) JP5318778B2 (https=)
KR (1) KR20090103903A (https=)
CN (1) CN101573338B (https=)
AT (1) ATE505458T1 (https=)
AU (1) AU2007338409B2 (https=)
BR (1) BRPI0720710A2 (https=)
CA (1) CA2673919C (https=)
CO (1) CO6210725A2 (https=)
DE (1) DE602007013950D1 (https=)
DK (1) DK2125744T3 (https=)
ES (1) ES2364511T3 (https=)
IL (1) IL199536A (https=)
MA (1) MA31023B1 (https=)
MX (1) MX2009005828A (https=)
MY (1) MY148514A (https=)
NO (1) NO20092431L (https=)
PT (1) PT2125744E (https=)
RU (1) RU2009128688A (https=)
WO (1) WO2008077553A1 (https=)
ZA (1) ZA200903553B (https=)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007008926A1 (en) 2005-07-11 2007-01-18 Aerie Pharmaceuticals, Inc. Isoquinoline compounds
WO2008036540A2 (en) 2006-09-20 2008-03-27 Boehringer Ingelheim International Gmbh Rho kinase inhibitors
US8455513B2 (en) 2007-01-10 2013-06-04 Aerie Pharmaceuticals, Inc. 6-aminoisoquinoline compounds
US8455514B2 (en) 2008-01-17 2013-06-04 Aerie Pharmaceuticals, Inc. 6-and 7-amino isoquinoline compounds and methods for making and using the same
CN102131784B (zh) * 2008-06-24 2014-08-27 赛诺菲-安万特 作为rho激酶抑制剂的取代的异喹啉和异喹啉酮
PT2313374E (pt) * 2008-06-24 2013-11-29 Sanofi Sa Isoquinolinas e isoquinolinonas 6-substituídas
HRP20131040T1 (hr) * 2008-06-24 2013-12-06 Sanofi Bi- i policikliäśki supstituirani izokinolin i derivati izokinolina kao inhibitori rho-kinaze
US8450344B2 (en) 2008-07-25 2013-05-28 Aerie Pharmaceuticals, Inc. Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
EP3053913B1 (en) 2009-05-01 2018-03-07 Aerie Pharmaceuticals, Inc. Dual mechanism inhibitors for the treatment of disease
AU2010261206B2 (en) 2009-06-19 2015-10-08 D. Western Therapeutics Institute, Inc. Substituted isoquinoline derivative
US20150202220A1 (en) * 2011-10-26 2015-07-23 Northwind Medical, Inc. Agents, methods, and devices for affecting nerve function
DK3811943T3 (da) 2013-03-15 2023-04-03 Aerie Pharmaceuticals Inc Forbindelse til anvendelse til behandling af øjenlidelser
FR3017868A1 (fr) 2014-02-21 2015-08-28 Servier Lab Derives d'isoquinoleine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
JP6695879B2 (ja) 2014-12-11 2020-05-20 シンジェンタ パーティシペーションズ アーゲー 硫黄含有置換基を有する殺有害生物的に活性な四環式誘導体
BR112017013440A2 (pt) 2014-12-24 2018-01-09 Gilead Sciences, Inc. compostos de isoquinolina para o tratamento de hiv
ES2735087T3 (es) 2014-12-24 2019-12-16 Gilead Sciences Inc Compuestos de pirimidina fusionados para el tratamiento de VIH
TWI699355B (zh) 2014-12-24 2020-07-21 美商基利科學股份有限公司 喹唑啉化合物
US9643927B1 (en) 2015-11-17 2017-05-09 Aerie Pharmaceuticals, Inc. Process for the preparation of kinase inhibitors and intermediates thereof
US10550087B2 (en) 2015-11-17 2020-02-04 Aerie Pharmaceuticals, Inc. Process for the preparation of kinase inhibitors and intermediates thereof
KR102568079B1 (ko) 2016-08-31 2023-08-17 에어리 파마슈티컬즈, 인코포레이티드 안과용 조성물
KR20190135027A (ko) 2017-03-31 2019-12-05 에어리 파마슈티컬즈, 인코포레이티드 아릴 시클로프로필-아미노-이소퀴놀리닐 아미드 화합물
AU2019337703B2 (en) 2018-09-14 2023-02-02 Aerie Pharmaceuticals, Inc. Aryl cyclopropyl-amino-isoquinolinyl amide compounds
CN112969694B (zh) 2018-11-09 2023-06-13 北京泰德制药股份有限公司 Rho相关蛋白激酶抑制剂、包含其的药物组合物及其用途
CN110670090B (zh) * 2019-11-13 2021-06-29 广西师范大学 一种基于电化学合成异喹啉酮类化合物的方法
KR102889687B1 (ko) * 2020-11-03 2025-11-21 주식회사 엘지화학 작물보호제용 신규 화합물

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005054202A1 (en) * 2003-11-25 2005-06-16 Eli Lilly And Company 7-phenyl-isoquinoline-5-sulfonylamino derivatives as inhibitors of akt (proteinkinase b)
CN1856476A (zh) * 2003-09-23 2006-11-01 默克公司 异喹啉酮钾通道抑制剂

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5480883A (en) * 1991-05-10 1996-01-02 Rhone-Poulenc Rorer Pharmaceuticals Inc. Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
TW575567B (en) * 1998-10-23 2004-02-11 Akzo Nobel Nv Serine protease inhibitor
IL150650A0 (en) * 2000-01-20 2003-02-12 Eisai Co Ltd Piperidine derivatives and pharmaceutical compositions containing the same
US7217722B2 (en) * 2000-02-01 2007-05-15 Kirin Beer Kabushiki Kaisha Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same
JPWO2002100833A1 (ja) * 2001-06-12 2004-09-24 住友製薬株式会社 Ｒｈｏキナーゼ阻害剤
SE0104340D0 (sv) 2001-12-20 2001-12-20 Astrazeneca Ab New compounds
AU2003281623B8 (en) * 2002-07-22 2009-06-11 Asahi Kasei Pharma Corporation 5-substituted isoquinoline derivative
JPWO2005035516A1 (ja) * 2003-10-10 2006-12-21 小野薬品工業株式会社 新規縮合複素環化合物およびその用途
JP2005232175A (ja) * 2004-01-21 2005-09-02 Asahi Kasei Pharma Kk ５−置換イソキノリン医薬
US7517991B2 (en) * 2004-10-12 2009-04-14 Bristol-Myers Squibb Company N-sulfonylpiperidine cannabinoid receptor 1 antagonists
NZ565040A (en) * 2005-06-28 2010-05-28 Sanofi Aventis Isoquinoline derivatives as inhibitors of RHO-kinase
US7618985B2 (en) * 2005-12-08 2009-11-17 N.V. Organon Isoquinoline derivatives
US7893088B2 (en) * 2006-08-18 2011-02-22 N.V. Organon 6-substituted isoquinoline derivatives

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1856476A (zh) * 2003-09-23 2006-11-01 默克公司 异喹啉酮钾通道抑制剂
WO2005054202A1 (en) * 2003-11-25 2005-06-16 Eli Lilly And Company 7-phenyl-isoquinoline-5-sulfonylamino derivatives as inhibitors of akt (proteinkinase b)

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Yoshiki Yoshida 等.Studies on Anti-Helicobacter pylori Agents. Part 1: Benzyloxyisoquinoline Derivatives.《Bioorganic & Medicinal Chemistry》.1999,第7卷(第11期),2647-2666. *

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CO6210725A2 (es) 2010-10-20
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CA2673919C (en) 2015-06-23
ZA200903553B (en) 2010-04-28
MY148514A (en) 2013-04-30
DE602007013950D1 (de) 2011-05-26
ES2364511T3 (es) 2011-09-05
MA31023B1 (fr) 2009-12-01
CN101573338A (zh) 2009-11-04
RU2009128688A (ru) 2011-02-10
JP5318778B2 (ja) 2013-10-16
MX2009005828A (es) 2009-06-16
PT2125744E (pt) 2011-07-01
ATE505458T1 (de) 2011-04-15
NO20092431L (no) 2009-09-21
JP2010514718A (ja) 2010-05-06
DK2125744T3 (da) 2011-08-01
US20100056568A1 (en) 2010-03-04
AU2007338409B2 (en) 2012-12-13
CA2673919A1 (en) 2008-07-03
HK1138583A1 (en) 2010-08-27
EP2125744A1 (en) 2009-12-02
BRPI0720710A2 (pt) 2014-12-23
KR20090103903A (ko) 2009-10-01
WO2008077553A1 (en) 2008-07-03
AU2007338409A1 (en) 2008-07-03

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