CN101573338B - 环烷基胺取代的异喹诺酮和异喹啉酮衍生物 - Google Patents

环烷基胺取代的异喹诺酮和异喹啉酮衍生物 Download PDF

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CN101573338B
CN101573338B CN2007800485212A CN200780048521A CN101573338B CN 101573338 B CN101573338 B CN 101573338B CN 2007800485212 A CN2007800485212 A CN 2007800485212A CN 200780048521 A CN200780048521 A CN 200780048521A CN 101573338 B CN101573338 B CN 101573338B
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alkyl
alkylene
aryl
formula
cycloalkyl
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CN101573338A (zh
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O·普来登伯格
A·霍夫迈斯特
J·格利策
M·勒恩
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Sanofi SRL
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    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
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CN2007800485212A 2006-12-27 2007-12-19 环烷基胺取代的异喹诺酮和异喹啉酮衍生物 Expired - Fee Related CN101573338B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06026895.0 2006-12-27
EP06026895 2006-12-27
PCT/EP2007/011166 WO2008077553A1 (en) 2006-12-27 2007-12-19 Cycloalkylamine substituted isoquinolone and isoquinolinone derivatives

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CN101573338A CN101573338A (zh) 2009-11-04
CN101573338B true CN101573338B (zh) 2013-03-20

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US (1) US20100056568A1 (https=)
EP (1) EP2125744B1 (https=)
JP (1) JP5318778B2 (https=)
KR (1) KR20090103903A (https=)
CN (1) CN101573338B (https=)
AT (1) ATE505458T1 (https=)
AU (1) AU2007338409B2 (https=)
BR (1) BRPI0720710A2 (https=)
CA (1) CA2673919C (https=)
CO (1) CO6210725A2 (https=)
DE (1) DE602007013950D1 (https=)
DK (1) DK2125744T3 (https=)
ES (1) ES2364511T3 (https=)
IL (1) IL199536A (https=)
MA (1) MA31023B1 (https=)
MX (1) MX2009005828A (https=)
MY (1) MY148514A (https=)
NO (1) NO20092431L (https=)
PT (1) PT2125744E (https=)
RU (1) RU2009128688A (https=)
WO (1) WO2008077553A1 (https=)
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Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7470787B2 (en) 2005-07-11 2008-12-30 Aerie Pharmaceuticals, Inc. Isoquinoline compounds
ES2729424T3 (es) 2006-09-20 2019-11-04 Aerie Pharmaceuticals Inc Inhibidores de Rho cinasa
US8455513B2 (en) 2007-01-10 2013-06-04 Aerie Pharmaceuticals, Inc. 6-aminoisoquinoline compounds
US8455514B2 (en) 2008-01-17 2013-06-04 Aerie Pharmaceuticals, Inc. 6-and 7-amino isoquinoline compounds and methods for making and using the same
CA2728137C (en) * 2008-06-24 2016-10-18 Sanofi-Aventis Substituted isoquinolines and isoquinolinones as rho kinase inhibitors
MY153615A (en) * 2008-06-24 2015-02-27 Sanofi Aventis 6-substituted isoquinolines and isoquinolinones
MY153756A (en) * 2008-06-24 2015-03-13 Sanofi Aventis Bi-and polycyclic substituted isoquinoline and isoquinoline derivatives as rho kinase inhibitors
US8450344B2 (en) 2008-07-25 2013-05-28 Aerie Pharmaceuticals, Inc. Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
EP3828172A1 (en) 2009-05-01 2021-06-02 Aerie Pharmaceuticals, Inc. Dual mechanism inhibitors for the treatment of disease
BRPI1011683B8 (pt) 2009-06-19 2021-05-25 D Western Therapeutics Inst Inc derivados de isoquinolina substituída, suas composições farmacêuticas e seus usos
CN104203233A (zh) * 2011-10-26 2014-12-10 艾米丽·A·斯坦 用于影响神经功能的药剂、方法和设备
ES2852377T3 (es) 2013-03-15 2021-09-13 Aerie Pharmaceuticals Inc Sales dimesilato de 4-(3-amino-1-(isoquinolin-6-ilamino)-1-oxopropan-2-il)bencilo, sus combinaciones con prostaglandinas y el uso de las mismas en el tratamiento de trastornos oculares
FR3017868A1 (fr) 2014-02-21 2015-08-28 Servier Lab Derives d'isoquinoleine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
ES2806598T3 (es) 2014-12-11 2021-02-18 Syngenta Participations Ag Derivados tetracíclicos activos como plaguicidas con sustituyentes que contienen azufre
TWI699355B (zh) 2014-12-24 2020-07-21 美商基利科學股份有限公司 喹唑啉化合物
BR112017013440A2 (pt) 2014-12-24 2018-01-09 Gilead Sciences, Inc. compostos de isoquinolina para o tratamento de hiv
SG11201705192PA (en) 2014-12-24 2017-07-28 Gilead Sciences Inc Fused pyrimidine compounds for the treatment of hiv
US9643927B1 (en) 2015-11-17 2017-05-09 Aerie Pharmaceuticals, Inc. Process for the preparation of kinase inhibitors and intermediates thereof
KR102579582B1 (ko) 2015-11-17 2023-09-15 에어리 파마슈티컬즈, 인코포레이티드 키나아제 억제제 및 이의 중간체의 제조 방법
KR102568079B1 (ko) 2016-08-31 2023-08-17 에어리 파마슈티컬즈, 인코포레이티드 안과용 조성물
AU2018243687C1 (en) 2017-03-31 2020-12-24 Alcon Inc. Aryl cyclopropyl-amino-isoquinolinyl amide compounds
CA3112391A1 (en) 2018-09-14 2020-03-19 Aerie Pharmaceuticals, Inc. Aryl cyclopropyl-amino-isoquinolinyl amide compounds
CN112969694B (zh) * 2018-11-09 2023-06-13 北京泰德制药股份有限公司 Rho相关蛋白激酶抑制剂、包含其的药物组合物及其用途
CN110670090B (zh) * 2019-11-13 2021-06-29 广西师范大学 一种基于电化学合成异喹啉酮类化合物的方法
KR102889687B1 (ko) * 2020-11-03 2025-11-21 주식회사 엘지화학 작물보호제용 신규 화합물

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005054202A1 (en) * 2003-11-25 2005-06-16 Eli Lilly And Company 7-phenyl-isoquinoline-5-sulfonylamino derivatives as inhibitors of akt (proteinkinase b)
CN1856476A (zh) * 2003-09-23 2006-11-01 默克公司 异喹啉酮钾通道抑制剂

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5480883A (en) * 1991-05-10 1996-01-02 Rhone-Poulenc Rorer Pharmaceuticals Inc. Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
TW575567B (en) * 1998-10-23 2004-02-11 Akzo Nobel Nv Serine protease inhibitor
BR0107732A (pt) * 2000-01-20 2003-03-11 Eisai Ltd Método para prevenir ou tratar uma doença
US7217722B2 (en) * 2000-02-01 2007-05-15 Kirin Beer Kabushiki Kaisha Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same
WO2002100833A1 (en) * 2001-06-12 2002-12-19 Sumitomo Pharmaceuticals Company, Limited Rho KINASE INHIBITORS
SE0104340D0 (sv) 2001-12-20 2001-12-20 Astrazeneca Ab New compounds
EP1541559A4 (en) * 2002-07-22 2007-08-22 Asahi Kasei Pharma Corp 5-SUBSTITUTED ISOQUINOLINE DERIVATIVE
US20070060595A1 (en) * 2003-10-10 2007-03-15 Toshio Yoshizawa Novel fused heterocyclic compound and use thereof
JP2005232175A (ja) * 2004-01-21 2005-09-02 Asahi Kasei Pharma Kk ５−置換イソキノリン医薬
US7517991B2 (en) * 2004-10-12 2009-04-14 Bristol-Myers Squibb Company N-sulfonylpiperidine cannabinoid receptor 1 antagonists
CN101213187B (zh) * 2005-06-28 2012-06-06 塞诺菲-安万特股份有限公司 作为rho-激酶抑制剂的异喹啉衍生物
US7618985B2 (en) * 2005-12-08 2009-11-17 N.V. Organon Isoquinoline derivatives
US7893088B2 (en) * 2006-08-18 2011-02-22 N.V. Organon 6-substituted isoquinoline derivatives

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1856476A (zh) * 2003-09-23 2006-11-01 默克公司 异喹啉酮钾通道抑制剂
WO2005054202A1 (en) * 2003-11-25 2005-06-16 Eli Lilly And Company 7-phenyl-isoquinoline-5-sulfonylamino derivatives as inhibitors of akt (proteinkinase b)

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Yoshiki Yoshida 等.Studies on Anti-Helicobacter pylori Agents. Part 1: Benzyloxyisoquinoline Derivatives.《Bioorganic & Medicinal Chemistry》.1999,第7卷(第11期),2647-2666. *

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ZA200903553B (en) 2010-04-28
DE602007013950D1 (de) 2011-05-26
AU2007338409A1 (en) 2008-07-03
IL199536A (en) 2014-07-31
KR20090103903A (ko) 2009-10-01
WO2008077553A1 (en) 2008-07-03
MA31023B1 (fr) 2009-12-01
JP2010514718A (ja) 2010-05-06
US20100056568A1 (en) 2010-03-04
CO6210725A2 (es) 2010-10-20
JP5318778B2 (ja) 2013-10-16
AU2007338409B2 (en) 2012-12-13
DK2125744T3 (da) 2011-08-01
BRPI0720710A2 (pt) 2014-12-23
MX2009005828A (es) 2009-06-16
CN101573338A (zh) 2009-11-04
EP2125744A1 (en) 2009-12-02
EP2125744B1 (en) 2011-04-13
ES2364511T3 (es) 2011-09-05
HK1138583A1 (en) 2010-08-27
NO20092431L (no) 2009-09-21
PT2125744E (pt) 2011-07-01
ATE505458T1 (de) 2011-04-15
MY148514A (en) 2013-04-30
CA2673919C (en) 2015-06-23
CA2673919A1 (en) 2008-07-03

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