CN101558991A - Vibration/motion training device for simulating weightless tail suspended rats - Google Patents
Vibration/motion training device for simulating weightless tail suspended rats Download PDFInfo
- Publication number
- CN101558991A CN101558991A CNA2009100827117A CN200910082711A CN101558991A CN 101558991 A CN101558991 A CN 101558991A CN A2009100827117 A CNA2009100827117 A CN A2009100827117A CN 200910082711 A CN200910082711 A CN 200910082711A CN 101558991 A CN101558991 A CN 101558991A
- Authority
- CN
- China
- Prior art keywords
- rat
- vibration
- training
- tail
- motion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Landscapes
- Catching Or Destruction (AREA)
Abstract
The invention discloses a tail-suspended rat fixing device, which comprises a rat fixing box, a tail suspension device and an angle adjusting device. The invention also provides a tail-suspended rat vibration/motion training device, which comprises a motion track limit device, a vibration training device, an active motion training device, a passive motion training device, a rat hind limb fixing device and a height adjusting device. The invention also provides a vibration/motion control device, which comprises a display screen, a key, a direct-current motor speed adjusting knob, a power supply adapter, a switch, a USB interface and an internal circuit, wherein the direct-current motor speed adjusting knob is used for adjusting the rotating speed of a direct-current motor during passive motion training; the power supply adapter and the switch are used for supplying power for the whole device; the USB interface is used for carrying out function expansion later; and the internal circuit is used for controlling and quantifying rat vibration/motion training and supplying power. The device can keep the same tail-suspended height, can carry out equal-length and equal-tension motion by combining vibration and motion training, and simultaneously achieves training quantification and control.
Description
Technical field
The present invention relates to space flight biomedical engineering research field, more particularly relate to a kind of can be under simulated weightlessness conditions tail-suspended rat the vibration/device of training.
Background technology
Serious weightlessness bone loss can take place in spaceman in long-time space flight, the bone loss rate in addition be far longer than postmenopausal women after annual bone loss rate (3%), have a strong impact on the operate as normal and the health of spaceman.So it is very urgent to seek the measure that can effectively resist weightlessness bone loss.
But because the limitation of space experiment, the data of this respect is mainly by obtaining at the weightless model of ground simulation at present.One of at present the most frequently used model is that model hangs in the rat tail of last century middle nineteen seventies foundation and development in NASA (NASA).This model is removed rat hindlimb by the afterbody suspention and is born a heavy burden, and forelimb still keeps bearing a heavy burden, and is not influencing simulation hind leg weightlessness bone loss effect under the endocrine situation of rat.
And about counter measure, multinomial zooperal data show that training is a kind of measure that resists weightlessness bone loss safely and effectively.In the model that utilizes training antagonism bone loss, training method commonly used has running (Ishihara et al., Effects of running exercise during recovery from hindlimb unloading on soleusmuscle fibers and their spinal motoneurons in rats.Neuroscience Research, 2004,48:119-127.), flywheel (J.D.Fluckey, E.E.Dupont-Verstgden, et al.A rat resistanceexercise regimen attenuates losses of musculoskeletal mass during hindlimbsuspension.Acta Physiol Scand, 2002,176:293-300.Esther E., Dupont-Versteegden, et al., Effect of flywheel-based resistance exercise onprocesses contributing to muscle atrophy during unloading in adult rats.J ApplPhysiol 2006,101:202-212.) and vibration (B.S.Oxlund, G.
Low-intensity, high-frequency vibration appears to prevent the decrease in strength of the femurand tibia associated with ovariectomy of adult rats.Science direct bone, 2003,32:69-77.) etc. several.
But how many above-mentioned several training methods exists defective.The training of wherein running can't guarantee that rat hangs under the state at tail to be carried out, or even the convalescent period after tail hangs trains; Though but flywheel training is to hang at tail to carry out under the state can not guarantee that tail hangs angle, training simultaneously be not only carry out also at hind leg can't load quantitative; What vibration training utilized is rat castration model, and training also is at rat body, and the rat tail that is not suitable for us hangs model.In addition, all present training methods all are to adopt single forms of motion, such as simple running or simple vibration.Whether such training method can only draw training effective to the antagonism bone loss, and motion antagonism bone loss that can't more specific certain form is more effective---and this is that our research of present stage more needs to pay close attention to.
Vincent etc. design a kind of rat training devices, and rat is entad produced or centrifugal contractile motion, can isometric grade open the training muscle of constant speed, and the load can obtain rat motor the time.But also there is serial problem in this design, for example: the implant electrode of need in the rat body, performing the operation, adopt alternating current to stimulate and to influence the electric current of organism own, and load or quantity of motion (Vincent J.Caiozzo when being difficult to the training of control rat by electricity irritation, Eugene MA, et al., A newanimal model for modulating myosin isoform expression by altered mechanicalactivity.J.Appl.Physiol., 1992,73 (4): 1432-1440.).
Therefore, pressing in this field provides a kind of and can keep same tail hang under the simulated weightlessness of angle, and rat is carried out various ways, quantitatively controlled training, and training process is not to the traumatogenic training devices of rat simultaneously.
Summary of the invention
Hang the rat tail that exists among the training devices and hang angle and can not keep in order to overcome present rat tail, forms of motion is single and cannot Quantitative Monitoring, controlled, needing before the training has problems such as invasive procedures or anaesthetic treatment, the invention provides and a kind ofly can keep same tail to hang angle, vibration combines with training, can carry out isometric and isotonic exercise, realize the training devices of training quantification and controlledization simultaneously, be used to study exploration and optimize the movement technique that antagonism weightlessness sclerotin is lost.
According to an aspect of the present invention, provide a kind of rat tail to hang fixture, be used for fixing rat and in training process, keep the rat tail to hang simulated weightlessness, it is characterized in that comprising: big mouse fixed case, be used to hold rat head trunk and forelimb, and keep its posture to fix; The tail device for hoisting is used to suspend in midair rat tails, keeps the simulated weightlessness in the training process; Angle regulator is used to regulate the angle between the base that described big mouse fixed case and described rat tail hang fixture, thereby guarantees that the rat trunk still keeps tail at ordinary times to hang a low level angle in training process.
Preferably, hang in the fixture at described rat tail, the higher end of described big mouse fixed case can folding, more conveniently holds rat and fixing rat; Its lower end is provided with the rat apparatus for adjusting position, can control the degree of depth of rat in big mouse fixed case, to adapt to the individuality of different length.
Preferably, hang in the fixture at described rat tail, described angle regulator comprises holder and fixing wheel carrier.Described holder comprises: the holder chassis, and it is fixed on described rat tail and hangs on the base of fixture; The holder support, it is fixed on the described holder chassis and has engraved several grades of height spacing holes on it; The holder crossbeam, it passes described height spacing hole, in order to support and to regulate the height of described big mouse fixed case; The holder supporting plate, it is supported by described holder crossbeam, in order to support the big mouse fixed case on it.It is fixed on described fixedly wheel carrier on the holder supporting plate, can regulate the angle of described big mouse fixed case, is consistent with a low level angle that tail at ordinary times hangs under the state in training process to guarantee the rat trunk
According to a second aspect of the invention, provide a kind of rat tail to hang vibration/motion training device, be used for rat is vibrated/training under tail hangs state, it is characterized in that comprising: the movement locus restraint device is used to limit the range of movement of rat; The vibration training devices is used for rat is vibrated training; The active exercise training devices is used for rat is carried out the active exercise training; Passive exercise training device is used for rat is carried out continuous passive motion; The rat hindlimb fixture is used to place and the fixing a pair of hind leg of rat, thus only guarantee at rat hindlimb but not all trunk train; And arrangement for adjusting height, be used to regulate the height that described rat tail hangs vibration/motion training device and hang the height of fixture to adapt to described rat tail.
Preferably, hang in vibration/motion training device at described rat tail, described movement locus restraint device comprises the movement locus confinement plate, the radius size of its length decision rat motor track; Rotate wheel carrier, it is fixed on the supporting plate of described vibration/motion training device, and described movement locus confinement plate is to be connected to described the rotation on the wheel carrier relative to the rotating form of described supporting plate; The load rubber band, the one end is fixed with respect to the base of described vibration/motion training device, and the other end is fixed on the end of described movement locus confinement plate near rat, can be by increasing rubber band quantity regulating rat motor load capacity; The first sports limiting bar, it is set at the end of described rotation wheel carrier near rat, and the lower end is fixed on the described supporting plate, and the height of described sports limiting bar can be regulated by rotating its vertical damping medicated cap in the upper end, thus control rat motor amplitude; The second sports limiting bar, it is set at described rotation wheel carrier and is fixed on the described supporting plate away from the end lower end of rat, and the height of described sports limiting bar can be regulated by rotating its vertical damping medicated cap in the upper end, thus control rat motor amplitude.
Preferably, hang in vibration/motion training device at described rat tail, described vibration training devices comprises motor and vibrating shaft.Described motor, it is fixed on described movement locus confinement plate a section near rat, accepts the vibration of the control generation corresponding frequencies of controllor for step-by-step motor.Described vibrating shaft is connected with described motor, and conduction vibration is to described rat hindlimb fixture.
Preferably, hang in vibration/motion training device at described rat tail, described active exercise training devices comprises electrostimulator, and its electrode tip is connected described rat hindlimb fixture, is used to give the electricity irritation of rat vola.Described electrostimulator has been used for reference people's such as Fan Yubo patent of invention " a kind of electric arc type electric-impulse stimulation instrument " (number of patent application 200810246661.7), and the acquisition inventor implements the right permission.
Preferably, hang in vibration/motion training device at described rat tail, described passive exercise training device comprises: direct current generator, be fixed on the described base, and provide power to spur described movement locus confinement plate, rat is carried out continuous passive motion; Pulley, it is fixed on the described supporting plate; Backguy, one end are fixed on the turning cylinder of described direct current generator, and the other end is fixed on the end of described movement locus confinement plate away from rat, and described pulley is passed in described backguy.
Preferably, hang in vibration/motion training device at described rat tail, described rat hindlimb fixture comprises a pair of pedal, and it is fixed on the described vibrating shaft, is used for supporting and fixing rat hindlimb.The electrode tip that connects described electrostimulator on the described pedal makes vibration training, active exercise training, continuous passive motion all only at rat hindlimb, rather than whole trunk.
Preferably, hang in vibration/motion training device at described rat tail, described arrangement for adjusting height comprises holder, it is the same that its structure and described rat tail hang in the fixture holder of angle regulator, is used to regulate the height that described rat tail hangs vibration/motion training device and hangs the height of fixture to adapt to described rat tail.
According to a third aspect of the present invention, provide a kind of vibration/motion control device, be used for rat vibration/training is controlled and quantized, it is characterized in that comprising: display screen is used for showing vibration/kinematic parameter; Button is used to be provided with vibration/kinematic parameter and controls whole training process; The DC motor speed-regulating knob, the rotating speed of described direct current generator when being used to regulate continuous passive motion; Power connection and switch, it is connected with external power source, is used to described vibration/motion control device and described rat tail to hang vibration/motion training device power supply is provided; USB interface is carried out the function expansion after being used for; And internal circuit, be used for rat vibration/training is controlled and quantized, and power supply is provided.
Optimize, in described vibration/motion control device, described USB interface is connected with single-chip microcomputer by the jtag interface circuit, after being used for again download control program carry out function and expand.
Optimize, in described vibration/motion control device, described internal circuit comprises: single-chip microcomputer is used for controlling described rat tail and hanging vibration/motion training device by controlling described vibration/motion control device; Controllor for step-by-step motor is used to control the direction and the rotating speed of described motor; DC motor controller is used to control the direction and the rotating speed of described direct current generator; Power circuit, it is connected in described power connection, is used for changing voltage and provides power supply for described vibration/motion control device and described rat tail hang vibration/motion training device.
Optimize, power circuit further comprises in described internal circuit: D.C. regulated power supply is used for external alternating current 220V is converted to direct current 24V; The direct current transformation module is used for direct current 24V is converted to direct current 5V; LM1117-3.3V is used for direct current 5V is converted to direct current 3.3V.
Wherein said rat tail hangs tail device for hoisting part in the fixture, described rat tail hangs in vibration/motion training device the movement locus restraint device and has partly used for reference people's such as Sun Lianwen patent of invention " a kind of active/passive exercise training device for simulated weightless tail-suspended rat " (number of patent application 200810114305.X), and obtains the inventor and implement the right permission.
The present invention has compared following beneficial effect with existing rat motor device:
The present invention has designed big mouse fixed case, and a higher end can folding, places more easily and fixing rat; Its lower end is provided with the rat apparatus for adjusting position, can control the degree of depth of rat in big mouse fixed case, to adapt to the individuality of different length.Fixed bin has designed angle regulator, can regulate the angle between the base that rat trunk and described rat tail hang fixture, thereby guarantees that the rat trunk still keeps tail at ordinary times to hang a low level angle in training process.Rat does not need to carry out anaesthetic treatment in the experimentation, and body posture is stable, the experimenter is not threatened, and because fixed bin can limit the motion of rat forelimb performance and head, thereby get rid of other limb motions of rat to the experiment influence.
The present invention has designed holder, be applied to the rat tail respectively and hang in fixture and the rat vibration/motion training device, by the height spacing hole on holder crossbeam and the holder support can adjusting device height, thereby can control the rat motor amplitude
The present invention has designed rat vibration/motion training device, can realize vibrating, active exercise, passive exercise, vibration combine with active exercise, the motion of vibration and various ways such as passive exercise combines.All vibration/trainings promptly are subjected to tail to hang the limb part that simulated weightlessness has the greatest impact all at rat hindlimb, have strengthened the training specific aim.And can realize the isometric contraction of rat by fixing described movement locus confinement plate, can realize the isotonic contraction of rat by keeping described load rubber band invariable number.The training that realizes various ways makes function of the present invention abundanter.
The present invention has designed vibration/motion control device.Make rat vibration/training quantification by vibration/kinematic parameter is set, make controlledization of training process by button setting and termination, thereby can control rat motor intensity.Can realize that by described USB interface function of the present invention can expand, increase motility of the present invention and using value.
The present invention fixture and training devices in carrying out training process do not have the limbs injury to tail-suspended rat, do not need to carry out anaesthetic treatment yet, thereby have realized the noinvasive experiment.
This shows that the present invention can realize the training at the multiple forms of motion of tail-suspended rat hind leg; Keep the rat tail to hang simulated weightlessness when can be implemented in training; Can realize form, the amplitude to rat vibration/training, the control of intensity; Can realize rat is not had the noinvasive experiment of injury.
Description of drawings
Fig. 1 is unitary construction figure according to an embodiment of the invention.
Fig. 2 is that rat tail according to an embodiment of the invention hangs the structural map of fixture.
Fig. 3 is the structural map that rat tail according to an embodiment of the invention hangs vibration/motion training device.
Fig. 4 A is the forward sight structural map of vibration/motion control device according to an embodiment of the invention.
Fig. 4 B is the back vision structure figure of vibration/motion control device according to an embodiment of the invention.
Fig. 5 is the hardware structure diagram of vibration according to an embodiment of the invention/motion control device internal circuit.
Fig. 6 is the hardware elementary diagram in the internal circuit according to an embodiment of the invention.
Fig. 7 is a control sequence flow chart according to an embodiment of the invention.
The specific embodiment
The present invention is described in further detail below in conjunction with drawings and Examples.
In Fig. 2, comprise big mouse fixed case 201, tail device for hoisting 202, base 203, rat apparatus for adjusting position 204, fixedly wheel carrier 205, holder chassis 206, holder support 207, holder crossbeam 208, holder supporting plate 209.
Wherein said tail device for hoisting 202 is fixed and is fixed on the base 203 with screw, is used to suspend in midair rat tails.
Wherein said holder is formed by 206,207,208,209, is used to support big mouse fixed case 201 and fixing wheel carrier 205.Wherein holder chassis 206 is fixed on the base 203 with screw, and holder support 207 is bonded on the holder chassis 206 by the chloroform organic solvent.Holder crossbeam 208 can move or be fixed in the height spacing hole on the described holder support 207, is used to adjust the height of described big mouse fixed case.
Wherein said big mouse fixed case 201 is fixed on the described fixedly wheel carrier 205, can regulate that fixing then to hang a low level angle consistent to guarantee in the training process hanging angle and tail at ordinary times by the rat tail with the angle of described base 203.Wherein big mouse fixed case 201 higher ends can the more convenient placement of folding and fixing rat, and there is shape of a saddle projection its below, is used for exposing and separating rat hindlimb; The depth that low end rat apparatus for adjusting position 204 can be regulated rat in the big mouse fixed case 201 by the length of adjusting screw is to adapt to the individuality of different length.
In Fig. 3, comprise movement locus confinement plate 301, rotate wheel carrier 302, the first sports limiting bar 303, the second sports limiting bar 304, motor 305, vibrating shaft 306, electrostimulator 307, direct current generator 308, pulley 309, backguy 310, pedal 311, holder chassis 312, holder support 313, holder crossbeam 314, holder supporting plate 315.
Wherein said holder chassis 312, holder support 313, holder crossbeam 314, holder supporting plate 315 structures are consistent with the described holder of Fig. 2, are used to adjust the height that described rat tail hangs vibration/motion training device.
Wherein said movement locus confinement plate 301 is fixed on described rotation wheel carrier 302, and its range of activity is subjected to described first sports limiting bar 303 and the restriction of the second sports limiting bar 304, can realize controlling the rat motor amplitude by adjusting 303 and 304 height.Simultaneously, 301 pairs of tail-suspended rats of fixed motion track confinement plate are implemented training and can be realized the isometric contraction campaign of rat.
Wherein said electrostimulator 307 is fixed on the base 203 described in Fig. 2, and the electrode tip of output is connected on the described pedal 311, is used for stimulation in rats and produces active exercise.
Wherein said backguy 310 is connected with described direct current generator 308 by pulley 309.Rotate by 308 both forward and reverse directions, spur 301 up and downly, be used for rat is carried out continuous passive motion.The wherein said second sports limiting bar 304 provides signal to described DC motor controller, makes the direct current generator backward rotation.
Wherein said motor 305 is selected the 42BY motor for use, is fixed on the described movement locus confinement plate 301, is connected with described pedal 311 by vibrating shaft 306, and being used for provides resistance and produce vibration the rat active exercise.
In Fig. 4 A, comprise display screen 401, button 402,403,404,405,406 and DC motor speed-regulating knob 407.
Wherein said display screen 401 is selected 12864 liquid crystal for use, is used for showing vibration/kinematic parameter, is convenient to be provided with and monitoring.
Wherein said button 402 is used to select motor pattern and parameter options, and button 403 and 404 is respectively applied for relevant parameters+1 and-1, and button 405 is used for determining to select and carry out, and button 406 is used for suspending carries out, recovers to carry out and return previous menu.
Wherein said DC motor speed-regulating knob 407 is used to regulate the rotating speed of direct current generator, thus the intensity of control rat continuous passive motion.
In Fig. 4 B, comprise power connection 408, switch 409 and USB interface 410.
Wherein said power connection 408 and switch 409 are used to connect outside 220V alternating current power supply, for whole device provides power.
Wherein said USB interface 410 is connected with single-chip microcomputer by described jtag interface circuit, after being used for again download control program carry out function expansion.
In Fig. 5, comprise single-chip microcomputer 501, controllor for step-by-step motor 502, DC motor controller 503, power circuit 504, jtag interface circuit 505, supervisory keyboard 506, kinestate decision circuitry 507, auditory tone cues electric circuit 508, display circuit 509, clock circuit 510, reset circuit 511 and electrical stimulation circuit 512.
In Fig. 6, comprise single-chip microcomputer 501, controllor for step-by-step motor 502, DC motor controller 503, power circuit 504, jtag interface circuit 505, supervisory keyboard 506, kinestate decision circuitry 507, auditory tone cues electric circuit 508, display circuit 509, clock circuit 510, the concrete schematic diagram of reset circuit 511 and electrical stimulation circuit 512.
Wherein said single-chip microcomputer 501 is selected the ATMEGA16 single-chip microcomputer of Atmel company for use, and the memory span of this single-chip microcomputer, I/O port, outer middle fracture quantity etc. can both satisfy the needs of the present invention's design, and have good autgmentability.
Comprise described DC motor speed-regulating knob 407 in the wherein said DC motor controller 503, control the rotating speed of direct current generator by changes in resistance.Its direction is subjected to described kinestate decision circuitry 507 controls in addition.
The outside is connected with described power connection 408 and switch 409 in the wherein said power circuit 504, comprises D.C. regulated power supply 601, is used for external alternating current 220V is converted to direct current 24V; Direct current transformation module 602 is used for direct current 24V is converted to direct current 5V; LM1117-3.3V603 is used for direct current 5V is converted to direct current 3.3V.
Wherein said jtag interface circuit 505 outsides are connected with described USB interface 410, and inside is connected with single-chip microcomputer 501.
Wherein said supervisory keyboard 506 is corresponding with described button 402,403,404,405,406.
Wherein said kinestate decision circuitry 507 is connected with the described second sports limiting bar 304.
Wherein said auditory tone cues electric circuit 508 is used for the sound alarm of sounding a buzzer under training end or other situations.
Wherein said electrical stimulation circuit 512 is connected with described electrostimulator 307, and the electrode tip discharge of control electrostimulator 307.
In Fig. 7, comprise functional modules such as initialization, parameter selection and setting, execution.
On the basis of above-mentioned hardware, the basic function of device is by programme-control that writes single-chip microcomputer and realization.Whole programs of this device are made of mastery routine, initialization subroutine, external interrupt subprogram and internal interrupt subprogram.Mastery routine is mainly finished following function: (1) keyboard scan program: judge whether keyboard is pressed, and the identification button, carry out the corresponding command then, the time-out of the selection of implementation pattern, the selection of parameter and setting, instrument and function such as restart.(2) display routine: I/O port output display command and displays content data by single-chip microcomputer are given liquid crystal display, will train persistent period and frequency of training to be presented on the liquid crystal display screen.(3) unlatching of relay and buzzer is controlled, realized the functional module of execution, and after being finished, send buzz and warn.Initialization subroutine is responsible for some internal storage location initializes in the single-chip microcomputer, and the statement of I/O port is opened and interrupted and to the intervalometer initialize.Whether the responsible external interrupt port to single-chip microcomputer of external interrupt subprogram has external interrupt signal (for example above-mentioned second sports limiting bar 304) input to detect and judges, and when eligible the requirement, turn to corresponding block operation, with control rat motor state.The internal interrupt subprogram interrupts applying for that the timer/counter by single-chip microcomputer inside sends, and intervalometer is accurately controlled the time of implementation according to program setting, and counter records is carried out number of times, with the quantification of implement device training.
Its idiographic flow is: finish initialization after the start, enter " model selection " (701) behind the liquid crystal display " BME ", comprising " 1 initiatively, and 2 is passive, and 3 vibrate, and 4 masters shake, and 5 are shaken " five kinds of patterns.Judge whether button 402 is pressed, by being that the relevant position adds 1 next time.Judge whether button 405 is pressed, and promptly judges whether to select the pattern of current location, button 402 realizes that circulation selection parameter (702) is provided with then.Wherein comprise parameter S T (electricity irritation time of origin), BT (interval between left and right), IT (twice stimulus intervals time), NoS (electricity irritation number of times) under the aggressive mode.Comprise parameter N oP (passive exercise number of times) under the Passive Mode.Comprise V parameter F (frequency of vibration) and VT (time of vibration) under the vibration mode.Comprise parameter S T, BT, IT, NoS and VF under the main pattern of shaking.Comprise parameter N oP and VF under the pattern of being shaken.Parameter is set increases parameter values (703), or button 404 reduces parameter value (704) and realizes by button 403.Push button after setting and 405 confirm to carry out (705), single-chip microcomputer 501 opening timing device sum counters (706) then, and starting relay or controller (707).The term of execution judge whether button 406 is pressed (708), if then program halt is carried out, be pressed once more up to button 406.If enumerator reaches preset value (709) back closed relay and starts buzzer (710), return " model selection " interface (701).
Earlier big mouse fixed case 201 higher ends are opened during use, mentioned rat tails, utilize the characteristic of getting into the cave of rat to make it initiatively pierce big mouse fixed case 201 near big mouse fixed case 201.Close afterwards and close big mouse fixed case 201, and utilize elastic band to prop up the rat buttocks, adjust the length of rat apparatus for adjusting position 204 screws simultaneously, cooperate elastic band to keep the stable of rat posture.Again rat tails is suspended to tail device for hoisting 202.With fixing wheel carrier 205 is axle, rotates big mouse fixed case 201 and adjusts with the angle of base 203 and for example fix big mouse fixed case 201 after 30 °.Rat all keeps the tail of 30 ° of low levels to hang state in whole sport training process like this, is consistent when not training.
The part that tail-suspended rat is had the greatest impact by simulated weightlessness is a hind leg, and the whole limbs of rat all are fixed in except that hind leg in the big mouse fixed case 201 in the training process of the present invention, other motions are restricted, and the vibration that applies, active exercise and continuous passive motion all only only carry out at rat hindlimb, have got rid of the interference of other limb motions of rat to experiment effectively.
It is to utilize its nature of getting into the cave that rat is placed into big mouse fixed case 201; Trunk fixedly brings realization by rat apparatus for adjusting position 204 and elastic force; Rat hindlimb also is to utilize the elastic band binding to be fixed on pedal 311.Whole fixation procedure rat does not need anaesthetic treatment can not produce wound to its limbs yet.The stimulation of active exercise training is a HVDC electric arc, does not form the loop and also can not produce wound to the rat limbs.Do not anaesthetize the noinvasive experiment and make experimentation more convenient, strengthened the sustainability of experiment.
Behind the device for opening, select " active exercise " pattern, by button 403 and 404 relevant parameters is set and pushes button and 405 confirm to carry out.The load of active exercise provides with motor 305 and load rubber band.Rat is experienced initiatively to shrink behind the electric arc that electrostimulator 307 electrode tips emit and mentions hind leg and resist load.The auditory tone cues electric circuit 508 that is finished can send the buzz prompting.
On the basis of active exercise, fixed motion track confinement plate 301 imposes electricity irritation simultaneously, owing to range of movement is fixed, so rat essence is to carry out the isometric contraction campaign.Same on the basis of active exercise, load is provided separately by motor 305, and the arm of force of proof load is constant to impose electricity irritation simultaneously, and then rat is to carry out the isotonic contraction campaign.
Carry out after setting relevant parameters, direct current generator 308 rotates and drives backguy 310, and movement locus confinement plate 301 is moved upward near rat one end, drives the passive contraction of rat hindlimb.When movement locus confinement plate 301 touches the second sports limiting bar 304, direct current generator 308 beginning counter-rotation drive the passive stretching, extension of rat hindlimb, finish a passive exercise.Regulate DC motor speed-regulating knob 407 in addition and can control the rotating speed of direct current generator 308, thus the control rat passive exercise cycle.The auditory tone cues electric circuit 508 that is finished can send the buzz prompting.
Frequency of vibration and time of vibration are set, confirm to carry out.Motor 305 drives pedal 311 reciprocating vibrations by vibrating shaft, thereby rat hindlimb is vibrated.The auditory tone cues electric circuit 508 that is finished can send the buzz prompting.
Select " initiatively-and vibration " pattern, the active exercise parameter is set, and vibration parameters has only frequency of vibration, time of vibration is determined by the active exercise number of times.After confirming to carry out, on the basis of active exercise training, carrying out the vibration training all the time.The auditory tone cues electric circuit 508 that is finished can send the buzz prompting.Selecting " passive-vibration " pattern, also is to carry out the vibration training on the basis of continuous passive motion all the time.
The height of the length of movement locus confinement plate 301 and the first sports limiting bar 303, the second sports limiting bar 304 and the height spacing hole on the holder support 207,313 all can be controlled the motion amplitude of rat hindlimb; During active exercise, select the load rubber band of different numbers for use, different motion loads can be provided; During vibration/training,, different frequency of training, cycle and frequency of vibration can control the intensity of rat training by being set.Can push button at any time in training process simultaneously and 406 suspend and recovers and carry out, realization is to controlledization of training process.
Claims (7)
1. a rat tail hangs vibration/motion training device, is used for rat is vibrated/training under tail hangs state, it is characterized in that comprising:
Movement locus restraint device (301,302,303,304) is used to limit the range of movement of rat;
Vibration training devices (301,305,306,311) is used for rat is vibrated training;
Active exercise training devices (307,311) is used for rat is carried out the active exercise training;
Passive exercise training device (308,309,310,304) is used for rat is carried out continuous passive motion;
Arrangement for adjusting height (312,313,314,315) is used to regulate the height that described rat tail hangs vibration/motion training device and hangs the height of fixture to adapt to described rat tail.
2. rat tail according to claim 1 hangs vibration/motion training device, it is characterized in that, described motor 305 is fixed on the described movement locus confinement plate 301, is connected with described pedal 311 by vibrating shaft 306, and being used for provides resistance and produce vibration the rat active exercise.
3. rat tail according to claim 1 hangs vibration/motion training device, it is characterized in that, described passive exercise training device comprises: backguy 310 is fixed on the described movement locus confinement plate 301, be connected with described direct current generator 308 by pulley 309, both forward and reverse directions by 308 rotates, spur 301 up and downly, be used for rat is carried out continuous passive motion.The wherein said second sports limiting bar 304 provides signal to described DC motor controller, makes the direct current generator backward rotation.
4. rat tail according to claim 1 hangs vibration/motion training device, it is characterized in that, described arrangement for adjusting height comprises: holder chassis 312 is fixed on the base 203, and holder support 313 is bonded on the holder chassis 312.Holder crossbeam 314 can move or be fixed in the height spacing hole on the described holder support 313, is used to adjust the height of described big mouse fixed case.
5. a rat tail hangs fixture, is used for fixing rat and keeps the rat tail to hang simulated weightlessness in training process, it is characterized in that comprising:
Big mouse fixed case (201,204,205,206,207,208,209) is used to hold rat head trunk and forelimb, and keeps its posture to fix;
Tail device for hoisting (202,203) is used to suspend in midair rat tails, keeps the simulated weightlessness in the training process;
Angle regulator is used to regulate the angle between the base that described big mouse fixed case and described rat tail hang fixture, thereby guarantees that the rat trunk still keeps tail at ordinary times to hang a low level angle in training process.
6. rat tail according to claim 5 hangs fixture, it is characterized in that, described big mouse fixed case 201 is fixed on the described fixedly wheel carrier 205, can regulate with the angle of described base 203 fixing then.Wherein big mouse fixed case 201 higher ends can the more convenient placement of folding and fixing rat; The depth that low end rat apparatus for adjusting position 204 can be regulated rat in the big mouse fixed case 201 by the length of adjusting screw.
7. hang vibration/motion training device according to any one described rat tail among the claim 1-4, it is characterized in that further comprising that rat tail as claimed in claim 5 hangs fixture.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2009100827117A CN101558991A (en) | 2009-04-29 | 2009-04-29 | Vibration/motion training device for simulating weightless tail suspended rats |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2009100827117A CN101558991A (en) | 2009-04-29 | 2009-04-29 | Vibration/motion training device for simulating weightless tail suspended rats |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101558991A true CN101558991A (en) | 2009-10-21 |
Family
ID=41218091
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2009100827117A Pending CN101558991A (en) | 2009-04-29 | 2009-04-29 | Vibration/motion training device for simulating weightless tail suspended rats |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101558991A (en) |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102641119A (en) * | 2012-04-25 | 2012-08-22 | 浙江中医药大学 | Animal tail suspension experiment device |
| CN102657101A (en) * | 2012-04-16 | 2012-09-12 | 中国人民解放军63919部队 | Non-human primate test animal medium and long-term weightlessness simulation model device |
| CN103999794A (en) * | 2014-05-28 | 2014-08-27 | 中国航天员科研训练中心 | Rat simulation weightless treadmill training method and rat simulation weightless treadmill |
| CN104160978A (en) * | 2014-04-25 | 2014-11-26 | 杨成 | Non-straddle small animal hind limb rehabilitation training instrument |
| CN103688877B (en) * | 2013-12-10 | 2016-02-17 | 中国航天员科研训练中心 | Animal simulation low-gravity exercise device |
| CN106212301A (en) * | 2016-07-28 | 2016-12-14 | 北京航空航天大学 | The adjusting means of rat body fluid compartments under a kind of simulated weightlessness |
| CN108012951A (en) * | 2017-12-12 | 2018-05-11 | 西安医学院 | A kind of rat integrated motion treadmill |
| CN109549822A (en) * | 2019-01-21 | 2019-04-02 | 上海市同济医院 | Toy limbs continuous passive motion machine |
| CN110345901A (en) * | 2019-06-28 | 2019-10-18 | 西安医学院 | A kind of suspention angle measurement and control system of tail suspended rats |
| CN111587808A (en) * | 2020-06-24 | 2020-08-28 | 河南大学 | Automatic centrifugal training device for rats and working method thereof |
| CN112120893A (en) * | 2020-09-27 | 2020-12-25 | 北京航空航天大学 | Animal hind limb stretching device |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101283675A (en) * | 2008-06-06 | 2008-10-15 | 北京航空航天大学 | Positive/passive exercise training device for simulating weightless tail suspended rats |
-
2009
- 2009-04-29 CN CNA2009100827117A patent/CN101558991A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101283675A (en) * | 2008-06-06 | 2008-10-15 | 北京航空航天大学 | Positive/passive exercise training device for simulating weightless tail suspended rats |
Non-Patent Citations (2)
| Title |
|---|
| B.X.OXLUND,ET AL: "low-intensity,high-frequency vibration appears to prevent the decrease in strength of the femur and tibia associated with ovariectomy of adult rats", 《BONE》 * |
| J.D.FLUCKEY,ET AL: "A rat resistance exercise regimen attenuates losses of musculoskeletal mass during hindlimb suspension", 《ACTA PHYSIOL SCAND》 * |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102657101A (en) * | 2012-04-16 | 2012-09-12 | 中国人民解放军63919部队 | Non-human primate test animal medium and long-term weightlessness simulation model device |
| CN102641119B (en) * | 2012-04-25 | 2013-11-13 | 浙江中医药大学 | Animal tail suspension experiment device |
| CN102641119A (en) * | 2012-04-25 | 2012-08-22 | 浙江中医药大学 | Animal tail suspension experiment device |
| CN103688877B (en) * | 2013-12-10 | 2016-02-17 | 中国航天员科研训练中心 | Animal simulation low-gravity exercise device |
| CN104160978A (en) * | 2014-04-25 | 2014-11-26 | 杨成 | Non-straddle small animal hind limb rehabilitation training instrument |
| CN103999794B (en) * | 2014-05-28 | 2016-08-24 | 中国航天员科研训练中心 | A kind of rat simulated weightlessness treadmill exercise method and rat simulated weightlessness treadmill |
| CN103999794A (en) * | 2014-05-28 | 2014-08-27 | 中国航天员科研训练中心 | Rat simulation weightless treadmill training method and rat simulation weightless treadmill |
| CN106212301A (en) * | 2016-07-28 | 2016-12-14 | 北京航空航天大学 | The adjusting means of rat body fluid compartments under a kind of simulated weightlessness |
| CN108012951A (en) * | 2017-12-12 | 2018-05-11 | 西安医学院 | A kind of rat integrated motion treadmill |
| CN109549822A (en) * | 2019-01-21 | 2019-04-02 | 上海市同济医院 | Toy limbs continuous passive motion machine |
| CN110345901A (en) * | 2019-06-28 | 2019-10-18 | 西安医学院 | A kind of suspention angle measurement and control system of tail suspended rats |
| CN111587808A (en) * | 2020-06-24 | 2020-08-28 | 河南大学 | Automatic centrifugal training device for rats and working method thereof |
| CN112120893A (en) * | 2020-09-27 | 2020-12-25 | 北京航空航天大学 | Animal hind limb stretching device |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101558991A (en) | Vibration/motion training device for simulating weightless tail suspended rats | |
| CN101283675B (en) | Positive/passive exercise training device for simulating weightless tail suspended rats | |
| Wang et al. | Woodpecker-mimic two-layer band energy harvester with a piezoelectric array for powering wrist-worn wearables | |
| US20090221407A1 (en) | Biomechanical stimulation training method and apparatus | |
| CN101703007B (en) | Positioning device for active/passive exercise training device for simulated weightless tail-suspended rat | |
| Paillard | Functional organization of afferent innervation of muscle studied in man by monosynaptic testing | |
| Logan et al. | Using a system identification approach to investigate subtask control during human locomotion | |
| US10706742B2 (en) | Method and system for creating a synthetic pulse | |
| CN109009978A (en) | A kind of apparatus for diagnosis and therapy of soft tissue of joint pain | |
| SE1400126A1 (en) | An apparatus and method for treating fascia | |
| CN101438997A (en) | Instrument for simulating massage technique | |
| Tang et al. | Modeling of muscle fatigue using Hill's model | |
| Osaki et al. | Relative contribution of walking velocity and stepping frequency to the neural control of locomotion | |
| Farahat et al. | An apparatus for characterization and control of isolated muscle | |
| JP2021027990A (en) | Muscle stimulation method and central nervous system stimulation method | |
| CN102579222A (en) | Portable biological resonance stimulation device | |
| Titcombe et al. | Mathematical Modelling of Parkinsonian Tremor. | |
| CN202537863U (en) | Portable bio-resonance stimulation device | |
| Eizad et al. | Development of a Wearable Haptic Feedback System for Limb Movement Symmetry Training | |
| CN107811351A (en) | A kind of vertical oscillation device | |
| CN207023408U (en) | A kind of vertical oscillation device | |
| Vasile et al. | Electro-magnetic actuated vibrating platform | |
| Afilal et al. | Modelling of the activation of a stretch reflex in view of improving the muscular force | |
| CN114099235B (en) | Rehabilitation robot and vibration and motion integrated control system and method thereof | |
| CN109550132A (en) | A kind of Proprioception training device and its application in neural rehabilitation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20091021 |