CN102657101A - Non-human primate test animal medium and long-term weightlessness simulation model device - Google Patents
Non-human primate test animal medium and long-term weightlessness simulation model device Download PDFInfo
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- CN102657101A CN102657101A CN2012101088970A CN201210108897A CN102657101A CN 102657101 A CN102657101 A CN 102657101A CN 2012101088970 A CN2012101088970 A CN 2012101088970A CN 201210108897 A CN201210108897 A CN 201210108897A CN 102657101 A CN102657101 A CN 102657101A
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Abstract
The invention belongs to the technical field of aerospace medicine and in particular relates to a device for performing a physiological test by simulating microgravity. The technical scheme is that the non-human primate test animal medium and long-term weightlessness simulation model device comprises a device main frame (100), a horizontal body position positioning device, a trunk side inclined angle positioning device, a feeding device (600), a water intake device (700) and a metabolin collecting disc (500), wherein a bed surface outer ring (401) of the horizontal body position positioning device is connected to the device main frame (100) through a connecting shaft (201) and is fixed by a locking handle (203); a bed surface inner ring (402) of the trunk side inclined angle positioning device is connected to the bed surface outer ring (401) through a positioning shaft (303) and is fixed by a locking device; and the metabolin collecting disc (500) is arranged below the device main frame (100). According to the invention, head low-position inclined angle and trunk side inclined angle can be positioned precisely by positioning and locking devices, and various zero-gravity environments can be simulated.
Description
Technical field
The invention belongs to the aerospace medicine technical field, particularly a kind of simulated microgravity carries out the device of Physiological Experiment.
Background technology
The spacefarer is when space travel, and being in a kind of is main with weightlessness effect, the space environment of other factors such as combined radiation, noise.Wherein medium-term and long-term weightlessness effect can cause the spacefarer that bone loss, amyotrophy, cardiovascular function disorder take place, and immunologic function degression etc., directly influence spacefarer's operation work efficiency, healthy and life security.Therefore, must carry out multi-level mechanism Journal of Sex Research to the midium or long term physiological effects of weightlessness that flies.
Utilize laboratory animal to set up the effective animal model important means that to carry out medium-term and long-term space travel Study on Physiological Effects be aerospace medicine research always.The non-human primates laboratory animal is a most popular senior laboratory animal in the animal model of human disease research; Closely similar with the mankind aspect morphosis, physiological function and biochemical metabolism; Use the result that they research and extrapolate the most exactly in the mankind, thereby also be to be engaged in one of laboratory animal the most frequently used in the aerospace medicine research.Utilizing the non-human primates laboratory animal to carry out one of key problem that medium-term and long-term simulated weightlessness animal model sets up research is to develop to meet the non-human primates physiologic characteristic, satisfy the simulated weightlessness experimental provision that laboratory animal welfare ethical standard requires, to simulate medium-term and long-term weightlessness effect.
At present, do not see the report of the medium-term and long-term simulated weightlessness model equipment of non-human primates laboratory animal abroad, China does not still have inhuman primate laboratory animal simulated weightlessness experimental provision.
Summary of the invention
The objective of the invention is: a kind of weightless model equipment that carries out medium-term and long-term simulated weightlessness experiment to the non-human primates laboratory animal is provided.
Technical scheme of the present invention is: the medium-term and long-term simulated weightlessness model equipment of a kind of non-human primates laboratory animal, and it comprises the device body frame, horizontal position positioner; Lateral bending of trunk angle positioner, bed surface, feeding device; Water feed apparatus, metabolite catch tray, animal subject are tied up solid vest;
Said device body frame is the bed mount structure of left and right sides band guardrail;
Said horizontal position positioner comprises the rule and the angle indicator at the said bed surface outer shroud of bed surface outer shroud, connecting axle, set lever and indication angle of inclination, and said bed surface outer shroud is connected the device body frame left and right sides through said connecting axle and is locked through said set lever;
Said lateral bending of trunk angle positioner comprises that ring is at the location of predetermined angular dial and location crank in ring in the bed surface, locating shaft and the fixing said bed surface, and ring is connected on the said bed surface outer shroud rear and front end through said locating shaft in the said bed surface;
Said bed surface adopts the flexible material with backbone support function, and periphery is provided with the contract hole, ties up with rope and in said bed surface, encircles admittedly; Bed surface has the porus excretorius of confession animal subject drainage and the permanent opening that a plurality of confession animal subject attitude setting tool is used;
Said feeding device comprises food dish and the more piece universal bar that is connected the food dish, and said more piece universal bar is connected on the said device body frame;
Said water feed apparatus is that water bottle is put into the water bottle case, and water nozzle stretches out through aperture, and said water bottle case connects the more piece universal bar, and said more piece universal bar is inserted and is connected on the said device body frame;
Said metabolite catch tray is arranged on the said device body frame below corresponding with said porus excretorius;
Said animal subject is tied up solid vest and is used for the animal subject attitude and fixes, and it is bound band and passes said permanent opening and be buckled in admittedly below the said bed surface during use.
The present invention can carry out the accurate location at a low level inclination angle and lateral bending of trunk angle through positioning and locking device; Device can not change the angle of animal subject head low level when left and right directions adjustment lateral bending of trunk angle, can simulate multiple weightlessness, and for the animal subject feed is intake, waste discharge provides condition.
Description of drawings
Accompanying drawing 1 is structure chart of the present invention;
Accompanying drawing 2 is device body frame figure among the present invention;
Accompanying drawing 3 is horizontal position positioner figure among the present invention;
Accompanying drawing 4 is lateral bending of trunk angle positioner figure among the present invention;
Accompanying drawing 5 is bed surface figure among the present invention;
Accompanying drawing 6 is tied up solid vest figure for animal subject among the present invention;
Accompanying drawing 7 is water feed apparatus figure among the present invention.
Embodiment
Embodiment 1: referring to accompanying drawing 1～6, and the medium-term and long-term simulated weightlessness model equipment of a kind of non-human primates laboratory animal, it is characterized in that: it comprises device body frame 100; Horizontal position positioner, lateral bending of trunk angle positioner, bed surface 403; Feeding device 600; Water feed apparatus 700, metabolite catch tray 500, animal subject are tied up solid vest 410;
Said device body frame 100 is the bed mount structure of left and right sides band guardrail;
Said horizontal position positioner comprises bed surface outer shroud 401, connecting axle 201, set lever 203 and indicates the rule 202 and the angle indicator at said bed surface outer shroud 401 angles of inclination that said bed surface outer shroud 401 is connected device body frame 100 left and right sides through said connecting axle 201 and is locked through said set lever 203;
Said lateral bending of trunk angle positioner comprise in ring 402 in the bed surface, locating shaft 303 and the fixing said bed surface ring 402 in the location of predetermined angular dial 301 and location crank 302, ring 402 is connected on said bed surface outer shroud 401 rear and front ends through said locating shaft 303 in the said bed surface;
Said bed surface 403 adopts the flexible material with backbone support function, and periphery is provided with the contract hole, ties up admittedly with rope and in said bed surface, encircles on 402; Bed surface 403 has the porus excretorius 405 of confession animal subject drainage and the permanent opening 404 of a plurality of confession animal subject attitude setting tools application;
Said feeding device 600 comprises food dish and the more piece universal bar that is connected the food dish, and said more piece universal bar is connected on the said device body frame 100;
Said water feed apparatus 700 is that water bottle is put into the water bottle case, and water nozzle stretches out through aperture, and said water bottle case connects the more piece universal bar, and said more piece universal bar is inserted and is connected on the said device body frame 100;
Said metabolite catch tray 500 is arranged on said device body frame 100 belows corresponding with said porus excretorius 405;
Said animal subject is tied up solid vest 410 and is used for the animal subject attitude and fixes, and its binding is with 411 to pass said permanent opening 404 and be buckled in admittedly below the said bed surface 403 during use.
Embodiment 2: referring to accompanying drawing 1～6; A kind of like the medium-term and long-term simulated weightlessness model equipment of embodiment 1 described non-human primates laboratory animal; Said bed surface 403 materials are that soft steel-sheet canvas is arranged in the interlayer; Because this material has certain pliability and air capacity of soils, the damage that can slow down the monkey extended immobilization and its skin caused when excited, the soft sheet metal in the canvas interlayer plays the backbone supporting role.
Embodiment 3: referring to accompanying drawing 1～7; According to embodiment 1 or the medium-term and long-term simulated weightlessness model equipment of 2 described non-human primates laboratory animal; It also comprises and is arranged on amusement ensuring equipment 800, medical treatment and the operation fluid infusion frame 900 of placing toy ball, minute surface and the recreation of other intelligence development classes in the middle of said device body frame 100 tops respectively.Said amusement ensuring equipment 800 is to be fixed on the feared state of mind and emergency reaction on the experimental bench for a long time in order to slow down and to eliminate animal subject, attracts and shifts its notice; Said medical treatment and operation fluid infusion frame 900 are used for disease treatment that animal subject is sent out or the operation fluid infusion of research purpose, anesthesia enforcement etc. are arranged.
Claims (3)
1. the medium-term and long-term simulated weightlessness model equipment of a non-human primates laboratory animal, it is characterized in that: it comprises device body frame (100), horizontal position positioner; Lateral bending of trunk angle positioner; Bed surface (403), feeding device (600), water feed apparatus (700); Metabolite catch tray (500), animal subject are tied up solid vest (410);
Said device body frame (100) is the bed mount structure of left and right sides band guardrail;
Said horizontal position positioner comprises the rule (202) and the angle indicator at bed surface outer shroud (401), connecting axle (201), set lever (203) and indication said bed surface outer shroud (401) angle of inclination, and said bed surface outer shroud (401) is connected device body frame (100) left and right sides through said connecting axle (201) and is locked through said set lever (203);
Said lateral bending of trunk angle positioner comprise in ring (402) in the bed surface, locating shaft (303) and the fixing said bed surface ring (402) in the location of predetermined angular dial (301) and location crank (302), interior encircle (402) of said bed surface are connected on said bed surface outer shroud (401) rear and front end through said locating shaft (303);
Said bed surface (403) adopts the flexible material with backbone support function, and periphery is provided with the contract hole, ties up admittedly with rope and in said bed surface, encircles on (402); Bed surface (403) has the porus excretorius (405) of confession animal subject drainage and the permanent opening (404) that a plurality of confession animal subject attitude setting tool is used;
Said feeding device (600) comprises food dish and the more piece universal bar that is connected the food dish, and said more piece universal bar is connected on the said device body frame (100);
Said water feed apparatus (700) is that water bottle is put into the water bottle case, and water nozzle stretches out through aperture, and said water bottle case connects the more piece universal bar, and said more piece universal bar is inserted and is connected on the said device body frame (100);
Said metabolite catch tray (500) is arranged on said device body frame (100) below corresponding with said porus excretorius (405);
Said animal subject is tied up solid vest (410) and is used for the animal subject attitude and fixes, and it is bound band (411) and passes said permanent opening (404) and be buckled in admittedly below the said bed surface (403) during use.
2. the medium-term and long-term simulated weightlessness model equipment of non-human primates laboratory animal according to claim 1, it is characterized in that: said bed surface (403) material is that soft steel-sheet canvas is arranged in the interlayer.
3. the medium-term and long-term simulated weightlessness model equipment of non-human primates laboratory animal according to claim 1 and 2; It is characterized in that: further comprising and be arranged on amusement ensuring equipment (800), medical treatment and the operation fluid infusion frame (900) of placing toy ball, minute surface and the recreation of other intelligence development classes in the middle of said device body frame (100) top respectively.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2012101088970A CN102657101A (en) | 2012-04-16 | 2012-04-16 | Non-human primate test animal medium and long-term weightlessness simulation model device |
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| CN2012101088970A CN102657101A (en) | 2012-04-16 | 2012-04-16 | Non-human primate test animal medium and long-term weightlessness simulation model device |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103283623A (en) * | 2013-06-08 | 2013-09-11 | 中国航天员科研训练中心 | Device monitoring suspension of stimulated animal weightlessness tails in real time |
| CN105280067A (en) * | 2015-11-24 | 2016-01-27 | 中国航天员科研训练中心 | Multi-gravity simulation living care bed |
| CN103688877B (en) * | 2013-12-10 | 2016-02-17 | 中国航天员科研训练中心 | Animal simulation low-gravity exercise device |
| CN106212301A (en) * | 2016-07-28 | 2016-12-14 | 北京航空航天大学 | The adjusting means of rat body fluid compartments under a kind of simulated weightlessness |
| CN110547927A (en) * | 2019-10-10 | 2019-12-10 | 上海市第十人民医院 | Electric noninvasive nasosinusitis treatment device |
| CN114514881A (en) * | 2021-12-16 | 2022-05-20 | 中国科学院深圳先进技术研究院 | Experimental equipment |
| CN115191363A (en) * | 2022-07-12 | 2022-10-18 | 广西医科大学第一附属医院 | Joint movement testing system and testing method for experimental animals |
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| CN101283675A (en) * | 2008-06-06 | 2008-10-15 | 北京航空航天大学 | Positive/passive exercise training device for simulating weightless tail suspended rats |
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| US4356577A (en) * | 1980-03-31 | 1982-11-02 | Taylor Gene E | Multipositional medical bed |
| SU1060181A1 (en) * | 1982-01-11 | 1983-12-15 | Предприятие П/Я А-3469 | Apparatus for fixing primates when conducting examinations |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103283623A (en) * | 2013-06-08 | 2013-09-11 | 中国航天员科研训练中心 | Device monitoring suspension of stimulated animal weightlessness tails in real time |
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| CN103688877B (en) * | 2013-12-10 | 2016-02-17 | 中国航天员科研训练中心 | Animal simulation low-gravity exercise device |
| CN105280067A (en) * | 2015-11-24 | 2016-01-27 | 中国航天员科研训练中心 | Multi-gravity simulation living care bed |
| CN106212301A (en) * | 2016-07-28 | 2016-12-14 | 北京航空航天大学 | The adjusting means of rat body fluid compartments under a kind of simulated weightlessness |
| CN110547927A (en) * | 2019-10-10 | 2019-12-10 | 上海市第十人民医院 | Electric noninvasive nasosinusitis treatment device |
| CN114514881A (en) * | 2021-12-16 | 2022-05-20 | 中国科学院深圳先进技术研究院 | Experimental equipment |
| CN114514881B (en) * | 2021-12-16 | 2023-04-21 | 中国科学院深圳先进技术研究院 | Experimental equipment |
| CN115191363A (en) * | 2022-07-12 | 2022-10-18 | 广西医科大学第一附属医院 | Joint movement testing system and testing method for experimental animals |
| CN115191363B (en) * | 2022-07-12 | 2023-05-26 | 广西医科大学第一附属医院 | Joint movement testing system and method for experimental animals |
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Application publication date: 20120912 |