CN101551340A - Gold spot quantitative determination optical device - Google Patents
Gold spot quantitative determination optical device Download PDFInfo
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- CN101551340A CN101551340A CNA2009100507369A CN200910050736A CN101551340A CN 101551340 A CN101551340 A CN 101551340A CN A2009100507369 A CNA2009100507369 A CN A2009100507369A CN 200910050736 A CN200910050736 A CN 200910050736A CN 101551340 A CN101551340 A CN 101551340A
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- light source
- image acquisition
- acquisition sensor
- lucifuge
- signal processor
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- 230000003287 optical effect Effects 0.000 title claims abstract description 15
- 241001363516 Plusia festucae Species 0.000 title claims abstract description 9
- 201000009310 astigmatism Diseases 0.000 claims description 18
- 239000011248 coating agent Substances 0.000 claims description 3
- 238000000576 coating method Methods 0.000 claims description 3
- 238000012360 testing method Methods 0.000 description 28
- 238000000034 method Methods 0.000 description 11
- 238000001514 detection method Methods 0.000 description 9
- 238000006243 chemical reaction Methods 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 5
- 238000011161 development Methods 0.000 description 5
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 5
- 230000008569 process Effects 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 102000011022 Chorionic Gonadotropin Human genes 0.000 description 2
- 108010062540 Chorionic Gonadotropin Proteins 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 239000010931 gold Substances 0.000 description 2
- 229910052737 gold Inorganic materials 0.000 description 2
- 229940084986 human chorionic gonadotropin Drugs 0.000 description 2
- 230000008676 import Effects 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 239000002966 varnish Substances 0.000 description 2
- 230000009471 action Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000009123 feedback regulation Effects 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000013332 literature search Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
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Abstract
The invention relates to a gold spot quantitative determination optical device, which comprises an image acquisition sensor, a light source and a dark box; the image acquisition sensor and the light source are fixed on the inner surface of the dark box top; the image acquisition sensor is connected with the control rod; the top of the control rod passes through the dark box top and is connected with the data signal processor; the output terminal of the data signal processor is connected to the light source; a drawer is disposed on the bottom of the dark box with center opposite the image acquisition sensor; The data signal processor is utilized to control the light source intensity based on the pulse width modulation principle, provides a stable, clear, weak reflection and weak shadow environment, thereby improves image quality.
Description
Technical field
The present invention relates to the device in a kind of quantitative measurement technology field, specifically is a kind of gold spot quantitative determination optical device.
Background technology
As everyone knows, detection paper is a kind of quick, portable, simple detection method, and it has been widely used in fields such as biology, chemistry and medical science.Based on different chromogenic reaction principles, the shade and the test agent concentration that show after test paper and the test agent reaction exist dull but nonlinear relation.Therefore test result can not rely on observer's experience to differentiate merely, but wants the detection by quantitative instrument of supporting specialty to measure, and obtains genuine and believable result of calculation with this.In the prior art, the gold marking spot detection by quantitative instrument based on colloidal gold technique is that human chorionic gonadotropin (Human chorionic gonadotropin hCG) provides the reliable detection scheme of improving.
Colloidal gold technique has been determined the corresponding relation between the colour developing degree of hCG concentration and test paper color development reaction.Gold marking spot method pick-up unit is by analyzing the monochrome information in the test paper image, and according to above-mentioned corresponding relation, infers the concentration that obtains test agent.The primary structure of this instrument comprises optical devices, data processing equipment and device displaying result.Wherein optical devices are the important steps that guarantee test paper picture quality, and it is made up of image acquisition sensor, light source (PWM controls light intensity) and lucifuge black box.Data processing equipment adopts digital signal processor (Digital Signal Processor DSP), and it can handle a large amount of numerical informations at a high speed accurately, can improve system performance greatly.
Width modulation (PWM) is an effective means of utilizing the digitizing output signal of microprocessor that mimic channel is controlled, the every aspect in the field such as it has been widely used in measuring, communication, medical treatment, biotechnology and laboratory fundamental research.By the dutycycle in the programming Control waveform, the pwm signal that DSP can export different capacity makes external circuit produce the action of expectation, and for example motor rotates and the light source adjustment.In above-mentioned detection by quantitative device, we can programme to DSP by software, export self-defining PWM wave mode, realize that the light intensity in the optical devices is controlled in real time, thereby obtain being decided by the optical detection environment of test agent concentration.
Find through literature search prior art, Chinese patent title: intelligent biosensor arrangement, the patent No.: 200420057304.3, this utility model is by detecting the result who produces after test paper to be measured and system self signal combination, whether fall in the parameter area of setting, judge reagent information.If the conversion coefficient of change parameter value, system can also realize the detection to different analytes, for example urine, cholesterol, blood sugar or pH value.Though this invention usable range is wide, can not effectively determine the concentration of test agent, and cross when low or too high when reagent concentration, can not reach good detection effect.
Summary of the invention
The objective of the invention is at the deficiencies in the prior art, a kind of gold spot quantitative determination optical device is provided, utilize digital signal processor (DSP) that the intensity of light source is carried out control based on width modulation (PWM) principle, for the test paper image acquisition provides the environment of stable, clear, weak reflective and weak shade, thereby improve picture quality.
The present invention is achieved by the following technical solutions:
The present invention includes: image acquisition sensor, light source and lucifuge black box, image acquisition sensor and light source are fixed on the medial surface on lucifuge black box box top, the image acquisition sensor is connected with control lever, the control lever top is passed lucifuge black box top and is connected with digital signal processor, the digital signal processor output terminal is connected with light source, lucifuge black box bottom is provided with drawer, and the center of drawer is over against the image acquisition sensor.In stable environment, sensor acquisition test paper image also imports digital signal processor (DSP) into and handles, thereby the waveform of judgment processing result control pulse width modulated wave (PWM) output then finally realizes the adjusting of the intensity of light source.
Described lucifuge black box outside scribbles coating, to cover extraneous light, avoids the conversion of external environment condition to have influence on the process of test paper image acquisition.
Described light source is equally distributed green glow astigmatism light emitting diode, under the green glow astigmatism light emitting diode shadow shield is set, and the quantity of described green glow astigmatism light emitting diode is 12.For image acquisition provides light source, its light intensity regulating then realizes by the external voltage that utilizes digital signal processor output PWM control green glow astigmatism light emitting diode in the lucifuge black box; Adopt green glow astigmatism light emitting diode as the light source irradiation test paper, can strengthen the contrast in spot and unreacted zone that develops the color on the test paper image like this, thereby improve the resolution of system.
Compared with prior art, the present invention has following beneficial effect:
At first, the introducing of PWM control technique has realized the real-time control of the intensity of light source and the servo-actuated control relevant with the test paper color development degree, and this improvement has not only improved system flexibility, has more strengthened system accuracy;
Secondly, the combination of equally distributed green glow astigmatism light emitting diode and shadow shield, for device provides light source stable, weak flicker, it weakened not only that electric voltage frequency, position are moved and temperature variation to the influence of system, and the image shade that can't eliminate when eliminating single green glow astigmatism light emitting diode as light source substantially and reflective further improves the quality of test paper image;
Once more, because the application scenarios of this device is defined in the colloidal gold technique of hCG and detects, shown in red after the test paper reaction, when we adopt green astigmatic light emitting diode to shine as light source, can strengthen the contrast of color of image information, thus enhanced system resolution.
Description of drawings
Fig. 1 is this device key diagram;
Fig. 2 is the work block diagram of this device embodiment.
Specific implementation method
Embodiment to this device elaborates below in conjunction with accompanying drawing: present embodiment provided detailed implementation method and concrete operating process, but the protection domain of this device is not limited to following embodiment being to implement under the prerequisite with this device technique scheme.
As shown in Figure 1, present embodiment comprises image acquisition sensor 3, light source and lucifuge black box 6, image acquisition sensor 3 and light source are fixed on the medial surface on lucifuge black box 6 boxes top, image acquisition sensor 3 is connected with control lever, the control lever top is passed lucifuge black box 6 tops and is connected with digital signal processor 7, digital signal processor 7 output terminals are connected with light source, and lucifuge black box 6 bottoms are provided with drawer 2, and the center of drawer 2 is over against image acquisition sensor 3.Test paper 1 to be measured is placed on the center of drawer 2, and this position is over against image acquisition sensor 3.The height of image acquisition sensor 3 can be regulated by the control lever that is attached thereto, and this control lever has guaranteed the level shooting of sensor to test paper, and can regulate the distance between sensor and the test paper easily.Described light source is equally distributed green glow astigmatism light emitting diode 5, and green glow astigmatism light emitting diode is provided with shadow shield 45 times, and the quantity of described green glow astigmatism light emitting diode is 12.Luminous after green glow astigmatism light emitting diode 5 adds the PWM waveform, strong multi beam light will be filtered into soft parallel light source by shadow shield 4 originally.Compare with the pointolite of single green glow astigmatism light emitting diode 5 irradiations, this light source can effectively reduce the shade of image and reflective, and weaken electric voltage frequency, move the position and the influence of ambient temperature to light source.Above-mentioned all elements all are placed in the lucifuge black box 6.Described lucifuge black box 6 outsides scribble the mute lac varnish coating of black, and black box 6 just can effectively shield the interference of external environment, thereby have guaranteed the stable of system testing.
As shown in Figure 2, in the present embodiment, described optical devices are mainly used in following operation.Image acquisition sensor 3 is made of jointly charge-coupled device (CCD) and microspur wide-angle lens, and it is responsible for gathering the image of test paper, and imports digital signal processor 7 into by data line, is converted to digital signal through video A/D converter and preserves afterwards.Result after digital signal processor 7 deal with data if reach setting threshold, illustrates that then light intensity exceeds existing environment requirement, need adjust by PWM, if do not reach threshold value, does not then adjust, directly display result.
Light source is made of jointly equally distributed 12 green glows astigmatism light emitting diode 5 and shadow shield 4, all green glow astigmatism light emitting diodes 5 in parallel, be connected to the PWM waveform output pin of digital signal processor 7 then, directly control light intensity magnitude by digital signal processor 7.Treated result will directly influence the amplitude size and the dutycycle of PWM waveform, thereby influence is input to the power of green glow astigmatism light emitting diode 5, finally realizes the adjusting of the intensity of light source.
Lucifuge black box 6 is that the outside scribbles the mute lac varnish of black, the rectangular box that can cover extraneous light, and it provides stable image capture environment for these optical devices.Test paper 1 to be measured will be placed on the center of drawer 2 at the bottom of the box.In image acquisition process, test paper 1 to be measured will can improve the symmetry and the stability of image like this over against the image acquisition sensor.
The test paper view data that is collected by image acquisition sensor 3 is at first imported digital signal processor 7 into by data line and is handled, and calculates the hormone concentration on the test paper to be measured.If this concentration reaches preset threshold (current threshold value is 7500mIU/ml), then the light intensity of the existing light source of explanation exceeds environmental requirement, and system is accurate result of calculation, therefore needs to adjust the PWM waveform and pass through the control line feedback regulation intensity of light source; If this concentration does not reach threshold value, then directly export the result and read for the user.At this, the positive pole of PWM ripple is by the output of the PWM pin on the development board, minus earth.These operations can effectively be strengthened picture contrast and improve system flexibility, thereby obtain result of calculation more accurately.
Among the embodiment, adopted Beijing to hear the TDS6437EVM digital video evaluation board of booth digital display circuit company limited product as development platform.This evaluation board is a low-power consumption stand-alone development platform.Equipment mainly comprises TMS320DM6437DSP chip, pci interface, 2 road video inputs mouths, 4 road video-out ports, 128MDDR2RAM, 16MFlash and 64M NAND Flash, JTAG emulation interface and 4 user lamps of TIX (TI) on the plate.
Among the embodiment, adopted common monochromatic ccd image sensor, its major parameter comprises: imaging CCD is that 1/3 SONY CCD, pixel are that PAL 500*582pixels, inter-sync, horizontal resolution are that 420 tv lines, white balance＞46dB, gamma characteristic are 0.45, minimal illumination is that 0.05Lux, fixed lens are that the block camera lens of 3.6mm, serviceability temperature are-10 ℃ ~+50 ℃, are of a size of 25mm*25mm.
Claims (4)
1, a kind of gold spot quantitative determination optical device, comprise image acquisition sensor, light source and lucifuge black box, image acquisition sensor and light source are fixed on the medial surface on lucifuge black box box top, it is characterized in that: the image acquisition sensor is connected with control lever, the control lever top is passed lucifuge black box top and is connected with digital signal processor, the digital signal processor output terminal is connected with light source, and lucifuge black box bottom is provided with drawer, and the center of drawer is over against the image acquisition sensor.
2, gold spot quantitative determination optical device according to claim 1 is characterized in that, described lucifuge black box outside scribbles coating.
3, gold spot quantitative determination optical device according to claim 1 is characterized in that, described light source is equally distributed green glow astigmatism light emitting diode, under the green glow astigmatism light emitting diode shadow shield is set.
4, gold spot quantitative determination optical device according to claim 1 is characterized in that, the quantity of described green glow astigmatism light emitting diode is 12.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100507369A CN101551340B (en) | 2009-05-07 | 2009-05-07 | Gold spot quantitative determination optical device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100507369A CN101551340B (en) | 2009-05-07 | 2009-05-07 | Gold spot quantitative determination optical device |
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| CN101551340A true CN101551340A (en) | 2009-10-07 |
| CN101551340B CN101551340B (en) | 2011-03-23 |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102183510A (en) * | 2011-01-26 | 2011-09-14 | 上海奥普生物医药有限公司 | Colloidal gold detecting method and device based on digital image processing |
| CN102590518A (en) * | 2012-02-08 | 2012-07-18 | 上海交通大学 | Immune colloidal gold test paper and method for quantitatively detecting configurable logic block (CLB) by matching with photoelectric sensor thereof |
| CN102628874A (en) * | 2012-04-28 | 2012-08-08 | 无锡瑞美电子科技有限公司 | Full-automatic colloidal gold detection method and full-automatic colloidal gold detection instrument |
| CN102944560A (en) * | 2012-10-10 | 2013-02-27 | 武汉明德生物科技有限责任公司 | High-biosecurity POCT (Point of Care Testing) instrument based on image or sensitizing scanning |
| CN104374767A (en) * | 2013-08-13 | 2015-02-25 | 嘉兴驰网工业自动化科技有限公司 | Portable type intelligent food safety detector |
| CN106680439A (en) * | 2015-11-09 | 2017-05-17 | 北京艾旗斯德科技有限公司 | Miniature food safety and in-vitro diagnosis analyzer |
-
2009
- 2009-05-07 CN CN2009100507369A patent/CN101551340B/en active Active
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102183510A (en) * | 2011-01-26 | 2011-09-14 | 上海奥普生物医药有限公司 | Colloidal gold detecting method and device based on digital image processing |
| CN102183510B (en) * | 2011-01-26 | 2012-11-14 | 上海奥普生物医药有限公司 | Colloidal gold detecting method and device based on digital image processing |
| CN102590518A (en) * | 2012-02-08 | 2012-07-18 | 上海交通大学 | Immune colloidal gold test paper and method for quantitatively detecting configurable logic block (CLB) by matching with photoelectric sensor thereof |
| CN102628874A (en) * | 2012-04-28 | 2012-08-08 | 无锡瑞美电子科技有限公司 | Full-automatic colloidal gold detection method and full-automatic colloidal gold detection instrument |
| CN102944560A (en) * | 2012-10-10 | 2013-02-27 | 武汉明德生物科技有限责任公司 | High-biosecurity POCT (Point of Care Testing) instrument based on image or sensitizing scanning |
| CN104374767A (en) * | 2013-08-13 | 2015-02-25 | 嘉兴驰网工业自动化科技有限公司 | Portable type intelligent food safety detector |
| CN106680439A (en) * | 2015-11-09 | 2017-05-17 | 北京艾旗斯德科技有限公司 | Miniature food safety and in-vitro diagnosis analyzer |
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| Publication number | Publication date |
|---|---|
| CN101551340B (en) | 2011-03-23 |
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