CN101548976A - Compound toltrazuril solution and method for preparing same - Google Patents
Compound toltrazuril solution and method for preparing same Download PDFInfo
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- CN101548976A CN101548976A CNA2009100649552A CN200910064955A CN101548976A CN 101548976 A CN101548976 A CN 101548976A CN A2009100649552 A CNA2009100649552 A CN A2009100649552A CN 200910064955 A CN200910064955 A CN 200910064955A CN 101548976 A CN101548976 A CN 101548976A
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- toltrazuril
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Abstract
The present invention provides a compound toltrazuril solution. Each 100 ml solution contains medicinal ingredient as follows: toltrazuril 2.5-5 g, nitazoxanide 3-8 g. The compound toltrazuril solution has advantages of low cost, better coccidiostat effect, wide antigen insert, low dose and no-easy drug-tolerance, the compound toltrazuril solution also can be added into drinking water for animal which is more convenient without adding and stirring to feed stuff.
Description
Technical field
The invention belongs to technical field of pharmaceuticals, relate to a kind of compound toltrazuril solution, relate to the preparation method of this solution simultaneously.
Background technology
Chicken coccidiosis is a kind of protozoacide of the chicken that caused by Eimeria, is one of disease that modern aviculture is common and harm is very serious.Coccidiosis often causes the chickling morbidity, and mortality rate is up to 80%, and the chick growth of recovering seriously lags behind, and resistance reduces, and easily suffers from other eqpidemic disease.Become the less morbidity of chicken, but can become the carrier, its body constitution and egg production capacity all can be affected, and often bring enormous economic loss to poultry husbandry.According to statistics, the annual whole world poultry husbandry of giving of coccidiosis causes 1.2 hundred million dollars economic loss.
The medicament categories of treatment coccidiosis is various at present, but also have many shortcomings: the use of some medicines causes animal body degradation untoward reaction under the feed intake to occur, the drug-fast generation that the use repeatedly of some medicines causes, especially the caused drug residue problem of some medicines greatly jeopardizes human beings'health especially.Common coccidiostat has Toltrazuril, belongs to triazineon compounds, is the wide spectrum coccidiostat of animal specific, and commodity hundred balls by name are clear, is mainly used in the control of animal's coccidiosis such as poultry, rabbit, lamb, piglet.Because its good disinsection effect, toxicity are low, be difficult for producing drug resistance, be widely used in Europe, Canada, Japan etc., China ratified material inlet in 1999.But single effect with Toltrazuril is very good not enough, and needs in use it is admixed in the feedstuff, comparatively bothers during use.
Summary of the invention
The purpose of this invention is to provide the compound toltrazuril solution that a kind of anticoccidial effect is good, convenient and swift when using, using dosage is low, be difficult for developing immunity to drugs.
Another object of the present invention provides a kind of preparation method of compound toltrazuril solution.
For achieving the above object, the present invention by the following technical solutions: compound toltrazuril solution, the medicinal ingredient in every 100ml solution is: Toltrazuril 2.5～5g, nitazoxanide 3～8g.
Adjuvant in every 100ml solution is: chelating agen 0.2～0.4g, antioxidant 0.2～0.5g, an amount of pH regulator agent and the solvent of surplus.
The consumption of described pH regulator agent is 9.0～10.0 to be as the criterion to adjust the solution pH value.
Described solvent is the propylene glycol of ethanol 7～10ml, Polyethylene Glycol-400 20～33ml and surplus, and described chelating agen is a disodiumedetate, and described antioxidant is sodium sulfite, and described pH regulator agent is a triethanolamine.
A kind of preparation method of compound toltrazuril solution, earlier 30～40ml propylene glycol and 20～33ml Polyethylene Glycol-400 mix homogeneously, be heated to 70～80 ℃, add 0.2～0.5g sodium sulfite, 0.2～0.4g disodiumedetate respectively and stir and make dissolving fully, adding an amount of triethanolamine regulator solution pH value again is 9.0～10.0; Then, add 2.5～5g Toltrazuril, 3～8g nitazoxanide respectively, stir to make and dissolve fully; After placing room temperature, add 7～10ml ethanol and mix, be settled to 100mL, filter with propylene glycol; Through after the assay was approved, canned, the sealing, the sterilization.
The present invention adopts Toltrazuril and nitazoxanide as medicinal ingredient, and the suitable technology of warp is made oral liquid, be used for prevention and treatment chicken coccidiosis, wherein, Toltrazuril is as the wide spectrum coccidiostat of animal specific, nitazoxanide is a kind of new broad-spectrum antiprotozoal drug, chemical name phenol acetic ester, its broad spectrum of activity are to the protozoon of numerous species, and be special in intestinal Sporulation class protozoon, and many common anthelmintics, comprise that cestode, nematicide and trematodiasis all have specially good effect.In addition, nitazoxanide also has activity to some anaerobism and microaerobe such as helicobacter pylori.The present invention is just with Toltrazuril and nitazoxanide coupling, Toltrazuril and nitazoxanide play synergism, Toltrazuril disturbs mitochondrion and the nucleus division of coccidiosis, add the influence to the protozoon respiratory metabolism of nitazoxanide, make this invention enlarge the protozoacide scope, also make the effect of anticoccidial more obvious.With low cost, advantages such as anticoccidial effect good, the protozoacide spectrum is wide, using dosage is low, difficult generation drug resistance that compound toltrazuril solution of the present invention has, and can directly add in use in the water that poultry drink, use more conveniently, do not need again in feedstuff, to add and to stir.
Below with the curative effect of animal experiment explanation compound toltrazuril solution of the present invention:
From the little chickling of the meat health of Henan eyas institutional purchase, feeding does not contain the feedstuff of medicine, and conventional the raising to 14 ages in days is divided into 4 groups of homogeneous according to body weight with it, 15 every group.Be respectively normal healthy controls group (A), infect matched group (B), Toltrazuril experimental group (C), compound toltrazuril solution experimental group of the present invention (D).
B group, C group, D organize every oral spore egg capsule 3.4 * 10 of chickling
5Individual, C organizes in infecting back the 3rd day with Toltrazuril 25mg/kg material feeding, and D organizes in infecting back the 3rd day with compound toltrazuril solution drinking-water of the present invention.Duration of test is observed the chicken group mental status, the situation of searching for food, hemafecia, morbidity and death condition every day; Test when stopping, cut open inspection and be dead chicken, the observation caecum lesion is also kept the score, and the chicken of duration of test death is also cutd open inspection.Keep the score by the relative weight gain rate, survival rate, caecum lesion, indexs such as egg capsule value draw ACI.
ACI be objective, accurately estimate the curative effect index of anticoccidial drug, calculate by the method for Merck ﹠ Co., Inc. (Merck), that is: ACI=(the relative weight gain rate+survival rate) * 100-(pathological changes value+egg capsule value).ACI＜120 are invalid, and ACI=120～160 are medium effective, and ACI=160～180 are that drug effect is good, and ACI＞180 are efficient.
Infect matched group B group and infected behind the coccidiosis the 4th day, chicken begins to discharge a small amount of hemafecia, the 5th, 6,7 day, especially the 6th day the most serious, discharge a large amount of hemafecias, spirit depressed, necking down is slow-witted upright, and drowsiness, feather is fluffy and disorderly, lack food or do not eat appearance death, survival rate 48%; pathological changes value 29; egg capsule value 40, anticoccidial index (ACI) is 57 only, and the coccidium infection that this test is described is successful.
The anticoccidial index (ACI) of D group compound toltrazuril solution of the present invention is 198, than single (ACI) 168 height with Toltrazuril of C group 30 points, compare with the anticoccidial index (ACI) 180 of determined curative effect, the anticoccidial index (ACI) 198 of compound toltrazuril solution of the present invention is than its obvious high 18 points, prove that compound toltrazuril solution of the present invention is very effective to chicken coccidiosis, have significant anticoccidial effect.
The specific embodiment
Embodiment 1: the composition in every 100ml solution is: Toltrazuril 2.5g, nitazoxanide 3g, ethanol 7ml, Polyethylene Glycol-400 33ml, disodiumedetate 0.2g, sodium sulfite 0.2g, triethanolamine 1.8ml, the propylene glycol of surplus.The consumption of triethanolamine is 9.0 to be as the criterion to adjust the solution pH value.
The preparation method of compound toltrazuril solution, earlier 30ml propylene glycol and 33ml Polyethylene Glycol-400 mix homogeneously, be heated to 70 ℃, add 0.2g sodium sulfite, 0.2g disodiumedetate respectively and stir and make dissolving fully, adding 1.8ml triethanolamine regulator solution pH value again is 9.0; Then, add 2.5g Toltrazuril, 3g nitazoxanide respectively, stir to make and dissolve fully; After placing room temperature, add 7ml ethanol and mix, be settled to 100mL, filter with propylene glycol; Through after the assay was approved, canned, the sealing, the sterilization.
Embodiment 2: the composition in every 100ml solution is: Toltrazuril 3.5g, nitazoxanide 6g, ethanol 9ml, Polyethylene Glycol-40025ml, disodiumedetate 0.3g, sodium sulfite 0.4g, triethanolamine 2.3ml, the propylene glycol of surplus.The consumption of triethanolamine is 9.5 to be as the criterion to adjust the solution pH value.
The preparation method of compound toltrazuril solution, earlier 35ml propylene glycol and 25ml Polyethylene Glycol-400 mix homogeneously, be heated to 75 ℃, add 0.4g sodium sulfite, 0.3g disodiumedetate respectively and stir and make dissolving fully, adding 2.3ml triethanolamine regulator solution pH value again is 9.5; Then, add 3.5g Toltrazuril, 6g nitazoxanide respectively, stir to make and dissolve fully; After placing room temperature, add 9ml ethanol and mix, be settled to 100mL, filter with propylene glycol; Through after the assay was approved, canned, the sealing, the sterilization.
Embodiment 3: the composition in every 100ml solution is: Toltrazuril 5g, nitazoxanide 8g, ethanol 10ml, Polyethylene Glycol-40020ml, disodiumedetate 0.4g, sodium sulfite 0.5g, triethanolamine 1.9ml, the propylene glycol of surplus.The consumption of triethanolamine is 10.0 to be as the criterion to adjust the solution pH value.
The preparation method of compound toltrazuril solution, earlier 40ml propylene glycol and 20ml Polyethylene Glycol-400 mix homogeneously, be heated to 80 ℃, add 0.5g sodium sulfite, 0.4g disodiumedetate respectively and stir and make dissolving fully, adding 1.9ml triethanolamine regulator solution pH value again is 10.0; Then, add 5g Toltrazuril, 8g nitazoxanide respectively, stir to make and dissolve fully; After placing room temperature, add 10ml ethanol and mix, be settled to 100mL, filter with propylene glycol; Through after the assay was approved, canned, the sealing, the sterilization.
Claims (5)
1, compound toltrazuril solution is characterized in that the medicinal ingredient in every 100ml solution is: Toltrazuril 2.5～5g, nitazoxanide 3～8g.
2, compound toltrazuril solution as claimed in claim 1 is characterized in that: the adjuvant in every 100ml solution is: chelating agen 0.2～0.4g, antioxidant 0.2～0.5g, an amount of pH regulator agent and the solvent of surplus.
3, compound toltrazuril solution as claimed in claim 2 is characterized in that: the consumption of described pH regulator agent is 9.0～10.0 to be as the criterion to adjust the solution pH value.
4, as claim 2 or 3 described compound toltrazuril solutions, it is characterized in that: described solvent is the propylene glycol of ethanol 7～10ml, Polyethylene Glycol-40020～33ml and surplus, described chelating agen is a disodiumedetate, described antioxidant is sodium sulfite, and described pH regulator agent is a triethanolamine.
5, a kind of preparation method of compound toltrazuril solution, it is characterized in that: earlier 30～40ml propylene glycol and 20～33ml Polyethylene Glycol-400 mix homogeneously, be heated to 70～80 ℃, add 0.2～0.5g sodium sulfite, 0.2～0.4g disodiumedetate respectively and stir and make dissolving fully, adding an amount of triethanolamine regulator solution pH value again is 9.0～10.0; Then, add 2.5～5g Toltrazuril, 3～8g nitazoxanide respectively, stir to make and dissolve fully; After placing room temperature, add 7～10ml ethanol and mix, be settled to 100mL, filter with propylene glycol; Through after the assay was approved, canned, the sealing, the sterilization.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2009100649552A CN101548976A (en) | 2009-05-19 | 2009-05-19 | Compound toltrazuril solution and method for preparing same |
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| CNA2009100649552A CN101548976A (en) | 2009-05-19 | 2009-05-19 | Compound toltrazuril solution and method for preparing same |
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| CN101548976A true CN101548976A (en) | 2009-10-07 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106906185A (en) * | 2017-04-26 | 2017-06-30 | 江南大学 | One plant of anti-Toltrazuril monoclonal antibody hybridoma cell strain K 5 and its application |
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2009
- 2009-05-19 CN CNA2009100649552A patent/CN101548976A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106906185A (en) * | 2017-04-26 | 2017-06-30 | 江南大学 | One plant of anti-Toltrazuril monoclonal antibody hybridoma cell strain K 5 and its application |
| CN106906185B (en) * | 2017-04-26 | 2019-11-12 | 江南大学 | One plant of anti-Toltrazuril monoclonal antibody hybridoma cell strain K-5 and its application |
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Open date: 20091007 |