CN101543558A - Medicine composition for treating facioplegia and preparation method thereof - Google Patents
Medicine composition for treating facioplegia and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicine composition for treating facioplegia and a preparation method thereof. The effective ingredients of the medicine composition are prepared by extracting more than ten medicinal materials such as arisaema cum bile, stiff silkworm, scorpion, scolopendra, Chinese angelica, ligusticum wallichii, red-rooted salvia root, red paeony root, peach kernel, radix astragali, codonopsis pilosula, bighead atractylodes rhizome, glabrous greenbrier rhizome, notopterygium root, radix sileris, gardenia, and the like. The medicinal active ingredients peculiar to the medicine composition have the efficacies of dispelling wind and reducing phlegm, promoting blood circulation and removing obstruction in channels, filling empty and benefiting vital energy and are applied to the facial muscle paralysis caused by the facioplegia.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine pharmacy, be specifically related to a kind of prosopoplegic drug regimen and preparation method thereof that is used for the treatment of.
Technical background
Facial paralysis, facial paralysis also are facial neuritises, facial hemiparalysis, mouthful out-of-the-way, facial paralysis.Be meant due to the nonsuppurative inflammation of nervus facialis the one-sided infranuclear facial palsy of acute onset.Any age all can fall ill, but how at 20-40 years old, child and old man also have generation, and the male is more than the women.Suffer from cold behind the facial gill history or pharyngeal infection history are arranged before sick more.Onset is anxious and poly-, and Chang Yuchen rises when washing one's face and rinsing one's mouth or catches sight of or found by the people during feed, can reach the peak in 1-2 days.
Clinical symptoms performance or sign? answer: all histrionic muscles paralysis of a side surface part, the left side is more than the right side.Sick side forehead wrinkle disappears, and eye dysraphism, palpebral fissure enlarge, ectropion of lid, can not do the wrinkle volume, grinningly, the drum cheek, action such as be in a pout and whistle.When firmly closing one's eyes, eyeball turns to outer top to expose white sclera.The Ipsilateral nasolabial fold shoals, ptosis of labial angle, when showing tooth bicker askew to strong side, grinningly or cry more obvious when laughing at.
Modern medicine thinks that facial paralysis patient Ke Yin part is caught a cold and onset by wind; Also may make nervous tissue's ischemia, edema, suffer oppression and cause a disease for the vasospasm of local trophic nerve.Or due to illness poison, bacterial infection, the aixs cylinder myelin sheath degeneration, or cause nervus facialis swelling, pressurized, blood circulatory disorder, degeneration, the downright bad facial paralysis that causes because of inflammation adhesion, hyperosteogeny, swollen thing compressing etc.
The traditional Chinese medical science is called facial paralysis " apoplexy ", belongs to apoplex involving the channels and collaterals, also claims " facial hemiparalysis ", " facial paralysis ", " mouth is out-of-the-way ".
Facial paralysis is many by human righteousness's deficiency, the passages through which vital energy circulates inanition, ailment said due to cold or exposure is held expectorant under the arm and is taken advantage of a weak point in opponent's defence into middle facial positive bright shaoyang meridians network, causes the resistance of QI and blood numbness, and the muscle arteries and veins loses supports, do not receive through flaccidity of tendon and muscle is slow, and the generation facial hemiparalysis, therefore, it forms with void, wind, expectorant, the stasis of blood is the basic pathology basis, the positive deficiency of vital energy is basis of disease, and wind, expectorant, the stasis of blood are the mark of disease.Dispelling pathogenic wind and eliminating phlegm, promoting blood circulation to remove obstruction in the collateral, the tonify deficiency QI invigorating is the basic rule of treatment of treatment primary disease.
Summary of the invention:
One of purpose of the present invention provides a kind of prosopoplegic drug regimen that is used for the treatment of.
Another object of the present invention provides the preparation method of this drug regimen.
Chinese medicine of the present invention is made up of active ingredient and/or pharmaceutically acceptable carrier, and wherein said active ingredient is made (part is unit of weight) by following raw materials according:
1, prescription
100-200 parts of 100-200 parts of Scorpios of 100-300 parts of Bombyx Batryticatus of Arisaema Cum Bile
100-300 parts of 100-300 parts of Rhizoma Chuanxiongs of 100-200 parts of Radix Angelicae Sinensis of Scolopendra
100-200 parts in 100-200 parts of Semen Persicaes of 100-300 parts of Radix Paeoniae Rubra of Radix Salviae Miltiorrhizae
100-200 parts of 100-300 parts of Rhizoma Atractylodis Macrocephalaes of 100-300 parts of Radix Codonopsis of the Radix Astragali
100-200 parts of 100-200 parts of Radix Saposhnikoviaes of 100-200 parts of Rhizoma Et Radix Notopterygiis of Poria
100-200 parts of Fructus Gardeniae
The active component that preferred following raw materials according is made, curative effect is better:
100 parts of 100 portions of Scorpios of 150 parts of Bombyx Batryticatus of Arisaema Cum Bile
150 parts of 150 parts of Rhizoma Chuanxiongs of 100 parts of Radix Angelicae Sinensis of Scolopendra
120 parts in 120 parts of Semen Persicaes of 120 parts of Radix Paeoniae Rubra of Radix Salviae Miltiorrhizae
120 parts of 150 parts of Rhizoma Atractylodis Macrocephalaes of 150 parts of Radix Codonopsis of the Radix Astragali
120 parts of 120 parts of Radix Saposhnikoviaes of 120 portions of Rhizoma Et Radix Notopterygiis of Poria
120 parts of Fructus Gardeniae
The active ingredient preparation method of Chinese medicine of the present invention can be that raw material is dry respectively, and levigation mixes.It also can be the conventional method preparation of adopting herbal pharmaceutical.These pharmacy conventional methods can be water extract-alcohol precipitation or ethanol extract from water precipitation, also have other extracting method in addition, specifically " pharmaceutics of Chinese drugs " published referring to Cao Chunlin chief editor's Shanghai science tech publishing house.
The following preparation method preparation of preferred employing:
2, preparation technology
(1) Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, the Radix Astragali add 80% alcohol dipping three times, flood 48 hours for the first time, and second and third time flooded respectively 24 hours, filter, and decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) medical materials such as all the other Arisaema Cum Bile, Bombyx Batryticatus, Scorpio, Scolopendra, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Semen Persicae, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, Rhizoma Et Radix Notopterygii, Radix Saposhnikoviae, Fructus Gardeniae add 10 times of decoctings and boil three times, 1 hour for the first time, second and third time 0.5 hour, filter, merging filtrate, filtrate is condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, be ground into fine powder, add acceptable accessories and make different preparations such as granule, sheet, capsule.
Adopt mutual compatibility of above-mentioned raw material of Chinese medicine and preparation method thereof, full side has dispelling pathogenic wind and eliminating phlegm, promoting blood circulation to remove obstruction in the collateral, the effect of tonify deficiency QI invigorating.Be used for the facial muscle paralysis that facial paralysis causes.
By the following examples technical scheme of the present invention is described further.
Embodiment 1: the preparation method of granule
1, prescription:
100 parts of 100 portions of Scorpios of 150 parts of Bombyx Batryticatus of Arisaema Cum Bile
150 parts of 150 parts of Rhizoma Chuanxiongs of 100 parts of Radix Angelicae Sinensis of Scolopendra
120 parts in 120 parts of Semen Persicaes of 120 parts of Radix Paeoniae Rubra of Radix Salviae Miltiorrhizae
120 parts of 150 parts of Rhizoma Atractylodis Macrocephalaes of 150 parts of Radix Codonopsis of the Radix Astragali
120 parts of 120 parts of Radix Saposhnikoviaes of 120 portions of Rhizoma Et Radix Notopterygiis of Poria
120 parts of Fructus Gardeniae
2, preparation technology
(1) Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, the Radix Astragali add 80% alcohol dipping three times, flood 48 hours for the first time, and second and third time flooded respectively 24 hours, filter, and decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) medical materials such as all the other Arisaema Cum Bile, Bombyx Batryticatus, Scorpio, Scolopendra, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Semen Persicae, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, Rhizoma Et Radix Notopterygii, Radix Saposhnikoviae, Fructus Gardeniae add 10 times of decoctings and boil three times, 1 hour for the first time, second and third time 0.5 hour, filter, merging filtrate, filtrate is condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, add cane sugar powder, mixing is made granule, drying, promptly.
Embodiment 2: the preparation method of tablet
1, prescription:
100 parts of 100 portions of Scorpios of 150 parts of Bombyx Batryticatus of Arisaema Cum Bile
150 parts of 150 parts of Rhizoma Chuanxiongs of 100 parts of Radix Angelicae Sinensis of Scolopendra
120 parts in 120 parts of Semen Persicaes of 120 parts of Radix Paeoniae Rubra of Radix Salviae Miltiorrhizae
120 parts of 150 parts of Rhizoma Atractylodis Macrocephalaes of 150 parts of Radix Codonopsis of the Radix Astragali
120 parts of 120 parts of Radix Saposhnikoviaes of 120 portions of Rhizoma Et Radix Notopterygiis of Poria
120 parts of Fructus Gardeniae
2, preparation technology
(1) Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, the Radix Astragali add 80% alcohol dipping three times, flood 48 hours for the first time, and second and third time flooded respectively 24 hours, filter, and decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) medical materials such as all the other Arisaema Cum Bile, Bombyx Batryticatus, Scorpio, Scolopendra, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Semen Persicae, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, Rhizoma Et Radix Notopterygii, Radix Saposhnikoviae, Fructus Gardeniae add 10 times of decoctings and boil three times, 1 hour for the first time, second and third time 0.5 hour, filter, merging filtrate, filtrate is condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, pulverize, sieve, add starch, magnesium stearate, tabletting, promptly.
Embodiment 3: the preparation method of capsule
1, prescription:
100 parts of 100 portions of Scorpios of 150 parts of Bombyx Batryticatus of Arisaema Cum Bile
150 parts of 150 parts of Rhizoma Chuanxiongs of 100 parts of Radix Angelicae Sinensis of Scolopendra
120 parts in 120 parts of Semen Persicaes of 120 parts of Radix Paeoniae Rubra of Radix Salviae Miltiorrhizae
120 parts of 150 parts of Rhizoma Atractylodis Macrocephalaes of 150 parts of Radix Codonopsis of the Radix Astragali
120 parts of 120 parts of Radix Saposhnikoviaes of 120 portions of Rhizoma Et Radix Notopterygiis of Poria
120 parts of Fructus Gardeniae
2. preparation technology
(1) Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, the Radix Astragali add 80% alcohol dipping three times, flood 48 hours for the first time, and second and third time flooded respectively 24 hours, filter, and decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) medical materials such as all the other Arisaema Cum Bile, Bombyx Batryticatus, Scorpio, Scolopendra, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Semen Persicae, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, Rhizoma Et Radix Notopterygii, Radix Saposhnikoviae, Fructus Gardeniae add 10 times of decoctings and boil three times, 1 hour for the first time, second and third time 0.5 hour, filter, merging filtrate, filtrate is condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, pulverize, sieve, add starch, mixing is made granule, and drying incapsulates, promptly.
Claims (5)
1, a kind ofly be used for the treatment of prosopoplegic drug regimen, it is characterized in that being made up of active ingredient and/or pharmaceutically acceptable carrier, wherein said active ingredient is made by following raw materials according:
100-200 parts of 100-200 parts of Scorpios of 100-300 parts of Bombyx Batryticatus of Arisaema Cum Bile
100-300 parts of 100-300 parts of Rhizoma Chuanxiongs of 100-200 parts of Radix Angelicae Sinensis of Scolopendra
100-200 parts in 100-200 parts of Semen Persicaes of 100-300 parts of Radix Paeoniae Rubra of Radix Salviae Miltiorrhizae
100-200 parts of 100-300 parts of Rhizoma Atractylodis Macrocephalaes of 100-300 parts of Radix Codonopsis of the Radix Astragali
100-200 parts of 100-200 parts of Radix Saposhnikoviaes of 100-200 parts of Rhizoma Et Radix Notopterygiis of Poria
100-200 parts of Fructus Gardeniae.
2, a kind of prosopoplegic drug regimen that is used for the treatment of according to claim 1 is characterized in that wherein preparing the preferred following raw materials according of described active ingredient:
100 parts of 100 portions of Scorpios of 150 parts of Bombyx Batryticatus of Arisaema Cum Bile
150 parts of 150 parts of Rhizoma Chuanxiongs of 100 parts of Radix Angelicae Sinensis of Scolopendra
120 parts in 120 parts of Semen Persicaes of 120 parts of Radix Paeoniae Rubra of Radix Salviae Miltiorrhizae
120 parts of 150 parts of Rhizoma Atractylodis Macrocephalaes of 150 parts of Radix Codonopsis of the Radix Astragali
120 parts of 120 parts of Radix Saposhnikoviaes of 120 portions of Rhizoma Et Radix Notopterygiis of Poria
120 parts of Fructus Gardeniae.
3, according to the described a kind of prosopoplegic drug regimen that is used for the treatment of of claim 1-2, it is characterized in that adopting following method to make:
(1) Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, the Radix Astragali add 80% alcohol dipping three times, flood 48 hours for the first time, and second and third time flooded respectively 24 hours, filter, and decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) medical materials such as all the other Arisaema Cum Bile, Bombyx Batryticatus, Scorpio, Scolopendra, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Semen Persicae, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, Rhizoma Et Radix Notopterygii, Radix Saposhnikoviae, Fructus Gardeniae add 10 times of decoctings and boil three times, 1 hour for the first time, second and third time 0.5 hour, filter, merging filtrate, filtrate is condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, be ground into fine powder, add acceptable accessories and make different preparations such as granule, sheet, capsule.
4, according to any one described a kind of prosopoplegic drug regimen that is used for the treatment of among the claim 1-3, it is characterized in that this Chinese medicine composition is an oral formulations.
5, according to the described a kind of prosopoplegic drug regimen that is used for the treatment of of claim 3-4, it is characterized in that this Chinese medicine composition can be made into granule, capsule, tablet.
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| CN200810102945A CN101543558A (en) | 2008-03-28 | 2008-03-28 | Medicine composition for treating facioplegia and preparation method thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526403A (en) * | 2012-02-05 | 2012-07-04 | 丛丽 | Chinese medicinal preparation for treating facial nerve paralysis |
| CN104800400A (en) * | 2015-04-20 | 2015-07-29 | 侯鹏志 | Traditional Chinese medicine formula for treating qi and blood deficiency type facial paralysis |
| CN105287724A (en) * | 2014-06-15 | 2016-02-03 | 张红伶 | Medicine for treating facioplegia |
| CN105770615A (en) * | 2014-12-22 | 2016-07-20 | 天津嘉创生物科技有限公司 | Traditional Chinese medicine suspension for treating rear-quarter palsy of dog and preparation method thereof |
| CN107582870A (en) * | 2017-10-26 | 2018-01-16 | 北京煜煌科技有限公司 | A kind of composition of facial paralysis and preparation method thereof |
| CN110075070A (en) * | 2019-05-09 | 2019-08-02 | 安徽中医药大学第一附属医院 | Seven taste face networks of one kind lead to particle and preparation method thereof |
-
2008
- 2008-03-28 CN CN200810102945A patent/CN101543558A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526403A (en) * | 2012-02-05 | 2012-07-04 | 丛丽 | Chinese medicinal preparation for treating facial nerve paralysis |
| CN105287724A (en) * | 2014-06-15 | 2016-02-03 | 张红伶 | Medicine for treating facioplegia |
| CN105770615A (en) * | 2014-12-22 | 2016-07-20 | 天津嘉创生物科技有限公司 | Traditional Chinese medicine suspension for treating rear-quarter palsy of dog and preparation method thereof |
| CN104800400A (en) * | 2015-04-20 | 2015-07-29 | 侯鹏志 | Traditional Chinese medicine formula for treating qi and blood deficiency type facial paralysis |
| CN107582870A (en) * | 2017-10-26 | 2018-01-16 | 北京煜煌科技有限公司 | A kind of composition of facial paralysis and preparation method thereof |
| CN110075070A (en) * | 2019-05-09 | 2019-08-02 | 安徽中医药大学第一附属医院 | Seven taste face networks of one kind lead to particle and preparation method thereof |
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Open date: 20090930 |