CN101537065B - Drug composition having functions of cleaning and bacteriostasis - Google Patents
Drug composition having functions of cleaning and bacteriostasis Download PDFInfo
- Publication number
- CN101537065B CN101537065B CN2009100823900A CN200910082390A CN101537065B CN 101537065 B CN101537065 B CN 101537065B CN 2009100823900 A CN2009100823900 A CN 2009100823900A CN 200910082390 A CN200910082390 A CN 200910082390A CN 101537065 B CN101537065 B CN 101537065B
- Authority
- CN
- China
- Prior art keywords
- weight portion
- weight
- mesh sieves
- pulverize
- radix
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to a drug composition applicable to cleaning and bacteriostasis on the human body surface. The drug composition is prepared into external preparations by lightyellow sophora root, amur corktree bark, Chinese gall, common cnidium fruit, garden burnet root and the like; the preparations comprise external powders, liniments and lotions. The composition has stronger functions of cleaning and bacteriostasis, and has stronger functions of bacteriostasis and sterilization to escherichia coli, staphylococcus aureus and candida albicans; and the product is mild and has no toxicity and stimulation.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition and preparation method thereof, particularly a kind of body surface cleaning and bacteriostatic pharmaceutical composition and preparation method thereof of being used for.
Background technology
At present, have various cleanings and germ-resistant medicine on the market, but mostly Western medicine has certain side effect, as chafe etc., and existing Chinese medicine has onset to wait shortcoming slowly.Still lack a kind of rapid-actionly at present, toxic and side effects is little, obvious results sterilization, sterile products.
Summary of the invention
The object of the invention is to provide a kind of body surface cleaning and bacteriostatic pharmaceutical composition of being used for; Another object of the present invention is to provide the preparation method of said composition.
The present invention seeks to be achieved through the following technical solutions:
The raw material of pharmaceutical composition of the present invention consists of:
Radix Sophorae Flavescentis 600-1200 weight portion Cortex Phellodendri 300-600 weight portion
Galla Chinensis 300-600 weight portion Fructus Cnidii 300-600 weight portion
Radix Sanguisorbae 600-900 weight portion Borneolum Syntheticum 30-80 weight portion
Oleum menthae 5-15 parts by volume dextrin 150-450 weight portion
Chlorhexidine gluconate 50-250 weight portion.
The raw material preferred group of pharmaceutical composition of the present invention becomes:
Radix Sophorae Flavescentis 900 weight portion Cortex Phellodendris 450 weight portion Galla Chinensiss 450 weight portions
Fructus Cnidii 450 weight portion Radix Sanguisorbaes 750 weight portion Borneolum Syntheticums 50 weight portions
Oleum menthae 10 parts by volume dextrin 300 weight portions
Chlorhexidine gluconate 150 weight portions.
The raw material preferred group of pharmaceutical composition of the present invention becomes:
Radix Sophorae Flavescentis 700 weight portion Cortex Phellodendris 550 weight portion Galla Chinensiss 350 weight portions
Fructus Cnidii 550 weight portion Radix Sanguisorbaes 700 weight portion Borneolum Syntheticums 70 weight portions
Oleum menthae 6 parts by volume dextrin 420 weight portions
Chlorhexidine gluconate 80 weight portions.
The raw material preferred group of pharmaceutical composition of the present invention becomes:
Radix Sophorae Flavescentis 1100 weight portion Cortex Phellodendris 350 weight portion Galla Chinensiss 550 weight portions
Fructus Cnidii 350 weight portion Radix Sanguisorbaes 880 weight portion Borneolum Syntheticums 40 weight portions
Oleum menthae 14 parts by volume dextrin 180 weight portions
Chlorhexidine gluconate 200 weight portions.
Preparation of drug combination method of the present invention comprises the steps:
Get Radix Sophorae Flavescentis, Cortex Phellodendri, Galla Chinensis, Fructus Cnidii, Radix Sanguisorbae five tastes medical material, the decocting that adds the 5-15 times of weight boils 1-3 time, filtered in every 1-3 hour, collecting decoction, being evaporated to relative density under 70-90 ℃ is 1.02-1.10, left standstill 20-75 hour, get supernatant, be condensed into thick paste, add dextrin, drying under reduced pressure gets dry extract; Get dry extract, pulverize, cross the 70-90 mesh sieve, add chlorhexidine gluconate, mixing is sprayed the ethanol that concentration is 80-90%, crosses the 13-15 mesh sieve and granulates, and 50-60 ℃ of following forced air drying, granulate is put into hermetic container; Getting Oleum menthae, to dissolve in concentration be 90-98% ethanol, sprays in the granule, airtight; Get Borneolum Syntheticum and pulverize, cross the 110-130 mesh sieve,, be up to the standards, promptly get pharmaceutical composition of the present invention with above-mentioned granule mixing.
Preparation of drug combination method of the present invention is preferably:
Get Radix Sophorae Flavescentis, Cortex Phellodendri, Galla Chinensis, Fructus Cnidii, Radix Sanguisorbae five tastes medical material, the decocting that adds 10 times of weight boils 2 times, per 2 hours, filters, collecting decoction, being concentrated into relative density under 80 ℃ is 1.05, leaves standstill 48 hours, gets supernatant, be condensed into thick paste, add dextrin, drying under reduced pressure gets dry extract; Get dry extract, pulverize, cross 80 mesh sieves, add chlorhexidine gluconate, mixing, the alcohol granulation with 85% is crossed 14 mesh sieves and is granulated, and 50-60 ℃ of following forced air drying, granulate is put into hermetic container; Getting Oleum menthae, to dissolve in concentration be 95% ethanol, sprays in the granule, airtight; Get Borneolum Syntheticum and pulverize, cross 120 mesh sieves,, be up to the standards, promptly get pharmaceutical composition of the present invention with above-mentioned granule mixing.
Preparation of drug combination method of the present invention is preferably:
Get Radix Sophorae Flavescentis, Cortex Phellodendri, Galla Chinensis, Fructus Cnidii, Radix Sanguisorbae five tastes medical material, the decocting that adds 6 times of weight boiled 3 hours, filtered collecting decoction, being concentrated into relative density under 75 ℃ is 1.03, leaves standstill 24 hours, gets supernatant, is condensed into thick paste, add dextrin, drying under reduced pressure gets dry extract; Get dry extract, pulverize, cross 70 mesh sieves, add chlorhexidine gluconate, mixing is sprayed concentration and is 80% ethanol, crosses 13 mesh sieves and granulates, and 50-60 ℃ of following forced air drying, granulate is put into hermetic container; Getting Oleum menthae, to dissolve in concentration be in 92% ethanol, sprays in the granule, airtight; Get Borneolum Syntheticum and pulverize, cross 120 mesh sieves,, be up to the standards, promptly get pharmaceutical composition of the present invention with above-mentioned granule mixing.
Preparation of drug combination method of the present invention is preferably:
Get Radix Sophorae Flavescentis, Cortex Phellodendri, Galla Chinensis, Fructus Cnidii, Radix Sanguisorbae five tastes medical material, the decocting that adds 13 times of weight boils 3 times, per 1 hour, filters, collecting decoction, being concentrated into relative density under 82 ℃ is 1.08, leaves standstill 72 hours, gets supernatant, be condensed into thick paste, add dextrin, drying under reduced pressure gets dry extract; Get dry extract, pulverize, cross 90 mesh sieves, add chlorhexidine gluconate, mixing is sprayed concentration and is 97% ethanol, crosses 15 mesh sieves and granulates, and 50-60 ℃ of following forced air drying, granulate is put into hermetic container; Getting Oleum menthae, to dissolve in concentration be in 96% ethanol, sprays in the granule, airtight; Get Borneolum Syntheticum and pulverize, cross 130 mesh sieves,, be up to the standards, promptly get pharmaceutical composition of the present invention with above-mentioned granule mixing.
Pharmaceutical composition of the present invention adds conventional adjuvant, according to common process, makes clinical or pharmaceutically acceptable external preparation: external pulvis, liniment, lotion.
Wherein, the relation of above-mentioned weight portion and parts by volume is the relation of g/ml.
This pharmaceutical composition is the preparation made from Radix Sophorae Flavescentis, Cortex Phellodendri, Galla Chinensis, Fructus Cnidii, Radix Sanguisorbae etc., all has stronger antibacterial and bactericidal action, effect remarkable to escherichia coli, Candida albicans, staphylococcus aureus.And the side effect of product moderate notoxic is fit to the cleaning and the sterilization of body surface, and effect is remarkable.
Following experimental example and embodiment are used to further specify but are not limited to the present invention.
Experimental example 1: pharmaceutical composition sterilization experiment of the present invention
One, equipment:
1, test strain: Candida albicans (ATCC 10231) the 5th generation (strain is provided by institute of section of army five); Staphylococcus aureus (ATCC 6538) the 3rd generation (strain is provided by institute of section of army five); The 4th generation of escherichia coli 8099 (strain is provided by Chinese common micro-organisms DSMZ).
2, the pharmaceutical composition of the present invention that antibacterial: embodiment 1 prepares, lot number are 070321
3, the PBS solution of 0.03mol/L
4, ordinary nutrient agar culture medium, husky fort agar culture medium
Two, method:
1, detect foundation: disposable use hygienic article sanitary standard (GB 15979-2002) (appendix C 4) stripping property resists (pressing down) bacterium product bacteriostasis property method of testing.
Test organisms 24h slant culture is washed with PBS, make bacteria suspension (concentration of requirement is: drip on the contrast print or in the 5mL sample liquid with 100 μ L, reclaiming the bacterium number is 1 * 104～9 * 104cfu/ sheet or mL).
Get that (2.0cm * 3.0cm) or sample liquid (5mL) and contrast print or sample liquid (with the sample homogeneous material, equal size, but do not contain anti-biotic material, and through sterilization treatment) each 4 (placing in the sterilization plate) or 4 are managed by coupons.
Get above-mentioned bacteria suspension, respectively each by coupons or sample liquid and contrast print or sample liquid on or interior dropping 100 μ L, evenly coating/mixing, pick up counting, effect 2,5,10,20min, respectively print or sample liquid (0.5mL) input are contained 5mLPBS in vitro with aseptic tweezer, abundant mixing, do suitably dilution, get wherein 2～3 dilution factors then, draw 0.5mL respectively, place two plates, nutrient agar (antibacterial) or sabouraud's agar (yeast) 15mL with cold to 40～45 ℃ pour into, rotate plate, make it full and uniform, it is dull and stereotyped that agar solidifies the back upset, cultivate 48h (antibacterial) or 72h (yeast), do the viable bacteria colony counting for 35 ℃ ± 2 ℃.
Test repeats 3 times, calculates bacteriostasis rate by formula (C2):
X4＝(A-B)/A×100％...(C1)
In the formula: X4---bacteriostasis rate, %;
A---the average clump count of control sample;
B---tested sample average clump count.
Evaluation criterion: bacteriostasis rate 〉=50%～90%, product has bacteriostasis, and bacteriostasis rate 〉=90%, product have strong bacteriostasis.
2, testing conditions: 20 ℃-22 ℃ of ambient temperatures, relative humidity 50%-52%, test repeats 3 times.
Three, result:
Under this experimental condition, pharmaceutical composition of the present invention diluent effect in 1: 50 was 61.21% (57.46%-66.99%) to the oidiomycetic bacteriostasis rate of white in 2 minutes, bacteriostasis is arranged, acting on 10 minutes to the oidiomycetic bacteriostasis rate of white is 92.70% (90.63%-93.75%), stronger bacteriostasis is arranged, the results are shown in Table 1.
1: 50 diluting effect of pharmaceutical composition of the present invention was 100% to colibacillary bacteriostasis rate in 2 minutes, and stronger bacteriostasis is arranged; The results are shown in Table 2.
Pharmaceutical composition of the present invention diluent effect in 1: 50 was 78.32% (69.85%-87.62%) to the staphylococcus aureus rate in 2 minutes, and bacteriostasis is arranged; Acting on 5 minutes bacteriostasis rates to staphylococcus aureus is 100%, and stronger bacteriostasis is arranged, and the results are shown in Table 3.
Table 1 pharmaceutical composition of the present invention is to the oidiomycetic bacteriostatic test result of white
Annotate: the average bacterium amount of control sample is 2.15 * 10
4Fu/ml (1.93 * 10
4Cfu/ml-3.60 * 10
4Cfu/ml)
Table 2 pharmaceutical composition of the present invention is to colibacillary bacteriostatic test result
Annotate: the average bacterium amount of control sample is 7.59 * 10
4Cfu/ml (6.75 * 10
4Cfu/ml-8.60 * 10
4Cfu/ml)
Table 3 pharmaceutical composition of the present invention is to the bacteriostatic test result of staphylococcus aureus
Annotate: the average bacterium amount of control sample is 4.39 * 10
4Fu/ml (1.96 * 10
4Cfu/ml-6.70 * 10
4Cfu/ml)
Following embodiment all can realize the effect of above-mentioned experimental example.
The specific embodiment
Embodiment 1: external pulvis
Radix Sophorae Flavescentis 900g Cortex Phellodendri 450g Galla Chinensis 450g
Fructus Cnidii 450g Radix Sanguisorbae 750g Borneolum Syntheticum 50g
Oleum menthae 10ml dextrin 300g
Chlorhexidine gluconate 150g;
Get Radix Sophorae Flavescentis, Cortex Phellodendri, Galla Chinensis, Fructus Cnidii, Radix Sanguisorbae five tastes medical material, the decocting that adds 10 times of weight boils 2 times, per 2 hours, filters, collecting decoction, being concentrated into relative density under 80 ℃ is 1.05, leaves standstill 48 hours, gets supernatant, be condensed into thick paste, add dextrin, drying under reduced pressure gets dry extract; Get dry extract, pulverize, cross 80 mesh sieves, add chlorhexidine gluconate, mixing, the alcohol granulation with 85% is crossed 14 mesh sieves and is granulated, and 50-60 ℃ of following forced air drying, granulate is put into hermetic container; Getting Oleum menthae, to dissolve in concentration be 95% ethanol, sprays in the granule, airtight; Get Borneolum Syntheticum and pulverize, cross 120 mesh sieves,, be up to the standards, promptly get external pulvis of the present invention with above-mentioned granule mixing.
Embodiment 2: liniment
Radix Sophorae Flavescentis 700g Cortex Phellodendri 550g Galla Chinensis 350g
Fructus Cnidii 550g Radix Sanguisorbae 700g Borneolum Syntheticum 70g
Oleum menthae 6ml dextrin 420g
Chlorhexidine gluconate 80g.
Get Radix Sophorae Flavescentis, Cortex Phellodendri, Galla Chinensis, Fructus Cnidii, Radix Sanguisorbae five tastes medical material, the decocting that adds 6 times of weight boiled 3 hours, filtered collecting decoction, being concentrated into relative density under 75 ℃ is 1.03, leaves standstill 24 hours, gets supernatant, is condensed into thick paste, add dextrin, drying under reduced pressure gets dry extract; Get dry extract, pulverize, cross 70 mesh sieves, add chlorhexidine gluconate, mixing is sprayed concentration and is 80% ethanol, crosses 13 mesh sieves and granulates, and 50-60 ℃ of following forced air drying, granulate is put into hermetic container; Getting Oleum menthae, to dissolve in concentration be in 92% ethanol, sprays in the granule, airtight; Get Borneolum Syntheticum and pulverize, cross 120 mesh sieves, with above-mentioned granule mixing, be up to the standards, technology makes liniment of the present invention routinely.
Embodiment 3: lotion
Radix Sophorae Flavescentis 1100g Cortex Phellodendri 350g Galla Chinensis 550g
Fructus Cnidii 350g Radix Sanguisorbae 880g Borneolum Syntheticum 40g
Oleum menthae 14ml dextrin 180g
Chlorhexidine gluconate 200g.
Get Radix Sophorae Flavescentis, Cortex Phellodendri, Galla Chinensis, Fructus Cnidii, Radix Sanguisorbae five tastes medical material, the decocting that adds 13 times of weight boils 3 times, per 1 hour, filters, collecting decoction, being concentrated into relative density under 82 ℃ is 1.03, leaves standstill 50 hours, gets supernatant, be condensed into thick paste, add dextrin, drying under reduced pressure gets dry extract; Get dry extract, pulverize, cross 90 mesh sieves, add chlorhexidine gluconate, mixing is sprayed concentration and is 88% ethanol, crosses 15 mesh sieves and granulates, and 50-60 ℃ of following forced air drying, granulate is put into hermetic container; Getting Oleum menthae, to dissolve in concentration be in 96% ethanol, sprays in the granule, airtight; Get Borneolum Syntheticum and pulverize, cross 130 mesh sieves, with above-mentioned granule mixing, be up to the standards, technology makes lotion of the present invention routinely.
Embodiment 4: external pulvis
Radix Sophorae Flavescentis 1100g Cortex Phellodendri 350g Galla Chinensis 550g
Fructus Cnidii 480g Radix Sanguisorbae 780g Borneolum Syntheticum 40g
Oleum menthae 8ml dextrin 420g
Chlorhexidine gluconate 200g.
Get Radix Sophorae Flavescentis, Cortex Phellodendri, Galla Chinensis, Fructus Cnidii, Radix Sanguisorbae five tastes medical material, the decocting that adds 10 times of weight boils 2 times, per 2 hours, filters, collecting decoction, being concentrated into relative density under 80 ℃ is 1.10, leaves standstill 24 hours, gets supernatant, be condensed into thick paste, add the dextrin drying under reduced pressure, get dry extract; Get dry extract, pulverize, cross 80 mesh sieves, add chlorhexidine gluconate, mixing, the alcohol granulation with 85% is crossed 14 mesh sieves and is granulated, and 50-60 ℃ of following forced air drying, granulate is put into hermetic container; Getting Oleum menthae, to dissolve in concentration be 95% ethanol, sprays in the granule, airtight; Get Borneolum Syntheticum and pulverize, cross 120 mesh sieves,, be up to the standards, promptly get external pulvis of the present invention with above-mentioned granule mixing.
Embodiment 5: liniment
Radix Sophorae Flavescentis 900g Cortex Phellodendri 450g Galla Chinensis 450g
Fructus Cnidii 450g Radix Sanguisorbae 750g Borneolum Syntheticum 50g
Oleum menthae 10ml dextrin 300g
Chlorhexidine gluconate 150g.
Get Radix Sophorae Flavescentis, Cortex Phellodendri, Galla Chinensis, Fructus Cnidii, Radix Sanguisorbae five tastes medical material, the decocting that adds 8 times of weight boils 1 time, per 3 hours, filters, collecting decoction, being concentrated into relative density under 75 ℃ is 10, leaves standstill 48 hours, gets supernatant, be condensed into thick paste, add dextrin, drying under reduced pressure gets dry extract; Get dry extract, pulverize, cross 70 mesh sieves, add chlorhexidine gluconate, mixing, the alcohol granulation with 80% is crossed 13 mesh sieves and is granulated, and 60 ℃ of-70 ℃ of following forced air dryings, granulate is put into hermetic container; Getting Oleum menthae, to dissolve in concentration be in 92% ethanol, sprays in the granule, airtight; Get Borneolum Syntheticum and pulverize, cross 120 mesh sieves, with above-mentioned granule mixing, be up to the standards, technology makes liniment of the present invention routinely.
Claims (7)
1. preparation of drug combination method with cleaning, bacteriostasis, it is characterized in that this method is: get Radix Sophorae Flavescentis, Cortex Phellodendri, Galla Chinensis, Fructus Cnidii, Radix Sanguisorbae five tastes medical material, the decocting that adds the 5-15 times of weight boils 1-3 time, filters in every 1-3 hour, collecting decoction, being evaporated to relative density under 70-90 ℃ is 1.02-1.10, leaves standstill 20-75 hour, gets supernatant, be condensed into thick paste, add dextrin, drying under reduced pressure gets dry extract; Get dry extract, pulverize, cross the 70-90 mesh sieve, add chlorhexidine gluconate, mixing is sprayed the ethanol that concentration is 80-90%, crosses the 13-15 mesh sieve and granulates, and 50-60 ℃ of following forced air drying, granulate is put into hermetic container; Getting Oleum menthae, to dissolve in concentration be 90-98% ethanol, sprays in the granule, airtight; Get Borneolum Syntheticum and pulverize, cross the 110-130 mesh sieve,,, make external pulvis, liniment, lotion again according to common process with above-mentioned granule mixing;
The crude drug of wherein said pharmaceutical composition consists of:
Radix Sophorae Flavescentis 600-1200 weight portion Cortex Phellodendri 300-600 weight portion
Galla Chinensis 300-600 weight portion Fructus Cnidii 300-600 weight portion
Radix Sanguisorbae 600-900 weight portion Borneolum Syntheticum 30-80 weight portion
Oleum menthae 5-15 parts by volume dextrin 150-450 weight portion
Chlorhexidine gluconate 50-250 weight portion.
2. preparation of drug combination method as claimed in claim 1 is characterized in that the crude drug of the pharmaceutical composition described in this method consists of:
Radix Sophorae Flavescentis 900 weight portion Cortex Phellodendris 450 weight portion Galla Chinensiss 450 weight portions
Fructus Cnidii 450 weight portion Radix Sanguisorbaes 750 weight portion Borneolum Syntheticums 50 weight portions
Oleum menthae 10 parts by volume dextrin 300 weight portions
Chlorhexidine gluconate 150 weight portions.
3. preparation of drug combination method as claimed in claim 1 is characterized in that the crude drug of the pharmaceutical composition described in this method consists of:
Radix Sophorae Flavescentis 700 weight portion Cortex Phellodendris 550 weight portion Galla Chinensiss 350 weight portions
Fructus Cnidii 550 weight portion Radix Sanguisorbaes 700 weight portion Borneolum Syntheticums 70 weight portions
Oleum menthae 6 parts by volume dextrin 420 weight portions
Chlorhexidine gluconate 80 weight portions.
4. preparation of drug combination method as claimed in claim 1 is characterized in that the crude drug of the pharmaceutical composition described in this method consists of:
Radix Sophorae Flavescentis 1100 weight portion Cortex Phellodendris 350 weight portion Galla Chinensiss 550 weight portions
Fructus Cnidii 350 weight portion Radix Sanguisorbaes 880 weight portion Borneolum Syntheticums 40 weight portions
Oleum menthae 14 parts by volume dextrin 180 weight portions
Chlorhexidine gluconate 200 weight portions.
5. as the arbitrary described preparation of drug combination method of claim 1-4, it is characterized in that this method is: get Radix Sophorae Flavescentis, Cortex Phellodendri, Galla Chinensis, Fructus Cnidii, Radix Sanguisorbae five tastes medical material, the decocting that adds 10 times of weight boils 2 times, per 2 hours, filter, collecting decoction, being concentrated into relative density under 80 ℃ is 1.05, left standstill 48 hours, get supernatant, be condensed into thick paste, add dextrin, drying under reduced pressure gets dry extract; Get dry extract, pulverize, cross 80 mesh sieves, add chlorhexidine gluconate, mixing, the alcohol granulation with 85% is crossed 14 mesh sieves and is granulated, and 50-60 ℃ of following forced air drying, granulate is put into hermetic container; Getting Oleum menthae, to dissolve in concentration be 95% ethanol, sprays in the granule, airtight; Get Borneolum Syntheticum and pulverize, cross 120 mesh sieves,,, make external pulvis, liniment, lotion again according to common process with above-mentioned granule mixing.
6. as the arbitrary described preparation of drug combination method of claim 1-4, it is characterized in that this method is: get Radix Sophorae Flavescentis, Cortex Phellodendri, Galla Chinensis, Fructus Cnidii, Radix Sanguisorbae five tastes medical material, the decocting that adds 6 times of weight boiled 3 hours, filtered, collecting decoction, being concentrated into relative density under 75 ℃ is 1.03, leaves standstill 24 hours, gets supernatant, be condensed into thick paste, add dextrin, drying under reduced pressure gets dry extract; Get dry extract, pulverize, cross 70 mesh sieves, add chlorhexidine gluconate, mixing is sprayed concentration and is 80% ethanol, crosses 13 mesh sieves and granulates, and 50-60 ℃ of following forced air drying, granulate is put into hermetic container; Getting Oleum menthae, to dissolve in concentration be in 92% ethanol, sprays in the granule, airtight; Get Borneolum Syntheticum and pulverize, cross 120 mesh sieves,,, make external pulvis, liniment, lotion again according to common process with above-mentioned granule mixing.
7. as the arbitrary described preparation of drug combination method of claim 1-4, it is characterized in that this method is: get Radix Sophorae Flavescentis, Cortex Phellodendri, Galla Chinensis, Fructus Cnidii, Radix Sanguisorbae five tastes medical material, the decocting that adds 13 times of weight boils 3 times, per 1 hour, filter, collecting decoction, being concentrated into relative density under 82 ℃ is 1.08, left standstill 72 hours, get supernatant, be condensed into thick paste, add dextrin, drying under reduced pressure gets dry extract; Get dry extract, pulverize, cross 90 mesh sieves, add chlorhexidine gluconate, mixing is sprayed concentration and is 97% ethanol, crosses 15 mesh sieves and granulates, and 50-60 ℃ of following forced air drying, granulate is put into hermetic container; Getting Oleum menthae, to dissolve in concentration be in 96% ethanol, sprays in the granule, airtight; Get Borneolum Syntheticum and pulverize, cross 130 mesh sieves,,, make external pulvis, liniment, lotion again according to common process with above-mentioned granule mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100823900A CN101537065B (en) | 2009-04-16 | 2009-04-16 | Drug composition having functions of cleaning and bacteriostasis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100823900A CN101537065B (en) | 2009-04-16 | 2009-04-16 | Drug composition having functions of cleaning and bacteriostasis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101537065A CN101537065A (en) | 2009-09-23 |
| CN101537065B true CN101537065B (en) | 2011-11-23 |
Family
ID=41120606
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009100823900A Expired - Fee Related CN101537065B (en) | 2009-04-16 | 2009-04-16 | Drug composition having functions of cleaning and bacteriostasis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101537065B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102670815B (en) * | 2011-03-14 | 2013-08-07 | 王力 | External traditional Chinese medicine for curing beriberi |
| CN102641368B (en) * | 2012-04-19 | 2016-04-20 | 王莲芬 | A kind of Chinese medicine for the treatment of beriberi |
| CN106259489A (en) * | 2015-05-18 | 2017-01-04 | 青海亚华生物科技有限公司 | A kind of novel skin antibacterial liquid and clothes soak |
| CN107375496A (en) * | 2017-07-27 | 2017-11-24 | 西南医科大学附属中医医院 | A kind of pharmaceutical composition and preparation method thereof with removing damp-heat, the antipruritic function of desinsection |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1977916A (en) * | 2006-12-20 | 2007-06-13 | 北京润德康医药技术有限公司 | Chinese medicine composition for treating skin disease |
-
2009
- 2009-04-16 CN CN2009100823900A patent/CN101537065B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1977916A (en) * | 2006-12-20 | 2007-06-13 | 北京润德康医药技术有限公司 | Chinese medicine composition for treating skin disease |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101537065A (en) | 2009-09-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Srivastava et al. | Phytochemicals of Azadirachta indica source of active medicinal constituent used for cure of various diseases: A Review | |
| Stanley et al. | Antimicrobial effects of Chromolaena odorata on some human pathogens | |
| CN103622865B (en) | A kind of medical handwashing liquid comprising plant extract quintessence oil and preparation method thereof | |
| CN104920518A (en) | Traditional Chinese medicine disinfection spray and preparation method thereof | |
| CN103316023B (en) | Novel lotion for females | |
| CN102895325B (en) | Traditional Chinese medicine bacteriostatic composition | |
| CN101537065B (en) | Drug composition having functions of cleaning and bacteriostasis | |
| CN106900781A (en) | Antibacterial bacteriostatic liquid prepared by a kind of vegetable Chinese herbal medicine | |
| CN103299802A (en) | Technology for preventing and curing soft rot of konjak | |
| CN104127779B (en) | A kind of Chinese herb compound washing lotion of anti-inflammation and preparation method thereof | |
| Arıkan et al. | Propolis extract-PVA nanocomposites of textile design: antimicrobial effect on gram positive and negative bacterias | |
| CN112226904A (en) | Preparation process and application of spunbonded non-woven fabric containing honeysuckle antipyretic extract | |
| CN103463576A (en) | Medicament for preoperative disinfection | |
| CN108041104A (en) | A kind of clinical laboratory Chinese medicine composite disinfection liquid and preparation method thereof | |
| CN104984196B (en) | A kind of bactericidal composition containing favus skin and preparation method thereof | |
| CN112007071A (en) | Use of cyclocarya paliurus leaf or extract thereof in preparation of antibacterial agent | |
| CN100571518C (en) | The active constituent of curcuma longa of inhibiting and killing plant pathogenic fungi and preparation thereof and application | |
| CN105394759A (en) | Method for preparing mulberry leaves chrysanthemum compound tablets | |
| CN101406558A (en) | Gynaecologic washing lotion for preventing and treating colpitis | |
| CN106929183A (en) | Efficient antibacterial liquid detergent and its production method | |
| KR102669103B1 (en) | Antimicrobial composition comprising the micro scaled powder of bast fiber of cannabis sativa l. | |
| CN108434042A (en) | A kind of novel daily use chemicals preservative and preparation method thereof | |
| CN1246001C (en) | 'Fufukang' Chinese traditional medicine preparation and preparing process thereof | |
| JP2887377B2 (en) | Mold control agent | |
| CN106421511A (en) | Aloe antibacterial composition and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20111123 Termination date: 20200416 |