CN101537048A - Application of buckwheat and bee pollen in preparing drugs and method for preparing capsules and tablets thereby - Google Patents
Application of buckwheat and bee pollen in preparing drugs and method for preparing capsules and tablets thereby Download PDFInfo
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- CN101537048A CN101537048A CN200910058932A CN200910058932A CN101537048A CN 101537048 A CN101537048 A CN 101537048A CN 200910058932 A CN200910058932 A CN 200910058932A CN 200910058932 A CN200910058932 A CN 200910058932A CN 101537048 A CN101537048 A CN 101537048A
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Abstract
The invention discloses the application of buckwheat and bee pollen in treating or preventing climacteric syndrome, body deficiency, anaemia, arteriosclerosis, hyperlipemia, low immune functioning and disease of premature senility. After the bee pollen is processed by the operation of wall breaking, the drug effect is enhanced by one time, obvious treatment effect can be realized, and the buckwheat and bee pollen is the novel traditional Chinese medicinal material for medical use. The invention also discloses various Chinese patent drugs prepared from the wall-breaking buckwheat and bee pollen used as raw materials, and the major function of each Chinese patent drug is identical to the major function of the buckwheat and bee pollen.
Description
Technical field
The present invention relates to pollen of Semen Fagopyri Esculenti with and application in medicine, especially the application in the medicine of pollen of Semen Fagopyri Esculenti, senilism disease low at preparation treatment or prevention climacteric syndrome, the empty anemia of body, arteriosclerosis, hyperlipidemia, immune function is a kind of new medicinal Chinese crude drug.The invention still further relates to the breaking cellular wall pollen of Semen Fagopyri Esculenti is that raw material is made various Chinese traditional patent formulation preparations, and its function cures mainly identical with pollen of Semen Fagopyri Esculenti.
Background technology
Raising day by day along with people's standard of living, the various pressure that people face also increase day by day, the change of dietary habit, various bad habits and environmental pollution or the like, these factors generally cause people to be in sub-health state, such as too fatigue, old and feeble quickening, immunity degradation, hypertension, hyperlipidemia, hyperglycemia etc.This is easy to bring out as cerebral thrombosis, cerebral hemorrhage, coronary heart disease, diabetes, arteriosclerosis etc. and is difficult to thoroughly cure and the great disease of sudden danger, and human beings'health has been caused very big threat, has also increased burden to society.
Pollen of Semen Fagopyri Esculenti is the pollen of buckwheat plant Semen Fagopyri Esculenti Fagopyrum esculentum Moench., collects the dry pollen agglomerate that obtains through honeybee.Natural pollen of Semen Fagopyri Esculenti as a kind of health food for many years in scattered use among the people, use separately in a jumble at the human body different situations different regions, different crowd, does not also have quantification treatment.The inventor has carried out many-sided pharmacodynamic experiment to pollen of Semen Fagopyri Esculenti, and various dose investigated, find that pollen of Semen Fagopyri Esculenti has very strong pharmacologically active, regulate the flow of vital energy in spleen invigorating, enrich blood, there is specially good effect aspect such as vessel softening, blood fat reducing, raising immune function, these effects there is no report.Through toxicological experiment research, pollen of Semen Fagopyri Esculenti toxicity is minimum, and taking does not for a long time have toxicity.Pollen of Semen Fagopyri Esculenti is not recorded by existing legal Chinese crude drug standard, does not take in the Chinese medicine books of the Records of the Historian yet, is a kind of new Chinese crude drug.
Summary of the invention
First purpose of the present invention provides the new purposes of pollen of Semen Fagopyri Esculenti in medicine, the application in the medicine of promptly low at preparation treatment or prevention climacteric syndrome, the empty anemia of body, arteriosclerosis, hyperlipidemia, immune function, senilism disease.
It is the Chinese traditional patent formulation preparation and preparation method thereof of raw material with the breaking cellular wall pollen of Semen Fagopyri Esculenti that second purpose of the present invention provides a kind of.
Described pollen of Semen Fagopyri Esculenti is prepared into various dosage forms according to the conventional production method of pharmaceutical field, and every dose of dose is 1.5～2g.Wherein as optimal way, described dosage form is a capsule, and every capsules contains pollen of Semen Fagopyri Esculenti 0.4g.Its preparation method is as follows:
A. determine required pollen of Semen Fagopyri Esculenti quality according to preparation capsule or tablet quantity;
B. take by weighing pollen of Semen Fagopyri Esculenti, after wall breaking pulverization is handled, make fine grained and incapsulate or suppress in flakes.
The present invention carries out chemical analysis experiment through gathering the pollen sample, mainly contains aminoacid and flavones ingredient.Further carried out many-sided effect experiment, and various dose investigated, find that " pollen of Semen Fagopyri Esculenti " has very strong pharmacologically active, confirmed that it has effects such as spleen invigorating is regulated the flow of vital energy, enriched blood, vessel softening, blood fat reducing, raising immune function, and found that pollen drug effect behind breaking cellular wall strengthens one times at least.After pollen broken wall was handled, a 1.5～2g 3 times on the one, can reach the obvious treatment effect.And toxicological experiment shows, this product is almost non-toxic, is the Chinese medicine simply that is worth deep development.
The specific embodiment
In order to understand essence of the present invention better, below in conjunction with embodiment the present invention is further specified, do not limit scope of the present invention with this.
Pollen of Semen Fagopyri Esculenti is to be formed through broken wall treatment by natural pollen of Semen Fagopyri Esculenti, and natural pollen of Semen Fagopyri Esculenti is the pollen of buckwheat plant Semen Fagopyri Esculenti Fagopyrum esculentum Moench., collects the dry pollen agglomerate that obtains through honeybee.This agglomerate out-of-shape, diameter 2～4mm, surperficial yellowish-brown is to rufous, injustice.Matter is softer, promptly the loosing of pressure, it is yellow that pollen is, sth. made by twisting soapy feeling arranged.Gas is special, and it is little sweet to distinguish the flavor of.The microscopically pollen grain is prolate spheroidal or spheroidal, polar view is three to split circle, diameter 30～60 μ m, tool three hole ditches, ditch is elongated, the endoporus similar round, diameter surpasses the width of ditch, two layers of outer walls, skin is thicker than internal layer, have and the vertical obvious rod of profile phase, outer bed thickness 2.5 μ m, the surface has tangible netted carving stricture of vagina or granule.Pollen of Semen Fagopyri Esculenti microscopically after broken wall treatment is observed, and sporoderm-broken rate is made up of the pollen of Semen Fagopyri Esculenti fragment more than 95%, diameter 5～10 μ m.
Gather the pollen sample and carry out chemical analysis, mainly contain aminoacid and flavones ingredient.Further carried out many-sided effect experiment after the broken wall treatment, and various dose investigated, find that pollen of Semen Fagopyri Esculenti has very strong pharmacologically active, confirmed that it has effects such as spleen invigorating is regulated the flow of vital energy, enriched blood, vessel softening, blood fat reducing, raising immune function, and find that pollen drug effect behind breaking cellular wall strengthens one times at least, be used for treatment of diseases such as climacteric syndrome, the empty anemia of body, arteriosclerosis, hyperlipidemia, immune function are low, senilism; Also can be used as the nourishing of cancer postoperative uses.
Consumption is lower than 1.5g according to medicine efficacy screening, and pharmacodynamics index is obviously on the low side, is higher than 2g, and pharmacodynamics index does not obviously increase, so drug effect is not directly proportional with consumption.At the various disease symptom, drug effect consumption flex point is not quite identical, between 1.5～2.0g simultaneously.Therefore, after pollen broken wall was handled, a 1.5～2.0g 3 times on the one, can reach the obvious treatment effect.Through toxicological experiment research, pollen of Semen Fagopyri Esculenti toxicity is minimum, and in above-mentioned taking dose scope, taking does not for a long time have toxicity.
Described pollen of Semen Fagopyri Esculenti is prepared into various dosage forms according to the conventional production method of pharmaceutical field, and wherein as optimal way, described dosage form is a capsule, and every capsules contains pollen of Semen Fagopyri Esculenti 0.4g.Its preparation process is as follows: (1) by making 1000 of finished product total amounts, the capsular prescription of pollen of Semen Fagopyri Esculenti is: pollen of Semen Fagopyri Esculenti 400g.(2) take by weighing pollen of Semen Fagopyri Esculenti, after wall breaking pulverization is handled, make fine grained and incapsulate or suppress in flakes.
Understand essence of the present invention for better, below we illustrate its new purposes at pharmaceutical field in conjunction with pharmacological effect test and result.
Test 1
Use the endogenous spleen colony algoscopy, give the 60Co ray of 30 mices irradiation 9Gy, administration group (oral 20,25,30mg/ only) and blank group (not administration) contrast.Experimental result shows that pollen of Semen Fagopyri Esculenti (breaking cellular wall) has obvious effect to the mouse spleen hemopoietic function, p value＜0.001, and hemopoietic colony (CFU-S) number ratio is (7.8 ± 6.3): (0.8 ± 0.9).Illustrate that pollen of Semen Fagopyri Esculenti has that spleen invigorating is regulated the flow of vital energy, the function of hemopoietic, and be good with 2.5mg/ dosage.
Test 2
With rat hyperlipidemia molding method, get the 200-350g male rat and be divided into 3 groups at random, 5 every group, respectively single cage is fed.Feed normal diet for first group, feed oily feedstuff (in normal diet, adding 10% Adeps Caprae seu ovis and 0.2% methylthiouracil) for second group, every Mus 25g/ day, press the 1ml/100g body weight and irritate stomach once to contain the skim milk of 5% cholesterol and 1% cholic acid morning every day simultaneously.Feed oily feedstuff for the 3rd group, only in milk, add pollen of Semen Fagopyri Esculenti 0.25g/.To rat plasma T-CHOL, plasma triglyceride level, blood plasma-lipoprotein, aorta T-CHOL, aorta triglyceride, total cholesterol of liver assay, found that pollen of Semen Fagopyri Esculenti has tangible blood fat reducing, prevents the arteriosclerosis effect after 6 weeks.
Test 3
Use the immune organ weight method, get 4 groups of 18g left and right sides mices, each 10, first group of blank, only irritate stomach pollen of Semen Fagopyri Esculenti 30mg/ second group of every day, gives meticortelone 0.3mg for the 3rd group, give meticortelone 0.3mg and pollen of Semen Fagopyri Esculenti 30mg for the 4th group, take by weighing each mice spleen after 6 days and weigh.The result shows that it is heavy that pollen of Semen Fagopyri Esculenti can significantly increase mice spleen, and immunosuppressant (meticortelone) is had strong antagonism.Pollen of Semen Fagopyri Esculenti improves the effect of immune function.
Claims (7)
1. the application of pollen of Semen Fagopyri Esculenti in preparation treatment or prevention climacteric syndrome medicine.
2. the application of pollen of Semen Fagopyri Esculenti in preparation treatment or the empty anemia medicine of prevention body.
3. the application of pollen of Semen Fagopyri Esculenti in preparation treatment or prevention of arterial sclerosis medicine.
4. the application of pollen of Semen Fagopyri Esculenti in preparation treatment or prevention hyperlipidemia medicine.
5. the application of pollen of Semen Fagopyri Esculenti in preparation treatment or epidemic prevention underactivity medicine.
6. the application of pollen of Semen Fagopyri Esculenti in preparation treatment or prevention senilism medicine.
7. the preparation method of pollen of Semen Fagopyri Esculenti capsule or tablet, it is characterized in that: this method is carried out as follows:
A. determine required pollen of Semen Fagopyri Esculenti quality according to preparation capsule or tablet quantity;
B. take by weighing pollen of Semen Fagopyri Esculenti, after wall breaking pulverization is handled, make fine grained and incapsulate or suppress in flakes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910058932A CN101537048A (en) | 2009-04-14 | 2009-04-14 | Application of buckwheat and bee pollen in preparing drugs and method for preparing capsules and tablets thereby |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910058932A CN101537048A (en) | 2009-04-14 | 2009-04-14 | Application of buckwheat and bee pollen in preparing drugs and method for preparing capsules and tablets thereby |
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| CN101537048A true CN101537048A (en) | 2009-09-23 |
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| CN200910058932A Pending CN101537048A (en) | 2009-04-14 | 2009-04-14 | Application of buckwheat and bee pollen in preparing drugs and method for preparing capsules and tablets thereby |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102114058A (en) * | 2010-12-28 | 2011-07-06 | 周斌 | Production method of bee pollen tablet for treating fatty liver |
| CN102119939A (en) * | 2010-12-28 | 2011-07-13 | 周斌 | Angiosperm bee pollen water extract for treating fatty liver and preparation method and application thereof |
-
2009
- 2009-04-14 CN CN200910058932A patent/CN101537048A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102114058A (en) * | 2010-12-28 | 2011-07-06 | 周斌 | Production method of bee pollen tablet for treating fatty liver |
| CN102119939A (en) * | 2010-12-28 | 2011-07-13 | 周斌 | Angiosperm bee pollen water extract for treating fatty liver and preparation method and application thereof |
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Application publication date: 20090923 |