CN102114058A - Production method of bee pollen tablet for treating fatty liver - Google Patents
Production method of bee pollen tablet for treating fatty liver Download PDFInfo
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- CN102114058A CN102114058A CN2010106074000A CN201010607400A CN102114058A CN 102114058 A CN102114058 A CN 102114058A CN 2010106074000 A CN2010106074000 A CN 2010106074000A CN 201010607400 A CN201010607400 A CN 201010607400A CN 102114058 A CN102114058 A CN 102114058A
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Abstract
The invention provides a production method of a bee pollen tablet for treating fatty liver, relating to production technologies of product tablets. The production method comprises the following steps of: performing air stream pulverization and wall breaking on impurities-removed bee pollen; soaking in water at normal pressure and temperature; performing ultrasonic treatment; centrifuging by a refrigerated centrifuge with the rotation speed of 8000-10000rpm, taking supernatant; separating the supernatant at the ambient temperature of -5 to 5 DEG C by a molecular sieve of below 2800D to obtain water-soluble bee pollen of which the molecular weight is smaller than 2800D; performing vacuum freeze drying on the water-soluble bee pollen of which the molecular weight is smaller than 2800D to form lybee pollen lyophilized powder with the moisture content below 4%; and mixing the lyophilized powder of bee pollen with water soluble starch and tabletting. According to the production method provided by the invention, the effective components in the bee pollen are extracted by water firstly and then prepared into lyophilized powder, thus being conductive to the subsequent tabletting processing, the tablet is convenient to take, the product activity is kept, and the medicament is not liable to oxidative deterioration and has a good absorption effect and rehydration.
Description
Technical field
The present invention relates to product tablet production technology, particularly treat the bee pollen tablets agent and process for producing same of fatty liver.
Background technology
Tablet grows up on the pill basis, created 19th-century forties, to 19 end of the centurys along with compression machinery is updated, tablet applications has obtained developing rapidly.In recent ten years, there is large development tablet manufacturing technology and plant equipment aspect, as boiling granulating, direct compression of full-powder, half film coating etc.The research of Chinese medicinal tablet and production start from the fifties in last century, and along with the comprehensive study of Chemistry for Chinese Traditional Medicine, pharmacology, preparation and clinical several respects, kind, the quantity of Chinese medicinal tablet constantly increase, and Technology is improved day by day, and the quality of tablet improves gradually.Chinese medicinal tablet on type except that general compressed tablet, coated tablet, also have microencapsule tablet, buccal tablet, external sheet and effervescent tablet etc.Find out a cover gradually at the tablet manufacturing process aspect and be applicable to the process conditions that Chinese medicinal tablet is produced, as preparation to fatty oil and volatile oil tablet, how to improve Chinese medicinal tablet hardness, improve disintegration, tablet coating etc. and accumulate experience gradually, quality is improved constantly.In a word, at present tablet become wide in variety, output is big, purposes is wide, use and store and transport conveniently, one of steady quality dosage form, tablet all accounts for more than 1/3 in the preparation that the pharmacopeia of China and other many countries is recorded, visible use wide.
Fatty liver is meant the pathological changes of fatty overheap in the hepatocyte that causes owing to a variety of causes, and the positive serious threat compatriots' of fatty liver disease health becomes the second largest hepatopathy that is only second to viral hepatitis, has been acknowledged as the common cause of disguised liver cirrhosis.Fatty liver is a kind of common clinical picture, but not a kind of independently disease.The lighter is asymptomatic in its clinical manifestation, weight person's state of an illness ferociousness.Generally speaking, fatty liver belongs to the reversibility disease, and early diagnosis and treatment in time often can recover normal.The formation of fatty liver generally is because the decomposition and the anabolism disequilibrium of fat in the liver or transport the generation obstacle, fat will be in hepatocyte excess accumulation, when fat content increases to more than 30%, then be called fatty liver.Fatty liver does not cause the etiopathogenesis difference of fatty liver on an equal basis by self voxel matter difference, dietary habit, generally can be divided into obesity, cross the feeding habits fatty liver, fatty liver after the hepatitis, alcoholic fatty liver, the deficiency disease fatty liver, the medicine fatty liver, diabetic fatty liver, the latent source property fatty liver of gestational fatty liver and unknown cause etc.Fatty liver is divided into slight fatty liver, moderate fatty liver and severe fatty liver again by the light and heavy degree difference.Slight fatty liver has become modern's common problem, and the best period that slight fatty liver is the treatment fatty liver takes place.The treatment of current fatty liver is still removing the cause of disease, Cure the Primary Disease and adhere to that the reasonable diet system is main, and medicine only plays the auxiliary treatment effect.So, the research of this disease has been become the common focus and the difficult point of domestic and international research.Up to the present, Western medicine does not still have lipotropic active drug, and for well, wherein Radix Polygoni Multiflori and Fructus Crataegi are best with the Chinese medicine long-time conditioning.
Bee pollen is angiospermous pollen, and China utilizes and one of edible bee pollen country the earliest in the world.The aboundresources of China's bee pollen, but waste is serious.
The research of China's bee pollen at present is in the leading level in the world; external research also is in the primary research stages such as analysis of nutritional labeling; and a series of difficult problems such as China has solved well that bee pollen is fresh-keeping, breaking cellular wall and production; realized large-scale production; and improved alimentation rate behind the edible bee pollen greatly, for bee pollen industry leading position in the world provides powerful guarantee.However external pollen product is but more extensive on using than China, and Sweden is applied to beauty treatment with pollen food, and Japan is used as nutriment with pollen food, and France is with the function food of pollen as the growth encourage childhood development.By comparison, though the developmental research of China's bee pollen has been carried out the more than ten years, a large amount of bee pollen products has appearred, but the comprehensive processing and utilization level is also not high, the product category of existing bee pollen is single on the market, and quality is uneven, and the degree of intensive processing is not high yet, exported product is rare especially, and the resource of valuable bee pollen is not well utilized.
Summary of the invention
The object of the invention be to invent a kind of be beneficial to long preservation, and can effectively keep the production method of its active bee pollen treatment fatty liver tablet.
The present invention includes following steps:
1) bee pollen with remove impurity is immersed in the normal pressure and temperature water after the comminution by gas stream broken wall treatment, after ultrasonic Treatment, through rotating speed is 8000～10000 refrigerated centrifuger centrifugal treating of changeing, get supernatant, again with supernatant under-5～5 ℃ ambient temperature, cross the following molecular sieve of 2800D, isolate the bee pollen hydrotrope of molecular weight less than 2800D;
2) with molecular weight less than the bee pollen hydrotrope of 2800D after lyophilisation, obtain water content and be lower than 4% Herba leucadis ciliatae lyophilized powder;
3) with described Herba leucadis ciliatae lyophilized powder and water soluble starch mixing film-making.
The present invention makes lyophilized powder earlier after active ingredient water is carried in the bee pollen, be beneficial to the processing of follow-up film-making, keeps the product activity, and also have following products characteristics: packing dosage is accurate.Conveniently take; Reservation function material activity; Medicine is difficult for oxidation deterioration; Good absorbing effect; Rehydration is good; Be fit to long-distance transport, long preservation and use.
In addition, the frequency of the classification motor of comminution by gas stream broken wall treatment is 55～60Hz in the step 1) of the present invention, and bleed pressure is 0.7～1.0MPa.
The described ultrasonic treatment time of described step 1) is 10～20 minutes.
Described step 2) during lyophilisation, temperature of charge is-40 ℃～70 ℃ when sublimation drying and desorbing, and vacuum condition is 3～7Pa.
During film-making, the mass ratio that feeds intake when lyophilized powder and water soluble starch mix is 1 ︰ 0.1～10.
In the described step 3), also can sneak into lecithin and microcrystalline Cellulose PH102 film-making, the mass ratio that feeds intake of described lyophilized powder, lecithin and microcrystalline Cellulose PH102 is 1 ︰, 0.1～10 ︰ 0.1～10.
The specific embodiment
One, the lyophilized powder of preparation treatment fatty liver bee pollen water extract:
1, go-on-go bee pollen: remove impurity in the bee pollen at normal temperatures.
2, breaking cellular wall: is 55～60Hz with the bee pollen of remove impurity in the frequency of classification motor, broken wall treatment under bleed pressure 0.7～1.0MPa.
3, soak supersound process: the bee pollen after the broken wall treatment is immersed in the normal pressure and temperature water, with ultrasonic Treatment 10～20 minutes.
4, remove impurity: it is centrifugal 8～12 minutes of 8000～10000 refrigerated centrifugers that change that the material after the supersound process is placed rotating speed, removes solid impurity, gets supernatant.
5, ultrafiltration: supernatant under-5～5 ℃ ambient temperature, is crossed the following molecular sieve of 2800D, isolate molecular weight, be the bee pollen hydrotrope that is used for the treatment of fatty liver less than 2800 the hydrotrope.
6, lyophilization: the bee pollen hydrotrope that will be used for the treatment of fatty liver is-40 ℃～70 ℃ at temperature of charge, and vacuum condition is lyophilization 30～50 hours under the condition of 3～7Pa, obtains water content and is lower than 4% lyophilized powder.
Two, tabletting:
1, prescription A:
Weight ratio when mixing by lyophilized powder and water soluble starch is 1 ︰, 0.1～10 weighing respectively.
Prescription B:
Weight ratio when mixing the PH102 mixing by lyophilized powder and lecithin, water soluble starch, microcrystalline Cellulose is 1 ︰, 0.1～10 ︰, 0.1～10 ︰, 0.1～10 weighing respectively.
2, production technology:
Mix: the prescription A or the prescription B of weighing are put into respectively in the batch mixer, build cover, open the batch mixer counter-rotating and stirred 10～20 minutes, just changeing again and stirring 5 minutes, behind the mix homogeneously, the material that mixes crossed 18 mesh sieves after, form two kinds of intermixtures, standby.
Tabletting: with two kinds of intermixtures difference tablettings.
Environmental condition is a relative humidity 45%～65% between the control tabletting, 18 ℃～26 ℃ of temperature, and it is 6～10kg/mm that tabletting hardness requires
2, sheet heavily is 0.6 gram.
Coating: syrup is with film coating pre-mix dose and 55%(percent by volume) ethanol continue to stir and became syrup in about 1 hour, cross 100 mesh sieves after, carry out coating.
Three, application and curative effect:
Certain man, 45 years old, the fatty liver symptom was: ultrasound diagnosis is the moderate fatty liver.
Take the bee pollen tablet 2-4 grain of making every day, continuously after 30-60 days, sx, ultrasound diagnosis is clearly better, and it is normal that multinomial enzyme value index is recovered.
Claims (6)
1. be used for the treatment of the production method of the bee pollen tablet of fatty liver, it is characterized in that may further comprise the steps:
1) bee pollen with remove impurity is immersed in the normal pressure and temperature water after the comminution by gas stream broken wall treatment, after ultrasonic Treatment, through rotating speed is 8000～10000 refrigerated centrifuger centrifugal treating of changeing, get supernatant, again with supernatant under-5～5 ℃ ambient temperature, cross the following molecular sieve of 2800D, isolate the bee pollen hydrotrope of molecular weight less than 2800D;
2) with molecular weight less than the bee pollen hydrotrope of 2800D after lyophilisation, obtain water content and be lower than 4% Herba leucadis ciliatae lyophilized powder;
3) with described Herba leucadis ciliatae lyophilized powder and water soluble starch mixing film-making.
2. according to the described production method that is used for the treatment of the bee pollen tablet of fatty liver of claim 1, the frequency that it is characterized in that the classification motor of comminution by gas stream broken wall treatment in the described step 1) is 55～60Hz, and bleed pressure is 0.7～1.0MPa.
3. according to the described production method that is used for the treatment of the bee pollen tablet of fatty liver of claim 1, it is characterized in that the described ultrasonic treatment time of described step 1) is 10～20 minutes.
4. according to the described production method that is used for the treatment of the bee pollen tablet of fatty liver of claim 1, it is characterized in that described step 2) during lyophilisation, temperature of charge is-40 ℃～70 ℃ when sublimation drying and desorbing, vacuum condition is 3～7Pa.
5. according to the described production method that is used for the treatment of the bee pollen tablet of fatty liver of claim 1, it is characterized in that the mass ratio that feeds intake when described lyophilized powder and water soluble starch mix is 1 ︰ 0.1～10.
6. according to the described production method that is used for the treatment of the bee pollen tablet of fatty liver of claim 1, it is characterized in that in the described step 3), sneak into lecithin and microcrystalline Cellulose PH102 film-making, the mass ratio that feeds intake of described lyophilized powder, lecithin and microcrystalline Cellulose PH102 is 1 ︰, 0.1～10 ︰ 0.1～10.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010106074000A CN102114058B (en) | 2010-12-28 | 2010-12-28 | Production method of bee pollen tablet for treating fatty liver |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010106074000A CN102114058B (en) | 2010-12-28 | 2010-12-28 | Production method of bee pollen tablet for treating fatty liver |
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| Publication Number | Publication Date |
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| CN102114058A true CN102114058A (en) | 2011-07-06 |
| CN102114058B CN102114058B (en) | 2012-06-27 |
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| CN2010106074000A Expired - Fee Related CN102114058B (en) | 2010-12-28 | 2010-12-28 | Production method of bee pollen tablet for treating fatty liver |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102697038A (en) * | 2012-05-29 | 2012-10-03 | 宁夏农林科学院 | Medlar bee pollen tablet |
| CN102940653A (en) * | 2012-11-30 | 2013-02-27 | 扬州大学 | Bee pollen water extract buccal tablet for preventing and treating alcoholic fatty liver |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1709140A (en) * | 2005-07-08 | 2005-12-21 | 周云川 | Composite melissa powder and its production process |
| CN101537048A (en) * | 2009-04-14 | 2009-09-23 | 文永盛 | Application of buckwheat and bee pollen in preparing drugs and method for preparing capsules and tablets thereby |
| CN101756088A (en) * | 2010-02-05 | 2010-06-30 | 王平 | Preparation method of novel pine pollen preparation |
-
2010
- 2010-12-28 CN CN2010106074000A patent/CN102114058B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1709140A (en) * | 2005-07-08 | 2005-12-21 | 周云川 | Composite melissa powder and its production process |
| CN101537048A (en) * | 2009-04-14 | 2009-09-23 | 文永盛 | Application of buckwheat and bee pollen in preparing drugs and method for preparing capsules and tablets thereby |
| CN101756088A (en) * | 2010-02-05 | 2010-06-30 | 王平 | Preparation method of novel pine pollen preparation |
Non-Patent Citations (4)
| Title |
|---|
| 《中国养蜂》 19981130 潘建国等 蜂花粉中过氧化氢酶活性测定新方法的探讨 第49卷, 第06期 * |
| 《中国蜂业》 20060228 陈崇羔等 不同破壁方法对蜂花粉超氧化物歧化酶活性的影响 , 第02期 2 * |
| 《浙江医学》 19890131 庄月明等 蜂花粉的护肝作用 , 第01期 2 * |
| 《蜜蜂杂志》 19890131 匡邦郁等 蜂花粉不同干燥方法试验 , 第01期 2 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102697038A (en) * | 2012-05-29 | 2012-10-03 | 宁夏农林科学院 | Medlar bee pollen tablet |
| CN102940653A (en) * | 2012-11-30 | 2013-02-27 | 扬州大学 | Bee pollen water extract buccal tablet for preventing and treating alcoholic fatty liver |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102114058B (en) | 2012-06-27 |
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Address after: 225800 Jiangsu city of Yangzhou province Baoying County West Industrial Zone Chuangye Road No. 26 Patentee after: Zhou Bin Patentee after: Ye Manhong Address before: 225001 Jiangsu City, Yangzhou Old City Lane seven 18-3 Patentee before: Zhou Bin Patentee before: Ye Manhong |
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Address after: No. 8, Dashan Industrial Park, Gao Hong Kong, Taizhou, Jiangsu Co-patentee after: Ye Manhong Patentee after: Zhou Bin Address before: 225800 Jiangsu city of Yangzhou province Baoying County West Industrial Zone Chuangye Road No. 26 Co-patentee before: Ye Manhong Patentee before: Zhou Bin |
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