CN101530102A - Sterilization composition containing fenbuconazole and thiophonate-methyl and application thereof - Google Patents
Sterilization composition containing fenbuconazole and thiophonate-methyl and application thereof Download PDFInfo
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- CN101530102A CN101530102A CN200810212002A CN200810212002A CN101530102A CN 101530102 A CN101530102 A CN 101530102A CN 200810212002 A CN200810212002 A CN 200810212002A CN 200810212002 A CN200810212002 A CN 200810212002A CN 101530102 A CN101530102 A CN 101530102A
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- China
- Prior art keywords
- methyl
- thiophanate
- thiophonate
- parts
- bactericidal composition
- Prior art date
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- RQDJADAKIFFEKQ-UHFFFAOYSA-N 4-(4-chlorophenyl)-2-phenyl-2-(1,2,4-triazol-1-ylmethyl)butanenitrile Chemical compound C1=CC(Cl)=CC=C1CCC(C=1C=CC=CC=1)(C#N)CN1N=CN=C1 RQDJADAKIFFEKQ-UHFFFAOYSA-N 0.000 title claims abstract description 64
- 239000000203 mixture Substances 0.000 title claims abstract description 30
- 230000001954 sterilising effect Effects 0.000 title abstract description 6
- 238000004659 sterilization and disinfection Methods 0.000 title abstract description 5
- 239000005775 Fenbuconazole Substances 0.000 title abstract description 4
- 201000010099 disease Diseases 0.000 claims abstract description 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 10
- 239000005842 Thiophanate-methyl Substances 0.000 claims description 52
- QGHREAKMXXNCOA-UHFFFAOYSA-N thiophanate-methyl Chemical compound COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC QGHREAKMXXNCOA-UHFFFAOYSA-N 0.000 claims description 51
- 239000000843 powder Substances 0.000 claims description 17
- 238000009736 wetting Methods 0.000 claims description 13
- 239000000375 suspending agent Substances 0.000 claims description 12
- 230000000844 anti-bacterial effect Effects 0.000 claims description 11
- 239000004562 water dispersible granule Substances 0.000 claims description 10
- 239000004480 active ingredient Substances 0.000 claims description 7
- 235000013399 edible fruits Nutrition 0.000 claims description 4
- 235000013311 vegetables Nutrition 0.000 claims description 4
- 239000002131 composite material Substances 0.000 claims description 2
- 239000002917 insecticide Substances 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 239000002671 adjuvant Substances 0.000 claims 1
- 235000011430 Malus pumila Nutrition 0.000 abstract description 9
- 235000015103 Malus silvestris Nutrition 0.000 abstract description 9
- 241000223600 Alternaria Species 0.000 abstract description 8
- 244000141359 Malus pumila Species 0.000 abstract description 2
- 206010059866 Drug resistance Diseases 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 9
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 8
- 239000002270 dispersing agent Substances 0.000 description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 7
- 244000070406 Malus silvestris Species 0.000 description 7
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 7
- 239000003814 drug Substances 0.000 description 7
- 238000009472 formulation Methods 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 239000005995 Aluminium silicate Substances 0.000 description 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 6
- 235000012211 aluminium silicate Nutrition 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 6
- 239000002202 Polyethylene glycol Substances 0.000 description 5
- 239000004372 Polyvinyl alcohol Substances 0.000 description 5
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 5
- 239000005864 Sulphur Substances 0.000 description 5
- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2r)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical group [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- -1 naphthyl sulfonate Chemical compound 0.000 description 5
- 229920001223 polyethylene glycol Polymers 0.000 description 5
- 229920002451 polyvinyl alcohol Polymers 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 239000001768 carboxy methyl cellulose Substances 0.000 description 4
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 4
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 4
- 229920001296 polysiloxane Polymers 0.000 description 4
- 229910052938 sodium sulfate Inorganic materials 0.000 description 4
- 235000011152 sodium sulphate Nutrition 0.000 description 4
- 239000000080 wetting agent Substances 0.000 description 4
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical group OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 description 3
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 3
- 239000000440 bentonite Substances 0.000 description 3
- 229910000278 bentonite Inorganic materials 0.000 description 3
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 3
- 239000000945 filler Substances 0.000 description 3
- 238000005469 granulation Methods 0.000 description 3
- 230000003179 granulation Effects 0.000 description 3
- 238000011835 investigation Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 150000003254 radicals Chemical class 0.000 description 3
- 238000012216 screening Methods 0.000 description 3
- 230000002195 synergetic effect Effects 0.000 description 3
- 239000002562 thickening agent Substances 0.000 description 3
- 230000001018 virulence Effects 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 240000007594 Oryza sativa Species 0.000 description 2
- 235000007164 Oryza sativa Nutrition 0.000 description 2
- 229920002125 Sokalan® Polymers 0.000 description 2
- 235000021307 Triticum Nutrition 0.000 description 2
- 244000098338 Triticum aestivum Species 0.000 description 2
- QYKIQEUNHZKYBP-UHFFFAOYSA-N Vinyl ether Chemical compound C=COC=C QYKIQEUNHZKYBP-UHFFFAOYSA-N 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 235000013339 cereals Nutrition 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000013530 defoamer Substances 0.000 description 2
- 230000035613 defoliation Effects 0.000 description 2
- 239000007884 disintegrant Substances 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 230000009036 growth inhibition Effects 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 230000000149 penetrating effect Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000003449 preventive effect Effects 0.000 description 2
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 2
- 238000010298 pulverizing process Methods 0.000 description 2
- 235000009566 rice Nutrition 0.000 description 2
- 159000000000 sodium salts Chemical class 0.000 description 2
- 235000014347 soups Nutrition 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 229920001285 xanthan gum Polymers 0.000 description 2
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 240000002791 Brassica napus Species 0.000 description 1
- 235000006008 Brassica napus var napus Nutrition 0.000 description 1
- 239000004151 Calcium iodate Substances 0.000 description 1
- TWFZGCMQGLPBSX-UHFFFAOYSA-N Carbendazim Natural products C1=CC=C2NC(NC(=O)OC)=NC2=C1 TWFZGCMQGLPBSX-UHFFFAOYSA-N 0.000 description 1
- RZXLPPRPEOUENN-UHFFFAOYSA-N Chlorfenson Chemical compound C1=CC(Cl)=CC=C1OS(=O)(=O)C1=CC=C(Cl)C=C1 RZXLPPRPEOUENN-UHFFFAOYSA-N 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 244000241257 Cucumis melo Species 0.000 description 1
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 1
- 241000221785 Erysiphales Species 0.000 description 1
- 241000223218 Fusarium Species 0.000 description 1
- 240000005979 Hordeum vulgare Species 0.000 description 1
- 235000007340 Hordeum vulgare Nutrition 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 244000017020 Ipomoea batatas Species 0.000 description 1
- 235000002678 Ipomoea batatas Nutrition 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 206010039509 Scab Diseases 0.000 description 1
- 241000221662 Sclerotinia Species 0.000 description 1
- 241001250070 Sporisorium reilianum Species 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000003905 agrochemical Substances 0.000 description 1
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 238000000498 ball milling Methods 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- UHWJJLGTKIWIJO-UHFFFAOYSA-L calcium iodate Chemical compound [Ca+2].[O-]I(=O)=O.[O-]I(=O)=O UHWJJLGTKIWIJO-UHFFFAOYSA-L 0.000 description 1
- 235000019390 calcium iodate Nutrition 0.000 description 1
- 239000006013 carbendazim Substances 0.000 description 1
- JNPZQRQPIHJYNM-UHFFFAOYSA-N carbendazim Chemical compound C1=C[CH]C2=NC(NC(=O)OC)=NC2=C1 JNPZQRQPIHJYNM-UHFFFAOYSA-N 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000007859 condensation product Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 235000021186 dishes Nutrition 0.000 description 1
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000008686 ergosterol biosynthesis Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 230000000855 fungicidal effect Effects 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 229920005610 lignin Polymers 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 235000010603 pastilles Nutrition 0.000 description 1
- 230000000361 pesticidal effect Effects 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- OJMIONKXNSYLSR-UHFFFAOYSA-N phosphorous acid Chemical class OP(O)O OJMIONKXNSYLSR-UHFFFAOYSA-N 0.000 description 1
- 229940051841 polyoxyethylene ether Drugs 0.000 description 1
- 229920000056 polyoxyethylene ether Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229940096992 potassium oleate Drugs 0.000 description 1
- MLICVSDCCDDWMD-KVVVOXFISA-M potassium;(z)-octadec-9-enoate Chemical compound [K+].CCCCCCCC\C=C/CCCCCCCC([O-])=O MLICVSDCCDDWMD-KVVVOXFISA-M 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 235000021003 saturated fats Nutrition 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 150000003871 sulfonates Chemical class 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 150000003852 triazoles Chemical class 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention provides a sterilization composition containing fenbuconazole and thiophonate-methyl. The effective components of the composition consist of the fenbuconazole and the thiophonate-methyl. The sterilization composition has obvious synergy and little dosage, is not easy to produce drug resistance by continuous use, is applicable to preventing various crop diseases, and is particularly applicable to controlling alternaria leaf spot of apple trees.
Description
Technical field
The invention belongs to technical field of pesticide, being specifically related to a kind of is the bactericidal composition and the application thereof of main active with RH-7592 and thiophanate-methyl.
Background technology
RH-7592 (fenbuconazole) colourless crystallization, fusing point 124-1 ℃, vapour pressure 0.005mpa (20 ℃), solvability 0.2mg/L in the water (2 ℃).Can be dissolved in most of organic solvents, in acetone, ether, ethanol and aromatic hydrocarbon, be insoluble in the aliphatic hydrocarbon.Under 300 ℃, stable in the dark.RH-7592 is the triazole type systemic fungicide, belongs to a kind of brand-new ergosterol biosynthesis inhibitor (EBI), has protection concurrently, cures the disease and killing action, and the energy that destroys germ by the respiration that suppresses germ synthesizes and loss of life power.RH-7592 has good crop safety and very outstanding Environmental compatibility.For obtaining best preventive effect, in the dispenser of disease initial stage of origination, should note filling up the water yield during spraying, the crop surface soup is fully covered.
RH-7592 is by The Dow Agrosciences, LLC.'s development product, and formulation products is 24% RH-7592 suspending agent, is mainly used in control vegetables, diseases of garden stuff, because its drug cost height uses not extensive.
Thiophanate-methyl (thiophanate-methyl) is a kind of efficient, low toxicity bactericide, has prevention and systemic action, because of medicament can change into carbendazim after entering in the plant corpus, so also belong to benzimidazole.Can be widely used in multiple diseases such as grain, cotton, oil, vegetables, fruit tree.Can prevent and treat gibberella zeaze petch of wheat and barley, stinking smut, wheat powdery mildew, leaf blast disease, the rice sheath blight, sclerotinia rot of colza etc.Can be used for sweet potato smut, the big leaf spot of corn, rice purple stalk disease, head smut of sorghum in addition.Thiophanate-methyl for a long time, repeatedly uses on Crop in China, and this makes the target germ strengthen gradually its resistance, and the cost that makes thiophanate-methyl prevent and treat disease increases and drug effect reduces greatly.
Summary of the invention
The objective of the invention is provides a kind of applied widely, plant sterilization composition that contains RH-7592 and thiophanate-methyl that cost is low, effective at above-mentioned technical problem.
A further object of the invention provides the purposes of this bactericidal composition.
The objective of the invention is to realize by following measures:
A kind of bactericidal composition, active ingredient is made up of RH-7592 and thiophanate-methyl, the percentage by weight of RH-7592 and thiophanate-methyl is 1～70:10～70, and through formulation screening test, the optimum percentage by weight of RH-7592 and thiophanate-methyl is 10～30:15～60.
Bactericidal composition of the present invention, wherein auxiliary agent and composite its active constituent content of water dispersible granules, suspending agent or wetting powder of making of excipient of RH-7592 and thiophanate-methyl and routine are 10%～70%.
Described water dispersible granules comprises the component of following weight portion:
1 part～70 parts of RH-7592;
10 parts～70 parts of thiophanate-methyls;
1 part～12 parts of dispersants;
1 part～5 parts of wetting agents;
1 part～5 parts of disintegrants;
1 part～5 parts of binding agents;
Filler adds to 100 parts.
Wherein, dispersant is selected from sodium lignin sulfonate, NO, NNO, carboxymethyl cellulose, two naphthyl sulfonate, acrylic acid polymers sodium salt, laruyl alcohol according in the oxygen vinethene one or more;
Described wetting agent is selected from lauryl sodium sulfate, draws back powder, among the wetting and penetrating agent F, spaonin powder, bay alcohol radical sodium sulphate, neopelex, alkylbenzenesulfonate one or more;
Described disintegrant is selected from one or more in ammonium sulfate, aluminium chloride, citric acid, succinic acid, the carbonic hydroammonium;
Described adhesive is selected from one or more in polyethylene glycol, polyvinyl alcohol, the polyvinylpyrrolidone;
Described carrier is selected from one or more in kaolin, diatomite, white carbon, the bentonite;
Above-mentioned formulation material is mixed, pulverize,, add then and carry out granulation, drying, screening in the fluidized bed prilling dryer after sample analysis is made water dispersible granules product of the present invention through mediating with micro jet.
Described suspending agent comprises the component of following weight portion:
1 part～70 parts of RH-7592;
10 parts～70 parts of thiophanate-methyls;
2 parts～10 parts of dispersants;
0.1 part～1 part of thickener;
0.1 part～1 part of defoamer;
1 part～10 parts of antifreezing agents;
0 part～5 parts of stabilizing agents
Add water to 100 parts.
Described dispersant is selected from one or more in sodium lignin sulfonate, NO, NNO, carboxymethyl cellulose, lignin calcium iodate, lauryl alcohol polyethylene glycol oxide base ether sodium sulfate, alkyl naphthalene formaldehyde condensate sulfonates, neopelex, lauryl sodium sulfate, potassium oleate, enuatrol, alkyl polyoxyethylene ether sulfonate, the alkylphenol-polyethenoxy base ether formaldehyde condensation products;
Described thickener is selected from one or more in xanthans, methylcellulose, Magnesiumaluminumsilicate or the polyvinyl alcohol;
Described defoamer is selected from one or more in silicone oil, silicone compound, C10-20 saturated fat acid compounds, the C8-10 aliphatic alcohols compound;
Described antifreezing agent is selected from one or more in ethylene glycol, glycerine, propane diols, glycerine, polyethylene glycol or the sorbierite;
Described stabilizing agent is selected from one or more among alkyl phosphate, phosphorous acid esters, polyalcohol, alkyl sulfonic ester, the BHT;
With above-mentioned formulation material, thickener and antifreezing agent are mixed back all the other components except that crossing active ingredient, mix through high speed shear, add active ingredient, ball milling is 2～3 hours in ball mill, makes particle diameter all below 5 μ m, makes the suspending agent product of mixture of the present invention.
Described wetting powder comprises the component of following weight portion:
1 part～70 parts of RH-7592;
10 parts～70 parts of thiophanate-methyls;
1 part～15 parts of dispersants;
1 part～15 parts of wetting agents;
Filler adds to 100 parts.
Wherein, dispersant is selected from sodium lignin sulfonate, NO, NNO, carboxymethyl cellulose, two naphthyl sulfonate, acrylic acid polymers sodium salt, laruyl alcohol according in the oxygen vinethene one or more;
Described wetting agent is selected from lauryl sodium sulfate, draws back powder, among the wetting and penetrating agent F, spaonin powder, bay alcohol radical sodium sulphate, neopelex, alkylbenzenesulfonate one or more;
Described filler is mineral carrier or synthetic vectors, one or more in available kaolin, diatomite, the white carbon;
Above-mentioned formulation material is mixed, in stirred tank, evenly stir, behind airslide disintegrating mill, mixing, promptly can be made into the wetting powder product of the present composition.
Bactericidal composition of the present invention is having fabulous effect aspect control cereal class, melon and fruit or the vegetable crop disease.
The invention has the advantages that: utilize two kinds of synergistic functions that active component is mixed and is produced, improved preventive effect, delay the generation of pest resistance to insecticide, reduced the consumption of active ingredient, reduced peasant's use cost and reduced to the pollution of environment with to operating personnel's danger coefficient.
Specific embodiments
The invention will be further described below in conjunction with embodiment.The preparation method of formulation is conventional method among the embodiment.
Embodiment 1 25% RH-7592 thiophanate-methyl water dispersible granules
RH-7592 3g, thiophanate-methyl 22g, two sodium naphthasulfonate 5g, spaonin powder 3g, citric acid 3g, polyethylene glycol 1g, kaolin add to 100g, the mixed 25% worm RH-7592 thiophanate-methyl water dispersible granules that gets.
Embodiment 2 40% RH-7592 thiophanate-methyl water dispersible granules
RH-7592 5g, thiophanate-methyl 35g, sodium lignin sulfonate 8g, neopelex 2g, polyvinyl alcohol 2g, carbonic hydroammonium 2g, bentonite 15g, kaolin are added to 100g, make 40% RH-7592 thiophanate-methyl water dispersible granules through pulverizing granulation.
Embodiment 3 55% RH-7592 thiophanate-methyl water dispersible granules
RH-7592 15g, thiophanate-methyl 40g, carboxymethyl cellulose 10g, neopelex 3g, polyvinyl alcohol 1g, succinic acid 3g, white carbon 15g, kaolin are added to 100g, make 55% RH-7592 thiophanate-methyl water dispersible granules through pulverizing granulation.
Embodiment 4 15% RH-7592 thiophanate-methyl suspending agents
RH-7592 3g, thiophanate-methyl 12g, neopelex 8g, xanthans 0.3g, organic silicone 0.5g, ethylene glycol 5g, water adds to 100g, the mixed 15% RH-7592 thiophanate-methyl suspending agent that gets.
Embodiment 5 30% RH-7592 thiophanate-methyl suspending agents
RH-7592 5g, thiophanate-methyl 25g, sodium lignin sulfonate 5g, Magnesiumaluminumsilicate 0.5g, organic silicone 0.5g, polyethylene glycol 4g, water adds to 100g, the mixed 30% RH-7592 thiophanate-methyl suspending agent that gets.
Embodiment 6 45% RH-7592 thiophanate-methyl suspending agents
RH-7592 7g, thiophanate-methyl 38g, SDS 8g, polyvinyl alcohol 0.6g, organic silicone 0.6g, propane diols 6g, water adds to 100g, the mixed 45% RH-7592 thiophanate-methyl suspending agent that gets.
Embodiment 7 20% RH-7592 thiophanate-methyl wetting powders
RH-7592 5g, thiophanate-methyl 15g, neopelex 5g, spaonin powder 4g, white carbon 5g, bentonite adds to 100g, the mixed 20% RH-7592 thiophanate-methyl wetting powder that gets.
Embodiment 8 50% RH-7592 thiophanate-methyl wetting powders
With RH-7592 10g, thiophanate-methyl 40g, neopelex 2g, dispersing agent NNO 4g, white carbon 10g, kaolin adds to 100g, and mixture carries out comminution by gas stream, makes 50% RH-7592 thiophanate-methyl wetting powder.
Embodiment 970% RH-7592 thiophanate-methyl wetting powder
RH-7592 10g, thiophanate-methyl 60g, dispersing agent NNO 8g, bay alcohol radical sodium sulphate 5g, white carbon 100g are mixed, make 70% RH-7592 thiophanate-methyl wetting powder.
Application Example one
Test with the pesticidal preparations control alternaria leaf spot of apple that the foregoing description makes.
1, test is handled this test medicine consumption and is established three concentration of treatment respectively according to the difference of each composition, and the contrast medicament is respectively commercially available agricultural chemicals 70% thiophanate-methyl wetting powder and 24% RH-7592 suspending agent and the test of blank clear water.
2, each sub-district one-tenth fruit tree in age of test method is no less than 6 strains, repeats 3 times; Detecting the control efficiency method before the dispenser after investigation and the dispenser is: investigation two strains in every sub-district, every strain press East, West, South, North, in 5 the investigation 2 current-year branches whole blades, write down total number of sheets, the sick number of sheets and scab number, detect the spot defoliation occurrence degree.
3, result of the test such as following table 1:
The field control effectiveness test result of 1～9 pair of alternaria leaf spot of apple of table 1 embodiment
Application Example two
RH-7592 and thiophanate-methyl different proportion are mixed to alternaria leaf spot of apple Toxicity Determination and formulation screening test.
Determine that through trial test two medicaments roughly after the valid density scope, establish 5 assembly ratio with RH-7592 and thiophanate-methyl by active ingredient, each single agent and different proportioning are respectively established 5 concentration gradients and are handled.Adopting the mycelial growth rate method, with alternaria leaf spot of apple germ bacterial strain PDA medium culture, treat that bacterium colony grows to culture dish 3/4ths when big or small, is that the card punch of 5mm punches from the edge with internal diameter, and the mycelia piece that breaks into is as inoculum.Get the soup 3ml for preparing respectively and evenly mix with quantitative 27ml sterilising medium, pour in 3 sterilization culture dishes, make the pastille flat board after the cooling, be mixed into contrast with equivalent aqua sterilisa and medium, 3 repetitions are established in every processing.To inoculate mycelia and be inverted in dull and stereotyped central authorities, and put into 27 ℃ of incubators and cultivate.Measure colony diameter with the right-angled intersection method behind the 120h, calculate and respectively handle clean amount of growth, mycelial growth inhibition rate.Computing formula is as follows:
Clean amount of growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into probit value (y), and liquor strength (μ g/ml) converts logarithm value (x) to, tries to achieve virulence regression equation (y=a+bx) with method of least squares, and calculates the EC of every kind of medicament thus
50Value.Simultaneously calculate the different proportioning synergy ratios (SR) of two medicaments according to the Wadley method, SR＜0.5 be an antagonism, and 0.5≤SR≤1.5 are summation action, SR〉1.5 be synergistic effect.Computing formula is as follows:
Wherein: a, b are respectively RH-7592 and thiophanate-methyl shared ratio in composition
A is a RH-7592
B is a thiophanate-methyl
Experimental result and analysis
Table 2 RH-7592 and thiophanate-methyl and be mixed to apple tree spot defoliation measurement result analytical table
| Reagent agent | Toxicity regression formula (y=a+bx) | EC 50(μ g/ml) (observed value) | EC 50(μ g/ml) (theoretical value) | Synergy ratio (SR) |
| RH-7592 | y＝5.0798+1.0935x | 0.60 | — | — |
| Thiophanate-methyl | y＝4.8514+1.3370x | 1.49 | — | — |
| RH-7592: first sulphur (3:22) | y＝4.9254+1.0445x | 1.11 | 1.26 | 1.14 |
| RH-7592: first sulphur (7:38) | y＝5.0005+0.9305x | 0.87 | 1.21 | 1.39 |
| RH-7592: first sulphur (10:40) | y＝5.0302+0.8999x | 0.71 | 1.15 | 1.62 |
| RH-7592: first sulphur (15:40) | y＝5.0586+0.8925x | 0.62 | 1.06 | 1.71 |
| RH-7592: first sulphur (10:60) | y＝5.0489+0.9039x | 0.75 | 1.23 | 1.64 |
As shown in Table 2, RH-7592 and thiophanate-methyl suppress the EC of alternaria leaf spot of apple
50Value is respectively 0.60 μ g/ml, 1.49 μ g/ml, shows that the virulence of RH-7592 is higher than the virulence of thiophanate-methyl.RH-7592 and thiophanate-methyl are used the inhibition alternaria leaf spot of apple with 3:22,7:38,10:40,15:40,10:60 ratio, and its synergy ratio is respectively 1.14,1.39,1.62,1.71,1.64, and certain synergistic effect is all arranged.
Field efficacy and toxicity test result show that RH-7592 and thiophanate-methyl composition have good control efficiency to alternaria leaf spot of apple, and control efficiency all is better than single agent kind.
Claims (4)
1, a kind of bactericidal composition is characterized in that active ingredient is made up of RH-7592 and thiophanate-methyl.
2, bactericidal composition according to claim 1 is characterized in that: the percentage by weight of active ingredient RH-7592 and thiophanate-methyl is 1～70:10～70.
3, bactericidal composition according to claim 1 and 2 is characterized in that: RH-7592 and thiophanate-methyl and conventional insecticides adjuvant and composite wetting powder, suspending agent or the water dispersible granules made of excipient.
4, according to the described bactericidal composition of claim 1 to 3 in the application aspect control fruit tree or the vegetable crop disease.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102057916A (en) * | 2011-01-21 | 2011-05-18 | 陕西美邦农药有限公司 | Bactericidal composition containing fenbuconazole and strobilurin compound |
| CN102067861A (en) * | 2011-01-20 | 2011-05-25 | 陕西美邦农药有限公司 | Fenbuconazole-containing bactericidal composition |
| CN102150683A (en) * | 2011-03-03 | 2011-08-17 | 陕西美邦农药有限公司 | Fenbuconazole-containing synergic sterilization composition |
| CN102165957A (en) * | 2011-03-05 | 2011-08-31 | 陕西美邦农药有限公司 | Synergic sterilizing composite containing fenbuconazole and triazole compound |
| CN102177899A (en) * | 2011-03-05 | 2011-09-14 | 陕西美邦农药有限公司 | Antibacterial composition containing fenbuconazole and triazole compound |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP1813152A1 (en) * | 2006-01-30 | 2007-08-01 | Basf Aktiengesellschaft | Fungicidal mixture based on 3,4-disubstituted biphenylanilides |
| US20090233916A1 (en) * | 2006-03-14 | 2009-09-17 | Basf Se | Method of inducing virus tolerance of plants |
| CN101171921B (en) * | 2007-10-15 | 2011-12-28 | 张少武 | Bactericide agent composition containing active ingredient of metiram |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102067861A (en) * | 2011-01-20 | 2011-05-25 | 陕西美邦农药有限公司 | Fenbuconazole-containing bactericidal composition |
| CN102057916A (en) * | 2011-01-21 | 2011-05-18 | 陕西美邦农药有限公司 | Bactericidal composition containing fenbuconazole and strobilurin compound |
| CN102150683A (en) * | 2011-03-03 | 2011-08-17 | 陕西美邦农药有限公司 | Fenbuconazole-containing synergic sterilization composition |
| CN102150683B (en) * | 2011-03-03 | 2013-10-09 | 陕西美邦农药有限公司 | Fenbuconazole-containing synergic sterilization composition |
| CN102165957A (en) * | 2011-03-05 | 2011-08-31 | 陕西美邦农药有限公司 | Synergic sterilizing composite containing fenbuconazole and triazole compound |
| CN102177899A (en) * | 2011-03-05 | 2011-09-14 | 陕西美邦农药有限公司 | Antibacterial composition containing fenbuconazole and triazole compound |
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