CN101518327A - Maitake proteoglycan sugar-reducing compound food - Google Patents
Maitake proteoglycan sugar-reducing compound food Download PDFInfo
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- CN101518327A CN101518327A CN200810037083A CN200810037083A CN101518327A CN 101518327 A CN101518327 A CN 101518327A CN 200810037083 A CN200810037083 A CN 200810037083A CN 200810037083 A CN200810037083 A CN 200810037083A CN 101518327 A CN101518327 A CN 101518327A
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- proteoglycan
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- maitake
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Abstract
The invention discloses a Maitake proteoglycan sugar-reducing compound food. The product is prepared by compounding Maitake proteoglycan dry powder, agaricus blazei water extract, coprinus comatus water extract and bitter melon freezing dry powder. The product has effect for non-insulin-dependent diabetes mellitus, can lead the patient with diabetes mellitus to eliminate the side effects for taking chemical sugar-reducing drugs for long period, improves the life quality of the patient with diabetes mellitus and is suitable for eating for long period.
Description
Affiliated technical field:
The present invention relates to the application of the proteoglycans in the edible and medical fungi grifola frondosus, relate in particular to a kind of Maitake proteoglycan sugar-reducing compound food.
Background technology:
Polysaccharose substance has many biologically actives in the grifola frondosus, promotes immunity, antiviral, anti-inflammatory, hypotensive, reducing blood lipid, hypoglycemic etc.External studies show that the component in the grifolan is effective to Non-Insulin Dependent Diabetes Mellitus.Up to now, the research to the proteoglycans in the grifola frondosus mainly is its immunocompetence and antitumor activity.At present, to the rare report of the application and development of Griflola frondosa proteoglycan, do not see research and the report of using Griflola frondosa proteoglycan and the composite antihypelipidemic product of other natural products.
Summary of the invention:
Technical problem to be solved by this invention is to provide a kind of Maitake proteoglycan sugar-reducing compound food, to address the deficiencies of the prior art.
The present invention utilizes the Griflola frondosa proteoglycan of the method preparation of autonomous invention, with Ji Songrong water extract, shaggy cap water extract, the composite blood sugar reducing health product of balsam pear freeze-dried powder, its formulation can be made capsule, tablet and electuary etc., also can directly use mixing in water for oral taking.
Maitake proteoglycan sugar-reducing compound food provided by the present invention comprises following components in weight percentage:
Griflola frondosa proteoglycan dry powder 30～60%,
Ji Songrong water extract 10～40%,
Shaggy cap water extract 10～40%,
Balsam pear freeze-dried powder 10～40%.
Preferred ingredients content is:
Griflola frondosa proteoglycan dry powder 40～50%,
Ji Songrong water extract 10～20%,
Shaggy cap water extract 10～20%,
Balsam pear freeze-dried powder 20～30%.
More preferred ingredients content is:
Griflola frondosa proteoglycan dry powder 50%,
Ji Songrong water extract 10%,
Shaggy cap water extract 20%,
Balsam pear freeze-dried powder 20%.
Wherein Griflola frondosa proteoglycan dry powder adopts following method to prepare: adopt the water logging of 10 times of volumes not have Grifola Frondosa sporophore, under 100 ℃ of conditions, be incubated 2 hours, repeat 3 times, extract milipore filter with 750,000 after coarse filtration carries out ultrafiltration, and collecting the part that is trapped is water-solubility protein glycan solution.Grifola Frondosa sporophore after water is carried adopts 6% edible alkali solution of 10 times of volumes, insulation below 30 ℃ 8 hours, repeats 2 times, and extract milipore filter with 750,000 after coarse filtration carries out ultrafiltration, and collecting the part that is trapped is alkali solubility proteoglycans solution.With water-soluble with alkali-soluble proteoglycans solution concentrate, dry (spraying or vacuum drying, freeze drying) promptly obtain Griflola frondosa proteoglycan dry powder.
Wherein Ji Songrong water extract and shaggy cap water extract are respectively to adopt the water logging of 15 times of volumes not do fructification with, and extracting in boiling water 2 hours repeats 2 times, extract spray after concentrated or vacuum drying promptly.
Wherein balsam pear freeze-dried powder be bright balsam pear through boiling water blanching postlyophilization, pulverize then and get.
Used grifola frondosus, Ji Songrong, shaggy cap and balsam pear all originate from Zhejiang.
Maitake proteoglycan sugar-reducing compound food provided by the present invention is effective to the diabetes of non-insulin-depending type, can reduce the blood glucose value of animal used as test.The immunocompetence that the while Griflola frondosa proteoglycan has can allow the diabetes patient break away from the side effect of taking the chemical sugar-lowering medicine for a long time, improves diabetes patient's life quality.Component in the antihypelipidemic foodstuff of the present invention is wholefood or edible mushroom, is free from side effects, and especially is fit to long-term edible.
The specific embodiment
Embodiment one:
Griflola frondosa proteoglycan dry powder 30%, Ji Songrong water extract 10%, shaggy cap water extract 20%, balsam pear freeze-dried powder 40%.
Embodiment two:
Griflola frondosa proteoglycan dry powder 40%, Ji Songrong water extract 20%, shaggy cap water extract 10%, balsam pear freeze-dried powder 30%.
Embodiment three:
Griflola frondosa proteoglycan dry powder 60%, Ji Songrong water extract 10%, shaggy cap water extract 10%, balsam pear freeze-dried powder 10%.
Embodiment four:
Griflola frondosa proteoglycan dry powder 50%, Ji Songrong water extract 10%, shaggy cap water extract 20%, balsam pear freeze-dried powder 20%.
Embodiment five: zoopery
1 experimental technique
1. the brown pulvis formed of the component of sample: embodiment four.The human body RD is 4g every day, in adult's body weight 60kg.
2. dosage design: a model control group and each dosage group are established in this experiment.The dosage group is 30 times and or 10 times of human body recommended amounts.The dosage group is respectively: 30 times of groups and 10 times of groups.30 multiple doses of animal and 10 times are that dosage is respectively 2g/kg and 0.67g/kg.The normal control group is given distilled water, and it is 30 days that given the test agent gives the time.
3. sample treatment: sample thief 10g adding distil water is to 100ml, 30 multiple doses.As test liquid, all the other dilute according to this.
4. give sample loading mode: irritate stomach, the filling gastric capacity is 0.4ml/20g.
5. animal used as test and raising condition: healthy Kunming kind male white mouse (cleaning level), 26 ± 2g, provide by animal used as test portion of Fudan University, the quality certification number: SCXK Shanghai 2002-0002, the temperature 18-22 of laboratory animal breeding room ℃, relative humidity 40-70%, Animal House credit number: the moving word of doctor 02-57 number.Animal freely ingests and drinks water.
6. alloxan (sigma chemical, co Lot 36H0101), mouse 50mg/kg BW iv is with preceding fresh configuration.Glucose kit selects for use Shanghai claim reagent Co., Ltd to produce batch number 20070201
7. experimental technique: by " health food check and assessment technique standard " (2003 editions).
2 results
2.1 influence to normal mouse blood sugar.
Reduce the fasting blood-glucose test: select the healthy adult animal by the grouping of 12 hours blood sugar level of fasting, select a model control group and a given the test agent group (high dose, i.e. 30 times of groups) at random.Be subjected to examination to organize the given the test agent to 2g/kg, model control group gives distilled water, continuous 30 days, surveys fasting blood sugar (fasting is preceding with experiment), relatively each treated animal blood glucose value.
Before table 1 mouse experiment and experiment back changes of weight (x ± s)
Changes of weight before and after mouse experiment finishes sees Table 1..Each experimental group the weight of animals is compared with control group before the experiment, learns check by statistics, no conspicuousness difference (p〉0.05).Body weight was compared with control group when experiment finished, no conspicuousness difference (p〉0.05).By table 1 as seen, sample does not have obvious influence to the weight of animals.
Mouse was carried out the continuous irrigation stomach after 30 days, and fasting blood-glucose is surveyed in fasting 12 hours morning next day.Experimental result sees Table 2.
The influence of table 2. pair normal mouse blood sugar (X ± s)
* compare with control group P＜0.05
By table 2 as seen, learn check by statistics, the blood glucose value of each dosage is compared with the blank group, does not have significant otherness (p〉0.05).
2.2 influence to the hyperglycaemia mouse blood sugar
Alloxan is a kind of β cytotoxic agent, optionally damages the beta Cell of islet of multiple animal, causes insulin secretion low, causes artificial diabetes.After the animal fasting 24 hours, give the alloxan moulding, injected in mice alloxan dosage is by 50mg/Kg the weight of animals, tail vein injection.Fasting is 12 hours after 3 days, surveys blood sugar.Blood glucose value 10-25mmol/L is a hyperglycemia model success animal.
Select the hyperglycemia model animal by the grouping of 12 hours blood sugar level of fasting, the dosage group of a model control group and each sample (difference is not more than 1.1mmol/L between group).The dosage group gives the variable concentrations given the test agent, and model control group gives distilled water, continuous 30 days, surveys fasting blood sugar (fasting is preceding with experiment), relatively each treated animal blood glucose value.
Table 4. sample is to the influence of the animal pattern fasting blood-glucose (mmol/L of X ± SD)
As shown in Table 4, get blood glucose value〉10mmol/L and＜mouse between the 25mmol/L, be divided into control group and each experimental group at random.When beginning experiment, the blood sugar level of control group and each experimental group does not have significant difference (p〉0.05).After 30 days, the blood glucose value of each dosage group is lower than control group, learns check by statistics, and conspicuousness is arranged.
2.3 influence to zoic model with hyperglycemia group sugar tolerance
Sugar tolerance experiment, hyperglycemia animal fasting 12 hours, the dosage group gives the given the test agent of variable concentrations, and model control group gives with volume distilled water, and per os gives glucose 2g/kg after 15 minutes, measures and gives behind the glucose 0,0.5,2 hours blood glucose value.Observe the variation of model control group and given the test agent group to area under each time point blood glucose curve behind the glucose.
The influence of table 5. pair zoic model with hyperglycemia sugar tolerance
By table 5 as seen, through variance analysis, area is compared with control group under each test group blood glucose curve
(p〉0.05 the conspicuousness difference is arranged.
3 brief summaries
According to the evaluation criterion of defined in " health food check and assessment technique standard (version in 2003) ", per os gives mouse various dose sample 30 days, can think that observing sample under this dosage has the auxiliary hyperglycemic effect.
Claims (3)
1. Maitake proteoglycan sugar-reducing compound food is characterized in that comprising following components in weight percentage:
Griflola frondosa proteoglycan dry powder 30～60%,
Ji Songrong water extract 10～40%,
Shaggy cap water extract 10～40%,
Balsam pear freeze-dried powder 10～40%.
2. Maitake proteoglycan sugar-reducing compound food according to claim 1 is characterized in that comprising the component of following weight percent hundred:
Griflola frondosa proteoglycan dry powder 40～50%,
Ji Songrong water extract 10～20%,
Shaggy cap water extract 10～20%,
Balsam pear freeze-dried powder 20～30%.
3. Maitake proteoglycan sugar-reducing compound food according to claim 1 and 2 is characterized in that comprising the component of following weight percent hundred:
Griflola frondosa proteoglycan dry powder 50%,
Ji Songrong water extract 10%,
Shaggy cap water extract 20%,
Balsam pear freeze-dried powder 20%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810037083A CN101518327A (en) | 2008-05-08 | 2008-05-08 | Maitake proteoglycan sugar-reducing compound food |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810037083A CN101518327A (en) | 2008-05-08 | 2008-05-08 | Maitake proteoglycan sugar-reducing compound food |
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| CN101518327A true CN101518327A (en) | 2009-09-02 |
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| CN200810037083A Pending CN101518327A (en) | 2008-05-08 | 2008-05-08 | Maitake proteoglycan sugar-reducing compound food |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106511404A (en) * | 2016-10-24 | 2017-03-22 | 范世锋 | Medicament having effects of regulating spleen and stomach, lowering blood fat and blood glucose, preventing diabetic complications and resisting tumors |
| CN116671634A (en) * | 2023-07-06 | 2023-09-01 | 电子科技大学 | Balsam pear powder capsule with health care effect and preparation method thereof |
-
2008
- 2008-05-08 CN CN200810037083A patent/CN101518327A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106511404A (en) * | 2016-10-24 | 2017-03-22 | 范世锋 | Medicament having effects of regulating spleen and stomach, lowering blood fat and blood glucose, preventing diabetic complications and resisting tumors |
| CN116671634A (en) * | 2023-07-06 | 2023-09-01 | 电子科技大学 | Balsam pear powder capsule with health care effect and preparation method thereof |
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Open date: 20090902 |