CN101516834B - 用作凝血因子IXa抑制剂的异丝氨酸衍生物 - Google Patents
用作凝血因子IXa抑制剂的异丝氨酸衍生物 Download PDFInfo
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- CN101516834B CN101516834B CN2007800341822A CN200780034182A CN101516834B CN 101516834 B CN101516834 B CN 101516834B CN 2007800341822 A CN2007800341822 A CN 2007800341822A CN 200780034182 A CN200780034182 A CN 200780034182A CN 101516834 B CN101516834 B CN 101516834B
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- 0 CCC(C1C)[C@@]1*1(*C1)C1*C(C2)C2C1 Chemical compound CCC(C1C)[C@@]1*1(*C1)C1*C(C2)C2C1 0.000 description 2
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102006042926 | 2006-09-13 | ||
| DE102006042926.5 | 2006-09-13 | ||
| PCT/EP2007/007613 WO2008031509A1 (de) | 2006-09-13 | 2007-08-31 | Isoserinderivate als inhibitoren des koagulationsfaktors ixa |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101516834A CN101516834A (zh) | 2009-08-26 |
| CN101516834B true CN101516834B (zh) | 2013-04-03 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2007800341822A Expired - Fee Related CN101516834B (zh) | 2006-09-13 | 2007-08-31 | 用作凝血因子IXa抑制剂的异丝氨酸衍生物 |
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Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2477604A1 (en) | 2002-03-13 | 2003-09-25 | Signum Biosciences, Inc. | Modulation of protein methylation and phosphoprotein phosphate |
| WO2006084033A1 (en) | 2005-02-03 | 2006-08-10 | Signum Biosciences, Inc. | Compositions and methods for enhancing cognitive function |
| US7923041B2 (en) | 2005-02-03 | 2011-04-12 | Signum Biosciences, Inc. | Compositions and methods for enhancing cognitive function |
| EP2049543B1 (en) * | 2006-09-07 | 2014-11-05 | Callaghan Innovation Research Limited | Acyclic amine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase |
| WO2009132051A1 (en) | 2008-04-21 | 2009-10-29 | Signum Biosciences, Inc. | Compounds, compositions and methods for making the same |
| AU2009322342A1 (en) | 2008-12-05 | 2011-06-30 | Merck Sharp & Dohme Corp. | Morpholinone compounds as factor IXa inhibitors |
| JP2013503163A (ja) * | 2009-08-31 | 2013-01-31 | 持田製薬株式会社 | 第IXa因子阻害薬としてのモルホリノン化合物 |
| WO2015160636A1 (en) | 2014-04-16 | 2015-10-22 | Merck Sharp & Dohme Corp. | Factor ixa inhibitors |
| CN109627218B (zh) * | 2018-11-27 | 2022-03-29 | 深圳市龙华区中心医院 | 一种抗凝小分子化合物及其应用和包含其的药物 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994022885A1 (en) * | 1993-03-29 | 1994-10-13 | Queen's University At Kingston | Anticoagulant compounds |
| CN1140709A (zh) * | 1995-06-06 | 1997-01-22 | 辉瑞大药厂 | 被取代的N-(吲哚-2-羰基)-β-丙氨酰胺与作为抗糖尿病药的衍生物 |
| US20010006977A1 (en) * | 1999-12-23 | 2001-07-05 | Uwe Ries | Benzimidazoles with antithrombotic activity |
| US7056932B2 (en) * | 2003-12-19 | 2006-06-06 | Hoffman-La Roche Inc. | Heterocyclyl substituted 1-alkoxy acetic acid amides |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4238260A1 (de) | 1992-11-12 | 1994-05-19 | Basf Ag | Substituierte ortho-Ethenylphenylessigsäurederivate |
| TW394760B (en) * | 1993-09-07 | 2000-06-21 | Hoffmann La Roche | Novel Carboxamides, process for their preparation and pharmaceutical composition containing the same |
| FI974437A0 (fi) * | 1995-06-06 | 1997-12-05 | Pfizer | Substituoituja N-(indoli-2-karbonyyli)amideja ja johdannaisia glykogeenifosforylaasi-inhibiittoreina |
| CZ298827B6 (cs) * | 1997-12-24 | 2008-02-20 | Sanofi - Aventis Deutschland GmbH | Deriváty indolu jako inhibitory faktoru Xa, zpusob jejich prípravy a farmaceutická kompozice, kteráje obsahuje |
| CO5271699A1 (es) * | 2000-01-24 | 2003-04-30 | Pfizer Prod Inc | Procedimiento para el tratamiento de cardiomiopatia utilizando inhibidores de la glucogeno fosforilasa |
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2007
- 2007-08-31 NZ NZ575603A patent/NZ575603A/en not_active IP Right Cessation
- 2007-08-31 CN CN2007800341822A patent/CN101516834B/zh not_active Expired - Fee Related
- 2007-08-31 SG SG2011058724A patent/SG174080A1/en unknown
- 2007-08-31 EP EP07802031.0A patent/EP2069289B1/de active Active
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- 2007-08-31 RU RU2009113602/04A patent/RU2446157C2/ru not_active IP Right Cessation
- 2007-08-31 WO PCT/EP2007/007613 patent/WO2008031509A1/de not_active Ceased
- 2007-08-31 KR KR1020097005160A patent/KR20090050081A/ko not_active Ceased
- 2007-08-31 MY MYPI20090791 patent/MY150745A/en unknown
- 2007-08-31 MX MX2009002047A patent/MX2009002047A/es active IP Right Grant
- 2007-09-11 UY UY30585A patent/UY30585A1/es not_active Application Discontinuation
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- 2007-09-11 TW TW096133788A patent/TWI394570B/zh not_active IP Right Cessation
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- 2009-03-09 IL IL197504A patent/IL197504A/en not_active IP Right Cessation
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Also Published As
| Publication number | Publication date |
|---|---|
| UY30585A1 (es) | 2008-05-02 |
| TW200829245A (en) | 2008-07-16 |
| NZ575603A (en) | 2011-03-31 |
| MX2009002047A (es) | 2009-03-06 |
| ZA200900807B (en) | 2009-11-25 |
| EP2069289A1 (de) | 2009-06-17 |
| IL197504A0 (en) | 2009-12-24 |
| AU2007297013A1 (en) | 2008-03-20 |
| IL197504A (en) | 2013-06-27 |
| AR063708A1 (es) | 2009-02-11 |
| JP2010503625A (ja) | 2010-02-04 |
| SG174080A1 (en) | 2011-09-29 |
| TWI394570B (zh) | 2013-05-01 |
| WO2008031509A1 (de) | 2008-03-20 |
| KR20090050081A (ko) | 2009-05-19 |
| CA2663544A1 (en) | 2008-03-20 |
| BRPI0716991A2 (pt) | 2013-10-08 |
| MA30707B1 (fr) | 2009-09-01 |
| JP5249226B2 (ja) | 2013-07-31 |
| CN101516834A (zh) | 2009-08-26 |
| NO20091110L (no) | 2009-06-09 |
| US8097758B2 (en) | 2012-01-17 |
| MY150745A (en) | 2014-02-28 |
| US20090233949A1 (en) | 2009-09-17 |
| AU2007297013B2 (en) | 2012-05-31 |
| RU2446157C2 (ru) | 2012-03-27 |
| RU2009113602A (ru) | 2010-10-20 |
| CL2007002652A1 (es) | 2008-02-08 |
| EP2069289B1 (de) | 2013-10-02 |
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