CN101507763B - Medicine combination capable of relieving or neutralizing the effect of alcohol and protecting the liver - Google Patents
Medicine combination capable of relieving or neutralizing the effect of alcohol and protecting the liver Download PDFInfo
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- CN101507763B CN101507763B CN2009100682207A CN200910068220A CN101507763B CN 101507763 B CN101507763 B CN 101507763B CN 2009100682207 A CN2009100682207 A CN 2009100682207A CN 200910068220 A CN200910068220 A CN 200910068220A CN 101507763 B CN101507763 B CN 101507763B
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Abstract
The invention discloses an antialcoholic and hepatoprotective medicinal composition, which is characterized in that the medicinal composition takes pueraria flower as a main medicine and Japanese raisin tree seeds as an auxiliary medicine, and also comprises one or more of poria, kudzu roots and Chinese yam. An oral preparation is prepared by taking the medicinal composition as a raw material. Pharmacology and clinical experiments show that the medicinal composition has good antialcoholic and hepatoprotective functions.
Description
Technical field
The present invention relates to medicine or health food technology field, be specifically related to a kind of medicament for sobering up and protecting liver compositions.
Background technology
The characteristics of Chinese food culture are the culture of wine table, no wine does not become to fete, people's rhythm of life is fast in the modern society, the seriously polluted people's liver load that causes of operating pressure overall situation is excessive, immunity degradation, and people's dinner party now are many, often participating in social activity entertains, commercial affairs are entertained, public affair is entertained, activities such as friend's party, these movable certainly will will drinking certainly will more increase the weight of body burden and drink, and present Chinese are paid attention to health very much, therefore, if a kind of natural liver protection medicine is arranged, the human injury that can solve drinks causes, that this medicine necessarily has extensive market prospects.
Summary of the invention
For these reasons, we determine a kind of pharmaceutical composition by the experiment of science, and wherein pharmaceutical composition is formed for the monarch medicine, and wherein monarch drug is a Flos puerariae lobatae, and ministerial drug is a Semen Hoveniae (Fructus Hoveniae); Flos puerariae lobatae, nature and flavor, Gan Xinping returns the taste warp, has the expelling pathogenic factors from muscles desuperheating, promoting the production of body fluid to quench thirst, the effect of yang invigorating antidiarrheal, this medicine commonly used among the people is separated drunk.Semen Hoveniae (Fructus Hoveniae), property is flat, sweet in the mouth is sour, goes into spleen, lung two warps, cures mainly drunk, dysphoria with smothery sensation, thirsty, vomiting, difficulty in urination and defecation.Having the human rabbit to make pharmacological evaluation, find that this medicine has significant diuresis, is a kind of good medicine that relieves the effect of alcohol.Modern medicine study shows that Semen Hoveniae (Fructus Hoveniae) contains glucose, fructose, potassium nitrate, peroxidase etc.Semen Hoveniae (Fructus Hoveniae) and compound recipe thereof can significantly reduce the concentration of ethanol in blood, promote alcoholic acid removing, eliminate the interior excessive free radicals that produces of body after drinking, hinder the formation of lipid peroxide, thereby alleviate the damage of ethanol, avoid alcoholism to cause various Developmental and Metabolic Disorder, bring out various diseases hepatic tissue.In addition, Semen Hoveniae (Fructus Hoveniae) still digests human body and crosses blubbery health fruit, and often eating can defatting beauty.Pharmacological evaluation shows that pharmaceutical composition of the present invention has the effect of good protection alcoholic liver injury.
The present invention is achieved through the following technical solutions.
A kind of medicament for sobering up and protecting liver compositions comprises Flos puerariae lobatae in the pharmaceutical composition, Semen Hoveniae (Fructus Hoveniae), Poria.The Chinese medicine use amount is used according to clinical common dose in the aforementioned pharmaceutical compositions.
Pharmaceutical composition also comprises Radix Puerariae.The Chinese medicine use amount is used according to clinical common dose in the aforementioned pharmaceutical compositions.
Pharmaceutical composition also comprises Rhizoma Dioscoreae.The Chinese medicine use amount is used according to clinical common dose in the aforementioned pharmaceutical compositions.
Pharmaceutical composition Flos puerariae lobatae 5-100 weight portion wherein, Semen Hoveniae (Fructus Hoveniae) 1-50 weight portion, Poria 1-50 weight portion.
Pharmaceutical composition Flos puerariae lobatae 5-100 weight portion wherein, Semen Hoveniae (Fructus Hoveniae) 1-50 weight portion, Poria 1-50 weight portion, Radix Puerariae 5-100 weight portion.
Pharmaceutical composition Flos puerariae lobatae 5-100 weight portion wherein, Semen Hoveniae (Fructus Hoveniae) 1-50 weight portion, Poria 1-50 weight portion, Radix Puerariae 5-100 weight portion, Rhizoma Dioscoreae 1-50 weight portion.
Described a kind of medicament for sobering up and protecting liver compositions, wherein pharmaceutical composition is the oral formulations of feedstock production.
Narrating oral formulations includes but not limited to following: tablet, capsule, oral liquid, granule, soft capsule, pellet etc.
Pharmacology embodiment
Embodiment 1
Experimental technique: all divide normal group at random with rat, the silymarin group, medicine group of the present invention, except that the normal control group, all the other respectively organize rat first in subcutaneous injection ethanol 5ml/kg, later on 2 back subcutaneous injection 40% ethanol 3ml/kg, totally 6 weeks weekly.Except that normal group, the 1st～2 week, each group all gave the Semen Maydis powder feedstuff that 20% Adeps Sus domestica adds 0.5% cholesterol at experimental session, and the 3rd～6 week raised with normal diet.Each administration group while abdominal cavity when modeling begins gives the medicinal liquid of corresponding dosage, administration volume 1ml/100g, and administration time is totally 12 weeks.Each is organized after the medication cycle finishes, and cuts open the belly under the etherization, through the lower chamber dooor venous blood collection, gets a part of hepatic tissue and makes liver homogenate, is used to detect hydroxyproline (Hyp) content.Experimental result sees Table 1:
The influence of Hyp in the table 1 pair Liver Fibrosis Model liver tissues of rats (X ± S)
Annotate: compare with the blank group,
*P＜0.01,
*P＜0.05;
Experiment 2
Protective effect to the rat chronic hepatic injury
Laboratory animal: the Wistar rat, male, body weight: 200 ± 2g.
Experimental technique: the Wistar rat is pressed the body weight random packet: blank group, administration group.Except that the blank group, other respectively organize subcutaneous injection 40%CCl
4Olive oil solution 5ml/kg, subcutaneous injection 40%CCl weekly later on
4Olive oil solution 3ml/kg twice continued for 6 weeks, and blank group gives the olive oil of equal volume.Simultaneously each group is according to identical pharmaceutical quantities gastric infusion every day 1 time, 6 weeks of successive administration, weigh weekly once, and adjust dosage according to the variation of body weight.After the last administration 24 hours, get the blood sample of animal, separation of serum is measured ALT, AST, TP and Alb respectively by automatic clinical chemistry analyzer.The animal of drug withdrawal time daily femoral artery sacrificed by exsanguination is cooked substantially and histopathologic examination.Measure the weight and the coefficient of liver, spleen; Take out each treated animal liver, the conventional dehydration of leftlobe of liver, embedding and section, histological examination is done in HE dyeing.
Experimental result: the liver khaki is observed in the model group gross anatomy, and surface and tangent plane are coarse, and the atrophy phenomenon is arranged, quality toughness; Microscopy finds that organizational structure reduces, swelling of liver cell, the degeneration of cavity sample and downright bad and early stage Fibrotic formation; Pharmaceutical composition group of the present invention has and model group, and lesion degree is lighter, illustrates that pharmaceutical composition group of the present invention has protective effect to liver.
Table 2 different pharmaceutical is to the influence of rat liver coefficient
Annotate: compare with model group
*P＜0.01,
*P＜0.01;
The clinical implementation example
Embodiment 1
One male, 36 years old, to drink after 0.5 kilogram, long liquor-saturatedly do not wake up gives the oral liquid of preparation of pharmaceutical compositions of the present invention, gastric infusion, administration 30 minutes is waken up and is changeed, and is giving said medicine, Consciousness after 30 minutes.
Embodiment 2
One women, 26 years old, because of job demand is often drunk, drink must be liquor-saturated at every turn, prepares once more to drink 30 minutes, gives the capsule that pharmaceutical composition of the present invention is a feedstock production, drank that there do not have to be liquor-saturated the same day, drinks later at every turn and must obey said medicine.
Embodiment 3
One male patient, 45 years old, clinical diagnosis was suffered from a deficiency of the kidney, and took pharmaceutical composition of the present invention 30 days, the clinical diagnosis healing of suffering from a deficiency of the kidney.
Preparation embodiment
Embodiment 1
Pharmaceutical composition, monarch drug are Flos puerariae lobatae, and ministerial drug is a Semen Hoveniae (Fructus Hoveniae); Get the aforementioned pharmaceutical compositions raw material,, be prepared into preparation according to the routine techniques extraction separation.
Embodiment 2
Pharmaceutical composition, monarch drug are Flos puerariae lobatae, and ministerial drug is a Semen Hoveniae (Fructus Hoveniae), and adjuvant drug is a Poria; Get the aforementioned pharmaceutical compositions raw material,, be prepared into preparation according to the routine techniques extraction separation.
Embodiment 3
Pharmaceutical composition, monarch drug are Flos puerariae lobatae, and ministerial drug is a Semen Hoveniae (Fructus Hoveniae), and adjuvant drug is a Radix Puerariae; Get the aforementioned pharmaceutical compositions raw material,, be prepared into preparation according to the routine techniques extraction separation.
Embodiment 4
Pharmaceutical composition, monarch drug are Flos puerariae lobatae, and ministerial drug is a Semen Hoveniae (Fructus Hoveniae), Poria and Radix Puerariae; Get the aforementioned pharmaceutical compositions raw material,, be prepared into preparation according to the routine techniques extraction separation.
Embodiment 5
Pharmaceutical composition, monarch drug are Flos puerariae lobatae, and ministerial drug is a Semen Hoveniae (Fructus Hoveniae), Poria and Rhizoma Dioscoreae, and messenger drug is a Radix Salviae Miltiorrhizae; Get the aforementioned pharmaceutical compositions raw material,, be prepared into preparation according to the routine techniques extraction separation.
Embodiment 6
Pharmaceutical composition, monarch drug are Flos puerariae lobatae, and ministerial drug is a Semen Hoveniae (Fructus Hoveniae), Poria, Radix Puerariae and Rhizoma Dioscoreae; Get the aforementioned pharmaceutical compositions raw material,, be prepared into preparation according to the routine techniques extraction separation.
The Chinese medicine use amount is used according to clinical common dose in the aforementioned pharmaceutical compositions.
Embodiment 7
Pharmaceutical composition, monarch drug are Flos puerariae lobatae 5g, and ministerial drug is Semen Hoveniae (Fructus Hoveniae) 1g; Get the aforementioned pharmaceutical compositions raw material,, be prepared into preparation according to the routine techniques extraction separation.
Embodiment 8
Pharmaceutical composition, monarch drug are Flos puerariae lobatae 100g, and ministerial drug is Semen Hoveniae (Fructus Hoveniae) 50g; Get the aforementioned pharmaceutical compositions raw material,, be prepared into preparation according to the routine techniques extraction separation.
Embodiment 9
Pharmaceutical composition, monarch drug are Flos puerariae lobatae 50g, and ministerial drug is Semen Hoveniae (Fructus Hoveniae) 35g; Get the aforementioned pharmaceutical compositions raw material,, be prepared into preparation according to the routine techniques extraction separation.
Embodiment 10
Pharmaceutical composition, monarch drug are Flos puerariae lobatae 24g, and ministerial drug is Semen Hoveniae (Fructus Hoveniae) 15g; Get the aforementioned pharmaceutical compositions raw material,, be prepared into preparation according to the routine techniques extraction separation.
Embodiment 11
Pharmaceutical composition, monarch drug are Flos puerariae lobatae 95g, and ministerial drug is Semen Hoveniae (Fructus Hoveniae) 45g; Get the aforementioned pharmaceutical compositions raw material,, be prepared into preparation according to the routine techniques extraction separation.
Embodiment 12
Pharmaceutical composition, monarch drug are Flos puerariae lobatae 85g, and ministerial drug is Semen Hoveniae (Fructus Hoveniae) 27g; Get the aforementioned pharmaceutical compositions raw material,, be prepared into preparation according to the routine techniques extraction separation.
Embodiment 13
Pharmaceutical composition, monarch drug are Flos puerariae lobatae 5g, and ministerial drug is Semen Hoveniae (Fructus Hoveniae) 1g, Poria 1g; Get the aforementioned pharmaceutical compositions raw material,, be prepared into preparation according to the routine techniques extraction separation.
Embodiment 14
Pharmaceutical composition, monarch drug are Flos puerariae lobatae 5g, and ministerial drug is Semen Hoveniae (Fructus Hoveniae) 1g, Radix Puerariae 5g; Get the aforementioned pharmaceutical compositions raw material,, be prepared into preparation according to the routine techniques extraction separation.
Embodiment 15
Pharmaceutical composition, monarch drug are Flos puerariae lobatae 5g, and ministerial drug is Semen Hoveniae (Fructus Hoveniae) 1g, Rhizoma Dioscoreae 1g; Get the aforementioned pharmaceutical compositions raw material,, be prepared into preparation according to the routine techniques extraction separation.
Embodiment 16
Pharmaceutical composition, monarch drug are Flos puerariae lobatae 100g, and ministerial drug is Semen Hoveniae (Fructus Hoveniae) 50g, Poria 50g; Get the aforementioned pharmaceutical compositions raw material,, be prepared into preparation according to the routine techniques extraction separation.
Embodiment 17
Pharmaceutical composition, monarch drug are Flos puerariae lobatae 100g, and ministerial drug is Semen Hoveniae (Fructus Hoveniae) 50g, Radix Puerariae 100g; Get the aforementioned pharmaceutical compositions raw material,, be prepared into preparation according to the routine techniques extraction separation.
Embodiment 18
Pharmaceutical composition, monarch drug are Flos puerariae lobatae 100g, and ministerial drug is Semen Hoveniae (Fructus Hoveniae) 50g, Rhizoma Dioscoreae 100g; Get the aforementioned pharmaceutical compositions raw material,, be prepared into preparation according to the routine techniques extraction separation.
Embodiment 19
Pharmaceutical composition, monarch drug are Flos puerariae lobatae 50g, and ministerial drug is Semen Hoveniae (Fructus Hoveniae) 35g, Poria 35g; Get the aforementioned pharmaceutical compositions raw material,, be prepared into preparation according to the routine techniques extraction separation.
Embodiment 20
Pharmaceutical composition, monarch drug are Flos puerariae lobatae 45g, and ministerial drug is Semen Hoveniae (Fructus Hoveniae) 25g, Radix Puerariae 60g; Get the aforementioned pharmaceutical compositions raw material,, be prepared into preparation according to the routine techniques extraction separation.
Embodiment 21
Pharmaceutical composition, monarch drug are Flos puerariae lobatae 45g, and ministerial drug is Semen Hoveniae (Fructus Hoveniae) 35g, Rhizoma Dioscoreae 60g; Get the aforementioned pharmaceutical compositions raw material,, be prepared into preparation according to the routine techniques extraction separation.
Embodiment 22
Pharmaceutical composition, monarch drug are Flos puerariae lobatae 5g, and ministerial drug is Semen Hoveniae (Fructus Hoveniae) 1g, Poria 1g, Radix Puerariae 5g, Rhizoma Dioscoreae 1g; Get the aforementioned pharmaceutical compositions raw material,, be prepared into preparation according to the routine techniques extraction separation.
Embodiment 23
Pharmaceutical composition, monarch drug are Flos puerariae lobatae 100g, and ministerial drug is Semen Hoveniae (Fructus Hoveniae) 50g, Poria 50g, Radix Puerariae 100g, Rhizoma Dioscoreae 50g; Get the aforementioned pharmaceutical compositions raw material,, be prepared into preparation according to the routine techniques extraction separation.
Embodiment 24
Pharmaceutical composition, monarch drug are Flos puerariae lobatae 50g, and ministerial drug is Semen Hoveniae (Fructus Hoveniae) 25g, Poria 30g, Radix Puerariae 55g, Rhizoma Dioscoreae 40g; Get the aforementioned pharmaceutical compositions raw material,, be prepared into preparation according to the routine techniques extraction separation.
Embodiment 25
Pharmaceutical composition, monarch drug are Flos puerariae lobatae 10g, and ministerial drug is Semen Hoveniae (Fructus Hoveniae) 5g, Poria 6g, Radix Puerariae 15g, Rhizoma Dioscoreae 25g; Get the aforementioned pharmaceutical compositions raw material,, be prepared into preparation according to the routine techniques extraction separation.
Embodiment 26
Pharmaceutical composition, monarch drug are Flos puerariae lobatae 95g, and ministerial drug is Semen Hoveniae (Fructus Hoveniae) 40g, Poria 35g, Radix Puerariae 59g, Rhizoma Dioscoreae 30g; Get the aforementioned pharmaceutical compositions raw material,, be prepared into preparation according to the routine techniques extraction separation.
Embodiment 27
Pharmaceutical composition, monarch drug are Flos puerariae lobatae 80g, and ministerial drug is Semen Hoveniae (Fructus Hoveniae) 45g, Poria 5g, Radix Puerariae 100g, Rhizoma Dioscoreae 35g, vitamin E 55g; Get the aforementioned pharmaceutical compositions raw material,, be prepared into preparation according to the routine techniques extraction separation.
Embodiment 28
Pharmaceutical composition, monarch drug are Flos puerariae lobatae 75g, and ministerial drug is Semen Hoveniae (Fructus Hoveniae) 35g, Poria 55g, Radix Puerariae 65g, Rhizoma Dioscoreae 44g, Herba Menthae 10g; Get the aforementioned pharmaceutical compositions raw material,, be prepared into preparation according to the routine techniques extraction separation.
Embodiment 29
Pharmaceutical composition, monarch drug are Flos puerariae lobatae 75g, and ministerial drug is Semen Hoveniae (Fructus Hoveniae) 15g, Poria 45g, Radix Puerariae 65g, Rhizoma Dioscoreae 50g, Radix Salviae Miltiorrhizae 35g, Herba Menthae 5g; Get the aforementioned pharmaceutical compositions raw material,, be prepared into preparation according to the routine techniques extraction separation.
Embodiment 30
Pharmaceutical composition, monarch drug are Flos puerariae lobatae 90g, and ministerial drug is Semen Hoveniae (Fructus Hoveniae) 45g, Poria 45g, Radix Puerariae 15g, Rhizoma Dioscoreae 45g; Get the aforementioned pharmaceutical compositions raw material,, be prepared into preparation according to the routine techniques extraction separation.
Claims (2)
1. a medicament for sobering up and protecting liver compositions is characterized in that pharmaceutical composition by Flos puerariae lobatae 5-100 weight portion, Semen Hoveniae (Fructus Hoveniae) 1-50 weight portion, and Poria 1-50 weight portion, Radix Puerariae 5-100 weight portion, Rhizoma Dioscoreae 1-50 weight portion is formed.
2. a kind of medicament for sobering up and protecting liver compositions according to claim 1, wherein pharmaceutical composition is the oral formulations of feedstock production.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2009100682207A CN101507763B (en) | 2009-03-23 | 2009-03-23 | Medicine combination capable of relieving or neutralizing the effect of alcohol and protecting the liver |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100682207A CN101507763B (en) | 2009-03-23 | 2009-03-23 | Medicine combination capable of relieving or neutralizing the effect of alcohol and protecting the liver |
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| Publication Number | Publication Date |
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| CN101507763A CN101507763A (en) | 2009-08-19 |
| CN101507763B true CN101507763B (en) | 2011-07-06 |
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| CN2009100682207A Expired - Fee Related CN101507763B (en) | 2009-03-23 | 2009-03-23 | Medicine combination capable of relieving or neutralizing the effect of alcohol and protecting the liver |
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| CN102379936B (en) * | 2011-11-08 | 2014-07-16 | 浙江省林业科学研究院 | Process for producing alcoholism-relieving and liver-protecting soft capsule |
| CN102697132A (en) * | 2012-05-31 | 2012-10-03 | 南京中医药大学 | Beverage for protecting liver, tonifying kidney and alleviating hangover, method for preparing same and application thereof |
| CN103040971B (en) * | 2012-12-28 | 2014-05-14 | 吉林省蚕业科学研究院 | Dealcoholic liver-protecting preparation and preparation process thereof |
| CN104055889A (en) * | 2013-11-26 | 2014-09-24 | 申志恩 | Drunkenness sobering drug and production method thereof |
| CN103750320B (en) * | 2014-01-22 | 2015-08-12 | 理想科技集团有限公司 | A kind of have relieve the effect of alcohol, the product of liver-protecting function and preparation method thereof |
| CN107007786A (en) * | 2016-01-28 | 2017-08-04 | 天津大奥医药科技发展有限公司 | A kind of pharmaceutical composition with relieve the effect of alcohol, protect kidney, hepatoprotective effect |
| CN105853498A (en) * | 2016-06-06 | 2016-08-17 | 太鲵生物科技（天津）有限公司 | Alcoholism relief and liver protection traditional Chinese medicine composition |
| CN107158118A (en) * | 2017-05-27 | 2017-09-15 | 江西中医药大学 | Solid beverage with anti-alcoholic function and sobering-up function and preparation method thereof |
| CN107412378A (en) * | 2017-05-27 | 2017-12-01 | 江西中医药大学 | Oral liquid with anti-alcoholic function and sobering-up function and preparation method thereof |
| CN107853700A (en) * | 2017-11-28 | 2018-03-30 | 爱可道生物科技有限公司 | A kind of globe artichoke liver protection fatigue-resistant drug composition |
| CN107822024A (en) * | 2017-12-07 | 2018-03-23 | 云南瑞药金方现代中药有限公司 | A kind of ready-to-eat food with shield stomach and anti-alcohol function and preparation method thereof |
| CN108607048A (en) * | 2018-05-14 | 2018-10-02 | 顾氏本元（北京）健康科技中心 | Solid beverage capable of dispelling effects of alcohol and nourishing liver and preparation method thereof |
| CN110575467A (en) * | 2018-06-07 | 2019-12-17 | 云南苏氏生物科技开发有限公司 | Hangover alleviating formula |
| CN114712424B (en) * | 2022-05-12 | 2023-09-12 | 沈阳美素生物科技有限公司 | Traditional Chinese medicine preparation with effects of dispelling effects of alcohol and protecting liver as well as preparation method and application thereof |
| CN116196377B (en) * | 2023-01-06 | 2024-07-23 | 福建省中医药科技开发有限公司 | Composition with liver protection effect and capable of accelerating alcohol metabolism, preparation method and application thereof |
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2009
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