CN101505787B - 软骨障碍的治疗 - Google Patents

软骨障碍的治疗 Download PDF

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Publication number
CN101505787B
CN101505787B CN2007800312016A CN200780031201A CN101505787B CN 101505787 B CN101505787 B CN 101505787B CN 2007800312016 A CN2007800312016 A CN 2007800312016A CN 200780031201 A CN200780031201 A CN 200780031201A CN 101505787 B CN101505787 B CN 101505787B
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CN
China
Prior art keywords
fgf
cartilage
application
treatment
chemical compound
Prior art date
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Active
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CN2007800312016A
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English (en)
Chinese (zh)
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CN101505787A (zh
Inventor
A·吉莫
C·H·雷德尔
E·冯鲍尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ares Trading SA
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Ares Trading SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Ares Trading SA filed Critical Ares Trading SA
Priority claimed from PCT/EP2007/058830 external-priority patent/WO2008023063A2/en
Publication of CN101505787A publication Critical patent/CN101505787A/zh
Application granted granted Critical
Publication of CN101505787B publication Critical patent/CN101505787B/zh
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN2007800312016A 2006-08-25 2007-08-24 软骨障碍的治疗 Active CN101505787B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP06119557 2006-08-25
EP06119557.4 2006-08-25
US84060006P 2006-08-28 2006-08-28
US60/840,600 2006-08-28
PCT/EP2007/058830 WO2008023063A2 (en) 2006-08-25 2007-08-24 Treatment of cartilage disorders with fgf-18

Publications (2)

Publication Number Publication Date
CN101505787A CN101505787A (zh) 2009-08-12
CN101505787B true CN101505787B (zh) 2013-09-04

Family

ID=37684849

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2007800312016A Active CN101505787B (zh) 2006-08-25 2007-08-24 软骨障碍的治疗

Country Status (11)

Country Link
CN (1) CN101505787B (sl)
BR (1) BRPI0715728A8 (sl)
DK (1) DK2054050T3 (sl)
ES (1) ES2392883T3 (sl)
MY (1) MY148277A (sl)
NZ (1) NZ574216A (sl)
PT (1) PT2054050E (sl)
RS (1) RS52710B (sl)
SI (1) SI2054050T1 (sl)
UA (1) UA99818C2 (sl)
ZA (1) ZA200900426B (sl)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104736723B (zh) * 2012-08-06 2017-10-31 默克专利有限公司 用于预测对fgf‑18化合物的响应性的遗传标记
US10086112B2 (en) * 2014-02-20 2018-10-02 Merck Patent Gmbh Implant comprising FGF-18
AR099557A1 (es) * 2014-02-20 2016-08-03 Merck Patent Gmbh Fgf-18 en trasplantes de injertos y procedimientos de ingeniería de tejido
SG11201606505UA (en) * 2014-02-20 2016-09-29 Merck Patent Gmbh Fgf-18 compound dosing regimen
US20180000736A1 (en) * 2015-01-08 2018-01-04 University Of Iowa Research Foundation Methods for the regeneration of articular cartilage in vivo
JP6951318B2 (ja) * 2015-07-15 2021-10-20 プロージット ソウル バイオテクノロジー （ベイジン） カンパニー リミテッド 融合ポリペプチドおよび使用方法
KR20180035911A (ko) * 2015-08-13 2018-04-06 메르크 파텐트 게엠베하 Fgf-18 화합물을 포함하는 조합 조성물
CA3162235A1 (en) * 2019-11-21 2021-05-27 Remedium Bio, Inc. Growth factor restoration
US11904006B2 (en) 2019-12-11 2024-02-20 University Of Iowa Research Foundation Poly(diaminosulfide) particle-based vaccine
CN117721115A (zh) * 2022-09-06 2024-03-19 深圳瑞吉生物科技有限公司 用于治疗骨关节炎的mRNA及其制备方法与应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004032849A2 (en) * 2002-10-07 2004-04-22 Zymogenetics, Inc. Methods of administering fgf18
WO2006014444A1 (en) * 2004-07-06 2006-02-09 Zymogenetics, Inc. Pharmaceutical composition comprising fgf18 and il-1 antagonist and method of use
US20060172384A1 (en) * 2004-12-10 2006-08-03 Reardon Brian J FGF18 production in prokaryotic hosts

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004032849A2 (en) * 2002-10-07 2004-04-22 Zymogenetics, Inc. Methods of administering fgf18
WO2006014444A1 (en) * 2004-07-06 2006-02-09 Zymogenetics, Inc. Pharmaceutical composition comprising fgf18 and il-1 antagonist and method of use
US20060172384A1 (en) * 2004-12-10 2006-08-03 Reardon Brian J FGF18 production in prokaryotic hosts

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
E. E. Moore et al..Fibroblast growth factor-18 stimulates chondrogenesis and cartilage repair in a rat model of injury-induced osteoarthritis.《OsteoArthritis and Cartilage》.2005,第13卷(第7期),623-631. *

Also Published As

Publication number Publication date
UA99818C2 (ru) 2012-10-10
DK2054050T3 (da) 2012-09-03
CN101505787A (zh) 2009-08-12
BRPI0715728A2 (pt) 2013-09-17
PT2054050E (pt) 2012-09-17
RS52710B (en) 2013-08-30
NZ574216A (en) 2011-11-25
ES2392883T3 (es) 2012-12-14
ZA200900426B (en) 2010-04-28
BRPI0715728A8 (pt) 2018-04-03
SI2054050T1 (sl) 2012-12-31
MY148277A (en) 2013-03-29

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JP2022058550A (ja) 関節痛を緩和する方法
KR20180035911A (ko) Fgf-18 화합물을 포함하는 조합 조성물

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