CN101502534B - Method for extracting medicinal material from Periplaneta americana - Google Patents
Method for extracting medicinal material from Periplaneta americana Download PDFInfo
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- CN101502534B CN101502534B CN2009100941907A CN200910094190A CN101502534B CN 101502534 B CN101502534 B CN 101502534B CN 2009100941907 A CN2009100941907 A CN 2009100941907A CN 200910094190 A CN200910094190 A CN 200910094190A CN 101502534 B CN101502534 B CN 101502534B
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Abstract
The invention provides a method for extracting medicinal substances from Periplaneta American Linn, which comprises the following steps: A, alcohol extraction: killing and soaking larvae in alcohol; freezing the larvae at a low temperature; cracking shells, carrying out coarse-sizing, placing in an extractor and soaking in alcohol; thermal-reflux alcohol-extracting, recovering the drug liquid, placing in a separator and carrying out the oil-water separation; filtering and concentrating the separated drug liquid; discharging and cooling the drug liquid to obtain the medicinal substances; and B, water extraction: pouring the materials of alcohol extraction into distilled water; carrying out heating extraction; recovering and placing the drug liquid in the separator and carrying out the oil-water separation; and filtering and concentrating to obtain the medicinal substances. Compared with the prior art, the method of the invention improves the extraction yield and increases the total content of amino acid as well as the contents of polypeptide, protein, chitin, chitosan and the like in the extracted medicinal substances, and is particularly characterized in that the unpleasant odor is eliminated by low-temperature freezing before the extraction, therefore, the extracted medicinal substances have almost no unpleasant odor from the original extract while more bioactive substances are preserved.
Description
Technical field
The present invention relates to the extraction process of medicine material, specifically the method for distilling of periplaneta americana medical substance.
Background technology
Periplaneta americana (Periplaneta American Linn) is a kind of insecticide.The medicinal liquid that periplaneta americana is extracted can be used for skin care item, medicine, health product etc.; Have healing of the tissue growth of promotion and antioxidation; Ability Soboring-up liver-protecting, nourishing the stomach; Promote the healing of gastric ulcer and duodenal ulcer, promote inflammation and ulcer healing, tumor and deficient syndrome, tuberculosis are had the auxiliary treatment effect.The method that existing periplaneta americana extraction process adopts is traditional alcohol extracting method, and most water-soluble amino acid does not propose, and extraction ratio is only 8.7～10.3%, and the aminoacid total content of product only reaches 29.8%.The patent No. be 031178049 patent of invention " the medicinal extractum extraction process of periplaneta americana " adopt be: 1) with the raw material Blatta seu periplaneta with 65～75 ℃ of hot water deactivations; 2) after 65～75 ℃ of heat temperature dryings, coarse pulverization, sieve; 3) putting in the container 80 degree ethanol soaked former charge level and soaked 48～50 hours.This method can be destroyed more bioactive substance.
Summary of the invention
It is high to the purpose of this invention is to provide a kind of extraction ratio, and amino acid content also improves greatly, and can reduce abnormal flavour, keeps the periplaneta americana medical substance method for distilling of more dirt active substances.
Method for distilling of the present invention carries out according to the following steps:
The A alcohol extraction:
1) bright worm (periplaneta americana) is catched and killed, with 75～80% (concentration) ethanol with weight ratio 2～3: 1 (ethanol: ratio bright worm) was with alcohol-pickled 4～6 hours;
2) advance low-temperature cold store with subzero 20 ℃ freezing 48 hours;
3) the broken shell coarse powder is placed in the extractor, adds 3～5 times 70% (concentration) alcohol-pickled 48 hours;
4) ethanol hot reflux extracting is 7～8 hours, recovered alcohol, 65～75 ℃ of the overall process temperature of alcohol extraction;
5) released liquor is put and is carried out oil-water separation in the separator;
6) separating medicinal liquid filters through microfilter;
7) filtrating is put vacuum concentrator and is concentrated concentration and reach 1: 1.3, emit cool off extractum, the concentration process temperature is less than 75 ℃;
The B water extraction:
1) with alcohol extraction the 4th) step reclaims the raw material behind the alcohol, injects 3～5 times of distilled water, heating extraction 4～7 hours, the overall process temperature that water is carried is 65～75 ℃:
2) released liquor is put in the separator, carries out oil-water separation.
3) separating medicinal liquid filters through microfilter;
4) filtrating is put vacuum concentrator and is concentrated concentration and reach 1: 1.3, emits cooling, must this medical substance.
Method for distilling of the present invention compared with prior art; Improved extraction ratio; The total amino acids content of the medical substance of carrying and polypeptide, protein, chitin, chitosan equal size all increase, and what have more characteristic is owing to extract through freezing again, has reduced the generation of abnormal flavour; The extract obtained abnormal flavour that does not have original extract has basically been preserved more dirt active substances simultaneously.
The specific embodiment
Embodiment 1:
Carry out the extraction of periplaneta americana according to the following steps:
The A alcohol extraction:
1) bright worm (periplaneta americana) is catched and killed, (ethanol: ratio bright worm) was with alcohol-pickled 4～6 hours in 2: 1 with weight ratio with 75% (concentration) ethanol;
2) advance low-temperature cold store with subzero 20 ℃ freezing about 48 hours;
3) the broken shell coarse powder is placed in the multi-functional extractor, adds 3 times 70% (concentration) alcohol-pickled about 48 hours;
4) ethanol hot reflux extracting is 7～8 hours, recovered alcohol, 65～75 ℃ of the overall process temperature of alcohol extraction;
5) released liquor is put and is carried out oil-water separation in the separator;
6) separating medicinal liquid filters through microfilter;
7) filtrating is put vacuum concentrator and is concentrated concentration and reach 1: 1.3, emit cool off this medical substance (extractum), the concentration process temperature is less than 75 ℃;
The B water extraction:
1) with alcohol extraction the 4th) step reclaims the raw material behind the alcohol, injects 3～5 times of distilled water, heating extraction 4～7 hours, the overall process temperature that water is carried is 65～75 ℃:
2) released liquor is put in the separator, carries out oil-water separation.
3) separating medicinal liquid filters through microfilter;
4) filtrating is put vacuum concentrator and is concentrated concentration and reach 1: 1.3, emits cooling, must this medical substance (extractum).
Embodiment 2:
1) bright worm (periplaneta americana) is catched and killed, (ethanol: ratio bright worm) was with alcohol-pickled 4～6 hours in 3: 1 with weight ratio with 80% (concentration) ethanol;
2) advance low-temperature cold store with subzero 20 ℃ freezing about 48 hours;
3) the broken shell coarse powder is placed in the multi-functional extractor, adds 5 times 70% (concentration) alcohol-pickled about 48 hours;
Following steps are identical with embodiment 1.
Claims (1)
1. periplaneta americana medical substance method for distilling is characterized in that extracting according to the following steps:
The A alcohol extraction:
1) bright worm is catched and killed, with 75～80% ethanol with weight ratio 2～3: 1, ethanol: the ratio of bright worm was with alcohol-pickled 4～6 hours;
2) advance low-temperature cold store with subzero 20 ℃ freezing 48 hours;
3) the broken shell coarse powder is placed in the extractor, add 3～5 times 70% alcohol-pickled 48 hours;
4) ethanol hot reflux extracting is 7～8 hours, recovered alcohol, 65～75 ℃ of the overall process temperature of alcohol extraction;
5) released liquor is put and is carried out oil-water separation in the separator;
6) separating medicinal liquid filters through microfilter;
7) filtrating is put vacuum concentrator and is concentrated concentration and reach 1: 1.3, emit cool off this medical substance, the concentration process temperature is less than 75 ℃;
The B water extraction:
1) with alcohol extraction the 4th) step reclaims the raw material behind the alcohol, injects 3～5 times of distilled water, heating extraction 4～7 hours, the overall process temperature that water is carried is 65～75 ℃:
2) released liquor is put in the separator, carries out oil-water separation;
3) separating medicinal liquid filters through microfilter;
4) filtrating is put vacuum concentrator and is concentrated concentration and reach 1: 1.3, emits cooling, must this medical substance.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100941907A CN101502534B (en) | 2009-03-11 | 2009-03-11 | Method for extracting medicinal material from Periplaneta americana |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2009100941907A CN101502534B (en) | 2009-03-11 | 2009-03-11 | Method for extracting medicinal material from Periplaneta americana |
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| CN101502534A CN101502534A (en) | 2009-08-12 |
| CN101502534B true CN101502534B (en) | 2012-05-23 |
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Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102846667B (en) * | 2012-08-23 | 2013-06-12 | 耿福能 | Preparation method for nanometer Periplaneta americana through low temperature drying |
| CN102973610A (en) * | 2012-12-22 | 2013-03-20 | 昆明赛诺制药有限公司 | Method for preparing phthisic adjuvant with extractum of Periplaneta americana |
| CN103222988B (en) * | 2013-01-15 | 2015-10-28 | 四川好医生攀西药业有限责任公司 | A kind of American-cockroach-extract and its preparation method and application |
| CN103239482A (en) * | 2013-05-29 | 2013-08-14 | 四川好医生攀西药业有限责任公司 | Intragastric floating tablet for periplaneta americana as well as preparation method and application of intragastric floating tablet |
| CN104341485A (en) * | 2013-08-02 | 2015-02-11 | 成都百草和济科技有限公司 | Extraction method for total protein of american cockroach |
| CN104017107A (en) * | 2014-06-19 | 2014-09-03 | 南京麦思德餐饮管理有限公司 | Preparation method of American cockroach chitin powder |
| CN104644684A (en) * | 2015-02-26 | 2015-05-27 | 王福明 | Periplaneta americana medicated wine as well as preparation method and application thereof |
| CN105176759A (en) * | 2015-09-28 | 2015-12-23 | 云南成满生物科技有限公司 | American cockroach health care liquor raw materials and American cockroach health care liquor |
| CA3156271A1 (en) * | 2019-10-11 | 2021-04-15 | Liangshan Jianengda Biomaterials Breeding Co., Ltd. | An extract of periplaneta americana l., preparation, a preparation method and use thereof |
| CN113520972A (en) * | 2020-04-17 | 2021-10-22 | 常州伟博海泰生物科技有限公司 | Periplaneta americana extract, odor-free extraction method thereof, anti-aging essence freeze-dried preparation containing Periplaneta americana extract and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1593467A (en) * | 2004-07-08 | 2005-03-16 | 严少宏 | Method for extracting medicinal and edible substance from dictyoptera |
| CN1961893A (en) * | 2005-11-08 | 2007-05-16 | 肖小芹 | Method for preparing extract of adult bombay canary |
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- 2009-03-11 CN CN2009100941907A patent/CN101502534B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1593467A (en) * | 2004-07-08 | 2005-03-16 | 严少宏 | Method for extracting medicinal and edible substance from dictyoptera |
| CN1961893A (en) * | 2005-11-08 | 2007-05-16 | 肖小芹 | Method for preparing extract of adult bombay canary |
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