CN101489620A - 输液装置泵 - Google Patents

输液装置泵 Download PDF

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CN101489620A
CN101489620A CNA2007800173634A CN200780017363A CN101489620A CN 101489620 A CN101489620 A CN 101489620A CN A2007800173634 A CNA2007800173634 A CN A2007800173634A CN 200780017363 A CN200780017363 A CN 200780017363A CN 101489620 A CN101489620 A CN 101489620A
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compressible tube
dish
liquid preparation
sleeve pipe
insulin
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克利夫顿·A·阿尔费尼斯
约翰·M·亚当斯
丹尼尔·霍金斯
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Calibra Medical LLC
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Abstract

一种一次性输液装置，包括底座、套管以及源，所述底座布置为粘附到病人皮肤上，所述套管布置为从底座延伸到病人皮肤下面，以便将液体药剂输送进入病人体内，所述源布置为向所述套管提供液体药剂。所述源包括可压缩管，该可压缩管将液体药剂泵送到所述套管中。

Description

输液装置泵
技术领域
本申请要求于2006年3月16号提交的美国临时申请No.60/782,941的优先权，其通过引用结合于此。
背景技术
在糖尿病1型(通常为幼发型)以及糖尿病2型(通常为成人晚发型)中对于胰岛素给药的严格控制，提高了糖尿病病人的生活质量以及整体健康水平。胰岛素的给药是通过长效胰岛素的皮下注射以满足病人的基本需求以及通过短效胰岛素以对饮食进行补偿来实施的。最近，电子外部胰岛素输液泵的发展已经允许针对维持基本需求的快效胰岛素的持续输液以及针对饮食的补偿剂量。这些输液系统改进了血糖水平的控制。然而，它们却有尺寸、成本以及复杂性方面的缺点，这阻挠了许多病人通过标准皮下注射来接受这一技术。这些泵被电子地控制，并且必须被编程以便提供要求量的基础胰岛素和大剂量胰岛素。
发明内容
在一个实施例中，本发明提供一种一次性输液装置，其包括底座、套管以及源，该底座布置为粘附到病人皮肤上，该套管布置为从底座延伸到病人的皮肤下面，以将液体药剂输送进入病人体内，而该源布置为向套管提供液体药剂。该源包括泵和可压缩管，该泵将液体药剂泵到套管中。
该源可以还包括容纳液体药剂的贮液器，该可压缩管优选地与贮液器连通。
该源可以还包括管压缩器，该管压缩器对一段长度的可压缩管进行压缩，以便将液体药剂泵送到套管中。该管压缩器可以包括带，该带固定到可压缩管的端部，并沿着可压缩管延伸。该管压缩器可以还包括致动器，该致动器相对于可压缩管拉动带，以便压缩可压缩管。该管压缩器可以还包括具有圆周表面的盘，该盘支撑可压缩管，致动器可以布置为拉动带，并相对于盘的圆周压缩可压缩管。装置还可以包括体积调节器，该体积调节器调节利用致动器的每次致动泵入套管中的液体药剂的体积。管压缩器可以还包括具有圆周表面的盘，该盘支撑可压缩管，而致动器可以布置为拉动带，并相对于盘的圆周压缩可压缩管，以及体积调节器可以包括在盘的圆周表面内的凹槽。该凹槽可以具有沿着盘圆周增加的深度，该深度布置为接收可压缩管。该盘优选地可旋转，以便改变凹槽的接收可压缩管的长度，从而调节利用致动器的每次致动泵入套管中的液体药剂的体积。该盘还可以布置为使得，当凹槽的接收可压缩管的长度减少时，被泵进套管的液体药剂的体积增加。
源可以包括容纳液体药剂的贮液器，而可压缩管优选地与贮液器连通。管压缩器则可以包括带，该带固定到可压缩管的端部，并沿着可压缩管延伸。致动器可以用来相对于可压缩管拉动带，以便压缩可压缩管。管压缩器可以还包括具有圆周表面的盘，该盘支撑可压缩管，致动器可以布置为相对于盘的圆周拉动带并压缩可压缩管。装置可以还包括体积调节器，该体积调节器调节在致动器的每次致动下被泵进套管中的液体药剂的体积。
在另一个实施例中，一次性输液装置包括底座、套管以及源，该底座布置为粘附到病人皮肤上，该套管布置为从底座延伸到病人的皮肤下面，以便输送液体药剂到病人体内，而该源布置为向套管提供液体药剂。该源可以包括容纳液体药剂的贮液器以及将液体药剂从贮液器泵进套管内的泵。该泵可以包括可压缩管和管压缩器，该管压缩器对一段长度的可压缩管进行压缩，以便将液体药剂泵进套管中。
管压缩器可以调节用于改变被压缩的可压缩管的长度。该管压缩器可以还包括具有圆周表面的盘，该盘支撑可压缩管，以及致动器可以布置为相对于盘的圆周拉动带并压缩可压缩管。盘的圆周表面可以包括凹槽，该凹槽布置为接收可压缩管，并且凹槽的接收可压缩管的长度可以调节，用于改变被压缩的可压缩管的长度。
附图说明
本发明的认为是新颖的特征具体在所附权利要求中阐明。本发明连同其进一步特征以及优点通过参考以下说明结合附图可以非常好地理解，在这几个附图中，相同的附图标记表示相同的构件，其中：
图1是输液端口的侧视图，该输液端口能用于实践本发明；
图2是根据本发明的一个实施例的输液端口、加载薄膜以及胰岛素贮液器的侧视图；
图2A是示例了图2中的系统的操作的一个潜在方式的示意图；
图2B是示例了图2中的系统的操作的另外一个潜在方式的示意图；
图3是根据本发明的另外一个实施例的包括机械计时器的一次性胰岛素输液系统部分剖掉的侧视图；
图4是根据本发明的一个实施例的一次性胰岛素输液系统的透视图，该一次性胰岛素输液系统提供胰岛素的基础输送及大剂量输送；
图4A示出了图4中的系统的操作的更多细节的部分剖掉的侧视图；
图5是一次性胰岛素输送系统的透视图，该一次性胰岛素输液系统向使用者提供胰岛素的基础输送速度调节以及大剂量输送；
图6是根据本发明的一个实施例的一次性胰岛素输液系统的侧视图，该一次性胰岛素输液系统包括恒定胰岛素输送装置以及单独配置大剂量输送装置；
图7是根据本发明的另外一个实施例的胰岛素输液系统部分剖掉的顶视图，该胰岛素输液系统的胰岛素输送速度由室压决定；
图7A是一个示意图，其示例了图7的系统的操作的一个潜在方式；
图8是根据本发明的一个实施例的胰岛素输液系统的侧视图，该胰岛素输液系统的胰岛素大剂量输送体积通过蠕动动作控制；
图9是图8的系统的端视图；
图10是实施本发明的另一个系统的示意图；
图11是大剂量泵的部分剖掉的侧视图，实施了在胰岛素输送之前的本发明；以及
图12是图11的大剂量泵的部分剖掉的侧视图，实施了在胰岛素输送之后的本发明。
具体实施方式
图1示出了输液端口10，诸如胰岛素或肠促胰岛素的液体药剂可以使用标准注射器用手注射进该输液端口10中。端口10包括漏斗端口12、插入针14以及注射薄膜16。端口10通过胶带20可以粘附到皮肤18上。这系统避免了需要多个每日经皮的针棍以完成胰岛素剂量的供应。
端口10还包括套管15。套管15由漏斗端口12支撑。由本领域中技术可知，一旦针14以及套管15被定位于皮肤18下面，如图所示，则针14就被移除而把套管15留在部署位置，并准备好将胰岛素输送到病人体中。
图2示出根据本发明的一个实施例的系统30。该系统30包括类似于端口10的输液端口32，用来输送长效胰岛素或短效胰岛素。在从套管41抽回针39之前示出端口32。系统30包括第一源31以及泵38，第一源31包括贮液器34，贮液器34可以通过端口36被快效胰岛素填满。可以提供另外一个贮液器，如后面将看到的。端口允许贮液器34在内部容纳诸如快效胰岛素的第一液体药剂，例如用于在用餐时输送，而端口32的漏斗端口33形成第二源43，并允许例如在早上醒来后输送诸如缓效胰岛素的第二液体药剂。通过泵38可以输送快效胰岛素，泵38可以用手指挤压。
当系统30包括多个贮液器时，系统30可以具有用于在任何给定时间选择哪种胰岛素进行输液的机构。系统30还通过让病人将致动器38按下需要次数来提供控制每种特定的胰岛素确定要输送多少。例如，每次致动可以输送0.5单位的胰岛素。因此，如果需要3单位的胰岛素，那么压下6次将输送所要求的量。
图2A示出了系统30的操作的一个方式。快效胰岛素可以通过装载端口36被装进贮液器34中。泵38可以是活塞泵，尤其是固定行程活塞泵，该固定行程活塞泵每次致动提供预定体积的胰岛素。因此，泵38的压下次数决定从贮液器34输送到端口32和套管41的快效胰岛素的量。当要输送缓效胰岛素时，诸如在早上醒来时，可以通过漏斗端口33输送缓效胰岛素。关于这一点，将注意到，泵33允许从诸如注射器39的系统30外的器械接收缓效胰岛素。还将注意到，输液系统30还包括单向阀45和47。阀45在泵38和贮液器34之间，而阀47在端口32和泵38之间。
图2B示出系统30可以操作的另一种方式。这里，除了用于快效胰岛素的贮液器34之外，系统包括另一个贮液器35来容纳缓效胰岛素。通过端口36将快效胰岛素加载到贮液器34中。可以通过端口37将缓效胰岛素加载到贮液器35中。阀40控制选择哪个贮液器以及传输所选择胰岛素的速度。泵38，可以是固定行程活塞泵，被用于通过端口32将所选择胰岛素泵送到病人体内。阀45和47保持在泵38的相对侧上。
图3示出了系统50，系统50用于每单位时间恒定输送固定量的胰岛素。随着时间输送的胰岛素是快效胰岛素，以便满足基础需求。该胰岛素容纳在贮液器52中。还提供附加端口54，用于针对饮食的快效胰岛素的注射。
在机械计时器泵56的控制下，恒定地输送在贮液器52中的胰岛素。在本领域技术中，计时器泵是已知类型，其包括卷绕机58、卷簧60和齿轮62。齿轮62驱动蜗轮63并引导螺杆65以驱动活塞67。活塞67由此增压贮液器52，以提供恒定流量的胰岛素到套管66。当诸如在用餐中需要大剂量的快效胰岛素时，端口54被用来将快效胰岛素注射进入到贮液器52中。当贮液器满时，进一步注射的胰岛素将从贮液器52排出同样量的胰岛素，以便将同样量的胰岛素注射进入和出套管66。
图4示出了具有输液端口加上用于针对饮食输送大剂量的机构的装置实施例70，该输液端口用于每单位时间输送固定量的快效胰岛素。提供滑块72，以便增压胰岛素室(未示出)。填充薄膜74允许室被填充。触发器76可以被压下，用于输送每个测量剂量的胰岛素。
现在参看图4A，在这里可以看到在病人部署套管73之后滑块72执行了附加功能。更具体来说，针71可以从套管73抽回，以便将套管73留在完全部署位置，用于将胰岛素输送到病人体中。为此目的，滑块72连接到容纳在输液管73中的装置针71上。随着滑块在箭头75的方向上向后滑，针71抽回。最后，针被针抓取室77抓取。滑块72更向后的移动最终使针头71a被针排出器79获取。当滑块72进一步向后移动时，针排出器79受到斜坡81的作用而使针头在箭头79a的方向上排出。该针头排出迫使针退出滑块72。此时，针在装置70内落下，且不能再使用。现在装置就安全了，并在其被使用完毕后准备好被抛弃。
图5示出了具有转盘的类似装置80，该转盘用于每单位时间输送使用者调节可变量的快效胰岛素。这一实施例对于在一天中不同时间可能需要不同量的基础胰岛素支持的病人特别有帮助。装置80还包括机构，该机构包括卷绕件84和触发器86，用于针对饮食输送大剂量胰岛素。提供填充薄膜88，以便用快效胰岛素填充胰岛素贮液器(未示出)。
图6示出了具有内部贮液器92的输液端口90的一个实施例，该内部贮液器92容纳快效胰岛素，用于每单位时间恒定输送固定量的胰岛素以满足病人的基础需求，以及利用附加大剂量模块94来提供单独的大剂量胰岛素输送。模块94配合到内部贮液器上，用于饮食的需要。模块94可以容纳足够的胰岛素，以便比容纳在贮液器92内的胰岛素维持得久得多。当贮液器92被排空时，模块94可以简单地与贮液器92那样与另外一个贮液器配合。通过输液管96可以输送恒定馈给的胰岛素和大剂量胰岛素。装置可以用胶带98粘附到皮肤上。
图7示出了一次性胰岛素输液装置100，该一次性胰岛素输液装置100利用基本恒定的压力源以及小流量控制孔来输送恒定流量的胰岛素。更具体地说，装置100包括贮液器101，贮液器101包括用于容纳快效胰岛素的室102。室102的壁104包括小孔106。室102的另外一个壁109在弹簧110的影响下是可移动的，弹簧110在扩展室112内。这增压了贮液器102，以便控制通过孔106并进入输液管或套管108中的胰岛素的流量。因此，图7中的装置100类似于图3中的装置，类似之处在于，胰岛素的贮液器被增压以便将恒定流量的胰岛素输送到套管中。
图7A是类似于图7的装置100的另外一个装置115的操作的示意图。在这里，可以看到，利用增压贮液器102内的气体对胰岛素增压。孔106通过到输液管或套管108的控制量来限制胰岛素的流量。另外，装置115包括大剂量泵114，以便从另外一个贮液器(或相同的贮液器)中将大剂量的快效胰岛素泵到输液管或套管108中。泵114可以是固定行程活塞泵。还有，如前一个实施例一样，单向阀45和47被设置在泵114的相对侧上。
图8和图9示出了实施本发明的另外一个一次性胰岛素输液装置120。这里，提供体积调节机构，以便控制利用每次致动输送的胰岛素的体积。这种致动可以是手动的，来调节针对饮食的大剂量胰岛素，或是用于每隔特定时间间隔对可调节的有效基础速度进行调节。
更具体来说，装置120包括用于容纳快效胰岛素的贮液器122。装置还包括具有凹槽126的盘124，凹槽126的深度沿着盘124的圆周增加。柔性管130从贮液器122绕着盘124并在凹槽126内延伸。带132从固定结点134沿着管130延伸到致动器136。随着盘在顺时针方向上旋转，管130保留在凹槽126中的长度增加。相反地，盘124的逆时针方向的旋转将使管130保留在凹槽126中的长度减小。当致动器136在箭头138的方向上移动时，带132对不在凹槽126内的管130的部分作用(压缩)，导致测量剂量的胰岛素被输送到输液管140中。因此，随着更多的管受到带132的作用，更大体积的剂量通过蠕动动作来输送。盘124可以利用转盘来旋转，该转盘诸如图5的装置86的转盘82。
图10示意性示出实施本发明的另一个一次性胰岛素输液装置150的操作。在这里，有分别用于快效胰岛素和缓效胰岛素的单独贮液器152和154。每个贮液器与其自身的泵相关联。贮液器152与泵156相关联，而贮液器154与泵158相关联。泵156和158可以是所示的固定行程活塞泵。贮液器152和154在泵156和158的泵送动作下将其各自的胰岛素输送到共用端口160，该共用端口160连接到套管162上。单向阀145和147在泵156的相对侧上，而单向阀141和143在泵158的相对侧上。
图11和图12示出了实施本发明的大剂量泵170。如所示例的，泵170采用的是圆顶泵(dome pump)的形式。图11示出了被病人的手指172压下之前的泵170，而图12示出了在压下之后的泵以及胰岛素的输送。泵170可以布置为在每次致动下输送0.5单位的胰岛素，并在泵的每次致动下提供触觉反馈。
可以注意到，泵包括有弹性的薄膜174，薄膜174通过密封环178密封到底座176上。底座可以通过胶带(未示出)粘附到病人皮肤上。泵170还包括进给阀180，当薄膜返回到图11所示出的构造时，进给阀180允许胰岛素进入到由薄膜174以及底座176形成的内腔184中。如图12所示，当薄膜被压下时，输出阀182允许胰岛素从腔184中流出。内腔可以布置为针对泵170的每次下压排出0.5单位体积的胰岛素。因此，例如，如果一顿饭需要3单位的胰岛素，那么泵170可以下压6次，以便将所需量的胰岛素输送到病人体中。
虽然示出并说明了本发明的具体实施例，但是可以有修改，因此意图在所附权利要求中涵盖本发明的权利要求所限定的真正精神以及范围之内的所有这样的变化以及修改。

Claims (20)

1.一种一次性输液装置，包括：
底座，其布置为粘附到病人皮肤上；
套管，其布置为从所述底座延伸到病人皮肤的下面，以便输送液体药剂到病人体内；以及
源，其布置为向所述套管提供液体药剂，所述源包括泵，所述泵将所述液体药剂泵送进所述套管中，所述泵包括可压缩管。
2.根据权利要求1所述的装置，其中，所述源还包括容纳所述液体药剂的贮液器，以及其中，所述可压缩管与所述贮液器连通。
3.根据权利要求1所述的装置，其中，所述源还包括管压缩器，所述管压缩器压缩一段长度的所述可压缩管，以便将所述液体药剂泵送进所述套管中。
4.根据权利要求3所述的装置，其中，所述管压缩器包括带，所述带固定到所述可压缩管的端部，并沿着所述可压缩管延伸。
5.根据权利要求4所述的装置，其中，所述管压缩器还包括致动器，所述致动器相对于所述可压缩管拉动所述带，以便压缩所述可压缩管。
6.根据权利要求5所述的装置，其中，所述管压缩器还包括具有圆周表面的盘，所述盘支撑所述可压缩管，以及其中，所述致动器布置为相对于所述盘的圆周拉动所述带并对所述可压缩管进行压缩。
7.根据权利要求5所述的装置，还包括体积调节器，所述体积调节器调节利用所述致动器的每次致动泵送进所述套管中的液体药剂的体积。
8.根据权利要求7所述的装置，其中，所述管压缩器还包括具有圆周表面的盘，所述盘支撑所述可压缩管，其中，所述致动器布置为相对于所述盘的圆周拉动所述带并压缩所述可压缩管，其中，所述体积调节器包括在所述盘的圆周表面内的凹槽，所述凹槽具有沿着所述盘的圆周增加的深度，所述凹槽布置为接收所述可压缩管，以及所述盘能够旋转以改变凹槽的接收所述可压缩管的长度，从而调节在所述致动器的每次致动下泵送进所述套管中的液体药剂的体积。
9.根据权利要求8所述的装置，其中，所述盘布置为，随着凹槽的接收所述可压缩管的长度减少，被泵进所述套管的液体药剂的体积增加。
10.根据权利要求3所述的装置，其中，所述源还包括容纳所述液体药剂的贮液器，以及其中，所述可压缩管与所述贮液器连通。
11.根据权利要求10所述的装置，其中，所述管压缩器包括带，所述带固定到所述可压缩管的端部，并沿着所述可压缩管延伸。
12.根据权利要求11所述的装置，其中，所述管压缩器还包括致动器，所述致动器相对于所述可压缩管拉动所述带，以压缩所述可压缩管。
13.根据权利要求12所述的装置，其中，所述管压缩器还包括具有圆周表面的盘，所述盘支撑所述可压缩管，以及其中，所述致动器布置为相对于所述盘的圆周拉动所述带并压缩所述可压缩管。
14.根据权利要求12所述的装置，还包括体积调节器，所述体积调节器调节在所述致动器的每次致动下被泵送进所述套管中的液体药剂的体积。
15.根据权利要求14所述的装置，其中，所述管压缩器还包括具有圆周表面的盘，所述盘支撑所述可压缩管，其中，所述致动器布置为相对于所述盘的圆周拉动所述带并压缩所述可压缩管，其中，所述体积调节器包括在所述盘的圆周表面内的凹槽，所述凹槽具有沿着所述盘的圆周增加的深度，所述凹槽布置为接收所述可压缩管，以及所述盘可以旋转以改变凹槽的接收所述可压缩管的长度，从而调节在所述致动器的每次致动下被泵送到所述套管中的液体药剂的体积。
16.根据权利要求15所述的装置，其中，所述盘布置为，随着所述凹槽的接收所述可压缩管的长度减少，被泵送到所述套管中的液体药剂的体积增加。
17.一种一次性输液装置，包括：
底座，所述底座布置为粘附到病人皮肤上；
套管，所述套管布置为从所述底座延伸到病人皮肤下面，以便将液体药剂输送到病人体内；以及
源，所述源布置为向所述套管提供液体药剂，所述源包括贮液器和泵，所述贮液器容纳所述液体药剂，所述泵将所述液体药剂从所述贮液器泵送到所述套管中，所述泵包括可压缩管和管压缩器，所述管压缩器压缩一段长度的所述可压缩管，以将所述液体药剂泵送进所述套管中。
18.根据权利要求17所述的装置，其中，所述管压缩器能够调节，用于改变被压缩的所述可压缩管的长度。
19.根据权利要求18所述的装置，其中，所述管压缩器还包括具有圆周表面的盘，所述盘支撑所述可压缩管，以及其中，所述致动器布置为相对于所述盘的圆周拉动所述带并压缩所述可压缩管。
20.根据权利要求19所述的装置，其中，所述盘的圆周表面包括凹槽，所述凹槽布置为接收所述可压缩管，以及其中，所述凹槽的接收所述可压缩管的长度能够调节以改变被压缩的所述可压缩管的长度。
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AU2007227638A1 (en) 2007-09-27
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US8114064B2 (en) 2012-02-14
JP2009529964A (ja) 2009-08-27
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EP1998841A2 (en) 2008-12-10
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JP2009529960A (ja) 2009-08-27
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EP1998839A2 (en) 2008-12-10
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CA2681789A1 (en) 2007-09-27
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