CN101485573A - Non-invasive blood sugar detection and monitoring instrument - Google Patents
Non-invasive blood sugar detection and monitoring instrument Download PDFInfo
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- CN101485573A CN101485573A CNA2009101054385A CN200910105438A CN101485573A CN 101485573 A CN101485573 A CN 101485573A CN A2009101054385 A CNA2009101054385 A CN A2009101054385A CN 200910105438 A CN200910105438 A CN 200910105438A CN 101485573 A CN101485573 A CN 101485573A
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Abstract
The invention discloses a noninvasive blood sugar detection monitor, which comprises an impulse device unit, a processor unit and a sensor unit, wherein the impulse device unit and the sensor unit are connected with the processor unit; the impulse device unit forms noninvasive impulse capable of changing blood sugar reaction at a sampling position according to preset impulse conditions; the sensor unit acquires the characteristic value of sugar reaction at the sampling position; a blood sugar value is calculated by the processor unit according to the characteristic value; and the impulse device unit comprises a closed module used to close the sampling position and form a closed space with the sampling position as well as an oxygen adjusting module used to adjust oxygen concentration inside the closed space. The blood sugar detection monitor does not form a cut at the sampling position and obtains the blood sugar value through acquiring the characteristic value after impulse reaction, thereby realizing noninvasive, simple and quick detection and monitoring of blood sugar.
Description
Technical field
The invention relates to a kind of non-invasive blood sugar detection and monitoring instrument that is used for the blood sugar test monitoring.
Background technology
The number of middle national trouble diabetes has occupied second in the whole world, and the epidemiological survey of China in 2007 shows that the prevalence of diabetes is up to 10.4%, and diabetes also are the 3rd diseases that causes national death.The blood sugar test technology is the key of diagnosis of diabetes and treatment.Blood glucose is meant the concentration of the glucose in the blood.Blood glucose can adopt venous blood and capillary blood to measure.The venous blood plasma glucose concentration detects and is mainly used in diagnosis of diabetes.The pocket rapid blood sugar instrument of measuring the blood capillary whole blood can be used for the blood glucose self-monitoring of emergency case's blood sugar monitoring and diabetics, should not be used for diagnosis.Present stage, the glucose assays carried out of China clinical laboratory was mainly glucoseoxidase (GOD) method, glucose hexokinase (HK) method and oxygen electrode performance rate method.But, being applied to clinical blood sugar test technology at present and resting on all the time on the method for wound, patient endures the double wound sufferings of injection of insulin and blood sugar test to the fullest extent.
Summary of the invention
Technical problem to be solved by this invention is, overcomes the deficiencies in the prior art, provides a kind of blood glucose noinvasive of can realizing to detect monitoring and detect the blood sugar detection and monitoring instrument of monitoring simple and fast.
The technical solution adopted for the present invention to solve the technical problems is: a kind of non-invasive blood sugar detection and monitoring instrument, comprise impulse unit, processor unit and sensor unit, impulse unit and sensor unit all are connected with processor unit, the impulse unit forms the noinvasive impulse that changes blood glucose response according to default impulse condition at the sampling position, the eigenvalue of sensor unit collection sampling position blood glucose response, processor unit draws blood glucose value according to this eigenvalue.
Described impulse unit comprise be used for airtight sampling position and and the sampling position between form the airtight module of confined space and be used to regulate the accent oxygen module of oxygen concentration in the confined space.Described impulse unit also comprises the voltage regulating module that is used to regulate the confined space internal gas pressure.
Described impulse unit comprises the reagent interpolation module that is used for smearing at the sampling position the responsive reagent of blood glucose.Described impulse unit comprises and is used for smearing at the sampling position and can adds module with the substance that show color of the substance that show color of blood glucose response colour developing.
Described sensor unit is selected from: carbon dioxide sensor, humidity sensor, sensors for hydrogen ion, oxygen sensor, blood oxygen transducer, imageing sensor, temperature sensor, electric-field sensor, magnetic field sensor.
Described processor unit also is connected with display unit.Described processor unit also is connected with the communications interface unit that is connected with outer signals.Described processor unit also signal is connected with the impulse condition enactment unit that is used to set the impulse condition, and processor unit is according to the work of impulse condition control impulse unit.Described blood glucose is the glucose in the blood.
The invention has the beneficial effects as follows that blood sugar detection and monitoring instrument can not form wound at the position of sampling, can draw blood glucose value, realized blood glucose noinvasive, simple and detection monitoring efficiently by gathering the reacted eigenvalue of impulse.
Description of drawings
Fig. 1 is the structured flowchart of present embodiment non-invasive blood sugar detection and monitoring instrument;
Fig. 2 is the workflow block diagram of present embodiment non-invasive blood sugar detection and monitoring instrument.
The specific embodiment
As shown in Figures 1 and 2, the present embodiment non-invasive blood sugar detection and monitoring instrument comprises processor unit, impulse condition enactment unit, impulse unit, sensor unit, display unit and communications interface unit, and impulse condition enactment unit, impulse unit, sensor unit, display unit and communications interface unit all are connected with this processor unit signal.Signal, control display unit that the work of impulse condition control impulse unit, analysis and the processes sensor unit that processor unit is used for setting according to impulse condition enactment unit feeds back show.Impulse condition enactment unit is used for carrying out the impulse condition setting for detecting the monitor operator.The impulse unit is used for forming the noinvasive impulse that changes blood glucose response according to default impulse condition at the sampling position, and can be for there be the sampling position in the wound blood sugar test at this sampling position.The impulse unit can be finished impulses such as sealing, adjust blood pressure or the negative pressure action to the sampling position, also can finish various test agent, supply of raw material, as the supply of oxygen, glucoseoxidase etc.The impulse that the impulse unit can be finished has: a) airtight sampling position and the sampling position transferred oxygen simultaneously; B) simultaneously airtight sampling position and to sampling position adjust blood pressure, transfer oxygen; C) airtight sampling position and the sampling position smeared the responsive reagent of blood glucose simultaneously; D) produce the motion that consumes blood glucose at the sampling position, as squeeze dynamometer; E) airtight sampling position and the sampling position heated up or cooling simultaneously, heat the sampling position as signal, waveform generation module by specific band, as the existing microwave generation module that can realize microwave heating, certainly, this signal, waveform generation module also can promote signal, the waveform generation module of blood glucose response liveness for other.Sensor unit is used to gather physics, chemistry, the bio signal at sampling position, promptly obtains the eigenvalue of sampling position blood glucose response, and this eigenvalue is fed back to processor unit.Sensor unit is selected from: temperature sensor, carbon dioxide sensor, humidity sensor, sensors for hydrogen ion, blood oxygen transducer, oxygen sensor, imageing sensor.Display unit is used for the signal of processor unit is shown, and realizes the demonstration directly perceived to the blood sugar test monitoring, this display unit such as existing LCD, LED, CRT, touch screen etc.Communications interface unit is used to realize that blood sugar detection and monitoring instrument is connected with extraneous signal, as existing network, communication interface such as wireless, wired.
Now the impulse condition with " sealing+accent oxygen " is the detection observation process of example explanation non-invasive blood sugar detection and monitoring instrument.The impulse unit comprises and is used for airtight module that sampling position and ambient air are separated, form confined space between this airtight module and the sampling position (skin), the impulse unit also comprises the accent oxygen module that is used to regulate oxygen concentration in the confined space, transfer the oxygen module by this, make the oxygen concentration in the confined space reach the setting oxygen concentration, this setting oxygen concentration can be higher or lower than the oxygen content of ambient air.Because blood glucose is to the oxygen concentration sensitivity, by forming confined space at the sampling position and adjusting oxygen concentration in this confined space, the percutaneous respiratory function of oxygen carry out dialysis in the blood and and blood glucose response, sensor unit is gathered the eigenvalue that blood glucose response obtains, and processor unit is handled this eigenvalue and drawn blood glucose value.
Because blood glucose and oxygen reaction generate carbon dioxide and water, carbon dioxide that this reaction generates and water can make carbon dioxide content and the humidity in the confined space change, gather the carbon dioxide content value and feed back to processor unit by carbon dioxide sensor, processor unit can obtain blood glucose value to this numerical value analysis.In like manner, also can gather humidity value in the confined space by humidity sensor, processor unit can draw blood glucose value according to this humidity value.
Because blood glucose and oxygen reaction can produce hydrion, hydrogen ion concentration in the confined space is changed, cause electric field, magnetic field to change, gather the hydrion content value and feed back to processor unit by sensors for hydrogen ion, processor unit can draw blood glucose value to this numerical value analysis.Certainly, also can gather electric field, magnetic field value and feed back to processor unit by electric field, magnetic field sensor.
Because when blood glucose and oxygen reaction, the oxygen content in the blood also can change, and gathers blood oxygen levels by blood oxygen transducer, draws blood glucose value by the processor unit analysis.
Because when blood glucose and oxygen reaction, remnant oxygen and concentration of carbon dioxide also can change in the confined space, gather remaining concentration value by oxygen sensor and carbon dioxide sensor, processor unit also can draw blood glucose value according to this residual concentration value.
Because when blood glucose and oxygen reaction, the color of sampling position skin can change, and gathers this image by imageing sensor, draws blood glucose value by processor unit according to this change color.Utilize change color to draw the situation of blood glucose value for this kind, the impulse unit can comprise that substance that show color adds module, this substance that show color and blood glucose response generate specific color, thereby can improve the precision of blood sugar test, this substance that show color such as copper sulfate, thioacetamide etc.
As shown in Figure 2, in the present embodiment, the operator sets the impulse condition by impulse condition enactment unit, the impulse unit is according to this impulse condition initialization (as adjust blood pressure, accent oxygen, airtight sampling position etc.), impulse condition when the sampling position reaches when imposing a condition, the eigenvalue of blood glucose response is gathered in sensor unit work, and this eigenvalue is fed back to processor unit, and processor unit carries out analyzing and processing and obtains blood glucose value this eigenvalue.In order to improve the degree of accuracy of detection, monitoring, can carry out duplicate detection to the sampling position.
In the present embodiment, the impulse unit comprises airtight module and accent oxygen module, and realization is to the airtight of sampling position and transfer oxygen, and behind the accent oxygen, the interior oxygen concentration of confined space reaches the setting oxygen concentration; The impulse unit also can comprise airtight module, transfer oxygen module and voltage regulating module, realize to the sampling position airtight, transfer oxygen and adjust blood pressure, after the adjust blood pressure, the air pressure in the confined space reaches setting air pressure.The impulse unit can comprise that airtight module and the responsive reagent of blood glucose add module, realize the airtight of position of sampling by airtight module, add module by reagent and add the responsive reagent of blood glucose, and then promote blood glucose response, this sensitivity reagent such as glucoseoxidase etc.The impulse unit can comprise signal, waveform generation module, and by the temperature or the adjustment blood glucose molecule liveness at this module adjustment sampling position, this module is as producing the microwave module of microwave.Various impulse units may be used alone, can also be used in combination.Various sensor units may be used alone, can also be used in combination, as using carbon dioxide sensor and humidity sensor simultaneously.For processor unit, can store corresponding relation or corresponding curve between eigenvalue and the blood glucose value in advance, after the eigenvalue that sensor unit collects fed back to processor unit, processor unit can draw blood glucose value; Certainly, processor unit also can draw blood glucose value by the alternate manner analysis.
Carrying out Woundless blood sugar detects when monitoring, can adopt dynamic, static method to judge blood glucose value, as before motion, gathering various eigenvalues (carbon dioxide content, humidity, blood oxygen etc. as the aforementioned) by sensor unit, also by sensor unit acquisition characteristics value, the variation by the comparative feature value draws blood glucose value after motion.Certainly, also can adopt oxygen uptake before, oxygen uptake compared afterwards, i.e. equal acquisition characteristics value before the oxygen uptake and after the oxygen uptake obtains blood glucose value by this eigenvalue relatively.Also can gather respectively and not add impulse condition and the eigenvalue when adding the impulse condition, draw blood glucose value by the variation of this eigenvalue relatively, as refer to leftward, toe, ear-lobe etc. add the impulse condition, and refer at the right hand, toe, ear-lobe etc. do not add the impulse condition; Perhaps the mode of taking respectively to add impulse and do not add impulse at two sampling positions draws two eigenvalues, is worth corresponding blood glucose value by comparative feature.
For non-invasive blood sugar detection and monitoring instrument, blood glucose can be the glucose in the blood or other saccharide.
Above content be in conjunction with concrete preferred implementation to further describing that the present invention did, can not assert that concrete enforcement of the present invention is confined to these explanations.For the general technical staff of the technical field of the invention, without departing from the inventive concept of the premise, can also make some simple deduction or replace, all should be considered as belonging to protection scope of the present invention.
Claims (10)
1. non-invasive blood sugar detection and monitoring instrument, it is characterized in that: comprise impulse unit, processor unit and sensor unit, impulse unit and sensor unit all are connected with processor unit, the impulse unit forms the noinvasive impulse that changes blood glucose response according to default impulse condition at the sampling position, the eigenvalue of sensor unit collection sampling position blood glucose response, processor unit draws blood glucose value according to this eigenvalue.
2. non-invasive blood sugar detection and monitoring instrument according to claim 1 is characterized in that: described impulse unit comprise be used for airtight sampling position and and the sampling position between form the airtight module of confined space and be used to regulate the accent oxygen module of oxygen concentration in the confined space.
3. non-invasive blood sugar detection and monitoring instrument according to claim 2 is characterized in that: described impulse unit also comprises the voltage regulating module that is used to regulate the confined space internal gas pressure.
4. non-invasive blood sugar detection and monitoring instrument according to claim 1 is characterized in that: described impulse unit comprises the reagent interpolation module that is used for smearing at the sampling position the responsive reagent of blood glucose.
5. non-invasive blood sugar detection and monitoring instrument according to claim 1 is characterized in that: described impulse unit comprises and is used for smearing at the sampling position and can adds module with the substance that show color of the substance that show color of blood glucose response colour developing.
6. according to any described non-invasive blood sugar detection and monitoring instrument among the claim 1-5, it is characterized in that: described sensor unit is selected from: carbon dioxide sensor, humidity sensor, sensors for hydrogen ion, oxygen sensor, blood oxygen transducer, imageing sensor, temperature sensor, electric-field sensor, magnetic field sensor.
7. non-invasive blood sugar detection and monitoring instrument according to claim 1 is characterized in that: described processor unit also is connected with display unit.
8. non-invasive blood sugar detection and monitoring instrument according to claim 1 is characterized in that: described processor unit also is connected with the communications interface unit that is connected with outer signals.
9. non-invasive blood sugar detection and monitoring instrument according to claim 1 is characterized in that: described processor unit also signal is connected with the impulse condition enactment unit that is used to set the impulse condition, and processor unit is according to the work of impulse condition control impulse unit.
10. non-invasive blood sugar detection and monitoring instrument according to claim 1 is characterized in that: described blood glucose is the glucose in the blood.
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| CN2009101054385A CN101485573B (en) | 2009-02-12 | 2009-02-12 | Non-invasive blood sugar detection and monitoring instrument |
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| CN2009101054385A CN101485573B (en) | 2009-02-12 | 2009-02-12 | Non-invasive blood sugar detection and monitoring instrument |
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| CN101485573A true CN101485573A (en) | 2009-07-22 |
| CN101485573B CN101485573B (en) | 2010-09-29 |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010121414A1 (en) * | 2009-04-21 | 2010-10-28 | Zhang Fan | Non-invasive blood sugar monitor and method to monitor the blood sugar |
| WO2010121413A1 (en) * | 2009-04-21 | 2010-10-28 | 中山大学 | Non-invasive blood glucose detection and monitoring device using impulse response and method therefor |
| CN103188993A (en) * | 2010-11-05 | 2013-07-03 | 自由医疗科技公司 | Apparatus and method for non-invasively detecting diseases that affect structural properties in biological tissues |
| CN108209942A (en) * | 2017-12-20 | 2018-06-29 | 清华大学 | A kind of non-invasive continuous blood sugar measuring system |
| CN108968977A (en) * | 2017-06-02 | 2018-12-11 | 昇阳国际半导体股份有限公司 | Blood sugar measuring device |
| CN109125037A (en) * | 2018-09-26 | 2019-01-04 | 济南普若培森智能科技有限公司 | A kind of auxiliary expectoration device and method with intelligent monitoring function |
-
2009
- 2009-02-12 CN CN2009101054385A patent/CN101485573B/en not_active Expired - Fee Related
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010121414A1 (en) * | 2009-04-21 | 2010-10-28 | Zhang Fan | Non-invasive blood sugar monitor and method to monitor the blood sugar |
| WO2010121413A1 (en) * | 2009-04-21 | 2010-10-28 | 中山大学 | Non-invasive blood glucose detection and monitoring device using impulse response and method therefor |
| CN103188993A (en) * | 2010-11-05 | 2013-07-03 | 自由医疗科技公司 | Apparatus and method for non-invasively detecting diseases that affect structural properties in biological tissues |
| CN108968977A (en) * | 2017-06-02 | 2018-12-11 | 昇阳国际半导体股份有限公司 | Blood sugar measuring device |
| CN108209942A (en) * | 2017-12-20 | 2018-06-29 | 清华大学 | A kind of non-invasive continuous blood sugar measuring system |
| CN108209942B (en) * | 2017-12-20 | 2019-05-24 | 清华大学 | A kind of non-invasive continuous blood sugar measuring system |
| WO2019119851A1 (en) * | 2017-12-20 | 2019-06-27 | 清华大学 | Non-invasive continuous blood glucose measurement system |
| CN109125037A (en) * | 2018-09-26 | 2019-01-04 | 济南普若培森智能科技有限公司 | A kind of auxiliary expectoration device and method with intelligent monitoring function |
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| Publication number | Publication date |
|---|---|
| CN101485573B (en) | 2010-09-29 |
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